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Nog Gene Detail
Summary
  • Symbol
    Nog
  • Name
    noggin
  • Feature Type
    protein coding gene
  • IDs
    MGI:104327
    NCBI Gene: 18121
  • Gene Overview
    MyGene.info: NOG
Location & Maps
more
  • Sequence Map
    Chr11:89300638-89302332 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1695 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 54.34 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    NOG, noggin
  • Vertebrate Orthologs
    12
  • Human Ortholog
    NOG, noggin
    Orthology source: HomoloGene
  • Synonyms
    SYM1, SYNS1, SYNS1A
  • Links
    NCBI Gene ID: 9241
    neXtProt AC: NX_Q13253

  • Chr Location
    17q22; chr17:56593699-56595590 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3979
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;3 zebrafish
  • HCOP
    human homology predictions: NOG
  • Protein SuperFamily
  • Gene Tree
    Nog
Human Diseases
more
  • Diseases
    1 with Nog mouse models; 5 with human NOG associations

Human Disease Mouse Models
       Tracheoesophageal Fistula with or without Esophageal Atresia   OMIM: 189960 View 1 model
       Brachydactyly, Type B2; BDB2   OMIM: 611377
Multiple Synostoses Syndrome 1; SYNS1   OMIM: 186500
Stapes Ankylosis with Broad Thumb and Toes   OMIM: 184460
Symphalangism, Proximal, 1A; SYM1A   OMIM: 185800
Tarsal-Carpal Coalition Syndrome; TCC   OMIM: 186570
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    113 phenotypes from 4 alleles in 15 genetic backgrounds
    67 phenotypes from multigenic genotypes
    66 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Targeted
    5
  • Transgenic
    4
  • Genomic Mutations
    4 involving Nog
  • Incidental Mutations
    APF
Homozygotes for a targeted null mutation exhibit failed closure of neural tube, exencephaly, wide club-shaped limbs, loss of tail vertebrae, shortened body axis, abnormal cartilage condensations, and lethality at birth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001321 VEGA Gene Model | MGI Sequence Detail 1695 C57BL/6J ±  kb
transcript OTTMUST00000002649 VEGA | MGI Sequence Detail 1695 Not Applicable  
polypeptide OTTMUSP00000001311 VEGA | MGI Sequence Detail 232 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    27 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 33
    Genomic 1
    cDNA 14
    Primer pair 4
    Other 14

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-25655
References
more
  • Summaries
    All 217
    Developmental Gene Expression 143
    Diseases 2
    Gene Ontology 29
    Phenotypes 66
  • Earliest
    J:28576 Valenzuela DM, et al., Identification of mammalian noggin and its expression in the adult nervous system. J Neurosci. 1995 Sep;15(9):6077-84
  • Latest
    J:230349 Leslie EJ, et al., Identification of functional variants for cleft lip with or without cleft palate in or near PAX7, FGFR2, and NOG by targeted sequencing of GWAS loci. Am J Hum Genet. 2015 Mar 5;96(3):397-411

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory