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Rai1 Gene Detail
Summary
  • Symbol
    Rai1
  • Name
    retinoic acid induced 1
  • Synonyms
    Gt1
  • Feature Type
    protein coding gene
  • IDs
    MGI:103291
    NCBI Gene: 19377
Location & Maps
more
  • Sequence Map
    Chr11:60105013-60199197 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      94185 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    RAI1, retinoic acid induced 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RAI1, retinoic acid induced 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SMCR, SMS
  • Links
    NCBI Gene ID: 10743
    neXtProt AC: NX_Q7Z5J4

  • Chr Location
    17p11.2; chr17:17681473-17811453 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 7508
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog
  • HCOP
    human homology predictions: RAI1
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with Rai1 mouse models; 1 with human RAI1 associations

Human Disease Mouse Models
       Smith-Magenis Syndrome; SMS   OMIM: 182290 View 2 models
       Potocki-Lupski Syndrome; PTLS   OMIM: 610883 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    8 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    44 phenotypes from 3 alleles in 3 genetic backgrounds
    22 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    57
  • Chemically induced (other)
    1
  • Gene trapped
    47
  • Targeted
    6
  • Transgenic
    3
  • Genomic Mutations
    4 involving Rai1
  • Incidental Mutations
Mice homozygous for disruptions of this gene usually die as embryos. Survivors have shortened life spans and show severe craniofacial and axial skeleton defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005811 VEGA Gene Model | MGI Sequence Detail 94185 C57BL/6J ±  kb
transcript OTTMUST00000012881 VEGA | MGI Sequence Detail 6921 Not Applicable  
polypeptide OTTMUSP00000005990 VEGA | MGI Sequence Detail 1889 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    403 from dbSNP Build 142
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000013692 retinoic acid-induced protein 1
  • InterPro Domains
    IPR001965 Zinc finger, PHD-type
Molecular
Reagents
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  • All nucleic 75
    Genomic 1
    cDNA 70
    Primer pair 3
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-24173
References
more
  • Summaries
    All 42
    Developmental Gene Expression 5
    Diseases 8
    Gene Ontology 7
    Phenotypes 25
  • Earliest
    J:26209 Imai Y, et al., Cloning of a retinoic acid-induced gene, GT1, in the embryonal carcinoma cell line P19: neuron-specific expression in the mouse brain. Brain Res Mol Brain Res. 1995 Jul;31(1-2):1-9
  • Latest
    J:218979 Alaimo JT, et al., Dietary regimens modify early onset of obesity in mice haploinsufficient for Rai1. PLoS One. 2014;9(8):e105077

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory