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Phenotypes Associated with This Genotype
involves: 129S4/SvJae * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mafbtm1.2Good mutation (0 available); any Mafb mutation (12 available)
Tg(Isl1-EGFP*)1Slp mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• E11.5 embryos show severe malformations of the hindbrain, with loss of rhombomeres 5 and 6
• embryos show aberrant extraocular muscle innervation
• by E12.5, an aberrant branch of the oculomotor nerve forms and contacts the developing lateral rectus muscle along the normal abducens nerve trajectory and other aberrant branches develop and contact the retractor bulbi muscle
• at E13.5, the oculomotor nerve forms a second, more distal aberrant branch that extends toward the lateral rectus muscle in addition to the more proximal aberrant branches contacting the lateral rectus and retractor bulbi muscles
• by E16.5, the lateral rectus muscle receives innervation form the distinct proximal and distal aberrant oculomotor nerve branches
• the diameter of the distal aberrant branch of the oculomotor nerve is greater than that of the proximal aberrant branch
• abducens nerves are missing in E11.5 embryos
• E11.5 embryos show fusion of the glossopharyngeal and vagus nerves
• oculomotor nerve forms aberrant branches that contact the retractor bulbi and lateral rectus muscles at E12.5 to E16.5

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Duane retraction syndrome DOID:12557 OMIM:126800

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory