Gene Expression Literature Summary

• Symbol: Ptger4
• Name: prostaglandin E receptor 4 (subtype EP4)
• ID: MGI:104311

15 matching records from 15 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E1.5	E2.5	E3.5	E4	E4.5	E5.5	E6.5	E7.5	E10.5	E11.5	E12.5	E13	E13.5	E14.5	E15	E15.5	E16	E16.5	E17	E17.5	E18	E18.5	E19	P
In situ RNA (section)	1		1	1	1	1	1	1	1	1		1	1		1	1		2		1		1		5		6
In situ RNA (whole mount)											1				1
Northern blot	1		1	1	1		1	1	1	1																2
Western blot																					1					1
RT-PCR	1	1		1	1									1			1		1				2	2	1	5

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Ptger4  prostaglandin E receptor 4 (subtype EP4)   (Synonyms: EP4, Ptgerep4)
Results	Reference
2	J:168442 Chang HY, Locker J, Lu R, Schuster VL, Failure of postnatal ductus arteriosus closure in prostaglandin transporter-deficient mice. Circulation. 2010 Feb 2;121(4):529-36
1	J:108241 Desai J, Shannon ME, Johnson MD, Ruff DW, Hughes LA, Kerley MK, Carpenter DA, Johnson DK, Rinchik EM, Culiat CT, Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects. Hum Mol Genet. 2006 Apr 15;15(8):1329-41
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
4*	J:336175 Fuchs MAA, Schrankl J, Leupold C, Wagner C, Kurtz A, Broeker KA, Intact prostaglandin signaling through EP2 and EP4 receptors in stromal progenitor cells is required for normal development of the renal cortex in mice. Am J Physiol Renal Physiol. 2022 Mar 1;322(3):F295-F307
4*	J:317897 Gruzdev A, Nguyen M, Kovarova M, Koller BH, PGE2 through the EP4 receptor controls smooth muscle gene expression patterns in the ductus arteriosus critical for remodeling at birth. Prostaglandins Other Lipid Mediat. 2012 Mar;97(3-4):109-19
2*	J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
3*	J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
5*	J:112870 Mager J, Schultz RM, Brunk BP, Bartolomei MS, Identification of candidate maternal-effect genes through comparison of multiple microarray data sets. Mamm Genome. 2006 Sep;17(9):941-9
6*	J:85979 Muller-Decker K, Leder C, Neumann M, Neufang G, Bayerl C, Schweizer J, Marks F, Furstenberger G, Expression of cyclooxygenase isozymes during morphogenesis and cycling of pelage hair follicles in mouse skin: precocious onset of the first catagen phase and alopecia upon cyclooxygenase-2 overexpression. J Invest Dermatol. 2003 Oct;121(4):661-8
2	J:44108 Nguyen M, Camenisch T, Snouwaert JN, Hicks E, Coffman TM, Anderson PA , Malouf NN , Koller BH, The prostaglandin receptor EP4 triggers remodelling of the cardiovascular system at birth. Nature. 1997 Nov 6;390(6655):78-81
2	J:47618 Segi E, Sugimoto Y, Yamasaki A, Aze Y, Oida H, Nishimura T, Murata T, Matsuoka T, Ushikubi F, Hirose M, Tanaka T, Yoshida N, Narumiya S, Ichikawa A, Patent ductus arteriosus and neonatal death in prostaglandin receptor EP4-deficient mice. Biochem Biophys Res Commun. 1998 May 8;246(1):7-12
2	J:128959 Wang H, Xie H, Sun X, Tranguch S, Zhang H, Jia X, Wang D, Das SK, Desvergne B, Wahli W, Dubois RN, Dey SK, Stage-specific Integration of Maternal and Embryonic Peroxisome Proliferator-activated Receptor {delta} Signaling Is Critical to Pregnancy Success. J Biol Chem. 2007 Dec 28;282(52):37770-37782
18	J:38309 Yang ZM, Das SK, Wang J, Sugimoto Y, Ichikawa A, Dey SK, Potential sites of prostaglandin actions in the periimplantation mouse uterus: differential expression and regulation of prostaglandin receptor genes. Biol Reprod. 1997 Feb;56(2):368-79
3	J:219318 Yokoyama U, Minamisawa S, Shioda A, Ishiwata R, Jin MH, Masuda M, Asou T, Sugimoto Y, Aoki H, Nakamura T, Ishikawa Y, Prostaglandin E2 inhibits elastogenesis in the ductus arteriosus via EP4 signaling. Circulation. 2014 Jan 28;129(4):487-96
4	J:334529 Zou M, Mangum KD, Magin JC, Cao HH, Yarboro MT, Shelton EL, Taylor JM, Reese J, Furey TS, Mack CP, Prdm6 drives ductus arteriosus closure by promoting ductus arteriosus smooth muscle cell identity and contractility. JCI Insight. 2023 Mar 8;8(5)