Phenotypes associated with this allele
normal phenotype
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• mice do not exhibit differences in behavior, motor function or body weight from controls
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behavior/neurological
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• decreased freezing behavior in contextual memory recall
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• decreased freezing behavior in cued recall
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behavior/neurological
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• decreased freezing behavior in contextual recall in trace fear-conditioning task
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• decreased freezing behavior in cued recall
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• increased time required to descend in pole test
• increased latency to fall in wire hang test
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growth/size/body
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• males and females become obese at 9 and 7 weeks, respectively and are 56% (males) and 116% (females) heavier than controls at 20 weeks
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Allelic Composition |
Rai1tm2.1Luo/Rai1+ Slc17a6tm2(cre)Lowl/?
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Genetic Background |
either: (involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6) |
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behavior/neurological
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• increased latency to fall in wire hang test
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growth/size/body
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• males and females exhibit 16% and 29% (respectively ) increased body weight as compared to controls
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1tm2.1Luo mutation
(1 available);
any
Rai1 mutation
(73 available)
Tg(Gfap-cre)73.12Mvs mutation
(2 available)
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normal phenotype
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• mice do not exhibit differences in behavior, motor function or body weight
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1tm2.1Luo mutation
(1 available);
any
Rai1 mutation
(73 available)
Tg(Nr5a1-cre)7Lowl mutation
(2 available)
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behavior/neurological
N |
• males exhibit no motor weakness in wire hang test
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growth/size/body
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• females are 27% heavier than controls at 20 weeks of age
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1tm2.1Luo mutation
(1 available);
any
Rai1 mutation
(73 available)
Tg(Sim1-cre)1Lowl mutation
(2 available)
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adipose tissue
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• increased fat pad weight: gonadal, subcutaneous, retroperitoneal, mesenteric and BAT
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behavior/neurological
N |
• males exhibit no motor weakness in wire hang test
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• hyperphagic with a 47% increase in average daily food intake
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• decreased horizontal locomotor activity
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growth/size/body
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• mice are 57% heavier than controls at 20 weeks of age
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homeostasis/metabolism
Allelic Composition |
Rai1tm2.1Luo/Rai1+ Tg(Sim1-cre)1Lowl/?
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Genetic Background |
either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB) |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1tm2.1Luo mutation
(1 available);
any
Rai1 mutation
(73 available)
Tg(Sim1-cre)1Lowl mutation
(2 available)
|
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growth/size/body
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• females are 12.7% heavier than controls at 20 weeks of age
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Allelic Composition |
Rai1tm2.1Luo/Rai1+ Tg(Nr5a1-cre)7Lowl/?
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Genetic Background |
either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB) |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1tm2.1Luo mutation
(1 available);
any
Rai1 mutation
(73 available)
Tg(Nr5a1-cre)7Lowl mutation
(2 available)
|
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growth/size/body
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• females are 27% heavier than controls at 20 weeks of age
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1tm2.1Luo mutation
(1 available);
any
Rai1 mutation
(73 available)
Tg(Nes-cre)1Kln mutation
(4 available)
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behavior/neurological
N |
• males perform similar to controls in assays for gait, velocity, vertical activity, anxiety, sociability and cognition
• males have normal hearing and pain responses
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• decreased freezing behavior after repeated tone-shock pairings during training
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• decreased freezing behavior in contextual recall in trace fear-conditioning task
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• decreased freezing behavior in cued recall
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• reduced tendency to explore new arm in Y maze
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• in pole test males slip from pole or climb down in a slow and uncoordinated fashion
• decreased latency to fall in wire hang test
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growth/size/body
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• female mice become overweight beginning at 5 weeks of age
• at 20 weeks female mice are 101% heavier than controls
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• mice are smaller than littermates prior to weaning
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mortality/aging
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• more than 80% of mice die before 25 weeks of age
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skeleton
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• kyphosis in 10% of mice that die before 10 weeks of age
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Allelic Composition |
Rai1tm2.1Luo/Rai1+ Tg(Nes-cre)1Kln/?
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Genetic Background |
either: (involves: 129S1/Sv * C57BL/6 * SJL) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL) |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1tm2.1Luo mutation
(1 available);
any
Rai1 mutation
(73 available)
Tg(Nes-cre)1Kln mutation
(4 available)
|
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behavior/neurological
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• males exhibit a decreased latency to fall in wire hang test
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growth/size/body
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• female mice become overweight beginning at 7 weeks of age
• at 20 weeks female mice are 35% heavier than controls
|
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rai1tm2.1Luo mutation
(1 available);
any
Rai1 mutation
(73 available)
Rai1tm2.2Luo mutation
(0 available);
any
Rai1 mutation
(73 available)
Tg(Nes-cre)1Kln mutation
(4 available)
|
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growth/size/body
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• female mice become overweight beginning at 7 weeks of age
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