Mafb
Gene Detail

Symbol Name ID

Mafb v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian) MGI:104555

Synonyms

Kreisler, Krml, Krml1

Feature Type

protein coding gene

Genetic Map

Chromosome 2

80.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr2:160363703-160367065 bp, - strand From VEGA annotation of GRCm38   3363 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:31315  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Protein SuperFamily: maf transforming protein
Gene Tree: Mafb

Human homologs

Human Homolog		MAFB, v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
NCBI Gene ID		9935
neXtProt AC		NX_Q9Y5Q3
Human Synonyms		KRML, MCTO
Human Chr (Location)		20q11.2-q13.1; chr20:39314515-39317876 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MAFB

Alleles and phenotypes

All alleles(4) : Targeted(2) Chemically induced(1) Radiation induced(1)
 

Mutant homozygotes exhibit segmentation defects in the caudal hindbrain, loss of facial motor neurons, impaired inner ear development, arrested maturation of kidney podocytes, reduced fertility, and, in some cases, lethality at birth from apnea.

 

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	brain segmentation, inner ear morphogenesis, ...
Component	nucleus, transcription factor complex
Function	DNA binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (95 records)
Data Summary: Results (441)    Tissues (248)    Images (90)
Theiler Stages: 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 28

Assay Type	Results
Immunohistochemistry	10
RNA in situ	387
In situ reporter (knock in)	1
Northern blot	10
RT-PCR	33

cDNA source data(28)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(60) Genomic(17) cDNA(30) Primer pair(3) Other(10)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000001175 (Evidence)
Ensembl Gene Model	ENSMUSG00000074622 (Evidence)
Entrez Gene	16658 (Evidence)
NIA Mouse Gene Index	U023599
PDB	2WTY, 2WT7
Consensus CDS Project	CCDS16994.1
International Mouse Knockout Project Status	Mafb

Sequences

Length	Strain/Species
genomic	OTTMUSG00000001175	VEGA Gene Model | MGI Sequence Detail	3363	C57BL/6J
transcript	OTTMUST00000002303	VEGA | MGI Sequence Detail	3363	Not Applicable
polypeptide	OTTMUSP00000001132	VEGA | MGI Sequence Detail	323	Not Applicable

All sequences(25) RefSeq(2) UniProt(2)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(14 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR004827	Basic-leucine zipper domain
InterPro	IPR004826	Basic leucine zipper domain, Maf-type
InterPro	IPR008917	Eukaryotic transcription factor, Skn-1-like, DNA-binding
InterPro	IPR013592	Maf transcription factor, N-terminal
InterPro	IPR024874	Transcription factor Maf
Protein Ontology	PR:000010048	transcription factor MafB

References

(Earliest) J:208 Hertwig P, Neue Mutationen und Koppelungsgruppen bei der Hausmaus. Z Indukt Abstamm Vererbungsl. 1942;80:220-246
(Latest) J:194051 Heliot C, et al., HNF1B controls proximal-intermediate nephron segment identity in vertebrates by regulating Notch signalling components and Irx1/2. Development. 2013 Feb;140(4):873-85
All references(148)

Other accession IDs

MGD-MRK-11595, MGD-MRK-25987