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Ptger4
Gene Detail
 Symbol
Name
ID
Ptger4
prostaglandin E receptor 4 (subtype EP4)
MGI:104311
Synonyms EP4, Ptgerep4
Feature Type protein coding gene
Genetic Map
Chromosome 15
1.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr15:5206661-5244187 bp, - strand
From VEGA annotation of GRCm38

  37527 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20261  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: prostaglandin E2 receptor EP4
Gene Tree: Ptger4

Human
homologs
Human Homolog PTGER4, prostaglandin E receptor 4 (subtype EP4)
NCBI Gene ID 5734
neXtProt AC  NX_P35408
Human Synonyms  EP4, EP4R
Human Chr (Location)  5p13.1; chr5:40679930-40696860 (+)  GRCh38
Alleles
and
phenotypes
All alleles(5) : Targeted(5)
 
Most homozygous targeted null mutants die shortly after birth due to failed closure of the ductus arteriosis. Survivors show decreased migration of Langerhans cells to lymph nodes, contact hypersensitivity and decreased incidence of induced arthritis.
 
Human Diseases Modeled Using Mouse Ptger4 (1)    Alleles Annotated to Human Diseases(2)   
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process adenylate cyclase-activating G-protein coupled receptor signaling pathway, adenylate cyclase-modulating G-protein coupled receptor signaling pathway, ...
Component integral component of membrane, intracellular, ...
Function G-protein coupled receptor activity, prostaglandin E receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (69)    Tissues (45)    Images (21)
Theiler Stages: 1, 2, 3, 5, 17, 19, 21, 23, 28
Assay TypeResults
RNA in situ 55
RT-PCR 14
cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(19) Genomic(3) cDNA(15) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000027987 (Evidence)
Ensembl Gene ModelENSMUSG00000039942 (Evidence)
Entrez Gene19219 (Evidence)
DFCITC1578282
DoTSDT.489993, DT.91348917
NIA Mouse Gene IndexU035981
Consensus CDS ProjectCCDS27365.1, CCDS49575.1
International Mouse Knockout Project StatusPtger4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027987 VEGA Gene Model | MGI Sequence Detail 37527 C57BL/6J ±  kb
transcript OTTMUST00000069329 VEGA | MGI Sequence Detail 3264 Not Applicable 
polypeptide OTTMUSP00000035194 VEGA | MGI Sequence Detail 513 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(4) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(148 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR001244 Prostaglandin DP receptor
InterPro IPR001758 Prostanoid EP4 receptor
InterPro IPR008365 Prostanoid receptor
Protein Ontology PR:000001548 prostaglandin E2 receptor EP4 subtype
References (Earliest) J:25578 Fuller JL, et al., Effects of retinal degeneration and brain size upon spatial reversal learning in mice. Percept Mot Skills. 1973 Jun;36(3):947-50
(Latest) J:203565 Choudhary S, et al., Prostaglandin E2 acts via bone marrow macrophages to block PTH-stimulated osteoblast differentiation in vitro. Bone. 2013 Sep;56(1):31-41
All references(120)
Other
accession IDs
MGD-MRK-25639

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory