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Phenotypes Associated with This Genotype
involves: 129S4/SvJae * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mafbtm1.2Good mutation (0 available); any Mafb mutation (12 available)
Tg(Isl1-EGFP*)1Slp mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• by E12.5, aberrant branches of the oculomotor nerve begin to form in the direction of the lateral rectus muscle and retractor bulbi muscle
• at E13.5, the oculomotor nerve forms a second, more distal aberrant branch that extends toward the lateral rectus muscle in addition to the more proximal aberrant branches contacting the lateral rectus and retractor bulbi muscles
• by E16.5, the abducens nerve remains hypoplastic but provides some innervation to the lateral rectus muscle
• by E16.5, the lateral rectus muscle receives innervation form the distinct proximal and distal aberrant oculomotor nerve branches
• the diameter of the distal aberrant branch of the oculomotor nerve is greater than that of the proximal aberrant branch
• E11.5 embryos show hypoplastic abducens nerves

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Duane retraction syndrome DOID:12557 OMIM:126800

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory