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Stat5b
Gene Detail
Symbol

Name
ID
Stat5b
signal transducer and activator of transcription 5B
MGI:103035
Feature Type
protein coding gene
Genetic Map
Chromosome 11
63.63 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr11:100780731-100850724 bp, - strand
From VEGA annotation of GRCm38

  69994 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55718  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: signal transducer and transcription activator STAT5A
Gene Tree: Stat5b

Human
homologs
Human Homolog STAT5B, signal transducer and activator of transcription 5B
NCBI Gene ID 6777
neXtProt AC  NX_P51692
Human Synonyms  STAT5
Human Chr (Location)  17q11.2; chr17:42199177-42276460 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human STAT5B
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(3) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this are reduced in size and mammary glands secrete reduced levels of some milk proteins during lactation.
 
Interactions
Stat5b interacts with 262 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (92 annotations)
Process 2-oxoglutarate metabolic process, acute-phase response, ...
Component cytoplasm, cytosol, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (196)    Tissues (110)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 106
RT-PCR 90
cDNA source data(89)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(100) Genomic(6) cDNA(90) Primer pair(4)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000002127 (Evidence)
Ensembl Gene ModelENSMUSG00000020919 (Evidence)
Entrez Gene20851 (Evidence)
UniGene34064
DFCITC1574816, TC1614990
DoTSDT.101402191, DT.492044, DT.94230572
NIA Mouse Gene IndexU033437
Consensus CDS ProjectCCDS25438.1
International Mouse Knockout Project StatusStat5b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002127 VEGA Gene Model | MGI Sequence Detail 69994 C57BL/6J ±  kb
transcript OTTMUST00000004319 VEGA | MGI Sequence Detail 5213 Not Applicable 
polypeptide OTTMUSP00000002051 VEGA | MGI Sequence Detail 786 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(6) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(305 from dbSNP Build 137)    SNPs within 2kb including multiple locations(319)
Protein-related
information
ResourceIDDescription
InterPro IPR011992 EF-hand-like domain
InterPro IPR008967 p53-like transcription factor, DNA-binding
InterPro IPR000980 SH2 domain
InterPro IPR013800 STAT transcription factor, all-alpha
InterPro IPR015988 STAT transcription factor, coiled coil
InterPro IPR001217 STAT transcription factor, core
InterPro IPR013801 STAT transcription factor, DNA-binding
InterPro IPR012345 STAT transcription factor, DNA-binding, subdomain
InterPro IPR013799 STAT transcription factor, protein interaction
Protein Ontology PR:000002092 signal transducer and activator of transcription 5b
References
(Earliest) J:24359 Mui AL, et al., Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs. EMBO J. 1995 Mar 15;14(6):1166-75
(Latest) J:214130 Robinson GW, et al., Coregulation of genetic programs by the transcription factors NFIB and STAT5. Mol Endocrinol. 2014 May;28(5):758-67
All references(225)
Other
accession IDs
MGD-MRK-23873

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory