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Mafb
Gene Detail
Symbol

Name
ID
Mafb
v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)
MGI:104555
Synonyms
Kreisler, Krml, Krml1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
80.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:160363703-160367065 bp, - strand
From VEGA annotation of GRCm38

  3363 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31315  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog

HCOP human homology predictions: MAFB
Protein SuperFamily: maf transforming protein
Gene Tree: Mafb

Human
homologs
MAFB, v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 9935
neXtProt AC: NX_Q9Y5Q3

Human Synonyms: KRML, MCTO

Human Chr (Location): 20q12; chr20:40685848-40689240 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human MAFB

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(1) Radiation induced(1) Targeted(5)
Incidental mutations (data from APF )
 
Mutant homozygotes exhibit segmentation defects in the caudal hindbrain, loss of facial motor neurons, impaired inner ear development, arrested maturation of kidney podocytes, reduced fertility, and, in some cases, lethality at birth from apnea.
 
Interactions
Mafb interacts with 256 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process brain segmentation, inner ear morphogenesis, ...
Component nucleus, transcription factor complex
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (108 records)
Data Summary: Results (442)    Tissues (249)    Images (90)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 10
RNA in situ 388
In situ reporter (knock in) 1
Northern blot 10
RT-PCR 33
cDNA source data(28)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA MAFB ; Xenbase mafb ; ZFIN mafba    NEW 
Molecular
reagents
All nucleic(60) Genomic(17) cDNA(30) Primer pair(3) Other(10)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000001175 (Evidence)
Ensembl Gene Model ENSMUSG00000074622 (Evidence)
Entrez Gene 16658 (Evidence)
NIA Mouse Gene Index U023599
PDB 4AUW, 2WTY, 2WT7
Consensus CDS Project CCDS16994.1
International Mouse Phenotyping Consortium Status Mafb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001175 VEGA Gene Model | MGI Sequence Detail 3363 C57BL/6J ±  kb
transcript OTTMUST00000002303 VEGA | MGI Sequence Detail 3363 Not Applicable 
polypeptide OTTMUSP00000001132 VEGA | MGI Sequence Detail 323 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(2)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(32 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
InterPro IPR004826 Basic leucine zipper domain, Maf-type
InterPro IPR008917 Eukaryotic transcription factor, Skn-1-like, DNA-binding
InterPro IPR013592 Maf transcription factor, N-terminal
InterPro IPR024874 Transcription factor Maf
Protein Ontology PR:000010048 transcription factor MafB
References
(Earliest) J:208 Hertwig P, Neue Mutationen und Koppelungsgruppen bei der Hausmaus. Z Indukt Abstamm Vererbungsl. 1942;80:220-246
(Latest) J:219768 Nishimura W, et al., MafA is critical for maintenance of the mature beta cell phenotype in mice. Diabetologia. 2015 Mar;58(3):566-74
All references(163)
Other
accession IDs
MGD-MRK-11595, MGD-MRK-25987

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory