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Pou4f2 Gene Detail
Summary
  • Symbol
    Pou4f2
  • Name
    POU domain, class 4, transcription factor 2
  • Synonyms
    Brn-3.2, Brn3b, Brn-3b, mBrn3-3R, Pou4f-rs1
  • Feature Type
    protein coding gene
  • IDs
    MGI:102524
    NCBI Gene: 18997
  • Gene Overview
    MyGene.info: POU4F2
Location & Maps
more
  • Sequence Map
    Chr8:78433010-78436645 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3636 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    POU4F2, POU class 4 homeobox 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    POU4F2, POU class 4 homeobox 2
    Orthology source: HomoloGene
  • Synonyms
    BRN3.2, Brn-3b, BRN3B
  • Links
    NCBI Gene ID: 5458
    neXtProt AC: NX_Q12837

  • Chr Location
    4q31.2; chr4:146638893-146642471 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    36 phenotypes from 11 alleles in 12 genetic backgrounds
    26 phenotypes from multigenic genotypes
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (other)
    1
  • Targeted
    12
  • Transgenic
    1
  • Genomic Mutations
    1 involving Pou4f2
  • Incidental Mutations
Homozygote null mice have a 70% reduction in retinal ganglion cells, a thin retina, and an optic nerve with a decreased diameter and disorganized axons. Eyes have miotic pupils and defective optokinetic reflexes that prevent photo-entrainment.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000039883 VEGA Gene Model | MGI Sequence Detail 3636 C57BL/6J ±  kb
transcript OTTMUST00000103645 VEGA | MGI Sequence Detail 3204 Not Applicable  
polypeptide OTTMUSP00000057927 VEGA | MGI Sequence Detail 411 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    6 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 33
    Genomic 7
    cDNA 16
    Primer pair 8
    Other 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-1631, MGD-MRK-19368, MGD-MRK-19462, MGI:102576
References
more
  • Summaries
    All 208
    Developmental Gene Expression 157
    Gene Ontology 18
    Phenotypes 42
  • Earliest
    J:9856 He X, et al., Expression of a large family of POU-domain regulatory genes in mammalian brain development [published erratum appears in Nature 1989 Aug 24;340(6235):662]. Nature. 1989 Jul 6;340(6228):35-41
  • Latest
    J:225537 Zhang J, et al., Ezh2 maintains retinal progenitor proliferation, transcriptional integrity, and the timing of late differentiation. Dev Biol. 2015 Jul 15;403(2):128-38

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory