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Ptger4 Gene Detail
Summary
  • Symbol
    Ptger4
  • Name
    prostaglandin E receptor 4 (subtype EP4)
  • Synonyms
    EP4, Ptgerep4
  • Feature Type
    protein coding gene
  • IDs
    MGI:104311
    NCBI Gene: 19219
  • Gene Overview
    MyGene.info: PTGER4
Location & Maps
more
  • Sequence Map
    Chr15:5206661-5244187 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      37527 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 1.99 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    PTGER4, prostaglandin E receptor 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PTGER4, prostaglandin E receptor 4
    Orthology source: HomoloGene
  • Synonyms
    EP4, EP4R
  • Links
    NCBI Gene ID: 5734
    neXtProt AC: NX_P35408

  • Chr Location
    5p13.1; chr5:40679498-40741764 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    47 phenotypes from 5 alleles in 6 genetic backgrounds
    70 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Most homozygous targeted null mutants die shortly after birth due to failed closure of the ductus arteriosis. Survivors show decreased migration of Langerhans cells to lymph nodes, contact hypersensitivity and decreased incidence of induced arthritis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027987 VEGA Gene Model | MGI Sequence Detail 37527 C57BL/6J ±  kb
transcript OTTMUST00000069329 VEGA | MGI Sequence Detail 3264 Not Applicable  
polypeptide OTTMUSP00000035194 VEGA | MGI Sequence Detail 513 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    144 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000001548 prostaglandin E2 receptor EP4 subtype
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR001244 Prostaglandin DP receptor
    IPR001758 Prostanoid EP4 receptor
    IPR008365 Prostanoid receptor
Molecular
Reagents
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  • All nucleic 19
    Genomic 3
    cDNA 15
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-25639
References
more
  • Summaries
    All 131
    Developmental Gene Expression 12
    Gene Ontology 11
    Phenotypes 70
  • Earliest
    J:25578 Fuller JL, et al., Effects of retinal degeneration and brain size upon spatial reversal learning in mice. Percept Mot Skills. 1973 Jun;36(3):947-50
  • Latest
    J:233777 Ray JP, et al., The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Immunity. 2015 Oct 20;43(4):690-702

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory