Rai1
Gene Detail

Symbol Name ID

Rai1 retinoic acid induced 1 MGI:103291

Synonyms

Gt1

Feature Type

protein coding gene

Genetic Map

Chromosome 11

37.81 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr11:60105013-60199197 bp, + strand From VEGA annotation of GRCm38   94185 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7508  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Rai1

Human homologs

Human Homolog		RAI1, retinoic acid induced 1
NCBI Gene ID		10743
neXtProt AC		NX_Q7Z5J4
Human Synonyms		SMCR, SMS
Human Chr (Location)		17p11.2; chr17:17584787-17714767 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human RAI1

Alleles and phenotypes

All alleles(49) : Targeted(2) Gene trapped(47)
 

Mice homozygous for disruptions of this gene usually die as embryos. Survivors have shortened life spans and show severe craniofacial and axial skeleton defects.

 
Human Diseases Modeled Using Mouse Rai1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	negative regulation of multicellular organism growth, regulation of transcription from RNA polymerase II promoter, ...
Component	cytoplasm, nucleus
Function	metal ion binding, zinc ion binding

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (79)    Tissues (58)    Images (10)
Theiler Stages: 15, 17, 19, 20, 23, 28

Assay Type	Results
RNA in situ	55
In situ reporter (knock in)	15
RT-PCR	9

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(21) Genomic(1) cDNA(16) Primer pair(3) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000005811 (Evidence)
Ensembl Gene Model	ENSMUSG00000062115 (Evidence)
Entrez Gene	19377 (Evidence)
DFCI	TC1578500, TC1594844, TC1623904
NIA Mouse Gene Index	U012692
Consensus CDS Project	CCDS24784.1
International Mouse Knockout Project Status	Rai1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005811	VEGA Gene Model | MGI Sequence Detail	94185	C57BL/6J
transcript	OTTMUST00000012881	VEGA | MGI Sequence Detail	6921	Not Applicable
polypeptide	OTTMUSP00000005990	VEGA | MGI Sequence Detail	1889	Not Applicable

All sequences(45) RefSeq(4) UniProt(5)

Polymorphisms

SNPs(262 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001965	Zinc finger, PHD-type
Protein Ontology	PR:000013692	retinoic acid-induced protein 1

References

(Earliest) J:26209 Imai Y, et al., Cloning of a retinoic acid-induced gene, GT1, in the embryonal carcinoma cell line P19: neuron-specific expression in the mouse brain. Brain Res Mol Brain Res. 1995 Jul;31(1-2):1-9
(Latest) J:185193 Lacaria M, et al., A Duplication CNV That Conveys Traits Reciprocal to Metabolic Syndrome and Protects against Diet-Induced Obesity in Mice and Men. PLoS Genet. 2012 May;8(5):e1002713
All references(39)

Other accession IDs

MGD-MRK-24173