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Pou4f2 Gene Detail
Summary
  • Symbol
    Pou4f2
  • Name
    POU domain, class 4, transcription factor 2
  • Synonyms
    Brn-3.2, Brn3b, Brn-3b, mBrn3-3R, Pou4f-rs1
  • Feature Type
    protein coding gene
  • IDs
    MGI:102524
    NCBI Gene: 18997
  • Gene Overview
    MyGene.info: POU4F2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:78433010-78436645 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3636 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 36.99 cM, cytoband F1-F5
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    POU4F2, POU class 4 homeobox 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    POU4F2, POU class 4 homeobox 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BRN3.2, Brn-3b, BRN3B
  • Links
    NCBI Gene ID: 5458
    neXtProt AC: NX_Q12837
    UniProt: Q12837

  • Chr Location
    4q31.22; chr4:146638893-146642471 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    38 phenotypes from 11 alleles in 13 genetic backgrounds
    23 phenotypes from multigenic genotypes
    52 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygote null mice have a 70% reduction in retinal ganglion cells, a thin retina, and an optic nerve with a decreased diameter and disorganized axons. Eyes have miotic pupils and defective optokinetic reflexes that prevent photo-entrainment.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000039883 VEGA Gene Model | MGI Sequence Detail 3636 C57BL/6J ±  kb
    transcript OTTMUST00000103645 VEGA | MGI Sequence Detail 3204 Not Applicable  
    polypeptide OTTMUSP00000057927 VEGA | MGI Sequence Detail 411 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      6 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 8
      cDNA 16
      Primer pair 8
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1631, MGD-MRK-19368, MGD-MRK-19462, MGI:102576
    References
    more
    • Summaries
      All 250
      Developmental Gene Expression 184
      Gene Ontology 31
      Phenotypes 52
    • Earliest
      J:9856 He X, et al., Expression of a large family of POU-domain regulatory genes in mammalian brain development [published erratum appears in Nature 1989 Aug 24;340(6235):662]. Nature. 1989 Jul 6;340(6228):35-41
    • Latest
      J:264387 Maurer KA, et al., Integral bHLH factor regulation of cell cycle exit and RGC differentiation. Dev Dyn. 2018 May 17;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory