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Pou4f2
Gene Detail
Symbol

Name
ID
Pou4f2
POU domain, class 4, transcription factor 2
MGI:102524
Synonyms
Brn-3.2, Brn3b, Brn-3b, mBrn3-3R, Pou4f-rs1
Feature Type
protein coding gene
Genetic Map
Chromosome 8
36.99 cM, cytoband F1-F5
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:78433010-78436645 bp, - strand
From VEGA annotation of GRCm38

  3636 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20959  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: POU4F2
Protein SuperFamily: POU domain class 4 transcription factor, Brn3 type
Gene Tree: Pou4f2

Human
homologs
POU4F2, POU class 4 homeobox 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5458
neXtProt AC: NX_Q12837

Human Synonyms: BRN3.2, Brn-3b, BRN3B

Human Chr (Location): 4q31.2; chr4:146638893-146642471 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Targeted(12)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygote null mice have a 70% reduction in retinal ganglion cells, a thin retina, and an optic nerve with a decreased diameter and disorganized axons. Eyes have miotic pupils and defective optokinetic reflexes that prevent photo-entrainment.
 
Interactions
Pou4f2 interacts with 344 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process axon extension, axon guidance, ...
Component intracellular, nucleus
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (152 records)
Data Summary: Results (161)    Tissues (103)    Images (60)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 29
RNA in situ 53
In situ reporter (knock in) 6
Northern blot 2
Western blot 2
RT-PCR 27
RNase protection 42
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pou4f2 ; ZFIN pou4f2    NEW 
Molecular
reagents
All nucleic(33) Genomic(7) cDNA(16) Primer pair(8) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000039883 (Evidence)
Ensembl Gene Model ENSMUSG00000031688 (Evidence)
Entrez Gene 18997 (Evidence)
UniGene 234261
DFCI TC1585350
DoTS DT.91381361
NIA Mouse Gene Index U029986
Consensus CDS Project CCDS22429.1
International Mouse Phenotyping Consortium Status Pou4f2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000039883 VEGA Gene Model | MGI Sequence Detail 3636 C57BL/6J ±  kb
transcript OTTMUST00000103645 VEGA | MGI Sequence Detail 3204 Not Applicable 
polypeptide OTTMUSP00000057927 VEGA | MGI Sequence Detail 411 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(6 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeobox domain
InterPro IPR009057 Homeodomain-like
InterPro IPR010982 Lambda repressor-like, DNA-binding domain
InterPro IPR013847 POU domain
InterPro IPR000327 POU-specific domain
Protein Ontology PR:000013042 POU domain, class 4, transcription factor 2
References
(Earliest) J:9856 He X, et al., Expression of a large family of POU-domain regulatory genes in mammalian brain development [published erratum appears in Nature 1989 Aug 24;340(6235):662]. Nature. 1989 Jul 6;340(6228):35-41
(Latest) J:220735 Wu F, et al., Two transcription factors, Pou4f2 and Isl1, are sufficient to specify the retinal ganglion cell fate. Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1559-68
All references(205)
Other
accession IDs
MGD-MRK-1631, MGD-MRK-19368, MGD-MRK-19462, MGI:102576

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory