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Nog
Gene Detail
Symbol

Name
ID
Nog
noggin
MGI:104327
Feature Type
protein coding gene
Genetic Map
Chromosome 11
54.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr11:89300638-89302332 bp, - strand
From VEGA annotation of GRCm38

  1695 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3979  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 3 zebrafish

Protein SuperFamily: noggin
Gene Tree: Nog

Human
homologs
Human Homolog NOG, noggin
NCBI Gene ID 9241
neXtProt AC  NX_Q13253
Human Synonyms  SYM1, SYNS1
Human Chr (Location)  17q22; chr17:56593699-56595590 (+)  GRCh38
Disease Associations  (5) Diseases Associated with Human NOG
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Genomic Mutations involving Nog (2)
Incidental mutations (data from APF )
 
Homozygotes for a targeted null mutation exhibit failed closure of neural tube, exencephaly, wide club-shaped limbs, loss of tail vertebrae, shortened body axis, abnormal cartilage condensations, and lethality at birth.
 
Human Diseases Modeled Using Mouse Nog (1)    Alleles Annotated to Human Diseases(2)   
Interactions
Nog interacts with 211 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (132 records)
Data Summary: Results (361)    Tissues (154)    Images (133)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 259
In situ reporter (knock in) 87
Northern blot 3
RT-PCR 8
cDNA source data(10)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(32) Genomic(1) cDNA(14) Primer pair(4) Other(13)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000001321 (Evidence)
Ensembl Gene ModelENSMUSG00000048616 (Evidence)
Entrez Gene18121 (Evidence)
UniGene135266
DFCITC1708861, TC1606803
DoTSDT.55119448
NIA Mouse Gene IndexU033256
Consensus CDS ProjectCCDS25236.1
International Mouse Knockout Project StatusNog
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001321 VEGA Gene Model | MGI Sequence Detail 1695 C57BL/6J ±  kb
transcript OTTMUST00000002649 VEGA | MGI Sequence Detail 1695 Not Applicable 
polypeptide OTTMUSP00000001311 VEGA | MGI Sequence Detail 232 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(27 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008717 Noggin
Protein Ontology PR:000000021 noggin
References
(Earliest) J:28576 Valenzuela DM, et al., Identification of mammalian noggin and its expression in the adult nervous system. J Neurosci. 1995 Sep;15(9):6077-84
(Latest) J:213659 Fausett SR, et al., BMP antagonism by Noggin is required in presumptive notochord cells for mammalian foregut morphogenesis. Dev Biol. 2014 Jul 1;391(1):111-24
All references(210)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-25655

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory