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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pou4f2
POU domain, class 4, transcription factor 2
MGI:102524
37 phenotypes from 11 alleles in 13 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Opn4tm1.1(cre)Saha/Opn4+
Pou4f2tm4(DTA)Whk/Pou4f2+
involves: 129S/SvEv * C57BL/6 		abnormal circadian behavior period J:174940
normal behavior/neurological phenotype J:174940
decreased retina ganglion cell number J:174940
impaired pupillary reflex J:174940
normal vision/eye phenotype J:174940
Opn4tm1.1(cre)Saha/Opn4+
Pou4f2tm4(DTA)Whk/Pou4f2+
Tg(CAG-Bgeo/ALPP)1Lbe/0
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal innervation J:174940
abnormal olivary pretectal nucleus morphology J:174940
decreased retina ganglion cell number J:174940
Opn4tm1.1(cre)Saha/Opn4+
Pou4f2tm2.1Nat/Pou4f2+
involves: 129 * C57BL/6 		abnormal innervation J:174940
abnormal suprachiasmatic nucleus morphology J:174940
Opn4tm2.1(cre/ERT2)Saha/Opn4+
Pou4f2tm2.1Nat/Pou4f2+
involves: 129 * C57BL/6 		abnormal innervation J:174940
abnormal suprachiasmatic nucleus morphology J:174940
Pou4f2tm1(ALPP)Whk/Pou4f2tm2Whk
Not Specified 		abnormal optic nerve innervation J:134978
abnormal optic nerve morphology J:96926
increased retina apoptosis J:96926
retina ganglion cell degeneration J:96926
Pou4f2tm1(Pou4f1)Gan/Pou4f2tm2Whk
involves: 129S7/SvEvBrd * C57BL/6J 		normal vision/eye phenotype J:96926
Pou4f2tm1.1(cre)Tcba/Pou4f2tm1.1(cre)Tcba
involves: 129 * C57BL/6 		no abnormal phenotype detected J:215125
Pou4f2tm1.1Xmu/Pou4f2tm1.1Xmu
involves: 129S6/SvEvTac * C57BL/6 		no abnormal phenotype detected J:151244
Pou4f2tm1Nat/Pou4f2tm1Nat
B6.129S7-Pou4f2tm1Nat 		abnormal eye electrophysiology J:135827
decreased retina ganglion cell number J:135827
Pou4f2tm1Nat/Pou4f2tm1Nat
involves: 129S7/SvEvBrd * C57BL/6 		abnormal circardian behavior entrainment J:147350
abnormal neuron physiology J:109300
abnormal visual pursuit J:147350
decreased retina ganglion cell number J:32903
impaired pupillary reflex J:147350
optic nerve hypoplasia J:32903
retina hypoplasia J:32903
shortened circadian behavior period J:147350
thin retina ganglion layer J:32903
thin retina inner nuclear layer J:32903
thin retina outer nuclear layer J:32903
Pou4f2tm1Nat/Pou4f2tm2.1Nat
Tg(Pax6-cre,GFP)2Pgr/?
involves: 129S7/SvEvBrd 		abnormal lateral geniculate nucleus morphology J:147350
abnormal optic tract morphology J:147350
abnormal retina ganglion cell morphology J:147350
abnormal superior colliculus morphology J:147350
decreased retina ganglion cell number J:147350
Pou4f2tm1Rsd/Pou4f2tm1Rsd
involves: 129S4/SvJae 		abnormal superior colliculus morphology J:33502
retina ganglion cell degeneration J:33502
Pou4f2tm2.1Gan/Pou4f2tm2.1Gan
Tg(CAG-cre/Esr1*)5Amc/0
involves: C57BL/6 * C57BL/6J * CBA 		normal vision/eye phenotype J:215207
Pou4f2tm3Whk/Pou4f2tm3Whk
Not Specified 		abnormal optic nerve morphology J:73779
abnormal retina ganglion cell morphology J:73779
abnormal retina morphology J:73779
abnormal retina nerve fiber layer morphology J:73779
abnormal sensory neuron innervation pattern J:73779
decreased retina ganglion cell number J:73779
increased amacrine cell number J:73779
thin retina ganglion layer J:73779
Pou4f2tm4(DTA)Whk/Pou4f2+
Tg(CAG-cre/Esr1*)5Amc/0
involves: 129S/SvEv * C57BL/6 * CBA 		abnormal optic nerve morphology J:146558
abnormal vision J:146558
gliosis J:146558
optic nerve atrophy J:146558
optic nerve degeneration J:146558
thin retina ganglion layer J:146558
Pou4f2tm4(DTA)Whk/Pou4f2tm4(DTA)Whk
Tg(Six3-cre)69Frty/?
involves: 129S/SvEv * C57BL/6 * DBA/2 		abnormal eye electrophysiology J:97089
abnormal optic disk morphology J:97089
abnormal optic nerve morphology J:97089
abnormal retina morphology J:97089
decreased total retina thickness J:97089
thin retina ganglion layer J:97089
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory