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Pou5f1
Gene Detail
Symbol

Name
ID
Pou5f1
POU domain, class 5, transcription factor 1
MGI:101893
Synonyms
Oct-3, Oct-3/4, Oct3/4, Oct4, Oct-4, Otf3, Otf-3, Otf3g, Otf3-rs7, Otf4, Otf-4
Feature Type
protein coding gene
Genetic Map
Chromosome 17
18.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr17:35506018-35510772 bp, + strand
From VEGA annotation of GRCm38

  4755 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8422  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: POU5F1
Protein SuperFamily: transcription factor Oct-3
Gene Tree: Pou5f1

Human
homologs
POU5F1, POU class 5 homeobox 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 5460
neXtProt AC: NX_Q01860

Human Synonyms: Oct-3, OCT3, Oct-4, OCT4, OTF3, OTF-3, OTF4

Human Chr (Location): 6p21.31; chr6:31164337-31170693 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(96) : Gene trapped(79) Targeted(16) Transgenic(1)
Genomic Mutations involving Pou5f1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygosity for a targeted null mutation results in peri-implantation lethality prior to the egg cylinder stage, associated with failure to develop a pluripotent inner cell mass. Conditional mutations show defects in reproduction.
 
Phenotype Images(1)
Interactions
Pou5f1 interacts with 32 markers (Mir24-1, Mir24-2, Mir103-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (107 annotations)
Process blastocyst growth, BMP signaling pathway involved in heart induction, ...
Component cytoplasm, cytosol, ...
Function chromatin binding, chromatin DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (347 records)
Data Summary: Results (706)    Tissues (258)    Images (246)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 128
RNA in situ 294
Northern blot 45
Western blot 1
RT-PCR 233
RNase protection 5
cDNA source data(55)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(123) Genomic(9) cDNA(61) Primer pair(31) Other(22)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000037235 (Evidence)
Ensembl Gene Model ENSMUSG00000024406 (Evidence)
Entrez Gene 18999 (Evidence)
UniGene 17031
DFCI TC1579170
DoTS DT.91336507, DT.492255
NIA Mouse Gene Index U017906
PDB 3L1P, 1OCP
Consensus CDS Project CCDS37600.1
International Mouse Phenotyping Consortium Status Pou5f1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037235 VEGA Gene Model | MGI Sequence Detail 4755 C57BL/6J ±  kb
transcript OTTMUST00000096009 VEGA | MGI Sequence Detail 1362 Not Applicable 
polypeptide OTTMUSP00000053597 VEGA | MGI Sequence Detail 352 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(8) UniProt(5)
Polymorphisms
RFLP(7) : SNPs within 2kb(38 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR010982 Lambda repressor-like, DNA-binding domain
InterPro IPR013847 POU domain
InterPro IPR015585 POU domain-containing protein, class 5
InterPro IPR000327 POU-specific
Protein Ontology PR:000013044 POU domain, class 5, transcription factor 1
References
(Earliest) J:10293 Okamoto K, et al., A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Cell. 1990 Feb 9;60(3):461-72
(Latest) J:219587 Geula S, et al., Stem cells. m6A mRNA methylation facilitates resolution of naive pluripotency toward differentiation. Science. 2015 Feb 27;347(6225):1002-6
All references(512)
Other
accession IDs
MGD-MRK-12976, MGD-MRK-12977, MGD-MRK-13063, MGD-MRK-13065, MGD-MRK-13070, MGD-MRK-13077, MGD-MRK-13080, MGD-MRK-18720, MGD-MRK-19416

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory