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Rai1
Gene Detail
Symbol

Name
ID
Rai1
retinoic acid induced 1
MGI:103291
Synonyms
Gt1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
37.81 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:60105013-60199197 bp, + strand
From VEGA annotation of GRCm38

  94185 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7508  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: RAI1
Gene Tree: Rai1

Human
homologs
RAI1, retinoic acid induced 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10743
neXtProt AC: NX_Q7Z5J4

Human Synonyms: SMCR, SMS

Human Chr (Location): 17p11.2; chr17:17681473-17811453 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human RAI1

Mutations,
alleles, and
phenotypes
All mutations/alleles(55) : Gene trapped(47) Targeted(6) Transgenic(2)
Genomic Mutations involving Rai1 (3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions of this gene usually die as embryos. Survivors have shortened life spans and show severe craniofacial and axial skeleton defects.
 
Human Diseases Modeled in Mice Using Rai1 (2)    Mutations Annotated to Human Diseases (6)   
Interactions
Rai1 interacts with 258 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process circadian regulation of gene expression, negative regulation of multicellular organism growth, ...
Component cytoplasm, mitochondrion, ...
Function enhancer binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (119)    Tissues (86)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 55
In situ reporter (knock in) 55
RT-PCR 9
cDNA source data(70)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA RAI1 ; Xenbase rai1    NEW 
Molecular
reagents
All nucleic(75) Genomic(1) cDNA(70) Primer pair(3) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000005811 (Evidence)
Ensembl Gene Model ENSMUSG00000062115 (Evidence)
Entrez Gene 19377 (Evidence)
UniGene 296366
DFCI TC1623904, TC1594844, TC1578500
NIA Mouse Gene Index U012692
Consensus CDS Project CCDS24784.1
International Mouse Phenotyping Consortium Status Rai1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005811 VEGA Gene Model | MGI Sequence Detail 94185 C57BL/6J ±  kb
transcript OTTMUST00000012881 VEGA | MGI Sequence Detail 6921 Not Applicable 
polypeptide OTTMUSP00000005990 VEGA | MGI Sequence Detail 1889 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(7) UniProt(5)
Polymorphisms
SNPs within 2kb(404 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001965 Zinc finger, PHD-type
Protein Ontology PR:000013692 retinoic acid-induced protein 1
References
(Earliest) J:26209 Imai Y, et al., Cloning of a retinoic acid-induced gene, GT1, in the embryonal carcinoma cell line P19: neuron-specific expression in the mouse brain. Brain Res Mol Brain Res. 1995 Jul;31(1-2):1-9
(Latest) J:218979 Alaimo JT, et al., Dietary regimens modify early onset of obesity in mice haploinsufficient for Rai1. PLoS One. 2014;9(8):e105077
All references(43)
Disease annotation references (5)
Other
accession IDs
MGD-MRK-24173

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory