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Vdr
Gene Detail
 Symbol
Name
ID
Vdr
vitamin D receptor
MGI:103076
Synonyms Nr1i1
Feature Type protein coding gene
Genetic Map
Chromosome 15
53.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:97854425-97910630 bp, - strand
From VEGA annotation of GRCm38

  56206 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37297  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: vitamin D3 receptor-like nuclear receptor
Gene Tree: Vdr

Human
homologs
Human Homolog VDR, vitamin D (1,25- dihydroxyvitamin D3) receptor
NCBI Gene ID 7421
neXtProt AC  NX_P11473
Human Synonyms  NR1I1
Human Chr (Location)  12q13.11; chr12:47841537-47905031 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human VDR
Alleles
and
phenotypes
All alleles(12) : Targeted(12)
 
Homozygous null mutants fail to thrive after weaning and may exhibit excess mortality. Postweaning mutant mice develop alopecia, hypocalcemia, infertility, and rickets. Mutant females exhibit uterine hypoplasia with impaired follicular development.
 
Human Diseases Modeled Using Mouse Vdr (2)    Alleles Annotated to Human Diseases(2)    Phenotype Images(3)
Gene Ontology
(GO)
classifications
All GO classifications: (60 annotations)
Process apoptotic signaling pathway, bile acid signaling pathway, ...
Component caveola, cytosol, ...
Function calcitriol binding, calcitriol receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (274)    Tissues (251)    Images (26)
Theiler Stages: 2, 3, 4, 5, 15, 17, 18, 21, 22, 23, 24, 25, 28
Assay TypeResults
RNA in situ 244
Northern blot 6
Western blot 6
RT-PCR 18
cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(20) Genomic(2) cDNA(11) Primer pair(6) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000026431 (Evidence)
Ensembl Gene ModelENSMUSG00000022479 (Evidence)
Entrez Gene22337 (Evidence)
DFCITC1576884, TC1616197
DoTSDT.489451
NIA Mouse Gene IndexU036607
Consensus CDS ProjectCCDS27784.1
International Mouse Knockout Project StatusVdr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026431 VEGA Gene Model | MGI Sequence Detail 56206 C57BL/6J ±  kb
transcript OTTMUST00000065367 VEGA | MGI Sequence Detail 4370 Not Applicable 
polypeptide OTTMUSP00000032572 VEGA | MGI Sequence Detail 422 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(2) UniProt(7)
Polymorphisms PCR(1) : SNPs within 2kb(826 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR001723 Steroid hormone receptor
InterPro IPR000324 Vitamin D receptor
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000017283 vitamin D3 receptor
References (Earliest) J:23756 Huang YC, et al., Effect of hormones and development on the expression of the rat 1,25-dihydroxyvitamin D3 receptor gene. Comparison with calbindin gene expression. J Biol Chem. 1989 Oct 15;264(29):17454-61
(Latest) J:206448 Andrukhova O, et al., FGF23 promotes renal calcium reabsorption through the TRPV5 channel. EMBO J. 2014 Feb 3;33(3):229-46
All references(233)
Other
accession IDs
MGD-MRK-23940

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory