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Cdkn1a Gene Detail
Summary
  • Symbol
    Cdkn1a
  • Name
    cyclin-dependent kinase inhibitor 1A (P21)
  • Synonyms
    CAP20, CDKI, Cdkn1, CIP1, mda6, P21, p21Cip1, p21WAF, p21WAF1/CIP1, SDI1, Waf1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104556
    NCBI Gene: 12575
  • Gene Overview
    MyGene.info: CDKN1A
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:29090979-29100722 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 15.12 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    239 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104556
protein coding gene Chr17:29090979-29100722 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023457
protein coding gene Chr17:28595126-28604828 (+)
A/J MGP_AJ_G0023415
protein coding gene Chr17:27607641-27617267 (+)
AKR/J MGP_AKRJ_G0023380
protein coding gene Chr17:27840697-27850366 (+)
BALB/cJ MGP_BALBcJ_G0023420
protein coding gene Chr17:27890913-27900571 (+)
C3H/HeJ MGP_C3HHeJ_G0023181
protein coding gene Chr17:28230407-28240043 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023862
protein coding gene Chr17:29733095-29744217 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021337
protein coding gene Chr17:24947624-24957361 (+)
CAST/EiJ MGP_CASTEiJ_G0022682
protein coding gene Chr17:28210147-28219845 (+)
CBA/J MGP_CBAJ_G0023156
protein coding gene Chr17:30842560-30854337 (+)
DBA/2J MGP_DBA2J_G0023286
protein coding gene Chr17:27150660-27160345 (+)
FVB/NJ MGP_FVBNJ_G0023256
protein coding gene Chr17:26979385-26989106 (+)
LP/J MGP_LPJ_G0023364
protein coding gene Chr17:28849520-28859212 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023274
protein coding gene Chr17:30190553-30202221 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023904
protein coding gene Chr17:28297310-28307114 (+)
PWK/PhJ MGP_PWKPhJ_G0022432
protein coding gene Chr17:25987506-25997324 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022250
protein coding gene Chr17:26292933-26302601 (+)
WSB/EiJ MGP_WSBEiJ_G0022744
protein coding gene Chr17:28262784-28272496 (+)



Homology
more
  • Human Ortholog
    CDKN1A, cyclin dependent kinase inhibitor 1A
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CDKN1A, cyclin dependent kinase inhibitor 1A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAP20, CDKN1, CIP1, MDA-6, P21, p21CIP1, SDI1, WAF1
  • Links
    NCBI Gene ID: 1026
    neXtProt AC: NX_P38936
    UniProt: P38936

  • Chr Location
    6p21.2; chr6:36676460-36687339 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Cdkn1a mouse models

Human Disease Mouse Models
      
IDs
View 4 models
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    105 phenotypes from 7 alleles in 14 genetic backgrounds
    167 phenotypes from multigenic genotypes
    287 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for knock-out alleles exhibit increased spontaneous tumorigenesis, altered resistance to induced tumors, abnormal immune system morphology and physiology, delayed cellular senescence, abnormal response to xenobiotics and injury, and autoimmunity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12575 NCBI Gene Model | MGI Sequence Detail 9744 C57BL/6J ±  kb
    transcript NM_001111099 RefSeq | MGI Sequence Detail 1943 C57BL/6  
    polypeptide P39689 UniProt | EBI | MGI Sequence Detail 159 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 197
      Genomic 2
      cDNA 170
      Primer pair 19
      Other 6

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-16760, MGD-MRK-25990
    References
    more
    • Summaries
      All 776
      Developmental Gene Expression 326
      Diseases 3
      Gene Ontology 25
      Phenotypes 287
    • Earliest
      J:21445 el-Deiry WS, et al., WAF1, a potential mediator of p53 tumor suppression. Cell. 1993 Nov 19;75(4):817-25
    • Latest
      J:266162 Bertram KL, et al., 17-DMAG regulates p21 expression to induce chondrogenesis in vitro and in vivo. Dis Model Mech. 2018 Oct 8;11(10)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory