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Cdkn1a Gene Detail
Summary
  • Symbol
    Cdkn1a
  • Name
    cyclin dependent kinase inhibitor 1A
  • Synonyms
    CAP20, CDKI, Cdkn1, CIP1, mda6, P21, p21Cip1, p21WAF, p21WAF1/CIP1, SDI1, Waf1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104556
    NCBI Gene: 12575
  • Alliance
    genome feature page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:29309953-29319696 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 15.12 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    279 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104556
 protein coding gene Chr17:29309950-29319701 (+)
129S1/SvImJ ENSMUSG00200053149
 protein coding gene Chr17:24968644-24978380 (+)
A/J ENSMUSG00195048957
 protein coding gene Chr17:25784302-25793997 (+)
AKR/J ENSMUSG00220052850
 protein coding gene Chr17:24831981-24841675 (+)
BALB/cJ ENSMUSG00180042709
 protein coding gene Chr17:25271140-25280877 (+)
C3H/HeJ ENSMUSG00175050884
 protein coding gene Chr17:24820278-24829971 (+)
C57BL/6NJ ENSMUSG00215050353
 protein coding gene Chr17:24822191-24831920 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021337
 protein coding gene Chr17:24947624-24957361 (+)
CAST/EiJ ENSTCUG00005047343
 protein coding gene Chr17:25559726-25569435 (+)
CBA/J ENSMUSG00210050123
 protein coding gene Chr17:24658700-24668393 (+)
DBA/2J ENSMUSG00185043650
 protein coding gene Chr17:26874763-26884498 (+)
FVB/NJ ENSMUSG00205021923
 protein coding gene Chr17:25137087-25146814 (+)
JF1/MsJ ENSUMUG00000042636
 protein coding gene Chr17:26343003-26352806 (+)
LP/J ENSMUSG00230054972
 protein coding gene Chr17:28394397-28404131 (+)
NOD/ShiLtJ ENSMUSG00190048390
 protein coding gene Chr17:24777579-24787347 (+)
NZO/HlLtJ ENSMUSG00225049610
 protein coding gene Chr17:30359745-30369476 (+)
PWK/PhJ ENSLUMG00010037108
 protein coding gene Chr17:24261619-24271412 (+)
SPRET/EiJ ENSMSPG00010049185
 protein coding gene Chr17:25554283-25564002 (+)
WSB/EiJ ENSIUOG00005048945
 protein coding gene Chr17:25529104-25538824 (+)



Homology
more
  • Human Ortholog
    CDKN1A, cyclin dependent kinase inhibitor 1A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDKN1A, cyclin dependent kinase inhibitor 1A
  • Synonyms
    CAP20, CDKN1, CIP1, MDA-6, P21, p21CIP1, SDI1, WAF1
  • Links
    NCBI Gene ID: 1026
    UniProt: P38936

  • Chr Location
    6p21.2; chr6:36676441-36687397 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Cdkn1a mouse models; 5 with human CDKN1A associations

Human Disease Mouse Models
      
IDs
 View 4 models
IDs
 View 2 models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    102 phenotypes from 6 alleles in 14 genetic backgrounds
    168 phenotypes from multigenic genotypes
    387 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for knock-out alleles exhibit increased spontaneous tumorigenesis, altered resistance to induced tumors, abnormal immune system morphology and physiology, delayed cellular senescence, abnormal response to xenobiotics and injury, and autoimmunity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    154
  • GO References
    33
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1978
  • Tissues
    487
  • cDNA Data
    169
  • Literature Summary
    484
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12575 NCBI Gene Model | MGI Sequence Detail 9744 C57BL/6J ±  kb
    transcript NM_001111099 RefSeq | MGI Sequence Detail 1943 ZRU/MplStud  
    polypeptide P39689 UniProt | EBI | MGI Sequence Detail 159 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000005274 cyclin-dependent kinase inhibitor 1
      (term hierarchy)
    • InterPro Domains
      IPR029841 Cyclin-dependent kinase inhibitor 1
      IPR003175 Cyclin-dependent kinase inhibitor domain
      IPR044898 Cyclin-dependent kinase inhibitor domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 250
      Genomic 2
      cDNA 174
      Primer pair 59
      Other 15
      Antibodies 41

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-16760, MGD-MRK-25990
    References
    more
    • Summaries
      All 1360
      Developmental Gene Expression 484
      Diseases 3
      Gene Ontology 33
      Phenotypes 387
    • Earliest
      J:21445 el-Deiry WS, et al., WAF1, a potential mediator of p53 tumor suppression. Cell. 1993 Nov 19;75(4):817-25
    • Latest
      J:390780 Qasrawi F, et al., DeltaNP63 regulates epithelial stratification and differentiation in the murine ureter. Am J Physiol Renal Physiol. 2026 Aug 1;331(2):F286-F303
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory