Stat5b
Gene Detail

Symbol Name ID

Stat5b signal transducer and activator of transcription 5B MGI:103035

Feature Type

protein coding gene

Genetic Map

Chromosome 11

63.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr11:100780731-100850724 bp, - strand From VEGA annotation of GRCm38   69994 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55718  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: signal transducer and transcription activator STAT5A
Gene Tree: Stat5b

Human homologs

Human Homolog		STAT5B, signal transducer and activator of transcription 5B
NCBI Gene ID		6777
neXtProt AC		NX_P51692
Human Synonyms		STAT5
Human Chr (Location)		17q11.2; chr17:40351195-40428424 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human STAT5B

Alleles and phenotypes

All alleles(13) : Targeted(10) Gene trapped(3)
 

Mice homozygous for disruptions in this are reduced in size and mammary glands secrete reduced levels of some milk proteins during lactation.

 

Gene Ontology (GO) classifications

All GO classifications: (84 annotations)

Process	2-oxoglutarate metabolic process, acute-phase response, ...
Component	cytoplasm, cytosol, ...
Function	calcium ion binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (14 records)
Data Summary: Results (201)    Tissues (106)    Images (32)
Theiler Stages: 2, 3, 4, 5, 17, 21, 23, 28

Assay Type	Results
RNA in situ	104
RT-PCR	97

cDNA source data(87)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(98) Genomic(6) cDNA(88) Primer pair(4)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000002127 (Evidence)
Ensembl Gene Model	ENSMUSG00000020919 (Evidence)
Entrez Gene	20851 (Evidence)
UniGene	34064
DFCI	TC1574816, TC1614990
DoTS	DT.101402191, DT.492044, DT.94230572
NIA Mouse Gene Index	U033437
Consensus CDS Project	CCDS25438.1
International Mouse Knockout Project Status	Stat5b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000002127	VEGA Gene Model | MGI Sequence Detail	69994	C57BL/6J
transcript	OTTMUST00000004318	VEGA | MGI Sequence Detail	5062	Not Applicable
polypeptide	OTTMUSP00000002050	VEGA | MGI Sequence Detail	786	Not Applicable

All sequences(44) RefSeq(4) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(193 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011992	EF-hand-like domain
InterPro	IPR008967	p53-like transcription factor, DNA-binding
InterPro	IPR000980	SH2 domain
InterPro	IPR013800	STAT transcription factor, all-alpha
InterPro	IPR015988	STAT transcription factor, coiled coil
InterPro	IPR001217	STAT transcription factor, core
InterPro	IPR013801	STAT transcription factor, DNA-binding
InterPro	IPR012345	STAT transcription factor, DNA-binding, subdomain
InterPro	IPR013799	STAT transcription factor, protein interaction
Protein Ontology	PR:000002092	signal transducer and activator of transcription 5b

References

(Earliest) J:24359 Mui AL, et al., Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs. EMBO J. 1995 Mar 15;14(6):1166-75
(Latest) J:194747 Bell BD, et al., The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses. Nat Immunol. 2013 Apr;14(4):364-71
All references(215)

Other accession IDs

MGD-MRK-23873