Phenotypes Associated with This Genotype

Genotype
MGI:3758726

• Allelic Composition: Dp(11Cops3-Rnf112)1Jrl/0; Tyr^c-Brd/Tyr^c-Brd
• Genetic Background: B6Brd.Cg-Tyr^c-Brd Dp(11Cops3-Rnf112)1Jrl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal contextual conditioning behavior ( J:114996 )

• mice exhibit impaired contextual conditioning (12.6+/-2.5% freezing to context compared to 36.0+/-6.5 in wild-type mice)

decreased exploration in new environment ( J:114996 )

• mice exhibit decreased center to total distance ratio explored (0.26+/-0.01 compared to 0.33+/-0.04 in wild-type mice)

increased anxiety-related response ( J:138598 )

• in an elevated plus maze

decreased vertical activity ( J:114996 )

• mice exhibit decreased vertical activity (305+/-22 incidents compared to 499+/-60 incidences in wild-type mice)

hyperactivity ( J:114996 )

abnormal social/conspecific interaction behavior ( J:138598 )

• mice exhibit increased dominance compared with wild-type mice

• however, mice exhibit normal aggression

abnormal nest building behavior ( J:138598 )

• 6.5 hours after introducing a paper towel to cages, only half of mice build nest compared with all wild-type mice

abnormal social investigation ( J:138598 )

• mice exhibit impaired sociability and response to social novelty compared with wild-type mice

decreased vocalization ( J:138598 )

• only half of mice vocalize during handling compared with all wild-type mice

nervous system

decreased brain weight ( J:138598 )

• at 12 weeks

growth/size/body

decreased body weight ( J:138598 )

• at 12 weeks

adipose tissue

decreased abdominal fat pad weight ( J:138598 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Potocki-Lupski syndrome		DOID:0060853	OMIM:610883	J:138598