Rai1^tm2.1Luo
Targeted Allele Detail

Summary

• Symbol: Rai1^tm2.1Luo
• Name: retinoic acid induced 1; targeted mutation 2.1, Liqun Luo
• MGI ID: MGI:5816464
• Synonyms: Rai1^flox, Rai1-flox
• Gene: Rai1 Location: Chr11:59995839-60090023 bp, + strand Genetic Position: Chr11, 37.81 cM, cytoband B2
• Alliance: Rai1^tm2.1Luo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:237687
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S1/Sv

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a FRT5-flanked neo cassette (frt5-pSV40-Neo-pA-frt5) and a loxP site upstream of exon 3, and a loxP downstream of exon 3. Flp-mediated recombination removed the FRT5-flanked neo cassette. (J:237687)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rai1 Mutation: 73 strains or lines available

References

• Original: J:237687 Huang WH, et al., Molecular and Neural Functions of Rai1, the Causal Gene for Smith-Magenis Syndrome. Neuron. 2016 Oct 19;92(2):392-406
• All: 4 reference(s)