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Pon1
Gene Detail
 Symbol
Name
ID
Pon1
paraoxonase 1
MGI:103295
Synonyms Pon
Feature Type protein coding gene
Genetic Map
Chromosome 6
1.99 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr6:5168090-5193946 bp, - strand
From VEGA annotation of GRCm38

  25857 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68058  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: paraoxonase
Gene Tree: Pon1

Human
homologs
Human Homolog PON1, paraoxonase 1
NCBI Gene ID 5444
neXtProt AC  NX_P27169
Human Synonyms  ESA, MVCD5, PON
Human Chr (Location)  7q21.3; chr7:95298357-95324572 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human PON1
Alleles
and
phenotypes
All alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in increased susceptibility to organophosphate toxicity and atherosclerosis when fed a high-fat/cholesterol diet. Females exhibit increased LDL and VLD cholesterol levels. Macrophages show increased oxidative stress.
 
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process aromatic compound catabolic process, blood circulation, ...
Component blood microparticle, extracellular region, ...
Function aryldialkylphosphatase activity, arylesterase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (152)    Tissues (140)    Images (3)
Theiler Stages: 22, 23, 28
Assay TypeResults
RNA in situ 94
RT-PCR 58
cDNA source data(61)
External Resources: GEO   ArrayExpress
Molecular
reagents
All nucleic(69) Genomic(3) cDNA(62) Primer pair(4)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000042263 (Evidence)
Ensembl Gene ModelENSMUSG00000002588 (Evidence)
Entrez Gene18979 (Evidence)
UniGene237657
DFCITC1580023, TC1692310
DoTSDT.110484174, DT.494236
NIA Mouse Gene IndexU027019
EC3.1.1.2, 3.1.1.81, 3.1.8.1
Consensus CDS ProjectCCDS19898.1
International Mouse Knockout Project StatusPon1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042263 VEGA Gene Model | MGI Sequence Detail 25857 C57BL/6J ±  kb
transcript OTTMUST00000111121 VEGA | MGI Sequence Detail 1513 Not Applicable 
polypeptide OTTMUSP00000062114 VEGA | MGI Sequence Detail 355 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(4) UniProt(3)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(149 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002640 Arylesterase
InterPro IPR008363 Paraoxonase1
InterPro IPR011042 Six-bladed beta-propeller, TolB-like
Protein Ontology PR:000013021 serum paraoxonase/arylesterase 1
References (Earliest) J:28139 Sorenson RC, et al., Reconsideration of the catalytic center and mechanism of mammalian paraoxonase/arylesterase. Proc Natl Acad Sci U S A. 1995 Aug 1;92(16):7187-91
(Latest) J:204816 Yamashita J, et al., Paraoxonase-1 suppresses experimental colitis via the inhibition of IFN-gamma production from CD4 T cells. J Immunol. 2013 Jul 15;191(2):949-60
All references(67)
Other
accession IDs
MGD-MRK-24177, MGD-MRK-37426, MGI:108386

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory