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Cdkn1a
Gene Detail
Symbol

Name
ID
Cdkn1a
cyclin-dependent kinase inhibitor 1A (P21)
MGI:104556
Synonyms
CAP20, CDKI, Cdkn1, CIP1, mda6, P21, p21Cip1, p21WAF, p21WAF1/CIP1, SDI1, Waf1
Feature Type
protein coding gene
Genetic Map
Chromosome 17
15.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr17:29090979-29100722 bp, + strand
From VEGA annotation of GRCm38

  9744 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:333  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: CDKN1A
Protein SuperFamily: cyclin-dependent kinase inhibitor p21
Gene Tree: Cdkn1a

Human
homologs
CDKN1A, cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1026
neXtProt AC: NX_P38936

Human Synonyms: CAP20, CDKN1, CIP1, MDA-6, P21, p21CIP1, SDI1, WAF1

Human Chr (Location): 6p21.2; chr6:36676460-36687339 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(12) Targeted(7)
 
Homozygotes for knock-out alleles exhibit increased spontaneous tumorigenesis, altered resistance to induced tumors, abnormal immune system morphology and physiology, delayed cellular senescence, abnormal response to xenobiotics and injury, and autoimmunity.
 
Human Diseases Modeled in Mice Using Cdkn1a (2)    Mutations Annotated to Human Diseases (3)   
Interactions
Cdkn1a interacts with 218 markers (Mir10a, Mir10b, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (61 annotations)
Process cell cycle, cell cycle arrest, ...
Component cyclin-dependent protein kinase holoenzyme complex, cytoplasm, ...
Function cyclin binding, cyclin-dependent protein kinase activating kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (249 records)
Data Summary: Results (522)    Tissues (289)    Images (85)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 19
RNA in situ 324
Northern blot 78
Western blot 60
RT-PCR 41
cDNA source data(164)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase cdkn1a ; ZFIN cdkn1a    NEW 
Molecular
reagents
All nucleic(188) Genomic(2) cDNA(169) Primer pair(13) Other(4)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000031654 (Evidence)
Ensembl Gene Model ENSMUSG00000023067 (Evidence)
Entrez Gene 12575 (Evidence)
UniGene 195663
DFCI TC1572105, TC1658697
DoTS DT.497056, DT.94345429
Consensus CDS Project CCDS28591.1
International Mouse Phenotyping Consortium Status Cdkn1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031654 VEGA Gene Model | MGI Sequence Detail 9744 C57BL/6J ±  kb
transcript OTTMUST00000078427 VEGA | MGI Sequence Detail 748 Not Applicable 
polypeptide OTTMUSP00000041699 VEGA | MGI Sequence Detail 159 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(3) : SNPs within 2kb(284 from dbSNP Build 137)    SNPs within 2kb including multiple locations(292)
Protein-related
information
ResourceIDDescription
InterPro IPR003175 Cyclin-dependent kinase inhibitor
Protein Ontology PR:000005274 cyclin-dependent kinase inhibitor 1
References
(Earliest) J:21445 el-Deiry WS, et al., WAF1, a potential mediator of p53 tumor suppression. Cell. 1993 Nov 19;75(4):817-25
(Latest) J:221894 Gonzalez-Valdes I, et al., Bmi1 limits dilated cardiomyopathy and heart failure by inhibiting cardiac senescence. Nat Commun. 2015;6:6473
All references(575)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-16760, MGD-MRK-25990

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory