Mafb MGI Mouse Gene Detail - MGI:104555 - v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)

Mafb Gene Detail

Symbol

Mafb
Name

v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)
Synonyms

Kreisler, Krml, Krml1

Feature Type

protein coding gene
IDs

MGI:104555
NCBI Gene: 16658
Gene Overview

MyGene.info: MAFB

Sequence Map

Chr2:160363703-160367065 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

3363 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 80.92 cM
Mapping Data

4 experiments

Human Ortholog

MAFB, MAF bZIP transcription factor B

Vertebrate Orthologs

8

Human Ortholog

MAFB, MAF bZIP transcription factor B
Orthology source: HomoloGene, HGNC
Synonyms

DURS3, KRML, MCTO
Links

HGNC:6408

NCBI Gene ID: 9935

neXtProt AC: NX_Q9Y5Q3

UniProt: Q9Y5Q3
Chr Location

20q12; chr20:40685848-40689240 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 31315
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 chicken;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: MAFB
Protein SuperFamily

maf transforming protein
Gene Tree

Mafb

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Phenotype Summary

56 phenotypes from 7 alleles in 9 genetic backgrounds
2 phenotypes from multigenic genotypes
43 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (ENU)

1
Radiation induced

1
Targeted

6
Incidental Mutations

APF
Find Mice (IMSR)

10 strains or lines available

Mutant homozygotes exhibit segmentation defects in the caudal hindbrain, loss of facial motor neurons, impaired inner ear development, arrested maturation of kidney podocytes, reduced fertility, and, in some cases, lethality at birth from apnea.

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All GO Annotations

30
GO References

14

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

455
Tissues

257
cDNA Data

28
Literature Summary

128

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA MAFB

ZFIN mafba

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Mafb interacts with 256 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

24
RefSeq

2
UniProt

2
CCDS

CCDS16994.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000001175	VEGA Gene Model \| MGI Sequence Detail	3363	C57BL/6J	± kb
transcript	OTTMUST00000002303	VEGA \| MGI Sequence Detail	3363	Not Applicable
polypeptide	OTTMUSP00000001132	VEGA \| MGI Sequence Detail	323	Not Applicable

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SNPs within 2kb

32 from dbSNP Build 142

PCR

1
RFLP

1

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UniProt

2 Sequences
Protein Ontology

PR:000010048 transcription factor MafB

(term hierarchy)
PDB

2WT7, 2WTY, 4AUW
InterPro Domains

IPR004827 Basic-leucine zipper domain

IPR004826 Basic leucine zipper domain, Maf-type

IPR013592 Maf transcription factor, N-terminal

IPR028571 Transcription factor MafB

IPR024874 Transcription factor Maf family

IPR008917 Transcription factor, Skn-1-like, DNA-binding domain

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All nucleic 63

Genomic 17

cDNA 31

Primer pair 5

Other 10

Microarray probesets 8

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MGD-MRK-11595, MGD-MRK-25987

Summaries

All 187

Developmental Gene Expression 128

Gene Ontology 14

Phenotypes 43
Earliest

J:208 Hertwig P, Neue Mutationen und Koppelungsgruppen bei der Hausmaus. Z Indukt Abstamm Vererbungsl. 1942;80:220-246
Latest

J:241960 Koshida R, et al., MafB is required for development of the hindbrain choroid plexus. Biochem Biophys Res Commun. 2017 Jan 29;483(1):288-293

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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