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Nog
Gene Detail
Symbol

Name
ID
Nog
noggin
MGI:104327
Feature Type
protein coding gene
Genetic Map
Chromosome 11
54.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr11:89300638-89302332 bp, - strand
From VEGA annotation of GRCm38

  1695 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3979  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 3 zebrafish

HCOP human homology predictions: NOG
Protein SuperFamily: noggin
Gene Tree: Nog

Human
homologs
NOG, noggin
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 9241
neXtProt AC: NX_Q13253

Human Synonyms: SYM1, SYNS1

Human Chr (Location): 17q22; chr17:56593699-56595590 (+)  GRCh38.p2

Disease Associations: (5) Diseases Associated with Human NOG

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(5) Transgenic(1)
Genomic Mutations involving Nog (3)
Incidental mutations (data from APF )
 
Homozygotes for a targeted null mutation exhibit failed closure of neural tube, exencephaly, wide club-shaped limbs, loss of tail vertebrae, shortened body axis, abnormal cartilage condensations, and lethality at birth.
 
Human Diseases Modeled in Mice Using Nog (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Nog interacts with 211 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (142 records)
Data Summary: Results (361)    Tissues (154)    Images (133)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 259
In situ reporter (knock in) 87
Northern blot 3
RT-PCR 8
cDNA source data(10)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA NOG ; Xenbase nog    NEW 
Molecular
reagents
All nucleic(32) Genomic(1) cDNA(14) Primer pair(4) Other(13)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000001321 (Evidence)
Ensembl Gene Model ENSMUSG00000048616 (Evidence)
Entrez Gene 18121 (Evidence)
UniGene 135266
DFCI TC1606803, TC1708861
DoTS DT.55119448
NIA Mouse Gene Index U033256
Consensus CDS Project CCDS25236.1
International Mouse Phenotyping Consortium Status Nog
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001321 VEGA Gene Model | MGI Sequence Detail 1695 C57BL/6J ±  kb
transcript OTTMUST00000002649 VEGA | MGI Sequence Detail 1695 Not Applicable 
polypeptide OTTMUSP00000001311 VEGA | MGI Sequence Detail 232 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(27 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR029034 Cystine-knot cytokine
InterPro IPR008717 Noggin
Protein Ontology PR:000000021 noggin
References
(Earliest) J:28576 Valenzuela DM, et al., Identification of mammalian noggin and its expression in the adult nervous system. J Neurosci. 1995 Sep;15(9):6077-84
(Latest) J:222290 Jiang M, et al., BMP-driven NRF2 activation in esophageal basal cell differentiation and eosinophilic esophagitis. J Clin Invest. 2015 Apr;125(4):1557-68
All references(218)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-25655

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory