About   Help   FAQ
Vdr
Gene Detail
Symbol

Name
ID
Vdr
vitamin D receptor
MGI:103076
Synonyms
Nr1i1
Feature Type
protein coding gene
Genetic Map
Chromosome 15
53.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:97854425-97910630 bp, - strand
From VEGA annotation of GRCm38

  56206 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37297  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: VDR
Protein SuperFamily: vitamin D3 receptor-like nuclear receptor
Gene Tree: Vdr

Human
homologs
VDR, vitamin D (1,25- dihydroxyvitamin D3) receptor
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7421
neXtProt AC: NX_P11473

Human Synonyms: NR1I1, PPP1R163

Human Chr (Location): 12q13.11; chr12:47841537-47905031 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human VDR

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Radiation induced(1) Targeted(12)
Genomic Mutations involving Vdr (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mutants fail to thrive after weaning and may exhibit excess mortality. Postweaning mutant mice develop alopecia, hypocalcemia, infertility, and rickets. Mutant females exhibit uterine hypoplasia with impaired follicular development.
 
Human Diseases Modeled in Mice Using Vdr (2)    Mutations Annotated to Human Diseases (2)    Phenotype Images(5)
Interactions
Vdr interacts with 357 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (63 annotations)
Process apoptotic signaling pathway, bile acid signaling pathway, ...
Component caveola, cell, ...
Function calcitriol binding, calcitriol receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (267)    Tissues (247)    Images (28)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 244
Northern blot 6
Western blot 6
RT-PCR 11
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase vdr ; ZFIN vdra, vdrb    NEW 
Molecular
reagents
All nucleic(20) Genomic(2) cDNA(11) Primer pair(6) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000026431 (Evidence)
Ensembl Gene Model ENSMUSG00000022479 (Evidence)
Entrez Gene 22337 (Evidence)
DFCI TC1576884, TC1616197
DoTS DT.489451
NIA Mouse Gene Index U036607
Consensus CDS Project CCDS27784.1
International Mouse Phenotyping Consortium Status Vdr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026431 VEGA Gene Model | MGI Sequence Detail 56206 C57BL/6J ±  kb
transcript OTTMUST00000065367 VEGA | MGI Sequence Detail 4370 Not Applicable 
polypeptide OTTMUSP00000032572 VEGA | MGI Sequence Detail 422 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(2) UniProt(7)
Polymorphisms
PCR(1) : SNPs within 2kb(826 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001723 Nuclear hormone receptor
InterPro IPR000536 Nuclear hormone receptor, ligand-binding domain
InterPro IPR000324 Vitamin D receptor
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000017283 vitamin D3 receptor
References
(Earliest) J:23756 Huang YC, et al., Effect of hormones and development on the expression of the rat 1,25-dihydroxyvitamin D3 receptor gene. Comparison with calbindin gene expression. J Biol Chem. 1989 Oct 15;264(29):17454-61
(Latest) J:218278 Peregrina K, et al., Vitamin D is a determinant of mouse intestinal Lgr5 stem cell functions. Carcinogenesis. 2015 Jan;36(1):25-31
All references(250)
Disease annotation references (4)
Other
accession IDs
MGD-MRK-23940

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory