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Pou5f1 Gene Detail
Summary
  • Symbol
    Pou5f1
  • Name
    POU domain, class 5, transcription factor 1
  • Synonyms
    Oct-3, Oct-3/4, Oct3/4, Oct4, Oct-4, Otf3, Otf-3, Otf3g, Otf3-rs7, Otf4, Otf-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:101893
    NCBI Gene: 18999
Location & Maps
more
  • Sequence Map
    Chr17:35506018-35510772 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4755 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    POU5F1, POU class 5 homeobox 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    POU5F1, POU class 5 homeobox 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    Oct-3, OCT3, Oct-4, OCT4, OTF3, OTF-3, OTF4
  • Links
    NCBI Gene ID: 5460
    neXtProt AC: NX_Q01860

  • Chr Location
    6p21.31; chr6:31164337-31170693 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 8 alleles in 10 genetic backgrounds
    22 phenotypes from multigenic genotypes
    52 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    96
  • Gene trapped
    79
  • Targeted
    16
  • Transgenic
    1
  • Genomic Mutations
    1 involving Pou5f1
  • Incidental Mutations
Homozygosity for a targeted null mutation results in peri-implantation lethality prior to the egg cylinder stage, associated with failure to develop a pluripotent inner cell mass. Conditional mutations show defects in reproduction.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037235 VEGA Gene Model | MGI Sequence Detail 4755 C57BL/6J ±  kb
transcript OTTMUST00000096009 VEGA | MGI Sequence Detail 1362 Not Applicable  
polypeptide OTTMUSP00000053597 VEGA | MGI Sequence Detail 352 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    38 from dbSNP Build 137
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 132
    Genomic 9
    cDNA 63
    Primer pair 37
    Other 23

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-12976, MGD-MRK-12977, MGD-MRK-13063, MGD-MRK-13065, MGD-MRK-13070, MGD-MRK-13077, MGD-MRK-13080, MGD-MRK-18720, MGD-MRK-19416
References
more
  • Summaries
    All 533
    Developmental Gene Expression 361
    Gene Ontology 73
    Phenotypes 52
  • Earliest
    J:10293 Okamoto K, et al., A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Cell. 1990 Feb 9;60(3):461-72
  • Latest
    J:226269 Bustamante-Marin XM, et al., Left-Biased Spermatogenic Failure in 129/SvJ Dnd1Ter/+ Mice Correlates with Differences in Vascular Architecture, Oxygen Availability, and Metabolites. Biol Reprod. 2015 Sep;93(3):78

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory