About   Help   FAQ
Cdkn1a Gene Detail
Summary
  • Symbol
    Cdkn1a
  • Name
    cyclin-dependent kinase inhibitor 1A (P21)
  • Synonyms
    CAP20, CDKI, Cdkn1, CIP1, mda6, P21, p21Cip1, p21WAF, p21WAF1/CIP1, SDI1, Waf1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104556
    NCBI Gene: 12575
  • Gene Overview
    MyGene.info: CDKN1A
Location & Maps
more
  • Sequence Map
    Chr17:29090979-29100722 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9744 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 15.12 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    CDKN1A, cyclin-dependent kinase inhibitor 1A
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CDKN1A, cyclin-dependent kinase inhibitor 1A
    Orthology source: HomoloGene
  • Synonyms
    CAP20, CDKN1, CIP1, MDA-6, P21, p21CIP1, SDI1, WAF1
  • Links
    NCBI Gene ID: 1026
    neXtProt AC: NX_P38936

  • Chr Location
    6p21.2; chr6:36676460-36687339 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Cdkn1a mouse models

Human Disease Mouse Models
       Hepatocellular Carcinoma   OMIM: 114550 View 4 models
Systemic Lupus Erythematosus; SLE   OMIM: 152700 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    103 phenotypes from 7 alleles in 13 genetic backgrounds
    167 phenotypes from multigenic genotypes
    258 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    22
  • Gene trapped
    12
  • Targeted
    9
  • Transgenic
    1
Homozygotes for knock-out alleles exhibit increased spontaneous tumorigenesis, altered resistance to induced tumors, abnormal immune system morphology and physiology, delayed cellular senescence, abnormal response to xenobiotics and injury, and autoimmunity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031654 VEGA Gene Model | MGI Sequence Detail 9744 C57BL/6J ±  kb
transcript OTTMUST00000078427 VEGA | MGI Sequence Detail 748 Not Applicable  
polypeptide OTTMUSP00000041699 VEGA | MGI Sequence Detail 159 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    239 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000005274 cyclin-dependent kinase inhibitor 1
  • InterPro Domains
    IPR003175 Cyclin-dependent kinase inhibitor
    IPR029841 Cyclin-dependent kinase inhibitor 1, vertebrate
Molecular
Reagents
less
  • All nucleic 191
    Genomic 2
    cDNA 169
    Primer pair 16
    Other 4

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-16760, MGD-MRK-25990
References
more
  • Summaries
    All 609
    Developmental Gene Expression 266
    Diseases 2
    Gene Ontology 22
    Phenotypes 258
  • Earliest
    J:21445 el-Deiry WS, et al., WAF1, a potential mediator of p53 tumor suppression. Cell. 1993 Nov 19;75(4):817-25
  • Latest
    J:231798 Chen CY, et al., Targeted inactivation of murine Ddx3x: essential roles of Ddx3x in placentation and embryogenesis. Hum Mol Genet. 2016 May 14;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/15/2016
MGI 6.04
The Jackson Laboratory