About   Help   FAQ
Ptger4
Gene Detail
Symbol

Name
ID
Ptger4
prostaglandin E receptor 4 (subtype EP4)
MGI:104311
Synonyms
EP4, Ptgerep4
Feature Type
protein coding gene
Genetic Map
Chromosome 15
1.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr15:5206661-5244187 bp, - strand
From VEGA annotation of GRCm38

  37527 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20261  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PTGER4
Protein SuperFamily: prostaglandin E2 receptor EP4
Gene Tree: Ptger4

Human
homologs
PTGER4, prostaglandin E receptor 4 (subtype EP4)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5734
neXtProt AC: NX_P35408

Human Synonyms: EP4, EP4R

Human Chr (Location): 5p13.1; chr5:40679498-40741764 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Most homozygous targeted null mutants die shortly after birth due to failed closure of the ductus arteriosis. Survivors show decreased migration of Langerhans cells to lymph nodes, contact hypersensitivity and decreased incidence of induced arthritis.
 
Human Diseases Modeled in Mice Using Ptger4 (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Ptger4 interacts with 253 markers (Mir7-2, Mir7b, Mir10a, ...)
Expression
Literature Summary: (12 records)
Data Summary: Results (65)    Tissues (43)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 55
RT-PCR 10
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ptger4 ; ZFIN ptger4a, ptger4b, ptger4c    NEW 
Molecular
reagents
All nucleic(19) Genomic(3) cDNA(15) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000027987 (Evidence)
Ensembl Gene Model ENSMUSG00000039942 (Evidence)
Entrez Gene 19219 (Evidence)
DFCI TC1578282
DoTS DT.489993, DT.91348917
NIA Mouse Gene Index U035981
Consensus CDS Project CCDS27365.1, CCDS49575.1
International Mouse Phenotyping Consortium Status Ptger4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027987 VEGA Gene Model | MGI Sequence Detail 37527 C57BL/6J ±  kb
transcript OTTMUST00000069329 VEGA | MGI Sequence Detail 3264 Not Applicable 
polypeptide OTTMUSP00000035194 VEGA | MGI Sequence Detail 513 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(4) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(148 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR001244 Prostaglandin DP receptor
InterPro IPR001758 Prostanoid EP4 receptor
InterPro IPR008365 Prostanoid receptor
Protein Ontology PR:000001548 prostaglandin E2 receptor EP4 subtype
References
(Earliest) J:25578 Fuller JL, et al., Effects of retinal degeneration and brain size upon spatial reversal learning in mice. Percept Mot Skills. 1973 Jun;36(3):947-50
(Latest) J:219828 Tang EH, et al., Activation of prostaglandin E2-EP4 signaling reduces chemokine production in adipose tissue. J Lipid Res. 2015 Feb;56(2):358-68
All references(126)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-25639

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory