Vdr
Gene Detail

Symbol Name ID

Vdr vitamin D receptor MGI:103076

Synonyms

Nr1i1

Feature Type

protein coding gene

Genetic Map

Chromosome 15

53.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr15:97854425-97910630 bp, - strand From VEGA annotation of GRCm38   56206 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37297  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: vitamin D3 receptor-like nuclear receptor
Gene Tree: Vdr

Human homologs

Human Homolog		VDR, vitamin D (1,25- dihydroxyvitamin D3) receptor
NCBI Gene ID		7421
neXtProt AC		NX_P11473
Human Synonyms		NR1I1
Human Chr (Location)		12q13.11; chr12:48235320-48298814 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human VDR

Alleles and phenotypes

All alleles(11) : Targeted(11)
 

Homozygous null mutants fail to thrive after weaning and may exhibit excess mortality. Postweaning mutant mice develop alopecia, hypocalcemia, infertility, and rickets. Mutant females exhibit uterine hypoplasia with impaired follicular development.

 
Human Diseases Modeled Using Mouse Vdr (2)    Alleles Annotated to Human Diseases(2)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (47 annotations)

Process	apoptotic signaling pathway, calcium ion transport, ...
Component	cytosol, intracellular membrane-bounded organelle, ...
Function	DNA binding, ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (19 records)
Data Summary: Results (260)    Tissues (240)    Images (25)
Theiler Stages: 2, 3, 4, 5, 15, 17, 18, 21, 22, 23, 24, 25, 28

Assay Type	Results
RNA in situ	230
Northern blot	6
Western blot	6
RT-PCR	18

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(20) Genomic(2) cDNA(11) Primer pair(6) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000026431 (Evidence)
Ensembl Gene Model	ENSMUSG00000022479 (Evidence)
Entrez Gene	22337 (Evidence)
DFCI	TC1576884, TC1616197
DoTS	DT.489451
NIA Mouse Gene Index	U036607
Consensus CDS Project	CCDS27784.1
International Mouse Knockout Project Status	Vdr

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026431	VEGA Gene Model | MGI Sequence Detail	56206	C57BL/6J
transcript	OTTMUST00000065367	VEGA | MGI Sequence Detail	4370	Not Applicable
polypeptide	OTTMUSP00000032572	VEGA | MGI Sequence Detail	422	Not Applicable

All sequences(47) RefSeq(2) UniProt(7)

Polymorphisms

PCR(1) : SNPs(694 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008946	Nuclear hormone receptor, ligand-binding
InterPro	IPR000536	Nuclear hormone receptor, ligand-binding, core
InterPro	IPR001723	Steroid hormone receptor
InterPro	IPR000324	Vitamin D receptor
InterPro	IPR013088	Zinc finger, NHR/GATA-type
InterPro	IPR001628	Zinc finger, nuclear hormone receptor-type
Protein Ontology	PR:000017283	vitamin D3 receptor

References

(Earliest) J:23756 Huang YC, et al., Effect of hormones and development on the expression of the rat 1,25-dihydroxyvitamin D3 receptor gene. Comparison with calbindin gene expression. J Biol Chem. 1989 Oct 15;264(29):17454-61
(Latest) J:194743 Chen Y, et al., 1,25-Dihydroxyvitamin D Promotes Negative Feedback Regulation of TLR Signaling via Targeting MicroRNA-155-SOCS1 in Macrophages. J Immunol. 2013 Apr 1;190(7):3687-95
All references(221)

Other accession IDs

MGD-MRK-23940