Pou4f2^{tm1(Pou4f1)Gan}
Targeted Allele Detail

Summary

• Symbol: Pou4f2^{tm1(Pou4f1)Gan}
• Name: POU domain, class 4, transcription factor 2; targeted mutation 1, Lin Gan
• MGI ID: MGI:3574584
• Synonyms: Brn3a^ki, Brn3b^3a, Pou4f2^{tm1(Pou4f1)Lg}
• Gene: Pou4f2 Location: Chr8:79159639-79163274 bp, - strand Genetic Position: Chr8, 36.99 cM, cytoband F1-F5
• Alliance: Pou4f2^{tm1(Pou4f1)Gan} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96926
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The coding region in 2 exons was replaced with the Pou4f1 cDNA sequence containing only the ORF. A lacZ sequence tag was inserted 3' to the Pou4f1 translational stop codon. Immunolabeling with Pou4f1 antibody detected expression beginning at E11.5 in the nuroblast and ganglion layers. (J:96926)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pou4f2 Mutation: 7 strains or lines available

References

• Original: J:96926 Pan L, et al., Functional equivalence of Brn3 POU-domain transcription factors in mouse retinal neurogenesis. Development. 2005 Feb;132(4):703-12
• All: 1 reference(s)