Homozygotes for knock-out alleles exhibit increased spontaneous tumorigenesis, altered resistance to induced tumors, abnormal immune system morphology and physiology, delayed cellular senescence, abnormal response to xenobiotics and injury, and autoimmunity.
|Process||activation of protein kinase activity, cell cycle, ...|
|Component||cyclin-dependent protein kinase holoenzyme complex, cytoplasm, ...|
|Function||cyclin binding, cyclin-dependent protein kinase activating kinase activity, ...|
|RNA in situ||324|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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