Nog
Gene Detail

Symbol Name ID

Nog noggin MGI:104327

Feature Type

protein coding gene

Genetic Map

Chromosome 11

54.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr11:89300638-89302332 bp, - strand From VEGA annotation of GRCm38   1695 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3979  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 3 zebrafish

Protein SuperFamily: noggin
Gene Tree: Nog

Human homologs

Human Homolog		NOG, noggin
NCBI Gene ID		9241
neXtProt AC		NX_Q13253
Human Synonyms		SYM1, SYNS1
Human Chr (Location)		17q22; chr17:54671060-54672951 (+)  GRCh37.p10
Disease Associations		(5) Diseases Associated with Human NOG

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Homozygotes for a targeted null mutation exhibit failed closure of neural tube, exencephaly, wide club-shaped limbs, loss of tail vertebrae, shortened body axis, abnormal cartilage condensations, and lethality at birth.

 
Human Diseases Modeled Using Mouse Nog (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (74 annotations)

Process	anatomical structure formation involved in morphogenesis, axial mesoderm development, ...
Component	extracellular region, extracellular space
Function	cytokine binding, protein complex binding, ...

External Resources: FuncBase

Expression

Literature Summary: (119 records)
Data Summary: Results (311)    Tissues (137)    Images (102)
Theiler Stages: 5, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	228
In situ reporter (knock in)	70
Northern blot	3
RT-PCR	8

cDNA source data(10)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(29) Genomic(1) cDNA(14) Primer pair(4) Other(10)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000001321 (Evidence)
Ensembl Gene Model	ENSMUSG00000048616 (Evidence)
Entrez Gene	18121 (Evidence)
UniGene	135266
DFCI	TC1606803, TC1708861
DoTS	DT.55119448
NIA Mouse Gene Index	U033256
Consensus CDS Project	CCDS25236.1
International Mouse Knockout Project Status	Nog

Sequences

Length	Strain/Species
genomic	OTTMUSG00000001321	VEGA Gene Model | MGI Sequence Detail	1695	C57BL/6J
transcript	OTTMUST00000002649	VEGA | MGI Sequence Detail	1695	Not Applicable
polypeptide	OTTMUSP00000001311	VEGA | MGI Sequence Detail	232	Not Applicable

All sequences(20) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(3 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008717	Noggin
Protein Ontology	PR:000000021	noggin

References

(Earliest) J:28576 Valenzuela DM, et al., Identification of mammalian noggin and its expression in the adult nervous system. J Neurosci. 1995 Sep;15(9):6077-84
(Latest) J:192712 Meadows SM, et al., Integration of repulsive guidance cues generates avascular zones that shape mammalian blood vessels. Circ Res. 2012 Jan 6;110(1):34-46
All references(193)

Other accession IDs

MGD-MRK-25655