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Pou5f1
Gene Detail
 Symbol
Name
ID
Pou5f1
POU domain, class 5, transcription factor 1
MGI:101893
Synonyms Oct-3, Oct-3/4, Oct3/4, Oct4, Oct-4, Otf3, Otf-3, Otf3g, Otf3-rs7, Otf4, Otf-4
Feature Type protein coding gene
Genetic Map
Chromosome 17
18.69 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr17:35506018-35510772 bp, + strand
From VEGA annotation of GRCm38

  4755 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8422  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Protein SuperFamily: transcription factor Oct-3
Gene Tree: Pou5f1

Human
homologs
Human Homolog POU5F1, POU class 5 homeobox 1
NCBI Gene ID 5460
neXtProt AC  NX_Q01860
Human Synonyms  Oct-3, OCT3, Oct-4, OCT4, OTF3, OTF-3, OTF4
Human Chr (Location)  6p21.31; chr6:31164337-31170693 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(88) : Gene trapped(79) Targeted(9)
Genomic Mutations involving Pou5f1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygosity for a targeted null mutation results in peri-implantation lethality prior to the egg cylinder stage, associated with failure to develop a pluripotent inner cell mass. Conditional mutations show defects in reproduction.
 
Interactions
Pou5f1 interacts with 32 markers (Mir24-1, Mir24-2, Mir103-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (97 annotations)
Process BMP signaling pathway involved in heart induction, cardiac cell fate determination, ...
Component cytoplasm, cytosol, ...
Function chromatin binding, DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (328 records)
Data Summary: Results (670)    Tissues (252)    Images (234)
Theiler Stages: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 122
RNA in situ 290
Northern blot 45
Western blot 1
RT-PCR 207
RNase protection 5
cDNA source data(55)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(118) Genomic(9) cDNA(61) Primer pair(27) Other(21)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000037235 (Evidence)
Ensembl Gene ModelENSMUSG00000024406 (Evidence)
Entrez Gene18999 (Evidence)
UniGene17031
DFCITC1579170
DoTSDT.492255, DT.91336507
NIA Mouse Gene IndexU017906
PDB1OCP, 3L1P
Consensus CDS ProjectCCDS37600.1
International Mouse Knockout Project StatusPou5f1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037235 VEGA Gene Model | MGI Sequence Detail 4755 C57BL/6J ±  kb
transcript OTTMUST00000096009 VEGA | MGI Sequence Detail 1362 Not Applicable 
polypeptide OTTMUSP00000053597 VEGA | MGI Sequence Detail 352 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(4) UniProt(5)
Polymorphisms RFLP(7) : SNPs within 2kb(38 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR010982 Lambda repressor-like, DNA-binding domain
InterPro IPR013847 POU domain
InterPro IPR015585 POU domain-containing protein, class 5
InterPro IPR000327 POU-specific
Protein Ontology PR:000013044 POU domain, class 5, transcription factor 1
References (Earliest) J:10293 Okamoto K, et al., A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Cell. 1990 Feb 9;60(3):461-72
(Latest) J:208425 Le Bin GC, et al., Oct4 is required for lineage priming in the developing inner cell mass of the mouse blastocyst. Development. 2014 Mar;141(5):1001-10
All references(493)
Other
accession IDs
MGD-MRK-12976, MGD-MRK-12977, MGD-MRK-13063, MGD-MRK-13065, MGD-MRK-13070, MGD-MRK-13077, MGD-MRK-13080, MGD-MRK-18720, MGD-MRK-19416

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory