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Pou5f1 Gene Detail
Summary
  • Symbol
    Pou5f1
  • Name
    POU domain, class 5, transcription factor 1
  • Synonyms
    Oct-3, Oct-3/4, Oct3/4, Oct4, Oct-4, Otf3, Otf-3, Otf3g, Otf3-rs7, Otf4, Otf-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:101893
    NCBI Gene: 18999
  • Gene Overview
    MyGene.info: POU5F1
Location & Maps
more
  • Sequence Map
    Chr17:35506018-35510772 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4755 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.69 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    POU5F1, POU class 5 homeobox 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    POU5F1, POU class 5 homeobox 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Oct-3, OCT3, Oct-4, OCT4, OTF3, OTF-3, OTF4
  • Links
    NCBI Gene ID: 5460
    neXtProt AC: NX_Q01860

  • Chr Location
    6p21.31; chr6:31164337-31170693 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 8 alleles in 10 genetic backgrounds
    22 phenotypes from multigenic genotypes
    54 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    96
  • Gene trapped
    79
  • Targeted
    16
  • Transgenic
    1
  • Genomic Mutations
    1 involving Pou5f1
  • Incidental Mutations
Homozygosity for a targeted null mutation results in peri-implantation lethality prior to the egg cylinder stage, associated with failure to develop a pluripotent inner cell mass. Conditional mutations show defects in reproduction.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037235 VEGA Gene Model | MGI Sequence Detail 4755 C57BL/6J ±  kb
transcript OTTMUST00000096009 VEGA | MGI Sequence Detail 1362 Not Applicable  
polypeptide OTTMUSP00000053597 VEGA | MGI Sequence Detail 352 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 133
    Genomic 9
    cDNA 63
    Primer pair 38
    Other 23

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-12976, MGD-MRK-12977, MGD-MRK-13063, MGD-MRK-13065, MGD-MRK-13070, MGD-MRK-13077, MGD-MRK-13080, MGD-MRK-18720, MGD-MRK-19416
References
more
  • Summaries
    All 550
    Developmental Gene Expression 374
    Gene Ontology 75
    Phenotypes 54
  • Earliest
    J:10293 Okamoto K, et al., A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Cell. 1990 Feb 9;60(3):461-72
  • Latest
    J:233340 Fang L, et al., H3K4 Methyltransferase Set1a Is A Key Oct4 Coactivator Essential for Generation of Oct4 Positive Inner Cell Mass. Stem Cells. 2016 Mar;34(3):565-80

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory