Cdkn1a
Gene Detail

Symbol Name ID

Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) MGI:104556

Synonyms

CAP20, CDKI, Cdkn1, CIP1, mda6, P21, p21Cip1, p21WAF, p21, SDI1, Waf1

Feature Type

protein coding gene

Genetic Map

Chromosome 17

15.12 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr17:29090979-29100722 bp, + strand From VEGA annotation of GRCm38   9744 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:333  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: cyclin-dependent kinase inhibitor p21
Gene Tree: Cdkn1a

Human homologs

Human Homolog		CDKN1A, cyclin-dependent kinase inhibitor 1A (p21, Cip1)
NCBI Gene ID		1026
neXtProt AC		NX_P38936
Human Synonyms		CAP20, CDKN1, CIP1, MDA-6, P21, p21CIP1, SDI1, WAF1
Human Chr (Location)		6p21.2; chr6:36644237-36655116 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(18) : Targeted(6) Gene trapped(12)
 

Homozygotes for knock-out alleles exhibit increased spontaneous tumorigenesis, altered resistance to induced tumors, abnormal immune system morphology and physiology, delayed cellular senescence, abnormal response to xenobiotics and injury, and autoimmunity.

 
Human Diseases Modeled Using Mouse Cdkn1a (2)    Alleles Annotated to Human Diseases(3)   

Gene Ontology (GO) classifications

All GO classifications: (52 annotations)

Process	cell cycle, cell cycle arrest, ...
Component	cyclin-dependent protein kinase holoenzyme complex, cytoplasm, ...
Function	cyclin binding, cyclin-dependent protein kinase activating kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (203 records)
Data Summary: Results (504)    Tissues (272)    Images (72)
Theiler Stages: 9, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	8
RNA in situ	318
Northern blot	87
Western blot	60
RT-PCR	31

cDNA source data(160)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(178) Genomic(2) cDNA(164) Primer pair(8) Other(4)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000031654 (Evidence)
Ensembl Gene Model	ENSMUSG00000023067 (Evidence)
Entrez Gene	12575 (Evidence)
UniGene	195663
DFCI	TC1572105, TC1658697
DoTS	DT.497056, DT.94345429
Consensus CDS Project	CCDS28591.1
International Mouse Knockout Project Status	Cdkn1a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031654	VEGA Gene Model | MGI Sequence Detail	9744	C57BL/6J
transcript	OTTMUST00000078425	VEGA | MGI Sequence Detail	1910	Not Applicable
polypeptide	OTTMUSP00000041697	VEGA | MGI Sequence Detail	159	Not Applicable

All sequences(41) RefSeq(4) UniProt(3)

Polymorphisms

RFLP(3) : SNPs(268 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003175	Cyclin-dependent kinase inhibitor
Protein Ontology	PR:000005274	cyclin-dependent kinase inhibitor 1

References

(Earliest) J:21445 el-Deiry WS, et al., WAF1, a potential mediator of p53 tumor suppression. Cell. 1993 Nov 19;75(4):817-25
(Latest) J:194049 Johansson PA, et al., The transcription factor Otx2 regulates choroid plexus development and function. Development. 2013 Mar;140(5):1055-66
All references(491)

Other accession IDs

MGD-MRK-16760, MGD-MRK-25990