Symbol
Name
ID

Cnr1
cannabinoid receptor 1
MGI:104615

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Decreased resting energy expenditure	Type II diabetes mellitus	Insulin resistance
Disease(s) Associated with CNR1	Decreased resting energy expenditure	Type II diabetes mellitus	Insulin resistance
obesity
type 2 diabetes mellitus

Mouse Phenotypes

homeostasis/metabolism phenotype

increased susceptibility to neuronal excitotoxicity

decreased susceptibility to diet-induced obesity

increased circulating estradiol level

increased circulating corticosterone level

decreased circulating insulin level

decreased circulating leptin level

increased circulating adrenocorticotropin level

decreased circulating progesterone level

edema

increased insulin sensitivity

increased follicle stimulating hormone level

increased susceptibility to xenobiotic induced morbidity/mortality

increased physiological sensitivity to xenobiotic

increased susceptibility to ischemic brain injury

increased cerebral infarct size

Availability

Mouse Genotype

Cnr1^{tm1.1(KOMP)Vlcg}/Cnr1^{tm1.1(KOMP)Vlcg}

Cnr1^tm1.1Kpm/Cnr1^tm1.1Kpm

Cnr1^tm1.1Ltz/Cnr1^tm1.1Ltz

Cnr1^tm1Map/Cnr1^tm1Map

Cnr1^tm1Ojm/Cnr1^tm1Ojm

Cnr1^tm1Zim/Cnr1^tm1Zim

Cnr1^tm2Ltz/Cnr1^tm2Ltz

Cnr1^{tm1.1(KOMP)Vlcg}/Cnr1⁺

Cnr1^tm1Map/Cnr1⁺

Cnr1^tm1.1Pcn/Cnr1^tm1.1Pcn
Tg(Phox2b-cre)1Jke/0 (conditional)

Cnr1^tm1.2Ltz/Cnr1^tm1.2Ltz
Tg(Camk2a-cre)2Gsc/0 (conditional)

Cnr1^tm2Ltz/Cnr1^tm2.1Ltz
Neurod6^tm1(cre)Kan/Neurod6⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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