Symbol
Name
ID

Nog
noggin
MGI:104327

Phenotype annotations related to skeleton

!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes

Frontal bossing

Prominent occiput

Biparietal narrowing

Brachycephaly

Brachyturricephaly

Craniosynostosis

Coronal craniosynostosis

Bicoronal synostosis

Unicoronal synostosis

Left unicoronal synostosis

Right unicoronal synostosis

Lambdoidal craniosynostosis

Pansynostosis

Sagittal craniosynostosis

Dolichocephaly

Scaphocephaly

Trigonocephaly

Turricephaly

Oxycephaly

Micrognathia

Retrognathia

Hypoplasia of the maxilla

Malar flattening

Shallow orbits

Microcephaly

Macrocephaly

Metopic synostosis

Wormian bones

Wide anterior fontanel

Genu valgum

Short middle phalanx of the 4th finger

Proximal/middle symphalangism of 4th finger

Short middle phalanx of the 5th finger

Proximal/middle symphalangism of 5th finger

Clinodactyly of the 5th finger

Absent phalangeal crease

Absent proximal finger flexion creases

Aplasia/Hypoplasia of the distal phalanges of the hand

Absent distal phalanges

Short distal phalanx of finger

Shortening of all distal phalanges of the fingers

Distal symphalangism of hands

Cone-shaped epiphyses of the phalanges of the hand

Aplasia/Hypoplasia of the middle phalanges of the hand

Shortening of all middle phalanges of the fingers

Camptodactyly of finger

Short 1st metacarpal

Symphalangism affecting the phalanges of the hand

Progressive fusion 2nd-5th pip joints

Proximal symphalangism of hands

Triphalangeal thumb

Proximal placement of thumb

Short finger

Finger clinodactyly

Radial deviation of finger

Arachnodactyly

Short middle phalanx of the 5th toe

Proximal/middle symphalangism of 5th toe

Proximal/middle symphalangism of 4th toe

Clinodactyly of the 4th toe

Short hallux

Hallux valgus

Cone-shaped epiphyses of the toes

Aplasia/Hypoplasia of the distal phalanges of the toes

Short distal phalanx of toe

Aplasia/Hypoplasia of the middle phalanges of the toes

Short toe

2-3 toe syndactyly

Cutaneous syndactyly of toes

Clinodactyly

Brachydactyly

Type B brachydactyly

Cutaneous finger syndactyly

Finger syndactyly

Metatarsus adductus

Tarsal synostosis

Short foot

Lower limb undergrowth

Short lower limbs

Metaphyseal widening

Dislocated radial head

Humeroradial synostosis

Hypoplasia of the ulna

Abnormal metacarpal morphology

Short 5th metacarpal

Metacarpophalangeal synostosis

Short humerus

Abnormality of the ankle

Genu recurvatum

Carpal bone malsegmentation

Carpal synostosis

Synostosis of carpal bones

Joint contracture of the hand

Cubitus valgus

Elbow ankylosis

Elbow dislocation

Abnormality of the wrist

Camptodactyly

Joint hypermobility

Proximal symphalangism

Lateral clavicle hook

Enlargement of the costochondral junction

Supernumerary ribs

Thin ribs

Short sternum

Pectus carinatum

Pectus excavatum

Scoliosis

C1-C2 vertebral abnormality

Hypoplastic spinal processes

Spinal canal stenosis

Osteopenia

Disease(s) Associated with NOG

brachydactyly type B2

craniosynostosis

multiple synostoses syndrome 1

proximal symphalangism

proximal symphalangism 1

tarsal-carpal coalition syndrome

Mouse Phenotypes

abnormal basicranium morphology

abnormal styloid process morphology

abnormal frontal bone morphology

abnormal interparietal bone morphology

abnormal occipital bone morphology

abnormal parietal bone morphology

abnormal mandible morphology

abnormal middle ear ossicle morphology

abnormal incus morphology

abnormal malleus morphology

abnormal stapes morphology

fusion of middle ear ossicles

spina bifida occulta

abnormal caudal vertebrae morphology

abnormal skeleton morphology

abnormal axial skeleton morphology

abnormal rib morphology

small thoracic cage

kyphosis

abnormal vertebrae morphology

abnormal vertebral arch morphology

absent vertebral arch

abnormal bone structure

abnormal cartilage morphology

abnormal cartilage development

fused synovial joints

abnormal skeleton development

abnormal bone mineralization

Availability

Mouse Genotype

Nog^tm1Amc/Nog^tm1Amc

Nog^em1(IMPC)Mbp/Nog⁺

Nog^tm1Amc/Nog⁺

Nog^tm1.1Rmh/Nog^tm1.1Rmh
Tmem163^{Tg(ACTB-cre)2Mrt}/0 (conditional)

Osr2^tm2(cre)Jian/Osr2⁺
Tg(CAG-Nog)1Ych/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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