Automated description from the Alliance of Genome Resources (Release 7.0.0)
Predicted to enable cytokine binding activity and protein homodimerization activity. Involved in several processes, including cell surface receptor signaling pathway; heart morphogenesis; and modulation of chemical synaptic transmission. Acts upstream of or within several processes, including embryonic morphogenesis; nervous system development; and regulation of gene expression. Located in extracellular space. Is expressed in several structures, including embryo ectoderm; embryo mesenchyme; heart; sensory organ; and skeletal system. Used to study esophageal atresia/tracheoesophageal fistula. Human ortholog(s) of this gene implicated in Huntington's disease; bone disease (multiple); cleft lip; and hyperopia. Orthologous to human NOG (noggin).