Pon1
Gene Detail

Symbol Name ID

Pon1 paraoxonase 1 MGI:103295

Synonyms

Pon

Feature Type

protein coding gene

Genetic Map

Chromosome 6

1.99 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr6:5168090-5193946 bp, - strand From VEGA annotation of GRCm38   25857 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68058  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: paraoxonase
Gene Tree: Pon1

Human homologs

Human Homolog		PON1, paraoxonase 1
NCBI Gene ID		5444
neXtProt AC		NX_P27169
Human Synonyms		ESA, MVCD5, PON
Human Chr (Location)		7q21.3; chr7:94927669-94953884 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human PON1

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygous mutation of this gene results in increased susceptibility to organophosphate toxicity and atherosclerosis when fed a high-fat/cholesterol diet. Females exhibit increased LDL and VLD cholesterol levels. Macrophages show increased oxidative stress.

 

Gene Ontology (GO) classifications

All GO classifications: (28 annotations)

Process	aromatic compound catabolic process, blood circulation, ...
Component	extracellular region, extracellular space, ...
Function	aryldialkylphosphatase activity, arylesterase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (152)    Tissues (140)    Images (3)
Theiler Stages: 22, 23, 28

Assay Type	Results
RNA in situ	94
RT-PCR	58

cDNA source data(61)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(69) Genomic(3) cDNA(62) Primer pair(4)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000042263 (Evidence)
Ensembl Gene Model	ENSMUSG00000002588 (Evidence)
Entrez Gene	18979 (Evidence)
UniGene	237657
DFCI	TC1580023, TC1692310
DoTS	DT.110484174, DT.494236
NIA Mouse Gene Index	U027019
EC	3.1.1.2, 3.1.1.81, 3.1.8.1
Consensus CDS Project	CCDS19898.1
International Mouse Knockout Project Status	Pon1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000042263	VEGA Gene Model | MGI Sequence Detail	25857	C57BL/6J
transcript	OTTMUST00000111121	VEGA | MGI Sequence Detail	1513	Not Applicable
polypeptide	OTTMUSP00000062114	VEGA | MGI Sequence Detail	355	Not Applicable

All sequences(48) RefSeq(2) UniProt(3)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(8 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002640	Arylesterase
InterPro	IPR008363	Paraoxonase1
InterPro	IPR011042	Six-bladed beta-propeller, TolB-like
Protein Ontology	PR:000013021	serum paraoxonase/arylesterase 1

References

(Earliest) J:28139 Sorenson RC, et al., Reconsideration of the catalytic center and mechanism of mammalian paraoxonase/arylesterase. Proc Natl Acad Sci U S A. 1995 Aug 1;92(16):7187-91
(Latest) J:190056 Xu Y, et al., Transcriptional programs controlling perinatal lung maturation. PLoS One. 2012;7(8):e37046
All references(62)

Other accession IDs

MGD-MRK-24177, MGD-MRK-37426, MGI:108386