About   Help   FAQ
Pou5f1 Gene Detail
Summary
  • Symbol
    Pou5f1
  • Name
    POU domain, class 5, transcription factor 1
  • Synonyms
    Oct-3, Oct-3/4, Oct3/4, Oct4, Oct-4, Otf3, Otf-3, Otf3g, Otf3-rs7, Otf4, Otf-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:101893
    NCBI Gene: 18999
  • Gene Overview
    MyGene.info: POU5F1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr17:35506018-35510772 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4755 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 18.69 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    POU5F1, POU class 5 homeobox 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    POU5F1, POU class 5 homeobox 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    Oct-3, OCT3, Oct-4, OCT4, OTF3, OTF-3, OTF4
  • Links
    NCBI Gene ID: 5460
    neXtProt AC: NX_Q01860
    UniProt: Q01860

  • Chr Location
    6p21.33; chr6:31164337-31170693 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 8 alleles in 10 genetic backgrounds
    22 phenotypes from multigenic genotypes
    75 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygosity for a targeted null mutation results in peri-implantation lethality prior to the egg cylinder stage, associated with failure to develop a pluripotent inner cell mass. Conditional mutations show defects in reproduction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000037235 VEGA Gene Model | MGI Sequence Detail 4755 C57BL/6J ±  kb
    transcript OTTMUST00000096009 VEGA | MGI Sequence Detail 1362 Not Applicable  
    polypeptide OTTMUSP00000053597 VEGA | MGI Sequence Detail 352 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      2 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 148
      Genomic 10
      cDNA 64
      Primer pair 43
      Other 31

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12976, MGD-MRK-12977, MGD-MRK-13063, MGD-MRK-13065, MGD-MRK-13070, MGD-MRK-13077, MGD-MRK-13080, MGD-MRK-18720, MGD-MRK-19416
    References
    more
    • Summaries
      All 695
      Developmental Gene Expression 430
      Gene Ontology 84
      Phenotypes 75
    • Earliest
      J:10293 Okamoto K, et al., A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Cell. 1990 Feb 9;60(3):461-72
    • Latest
      J:264256 Bernardo AS, et al., Mammalian embryo comparison identifies novel pluripotency genes associated with the naive or primed state. Biol Open. 2018 Aug 17;7(8)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory