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Stat5b Gene Detail
Summary
  • Symbol
    Stat5b
  • Name
    signal transducer and activator of transcription 5B
  • Feature Type
    protein coding gene
  • IDs
    MGI:103035
    NCBI Gene: 20851
  • Gene Overview
    MyGene.info: STAT5B
Location & Maps
more
  • Sequence Map
    Chr11:100780731-100850724 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      69994 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    STAT5B, signal transducer and activator of transcription 5B
  • Vertebrate Orthologs
    11
  • Human Ortholog
    STAT5B, signal transducer and activator of transcription 5B
    Orthology source: HGNC, HomoloGene
  • Synonyms
    STAT5
  • Links
    NCBI Gene ID: 6777
    neXtProt AC: NX_P51692

  • Chr Location
    17q11.2; chr17:42199177-42276460 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human STAT5B associations

Human Disease Mouse Models
       Growth Hormone Insensitivity with Immunodeficiency   OMIM: 245590
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    79 phenotypes from 4 alleles in 15 genetic backgrounds
    79 phenotypes from multigenic genotypes
    145 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Gene trapped
    3
  • Targeted
    12
  • Transgenic
    1
  • Genomic Mutations
    2 involving Stat5b
  • Incidental Mutations
Mice homozygous for disruptions in this are reduced in size and mammary glands secrete reduced levels of some milk proteins during lactation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002127 VEGA Gene Model | MGI Sequence Detail 69994 C57BL/6J ±  kb
transcript OTTMUST00000004319 VEGA | MGI Sequence Detail 5213 Not Applicable  
polypeptide OTTMUSP00000002051 VEGA | MGI Sequence Detail 786 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    334 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000002092 signal transducer and activator of transcription 5b
  • InterPro Domains
    IPR011992 EF-hand domain pair
    IPR008967 p53-like transcription factor, DNA-binding
    IPR000980 SH2 domain
    IPR013800 STAT transcription factor, all-alpha domain
    IPR015988 STAT transcription factor, coiled coil
    IPR013801 STAT transcription factor, DNA-binding
    IPR012345 STAT transcription factor, DNA-binding, subdomain
    IPR013799 STAT transcription factor, protein interaction
    IPR001217 Transcription factor STAT
Molecular
Reagents
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  • All nucleic 100
    Genomic 6
    cDNA 90
    Primer pair 4

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-23873
References
more
  • Summaries
    All 225
    Developmental Gene Expression 15
    Gene Ontology 26
    Phenotypes 145
  • Earliest
    J:24359 Mui AL, et al., Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs. EMBO J. 1995 Mar 15;14(6):1166-75
  • Latest
    J:228007 Haetscher N, et al., STAT5-regulated microRNA-193b controls haematopoietic stem and progenitor cell expansion by modulating cytokine receptor signalling. Nat Commun. 2015;6:8928

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory