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Gene Expression Literature Summary
Symbol
Name
ID
Pou5f1
POU domain, class 5, transcription factor 1
MGI:101893

565 matching records from 565 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.
Age E0.5 E1 E1.5 E2 E2.5 E3 E3.5 E4 E4.5 E5 E5.5 E6 E6.5 E7 E7.5 E8 E8.5 E9 E9.5 E10 E10.5 E11 E11.5 E12 E12.5 E13 E13.5 E14 E14.5 E15 E15.5 E16 E16.5 E17 E17.5 E18 E18.5 E19 E19.5 E P
Immunohistochemistry (section) 1 1 4 18 5 23 3 28 6 30 13 30 3 16 3 16 1 14 1 27 5 21 2 33 18 6 8 2 3 2 1 1 2 20
In situ RNA (section) 1 1 1 2 1 4 2 2 2 3 7 1 9 4 5 3 2 2 6 1 2 17 2 3 1 4 1 2 10
Immunohistochemistry (whole mount) 6 8 2 5 16 19 70 14 24 4 12 2 14 4 9 1 5 3 3 3 1 1 1 2 3
In situ RNA (whole mount) 2 3 3 3 3 8 4 7 7 13 5 33 9 35 11 15 3 8 7 1 9 13 2 20 10 6 2 3 1
In situ reporter (knock in) 1
Northern blot 1 1 1 1 1 1 1 4
Western blot 1 1 1 1 2 1 1 3 1 2 1 1 6
RT-PCR 12 18 5 17 20 18 44 7 9 1 2 18 4 17 2 13 3 8 2 7 10 2 16 25 2 19 1 18 7 8 12 2 4 49
cDNA clones 1 1
RNase protection 1 1 1 1 1 1 1 2

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Pou5f1  POU domain, class 5, transcription factor 1   (Synonyms: Oct-3, Oct-3/4, Oct3/4, Oct4, Oct-4, Otf3, Otf-3, Otf3g, Otf3-rs7, Otf4, Otf-4)
Results  Reference
1J:222738 Abboud N, Moore-Morris T, Hiriart E, Yang H, Bezerra H, Gualazzi MG, Stefanovic S, Guenantin AC, Evans SM, Puceat M, A cohesin-OCT4 complex mediates Sox enhancers to prime an early embryonic lineage. Nat Commun. 2015;6:6749
1*J:231231 Abby E, Tourpin S, Ribeiro J, Daniel K, Messiaen S, Moison D, Guerquin J, Gaillard JC, Armengaud J, Langa F, Toth A, Martini E, Livera G, Implementation of meiosis prophase I programme requires a conserved retinoid-independent stabilizer of meiotic transcripts. Nat Commun. 2016;7:10324
2J:332401 Abuhashem A, Chivu AG, Zhao Y, Rice EJ, Siepel A, Danko CG, Hadjantonakis AK, RNA Pol II pausing facilitates phased pluripotency transitions by buffering transcription. Genes Dev. 2022 Aug 18;36(13-14):770-89
2J:191079 Acampora D, Di Giovannantonio LG, Simeone A, Otx2 is an intrinsic determinant of the embryonic stem cell state and is required for transition to a stable epiblast stem cell condition. Development. 2013 Jan 1;140(1):43-55
7J:238298 Acampora D, Omodei D, Petrosino G, Garofalo A, Savarese M, Nigro V, Di Giovannantonio LG, Mercadante V, Simeone A, Loss of the Otx2-Binding Site in the Nanog Promoter Affects the Integrity of Embryonic Stem Cell Subtypes and Specification of Inner Cell Mass-Derived Epiblast. Cell Rep. 2016 Jun 21;15(12):2651-64
6*J:118938 Adachi K, Soeta-Saneyoshi C, Sagara H, Iwakura Y, Crucial role of Bysl in mammalian preimplantation development as an integral factor for 40S ribosome biogenesis. Mol Cell Biol. 2007 Mar;27(6):2202-14
2J:306539 Aeby E, Lee HG, Lee YW, Kriz A, Del Rosario BC, Oh HJ, Boukhali M, Haas W, Lee JT, Decapping enzyme 1A breaks X-chromosome symmetry by controlling Tsix elongation and RNA turnover. Nat Cell Biol. 2020 Sep;22(9):1116-1129
1J:160922 Ahmed K, Dehghani H, Rugg-Gunn P, Fussner E, Rossant J, Bazett-Jones DP, Global chromatin architecture reflects pluripotency and lineage commitment in the early mouse embryo. PLoS One. 2010;5(5):e10531
2*J:236309 Aires R, Jurberg AD, Leal F, Novoa A, Cohn MJ, Mallo M, Oct4 Is a Key Regulator of Vertebrate Trunk Length Diversity. Dev Cell. 2016 Aug 8;38(3):262-74
1J:146589 Akamatsu W, DeVeale B, Okano H, Cooney AJ, van der Kooy D, Suppression of Oct4 by germ cell nuclear factor restricts pluripotency and promotes neural stem cell development in the early neural lineage. J Neurosci. 2009 Feb 18;29(7):2113-24
2J:195303 Aksoy I, Jauch R, Chen J, Dyla M, Divakar U, Bogu GK, Teo R, Leng Ng CK, Herath W, Lili S, Hutchins AP, Robson P, Kolatkar PR, Stanton LW, Oct4 switches partnering from Sox2 to Sox17 to reinterpret the enhancer code and specify endoderm. EMBO J. 2013 Apr 3;32(7):938-53
2J:163855 Alder O, Lavial F, Helness A, Brookes E, Pinho S, Chandrashekran A, Arnaud P, Pombo A, O'Neill L, Azuara V, Ring1B and Suv39h1 delineate distinct chromatin states at bivalent genes during early mouse lineage commitment. Development. 2010 Aug 1;137(15):2483-92
3J:326354 Allegre N, Chauveau S, Dennis C, Renaud Y, Meistermann D, Estrella LV, Pouchin P, Cohen-Tannoudji M, David L, Chazaud C, NANOG initiates epiblast fate through the coordination of pluripotency genes expression. Nat Commun. 2022 Jun 21;13(1):3550
1*J:239949 Amakawa Y, Sakata Y, Hoki Y, Arata S, Shioda S, Fukagawa T, Sasaki H, Sado T, A new Xist allele driven by a constitutively active promoter is dominated by Xist locus environment and exhibits the parent-of-origin effects. Development. 2015 Dec 15;142(24):4299-308
1J:270141 An Y, Sekinaka T, Tando Y, Okamura D, Tanaka K, Ito-Matsuoka Y, Takehara A, Yaegashi N, Matsui Y, Derivation of pluripotent stem cells from nascent undifferentiated teratoma. Dev Biol. 2019 Feb 1;446(1):43-55
1*J:55247 Anderson R, Fassler R, Georges-Labouesse E, Hynes RO, Bader BL, Kreidberg JA, Schaible K, Heasman J, Wylie C, Mouse primordial germ cells lacking beta1 integrins enter the germline but fail to migrate normally to the gonads. Development. 1999 Apr;126(8):1655-64
1*J:184591 Aoyama M, Sun-Wada GH, Yamamoto A, Yamamoto M, Hamada H, Wada Y, Spatial Restriction of Bone Morphogenetic Protein Signaling in Mouse Gastrula through the mVam2-Dependent Endocytic Pathway. Dev Cell. 2012 Jun 12;22(6):1163-75
1J:247201 Arora R, Abby E, Ross AD, Cantu AV, Kissner MD, Castro V, Ho HY, Livera G, Laird DJ, Meiotic onset is reliant on spatial distribution but independent of germ cell number in the mouse ovary. J Cell Sci. 2016 Jul 01;129(13):2493-9
2*J:81180 Avilion AA, Nicolis SK, Pevny LH, Perez L, Vivian N, Lovell-Badge R, Multipotent cell lineages in early mouse development depend on SOX2 function. Genes Dev. 2003 Jan 1;17(1):126-40
2J:245724 Azami T, Waku T, Matsumoto K, Jeon H, Muratani M, Kawashima A, Yanagisawa J, Manabe I, Nagai R, Kunath T, Nakamura T, Kurimoto K, Saitou M, Takahashi S, Ema M, Klf5 maintains the balance of primitive endoderm versus epiblast specification during mouse embryonic development by suppression of Fgf4. Development. 2017 Oct 15;144(20):3706-3718
3J:314663 Bang J, Han M, Yoo TJ, Qiao L, Jung J, Na J, Carlson BA, Gladyshev VN, Hatfield DL, Kim JH, Kim LK, Lee BJ, Identification of Signaling Pathways for Early Embryonic Lethality and Developmental Retardation in Sephs1(-/-) Mice. Int J Mol Sci. 2021 Oct 28;22(21)
1J:130205 Barrow JR, Howell WD, Rule M, Hayashi S, Thomas KR, Capecchi MR, McMahon AP, Wnt3 signaling in the epiblast is required for proper orientation of the anteroposterior axis. Dev Biol. 2007 Dec 1;312(1):312-20
1*J:99569 Barrow KM, Ward CM, Rutter J, Ali S, Stern PL, Embryonic expression of murine 5T4 oncofoetal antigen is associated with morphogenetic events at implantation and in developing epithelia. Dev Dyn. 2005 Aug;233(4):1535-45
1J:253960 Basilicata MF, Frank M, Solter D, Brabletz T, Stemmler MP, Inappropriate cadherin switching in the mouse epiblast compromises proper signaling between the epiblast and the extraembryonic ectoderm during gastrulation. Sci Rep. 2016 May 24;6:26562
1J:81247 Beck S, Le Good JA, Guzman M, Ben Haim N, Roy K, Beermann F, Constam DB, Extraembryonic proteases regulate Nodal signalling during gastrulation. Nat Cell Biol. 2002 Dec;4(12):981-5
1*J:329966 Bell CJ, Gupta N, Tremblay KD, Mager J, Borcs6 is required for endo-lysosomal degradation during early development. Mol Reprod Dev. 2022 Aug;89(8):337-350
1J:201097 Beraldo FH, Soares IN, Goncalves DF, Fan J, Thomas AA, Santos TG, Mohammad AH, Roffe M, Calder MD, Nikolova S, Hajj GN, Guimaraes AL, Massensini AR, Welch I, Betts DH, Gros R, Drangova M, Watson AJ, Bartha R, Prado VF, Martins VR, Prado MA, Stress-inducible phosphoprotein 1 has unique cochaperone activity during development and regulates cellular response to ischemia via the prion protein. FASEB J. 2013 Sep;27(9):3594-607
5*J:264256 Bernardo AS, Jouneau A, Marks H, Kensche P, Kobolak J, Freude K, Hall V, Feher A, Polgar Z, Sartori C, Bock I, Louet C, Faial T, Kerstens HHD, Bouissou C, Parsonage G, Mashayekhi K, Smith JC, Lazzari G, Hyttel P, Stunnenberg HG, Huynen M, Pedersen RA, Dinnyes A, Mammalian embryo comparison identifies novel pluripotency genes associated with the naive or primed state. Biol Open. 2018 Aug 17;7(8):bio033282
1*J:86391 Bernstein E, Kim SY, Carmell MA, Murchison EP, Alcorn H, Li MZ, Mills AA, Elledge SJ, Anderson KV, Hannon GJ, Dicer is essential for mouse development. Nat Genet. 2003 Nov;35(3):215-7
1J:221596 Bertero A, Madrigal P, Galli A, Hubner NC, Moreno I, Burks D, Brown S, Pedersen RA, Gaffney D, Mendjan S, Pauklin S, Vallier L, Activin/nodal signaling and NANOG orchestrate human embryonic stem cell fate decisions by controlling the H3K4me3 chromatin mark. Genes Dev. 2015 Apr 1;29(7):702-17
2J:227651 Bessonnard S, Mesnard D, Constam DB, PC7 and the related proteases Furin and Pace4 regulate E-cadherin function during blastocyst formation. J Cell Biol. 2015 Sep 28;210(7):1185-97
1J:201276 Betschinger J, Nichols J, Dietmann S, Corrin PD, Paddison PJ, Smith A, Exit from pluripotency is gated by intracellular redistribution of the bHLH transcription factor Tfe3. Cell. 2013 Apr 11;153(2):335-47
1*J:150223 Beverdam A, Svingen T, Bagheri-Fam S, Bernard P, McClive P, Robson M, Khojasteh MB, Salehi M, Sinclair AH, Harley VR, Koopman P, Sox9-dependent expression of Gstm6 in Sertoli cells during testis development in mice. Reproduction. 2009 Mar;137(3):481-6
2J:254597 Bhargava S, Cox B, Polydorou C, Gresakova V, Korinek V, Strnad H, Sedlacek R, Epp TA, Chawengsaksophak K, The epigenetic modifier Fam208a is required to maintain epiblast cell fitness. Sci Rep. 2017 Aug 24;7(1):9322
1*J:198636 Biechele S, Cockburn K, Lanner F, Cox BJ, Rossant J, Porcn-dependent Wnt signaling is not required prior to mouse gastrulation. Development. 2013 Jul;140(14):2961-71
2J:74982 Bleckmann SC, Blendy JA, Rudolph D, Monaghan AP, Schmid W, Schutz G, Activating transcription factor 1 and CREB are important for cell survival during early mouse development. Mol Cell Biol. 2002 Mar;22(6):1919-25
2J:153050 Bogani D, Siggers P, Brixey R, Warr N, Beddow S, Edwards J, Williams D, Wilhelm D, Koopman P, Flavell RA, Chi H, Ostrer H, Wells S, Cheeseman M, Greenfield A, Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination. PLoS Biol. 2009 Sep;7(9):e1000196
3J:340618 Bondarenko V, Nikolaev M, Kromm D, Belousov R, Wolny A, Blotenburg M, Zeller P, Rezakhani S, Hugger J, Uhlmann V, Hufnagel L, Kreshuk A, Ellenberg J, van Oudenaarden A, Erzberger A, Lutolf MP, Hiiragi T, Embryo-uterine interaction coordinates mouse embryogenesis during implantation. EMBO J. 2023 Sep 4;42(17):e113280
6J:219394 Boroviak T, Loos R, Bertone P, Smith A, Nichols J, The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification. Nat Cell Biol. 2014 Jun;16(6):516-28
9J:82465 Bortvin A, Eggan K, Skaletsky H, Akutsu H, Berry DL, Yanagimachi R, Page DC, Jaenisch R, Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei. Development. 2003 Apr;130(8):1673-80
1J:112229 Bosman EA, Lawson KA, Debruyn J, Beek L, Francis A, Schoonjans L, Huylebroeck D, Zwijsen A, Smad5 determines murine amnion fate through the control of bone morphogenetic protein expression and signalling levels. Development. 2006 Sep;133(17):3399-409
3*J:48570 Botquin V, Hess H, Fuhrmann G, Anastassiadis C, Gross MK, Vriend G, Scholer HR, New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2. Genes Dev. 1998 Jul 1;12(13):2073-90
1J:64333 Bowles J, Bullejos M, Koopman P, A subtractive gene expression screen suggests a role for vanin-1 in testis development in mice. Genesis. 2000 Jul;27(3):124-35
3*J:164280 Bowles J, Feng CW, Spiller C, Davidson TL, Jackson A, Koopman P, FGF9 suppresses meiosis and promotes male germ cell fate in mice. Dev Cell. 2010 Sep 14;19(3):440-9
3*J:87105 Bowles J, Teasdale RP, James K, Koopman P, Dppa3 is a marker of pluripotency and has a human homologue that is expressed in germ cell tumours. Cytogenet Genome Res. 2003;101(3-4):261-5
1J:149785 Bradford ST, Hiramatsu R, Maddugoda MP, Bernard P, Chaboissier MC, Sinclair A, Schedl A, Harley V, Kanai Y, Koopman P, Wilhelm D, The cerebellin 4 precursor gene is a direct target of SRY and SOX9 in mice. Biol Reprod. 2009 Jun;80(6):1178-88
1*J:151715 Bradford ST, Wilhelm D, Bandiera R, Vidal V, Schedl A, Koopman P, A cell-autonomous role for WT1 in regulating Sry in vivo. Hum Mol Genet. 2009 Sep 15;18(18):3429-38
1J:70006 Brennan J, Lu CC, Norris DP, Rodriguez TA, Beddington RS, Robertson EJ, Nodal signalling in the epiblast patterns the early mouse embryo. Nature. 2001 Jun 21;411(6840):965-9
1*J:334521 Burnet G, Feng CA, Cheung KMF, Bowles J, Spiller CM, Generation and characterization of a Ddx4-iCre transgenic line for deletion in the germline beginning at genital ridge colonization. Genesis. 2023 Mar;61(1-2):e23511
7J:203762 Burton A, Muller J, Tu S, Padilla-Longoria P, Guccione E, Torres-Padilla ME, Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo. Cell Rep. 2013 Nov 14;5(3):687-701
1J:185482 Burtscher I, Barkey W, Schwarzfischer M, Theis FJ, Lickert H, The Sox17-mCherry fusion mouse line allows visualization of endoderm and vascular endothelial development. Genesis. 2012 Jun;50(6):496-505
1J:82463 Cachaco AS, Chuva de Sousa Lopes SM, Kuikman I, Bajanca F, Abe K, Baudoin C, Sonnenberg A, Mummery CL, Thorsteinsdottir S, Knock-in of integrin beta 1D affects primary but not secondary myogenesis in mice. Development. 2003 Apr;130(8):1659-71
2*J:139638 Cai KQ, Capo-Chichi CD, Rula ME, Yang DH, Xu XX, Dynamic GATA6 expression in primitive endoderm formation and maturation in early mouse embryogenesis. Dev Dyn. 2008 Sep 24;237(10):2820-2829
1J:196968 Campolo F, Gori M, Favaro R, Nicolis S, Pellegrini M, Botti F, Rossi P, Jannini EA, Dolci S, Essential role of Sox2 for the establishment and maintenance of the germ cell line. Stem Cells. 2013 Jul;31(7):1408-21
1*J:165230 Carayannopoulos LN, Barks JL, Yokoyama WM, Riley JK, Murine trophoblast cells induce NK cell interferon-gamma production through KLRK1. Biol Reprod. 2010 Sep;83(3):404-14
5*J:140626 Card DA, Hebbar PB, Li L, Trotter KW, Komatsu Y, Mishina Y, Archer TK, Oct4/Sox2-regulated miR-302 targets cyclin D1 in human embryonic stem cells. Mol Cell Biol. 2008 Oct;28(20):6426-38
17*J:186276 Celebi C, van Montfoort A, Skory V, Kieffer E, Kuntz S, Mark M, Viville S, Tex 19 Paralogs Exhibit a Gonad and Placenta-Specific Expression in the Mouse. J Reprod Dev. 2012 Jul 3;58(3):360-5
3*J:70069 Chang H, Matzuk MM, Smad5 is required for mouse primordial germ cell development. Mech Dev. 2001 Jun;104(1-2):61-7
5*J:331510 Chang WF, Lin TY, Peng M, Chang CC, Xu J, Hsieh-Li HM, Liu JL, Sung LY, Survival Motor Neuron Enhances Pluripotent Gene Expression and Facilitates Cell Reprogramming. Stem Cells Dev. 2022 Nov;31(21-22):696-705
2J:179634 Chassot AA, Gregoire EP, Lavery R, Taketo MM, de Rooij DG, Adams IR, Chaboissier MC, RSPO1/beta-catenin signaling pathway regulates oogonia differentiation and entry into meiosis in the mouse fetal ovary. PLoS One. 2011;6(10):e25641
2*J:299356 Chassot AA, Le Rolle M, Jolivet G, Stevant I, Guigonis JM, Da Silva F, Nef S, Pailhoux E, Schedl A, Ghyselinck NB, Chaboissier MC, Retinoic acid synthesis by ALDH1A proteins is dispensable for meiosis initiation in the mouse fetal ovary. Sci Adv. 2020 May;6(21):eaaz1261
1J:133933 Chassot AA, Ranc F, Gregoire EP, Roepers-Gajadien HL, Taketo MM, Camerino G, de Rooij DG, Schedl A, Chaboissier MC, Activation of beta-catenin signaling by Rspo1 controls differentiation of the mammalian ovary. Hum Mol Genet. 2008 May 1;17(9):1264-77
5J:185786 Chawengsaksophak K, Svingen T, Ng ET, Epp T, Spiller CM, Clark C, Cooper H, Koopman P, Loss of Wnt5a disrupts primordial germ cell migration and male sexual development in mice. Biol Reprod. 2012 Jan;86(1):1-12
3J:112232 Chazaud C, Rossant J, Disruption of early proximodistal patterning and AVE formation in Apc mutants. Development. 2006 Sep;133(17):3379-87
2J:108748 Chazaud C, Yamanaka Y, Pawson T, Rossant J, Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-MAPK pathway. Dev Cell. 2006 May;10(5):615-24
3J:231798 Chen CY, Chan CH, Chen CM, Tsai YS, Tsai TY, Wu Lee YH, You LR, Targeted inactivation of murine Ddx3x: essential roles of Ddx3x in placentation and embryogenesis. Hum Mol Genet. 2016 July 15;25(14):2905-2922
2*J:320425 Chen CY, Lee DS, Yan YT, Shen CN, Hwang SM, Lee ST, Hsieh PC, Bcl3 Bridges LIF-STAT3 to Oct4 Signaling in the Maintenance of Naive Pluripotency. Stem Cells. 2015 Dec;33(12):3468-80
2J:277240 Chen CY, Yu IS, Pai CH, Lin CY, Lin SR, Chen YT, Lin SW, Embryonic Cul4b is important for epiblast growth and location of primitive streak layer cells. PLoS One. 2019;14(7):e0219221
1J:316527 Chen HH, Welling M, Bloch DB, Munoz J, Mientjes E, Chen X, Tramp C, Wu J, Yabuuchi A, Chou YF, Buecker C, Krainer A, Willemsen R, Heck AJ, Geijsen N, DAZL limits pluripotency, differentiation, and apoptosis in developing primordial germ cells. Stem Cell Reports. 2014 Nov 11;3(5):892-904
1J:110693 Chen HJ, Lin CM, Lin CS, Perez-Olle R, Leung CL, Liem RK, The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway. Genes Dev. 2006 Jul 15;20(14):1933-45
3J:301138 Chen SH, Lu CH, Tsai MJ, TCTP is Essential for Cell Proliferation and Survival during CNS Development. Cells. 2020 Jan 6;9(1):133
2J:225062 Chen SR, Zheng QS, Zhang Y, Gao F, Liu YX, Disruption of genital ridge development causes aberrant primordial germ cell proliferation but does not affect their directional migration. BMC Biol. 2013;11:22
1J:310811 Chen Y, Damayanti NP, Irudayaraj J, Dunn K, Zhou FC, Diversity of two forms of DNA methylation in the brain. Front Genet. 2014;5:46
4*J:124183 Cheng WC, Hsieh-Li HM, Yeh YJ, Li H, Mice lacking the Obox6 homeobox gene undergo normal early embryonic development and are fertile. Dev Dyn. 2007 Sep;236(9):2636-42
2*J:290315 Cheong A, Archambault D, Degani R, Iverson E, Tremblay KD, Mager J, Nuclear-encoded mitochondrial ribosomal proteins are required to initiate gastrulation. Development. 2020 May 26;147(10):dev188714
2J:301744 Chi RA, Wang T, Huang CL, Wu SP, Young SL, Lydon JP, DeMayo FJ, WNK1 regulates uterine homeostasis and its ability to support pregnancy. JCI Insight. 2020 Nov 19;5(22)
3J:238771 Choi YJ, Lin CP, Risso D, Chen S, Kim TA, Tan MH, Li JB, Wu Y, Chen C, Xuan Z, Macfarlan T, Peng W, Lloyd KC, Kim SY, Speed TP, He L, Deficiency of microRNA miR-34a expands cell fate potential in pluripotent stem cells. Science. 2017 Feb 10;355(6325)
1J:92066 Chu GC, Dunn NR, Anderson DC, Oxburgh L, Robertson EJ, Differential requirements for Smad4 in TGFbeta-dependent patterning of the early mouse embryo. Development. 2004 Aug;131(15):3501-12
2J:160475 Chu J, Shen MM, Functional redundancy of EGF-CFC genes in epiblast and extraembryonic patterning during early mouse embryogenesis. Dev Biol. 2010 Jun 1;342(1):63-73
3J:67053 Chuma S, Nakatsuji N, Autonomous transition into meiosis of mouse fetal germ cells in vitro and its inhibition by gp130-mediated signaling. Dev Biol. 2001 Jan 15;229(2):468-79
1J:249198 Claveria C, Giovinazzo G, Sierra R, Torres M, Myc-driven endogenous cell competition in the early mammalian embryo. Nature. 2013 Aug 1;500(7460):39-44
1J:199463 Cockburn K, Biechele S, Garner J, Rossant J, The hippo pathway member nf2 is required for inner cell mass specification. Curr Biol. 2013 Jul 8;23(13):1195-201
8*J:148410 Combes AN, Lesieur E, Harley VR, Sinclair AH, Little MH, Wilhelm D, Koopman P, Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development. Dev Dyn. 2009 May;238(5):1033-41
1J:158334 Combes AN, Spiller CM, Harley VR, Sinclair AH, Dunwoodie SL, Wilhelm D, Koopman P, Gonadal defects in Cited2-mutant mice indicate a role for SF1 in both testis and ovary differentiation. Int J Dev Biol. 2010;54(4):683-9
5J:167041 Cook MS, Munger SC, Nadeau JH, Capel B, Regulation of male germ cell cycle arrest and differentiation by DND1 is modulated by genetic background. Development. 2011 Jan;138(1):23-32
2J:112036 Costa Y, Speed RM, Gautier P, Semple CA, Maratou K, Turner JM, Cooke HJ, Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway?. Hum Mol Genet. 2006 Aug 1;15(15):2324-34
1J:154783 Costello I, Biondi CA, Taylor JM, Bikoff EK, Robertson EJ, Smad4-dependent pathways control basement membrane deposition and endodermal cell migration at early stages of mouse development. BMC Dev Biol. 2009;9:54
3J:105812 Covello KL, Kehler J, Yu H, Gordan JD, Arsham AM, Hu CJ, Labosky PA, Simon MC, Keith B, HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth. Genes Dev. 2006 Mar 1;20(5):557-70
1*J:163340 Cox BJ, Vollmer M, Tamplin O, Lu M, Biechele S, Gertsenstein M, van Campenhout C, Floss T, Kuhn R, Wurst W, Lickert H, Rossant J, Phenotypic annotation of the mouse X chromosome. Genome Res. 2010 Aug;20(8):1154-64
1*J:222418 Czechanski A, Kim H, Byers C, Greenstein I, Stumpff J, Reinholdt LG, Kif18a is specifically required for mitotic progression during germ line development. Dev Biol. 2015 Jun 15;402(2):253-62
2J:239417 Dai HQ, Wang BA, Yang L, Chen JJ, Zhu GC, Sun ML, Ge H, Wang R, Chapman DL, Tang F, Sun X, Xu GL, TET-mediated DNA demethylation controls gastrulation by regulating Lefty-Nodal signalling. Nature. 2016 Oct 27;538(7626):528-532
1J:344642 de la Rosa S, Del Mar Rigual M, Vargiu P, Ortega S, Djouder N, Endogenous retroviruses shape pluripotency specification in mouse embryos. Sci Adv. 2024 Jan 26;10(4):eadk9394
7*J:138685 de Vries WN, Evsikov AV, Brogan LJ, Anderson CP, Graber JH, Knowles BB, Solter D, Reprogramming and differentiation in mammals: motifs and mechanisms. Cold Spring Harb Symp Quant Biol. 2008;73:33-8
2J:317152 Dehghan Z, Mohammadi-Yeganeh S, Rezaee D, Salehi M, MicroRNA-21 is involved in oocyte maturation, blastocyst formation, and pre-implantation embryo development. Dev Biol. 2021 Dec;480:69-77
2J:245871 Del Rosario BC, Del Rosario AM, Anselmo A, Wang PI, Sadreyev RI, Lee JT, Genetic Intersection of Tsix and Hedgehog Signaling during the Initiation of X-Chromosome Inactivation. Dev Cell. 2017 Nov 06;43(3):359-371.e6
12*J:143899 Dettman EJ, Justice MJ, The zinc finger SET domain gene Prdm14 is overexpressed in lymphoblastic lymphomas with retroviral insertions at Evi32. PLoS One. 2008;3(11):e3823
1J:226026 Deuve JL, Bonnet-Garnier A, Beaujean N, Avner P, Morey C, Antagonist Xist and Tsix co-transcription during mouse oogenesis and maternal Xist expression during pre-implantation development calls into question the nature of the maternal imprint on the X chromosome. Epigenetics. 2015 Oct 3;10(10):931-42
2J:124681 Di-Gregorio A, Sancho M, Stuckey DW, Crompton LA, Godwin J, Mishina Y, Rodriguez TA, BMP signalling inhibits premature neural differentiation in the mouse embryo. Development. 2007 Sep;134(18):3359-69
2*J:224530 Dietrich JE, Panavaite L, Gunther S, Wennekamp S, Groner AC, Pigge A, Salvenmoser S, Trono D, Hufnagel L, Hiiragi T, Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages. EMBO Rep. 2015 Aug;16(8):1005-21
1J:50343 Ding J, Yang L, Yan YT, Chen A, Desai N, Wynshaw-Boris A, Shen MM, Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo [see comments]. Nature. 1998 Oct 15;395(6703):702-7
8J:199467 Do DV, Ueda J, Messerschmidt DM, Lorthongpanich C, Zhou Y, Feng B, Guo G, Lin PJ, Hossain MZ, Zhang W, Moh A, Wu Q, Robson P, Ng HH, Poellinger L, Knowles BB, Solter D, Fu XY, A genetic and developmental pathway from STAT3 to the OCT4-NANOG circuit is essential for maintenance of ICM lineages in vivo. Genes Dev. 2013 Jun 15;27(12):1378-90
1*J:263987 Dobreva MP, Abon Escalona V, Lawson KA, Sanchez MN, Ponomarev LC, Pereira PNG, Stryjewska A, Criem N, Huylebroeck D, Chuva de Sousa Lopes SM, Aerts S, Zwijsen A, Amniotic ectoderm expansion in mouse occurs via distinct modes and requires SMAD5-mediated signalling. Development. 2018 Jul 2;145(13):dev157222
7J:36227 Dominov JA, Miller JB, POU homeodomain genes and myogenesis. Dev Genet. 1996;19(2):108-18
3J:98382 Donnison M, Beaton A, Davey HW, Broadhurst R, L'huillier P, Pfeffer PL, Loss of the extraembryonic ectoderm in Elf5 mutants leads to defects in embryonic patterning. Development. 2005 May;132(10):2299-308
1J:218169 Donnison M, Broadhurst R, Pfeffer PL, Elf5 and Ets2 maintain the mouse extraembryonic ectoderm in a dosage dependent synergistic manner. Dev Biol. 2015 Jan 1;397(1):77-88
3*J:179731 Douglas NC, Heng K, Sauer MV, Papaioannou VE, Dynamic expression of Tbx2 subfamily genes in development of the mouse reproductive system. Dev Dyn. 2012 Feb;241(2):365-75
6*J:247900 Downs KM, Systematic localization of Oct-3/4 to the gastrulating mouse conceptus suggests manifold roles in mammalian development. Dev Dyn. 2008 Feb;237(2):464-75
3J:146503 Downs KM, Inman KE, Jin DX, Enders AC, The Allantoic Core Domain: New insights into development of the murine allantois and its relation to the primitive streak. Dev Dyn. 2009 Mar;238(3):532-53
1*J:165751 Du J, Takeuchi H, Leonhard-Melief C, Shroyer KR, Dlugosz M, Haltiwanger RS, Holdener BC, O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation. Dev Biol. 2010 Oct 1;346(1):25-38
1J:89189 Dunn NR, Vincent SD, Oxburgh L, Robertson EJ, Bikoff EK, Combinatorial activities of Smad2 and Smad3 regulate mesoderm formation and patterning in the mouse embryo. Development. 2004 Apr;131(8):1717-28
3*J:227640 Economou C, Tsakiridis A, Wymeersch FJ, Gordon-Keylock S, Dewhurst RE, Fisher D, Medvinsky A, Smith AJ, Wilson V, Intrinsic factors and the embryonic environment influence the formation of extragonadal teratomas during gestation. BMC Dev Biol. 2015;15:35
4J:115635 Elling U, Klasen C, Eisenberger T, Anlag K, Treier M, Murine inner cell mass-derived lineages depend on Sall4 function. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16319-24
1J:127542 Elliott AM, de Miguel MP, Rebel VI, Donovan PJ, Identifying genes differentially expressed between PGCs and ES cells reveals a role for CREB-binding protein in germ cell survival. Dev Biol. 2007 Nov 15;311(2):347-58
3J:168358 Ewen K, Jackson A, Wilhelm D, Koopman P, A male-specific role for p38 mitogen-activated protein kinase in germ cell sex differentiation in mice. Biol Reprod. 2010 Dec;83(6):1005-14
1J:120782 Falco G, Lee SL, Stanghellini I, Bassey UC, Hamatani T, Ko MS, Zscan4: A novel gene expressed exclusively in late 2-cell embryos and embryonic stem cells. Dev Biol. 2007 Jul 15;307(2):539-50
14J:116786 Falco G, Stanghellini I, Ko MS, Use of Chuk as an internal standard suitable for quantitative RT-PCR in mouse preimplantation embryos. Reprod Biomed Online. 2006 Sep;13(3):394-403
2*J:297709 Fan R, Kim YS, Wu J, Chen R, Zeuschner D, Mildner K, Adachi K, Wu G, Galatidou S, Li J, Scholer HR, Leidel SA, Bedzhov I, Wnt/Beta-catenin/Esrrb signalling controls the tissue-scale reorganization and maintenance of the pluripotent lineage during murine embryonic diapause. Nat Commun. 2020 Oct 30;11(1):5499
1*J:233340 Fang L, Zhang J, Zhang H, Yang X, Jin X, Zhang L, Skalnik DG, Jin Y, Zhang Y, Huang X, Li J, Wong J, H3K4 Methyltransferase Set1a Is A Key Oct4 Coactivator Essential for Generation of Oct4 Positive Inner Cell Mass. Stem Cells. 2016 Mar;34(3):565-80
2J:154368 Farkas DR, Chapman DL, Kinked tail mutation results in notochord defects in heterozygotes and distal visceral endoderm defects in homozygotes. Dev Dyn. 2009 Oct 29;238(12):3237-3247
2J:303699 Feng CW, Burnet G, Spiller CM, Cheung FKM, Chawengsaksophak K, Koopman P, Bowles J, Identification of regulatory elements required for Stra8 expression in fetal ovarian germ cells of the mouse. Development. 2021 Mar 9;148(5):dev194977
8J:165811 Fernandez-Diaz LC, Laurent A, Girasoli S, Turco M, Longobardi E, Iotti G, Jenkins NA, Fiorenza MT, Copeland NG, Blasi F, The absence of Prep1 causes p53-dependent apoptosis of mouse pluripotent epiblast cells. Development. 2010 Oct;137(20):3393-403
2J:187965 Fleming A, Ghahramani N, Zhu MX, Delot EC, Vilain E, Membrane beta-catenin and adherens junctions in early gonadal patterning. Dev Dyn. 2012 Nov;241(11):1782-98
4*J:71786 Fuhrmann G, Chung AC, Jackson KJ, Hummelke G, Baniahmad A, Sutter J, Sylvester I, Scholer HR, Cooney AJ, Mouse germline restriction of Oct4 expression by germ cell nuclear factor. Dev Cell. 2001 Sep;1(3):377-87
1J:249245 Fujita K, Ogawa R, Ito K, CHD7, Oct3/4, Sox2, and Nanog control FoxD3 expression during mouse neural crest-derived stem cell formation. FEBS J. 2016 Oct;283(20):3791-3806
1J:183346 Futterer A, Raya A, Llorente M, Izpisua-Belmonte JC, de la Pompa JL, Klatt P, Martinez-A C, Ablation of Dido3 compromises lineage commitment of stem cells in vitro and during early embryonic development. Cell Death Differ. 2012 Jan;19(1):132-43
6*J:134633 Gao X, Tate P, Hu P, Tjian R, Skarnes WC, Wang Z, ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a. Proc Natl Acad Sci U S A. 2008 May 6;105(18):6656-61
1J:152858 Garcia-Ortiz JE, Pelosi E, Omari S, Nedorezov T, Piao Y, Karmazin J, Uda M, Cao A, Cole SW, Forabosco A, Schlessinger D, Ottolenghi C, Foxl2 functions in sex determination and histogenesis throughout mouse ovary development. BMC Dev Biol. 2009;9:36
2J:106548 Georgiades P, Rossant J, Ets2 is necessary in trophoblast for normal embryonic anteroposterior axis development. Development. 2006 Mar;133(6):1059-68
5J:219587 Geula S, Moshitch-Moshkovitz S, Dominissini D, Mansour AA, Kol N, Salmon-Divon M, Hershkovitz V, Peer E, Mor N, Manor YS, Ben-Haim MS, Eyal E, Yunger S, Pinto Y, Jaitin DA, Viukov S, Rais Y, Krupalnik V, Chomsky E, Zerbib M, Maza I, Rechavi Y, Massarwa R, Hanna S, Amit I, Levanon EY, Amariglio N, Stern-Ginossar N, Novershtern N, Rechavi G, Hanna JH, Stem cells. m6A mRNA methylation facilitates resolution of naive pluripotency toward differentiation. Science. 2015 Feb 27;347(6225):1002-6
1*J:237226 Ghule PN, Xie RL, Colby JL, Rivera-Perez JA, Jones SN, Lian JB, Stein JL, van Wijnen AJ, Stein GS, Maternal expression and early induction of histone gene transcription factor Hinfp sustains development in pre-implantation embryos. Dev Biol. 2016 Nov 15;419(2):311-320
1J:191095 Gierl MS, Gruhn WH, von Seggern A, Maltry N, Niehrs C, GADD45G functions in male sex determination by promoting p38 signaling and Sry expression. Dev Cell. 2012 Nov 13;23(5):1032-42
5J:172213 Gill ME, Hu YC, Lin Y, Page DC, Licensing of gametogenesis, dependent on RNA binding protein DAZL, as a gateway to sexual differentiation of fetal germ cells. Proc Natl Acad Sci U S A. 2011 May 3;108(18):7443-8
3*J:83729 Goldin SN, Papaioannou VE, Paracrine action of FGF4 during periimplantation development maintains trophectoderm and primitive endoderm. Genesis. 2003 May;36(1):40-7
1J:142592 Goller T, Vauti F, Ramasamy S, Arnold HH, Transcriptional regulator BPTF/FAC1 is essential for trophoblast differentiation during early mouse development. Mol Cell Biol. 2008 Nov;28(22):6819-27
1J:292025 Gomez-Redondo I, Ramos-Ibeas P, Pericuesta E, Fernandez-Gonzalez R, Laguna-Barraza R, Gutierrez-Adan A, Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion. Int J Mol Sci. 2020 Jun 9;21(11):4115
3J:267576 Gontan C, Mira-Bontenbal H, Magaraki A, Dupont C, Barakat TS, Rentmeester E, Demmers J, Gribnau J, REX1 is the critical target of RNF12 in imprinted X chromosome inactivation in mice. Nat Commun. 2018 Nov 12;9(1):4752
1*J:110696 Gonzalez MA, Tachibana KE, Adams DJ, van der Weyden L, Hemberger M, Coleman N, Bradley A, Laskey RA, Geminin is essential to prevent endoreduplication and to form pluripotent cells during mammalian development. Genes Dev. 2006 Jul 15;20(14):1880-4
1J:292336 Goolam M, Xypolita ME, Costello I, Lydon JP, DeMayo FJ, Bikoff EK, Robertson EJ, Mould AW, The transcriptional repressor Blimp1/PRDM1 regulates the maternal decidual response in mice. Nat Commun. 2020 Jun 3;11(1):2782
4J:324723 Gordeeva O, Gordeev A, Erokhov P, Archetypal Architecture Construction, Patterning, and Scaling Invariance in a 3D Embryoid Body Differentiation Model. Front Cell Dev Biol. 2022;10:852071
2J:310310 Gordeeva O, Gordeev A, Khaydukov S, Expression dynamics of Mage family genes during self-renewal and differentiation of mouse pluripotent stem and teratocarcinoma cells. Oncotarget. 2019 May 14;10(35):3248-3266
3J:316177 Govindasamy N, Long H, Jeong HW, Raman R, Ozcifci B, Probst S, Arnold SJ, Riehemann K, Ranga A, Adams RH, Trappmann B, Bedzhov I, 3D biomimetic platform reveals the first interactions of the embryo and the maternal blood vessels. Dev Cell. 2021 Dec 6;56(23):3276-3287.e8
2J:200019 Grabole N, Tischler J, Hackett JA, Kim S, Tang F, Leitch HG, Magnusdottir E, Surani MA, Prdm14 promotes germline fate and naive pluripotency by repressing FGF signalling and DNA methylation. EMBO Rep. 2013 Jul;14(7):629-37
1*J:76264 Gratsch TE, O'Shea KS, Noggin and chordin have distinct activities in promoting lineage commitment of mouse embryonic stem (ES) cells. Dev Biol. 2002 May 1;245(1):83-94
2*J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
1J:145878 Greenbaum MP, Iwamori N, Agno JE, Matzuk MM, Mouse TEX14 Is Required for Embryonic Germ Cell Intercellular Bridges but Not Female Fertility. Biol Reprod. 2009 Mar;80(3):449-57
1J:267191 Gregoire EP, Stevant I, Chassot AA, Martin L, Lachambre S, Mondin M, de Rooij DG, Nef S, Chaboissier MC, NRG1 signalling regulates the establishment of Sertoli cell stock in the mouse testis. Mol Cell Endocrinol. 2018 Dec 15;478:17-31
1*J:62920 Grimmond S, Hateren NV, Siggers P, Arkell R, Larder R, Soares MB, Bonaldo Md, Smith L, Tymowska-Lalanne Z, Wells C, Greenfield A, Sexually dimorphic expression of protease nexin-1 and vanin-1 in the developing mouse gonad prior to overt differentiation suggests a role in mammalian sexual development. Hum Mol Genet. 2000 Jun 12;9(10):1553-60
6*J:97625 Gu P, Goodwin B, Chung AC, Xu X, Wheeler DA, Price RR, Galardi C, Peng L, Latour AM, Koller BH, Gossen J, Kliewer SA, Cooney AJ, Orphan Nuclear Receptor LRH-1 Is Required To Maintain Oct4 Expression at the Epiblast Stage of Embryonic Development. Mol Cell Biol. 2005 May;25(9):3492-505
1J:117667 Gu P, Le Menuet D, Chung AC, Cooney AJ, Differential recruitment of methylated CpG binding domains by the orphan receptor GCNF initiates the repression and silencing of Oct4 expression. Mol Cell Biol. 2006 Dec;26(24):9471-83
1J:334094 Gu X, Heinrich A, Li SY, DeFalco T, Testicular macrophages are recruited during a narrow fetal time window and promote organ-specific developmental functions. Nat Commun. 2023 Mar 15;14(1):1439
4*J:171409 GUDMAP Consortium, GUDMAP: the GenitoUrinary Development Molecular Anatomy Project. www.gudmap.org. 2004;
1J:165736 Guerquin MJ, Duquenne C, Lahaye JB, Tourpin S, Habert R, Livera G, New testicular mechanisms involved in the prevention of fetal meiotic initiation in mice. Dev Biol. 2010 Oct 15;346(2):320-30
8*J:140465 Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P, Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Dev Cell. 2010 Apr 20;18(4):675-85
2*J:217689 Guzman-Ayala M, Sachs M, Koh FM, Onodera C, Bulut-Karslioglu A, Lin CJ, Wong P, Nitta R, Song JS, Ramalho-Santos M, Chd1 is essential for the high transcriptional output and rapid growth of the mouse epiblast. Development. 2015 Jan 1;142(1):118-27
1J:98557 Haines BP, Gupta R, Michael Jones C, Summerbell D, Rigby PW, The NLRR gene family and mouse development: Modified differential display PCR identifies NLRR-1 as a gene expressed in early somitic myoblasts. Dev Biol. 2005 May 15;281(2):145-59
1*J:294860 Han BY, Seah MKY, Brooks IR, Quek DHP, Huxley DR, Foo CS, Lee LT, Wollmann H, Guo H, Messerschmidt DM, Guccione E, Global translation during early development depends on the essential transcription factor PRDM10. Nat Commun. 2020 Jul 17;11(1):3603
4J:321523 Han D, Wu G, Chen R, Drexler HCA, MacCarthy CM, Kim KP, Adachi K, Gerovska D, Mavrommatis L, Bedzhov I, Arauzo-Bravo MJ, Scholer HR, A balanced Oct4 interactome is crucial for maintaining pluripotency. Sci Adv. 2022 Feb 18;8(7):eabe4375
5J:79491 Hanna LA, Foreman RK, Tarasenko IA, Kessler DS, Labosky PA, Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo. Genes Dev. 2002 Oct 15;16(20):2650-61
3J:308478 Haramoto Y, Sakata M, Kobayashi S, Visualization of X chromosome reactivation in mouse primordial germ cells in vivo. Biol Open. 2021 Apr 15;10(4):bio058602
1J:236382 Hargan-Calvopina J, Taylor S, Cook H, Hu Z, Lee SA, Yen MR, Chiang YS, Chen PY, Clark AT, Stage-Specific Demethylation in Primordial Germ Cells Safeguards against Precocious Differentiation. Dev Cell. 2016 Oct 10;39(1):75-86
1J:262492 Harris A, Siggers P, Corrochano S, Warr N, Sagar D, Grimes DT, Suzuki M, Burdine RD, Cong F, Koo BK, Clevers H, Stevant I, Nef S, Wells S, Brauner R, Ben Rhouma B, Belguith N, Eozenou C, Bignon-Topalovic J, Bashamboo A, McElreavey K, Greenfield A, ZNRF3 functions in mammalian sex determination by inhibiting canonical WNT signaling. Proc Natl Acad Sci U S A. 2018 May 22;115(21):5474-5479
2J:242068 Harrison SE, Sozen B, Christodoulou N, Kyprianou C, Zernicka-Goetz M, Assembly of embryonic and extraembryonic stem cells to mimic embryogenesis in vitro. Science. 2017 Apr 14;356(6334)
2*J:90050 Hart AH, Hartley L, Ibrahim M, Robb L, Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human. Dev Dyn. 2004 May;230(1):187-98
2*J:89483 Hattori N, Nishino K, Ko YG, Hattori N, Ohgane J, Tanaka S, Shiota K, Epigenetic control of mouse Oct-4 gene expression in embryonic stem cells and trophoblast stem cells. J Biol Chem. 2004 Apr 23;279(17):17063-9
2J:307968 He Y, Chen Q, Dai J, Cui Y, Zhang C, Wen X, Li J, Xiao Y, Peng X, Liu M, Shen B, Sha J, Hu Z, Li J, Shu W, Single-cell RNA-Seq reveals a highly coordinated transcriptional program in mouse germ cells during primordial follicle formation. Aging Cell. 2021 Jul;20(7):e13424
1J:293102 Heinrich A, Potter SJ, Guo L, Ratner N, DeFalco T, Distinct Roles for Rac1 in Sertoli Cell Function during Testicular Development and Spermatogenesis. Cell Rep. 2020 Apr 14;31(2):107513
1*J:30820 Hermesz E, Mackem S, Mahon KA, Rpx: a novel anterior-restricted homeobox gene progressively activated in the prechordal plate, anterior neural plate and Rathke's pouch of the mouse embryo. Development. 1996 Jan;122(1):41-52
1J:170392 Herzog M, Wendling O, Guillou F, Chambon P, Mark M, Losson R, Cammas F, TIF1beta association with HP1 is essential for post-gastrulation development, but not for Sertoli cell functions during spermatogenesis. Dev Biol. 2011 Feb 15;350(2):548-58
4*J:143379 Hirasawa R, Sasaki H, Dynamic transition of Dnmt3b expression in mouse pre- and early post-implantation embryos. Gene Expr Patterns. 2009 Jan;9(1):27-30
7J:195125 Hoffman JA, Wu CI, Merrill BJ, Tcf7l1 prepares epiblast cells in the gastrulating mouse embryo for lineage specification. Development. 2013 Apr;140(8):1665-75
1J:82316 Hsieh JC, Lee L, Zhang L, Wefer S, Brown K, DeRossi C, Wines ME, Rosenquist T, Holdener BC, Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity. Cell. 2003 Feb 7;112(3):355-67
1J:250152 Hu X, Tang Z, Li Y, Liu W, Zhang S, Wang B, Tian Y, Zhao Y, Ran H, Liu W, Feng GS, Shuai J, Wang H, Lu Z, Deletion of the tyrosine phosphatase Shp2 in Sertoli cells causes infertility in mice. Sci Rep. 2015 Aug 12;5:12982
2J:224163 Hu YC, Nicholls PK, Soh YQ, Daniele JR, Junker JP, van Oudenaarden A, Page DC, Licensing of primordial germ cells for gametogenesis depends on genital ridge signaling. PLoS Genet. 2015 Mar;11(3):e1005019
4J:326085 Huang TC, Wang YF, Vazquez-Ferrer E, Theofel I, Requena CE, Hanna CW, Kelsey G, Hajkova P, Sex-specific chromatin remodelling safeguards transcription in germ cells. Nature. 2021 Dec;600(7890):737-742
2J:254969 Huang X, Balmer S, Yang F, Fidalgo M, Li D, Guallar D, Hadjantonakis AK, Wang J, Zfp281 is essential for mouse epiblast maturation through transcriptional and epigenetic control of Nodal signaling. Elife. 2017 Nov 23;6:e33333
1J:60391 Huelsken J, Vogel R, Brinkmann V, Erdmann B, Birchmeier C, Birchmeier W, Requirement for beta-catenin in anterior-posterior axis formation in mice. J Cell Biol. 2000 Feb 7;148(3):567-78
1*J:88265 Hurley TM, McClive PJ, Sarraj MA, Sinclair AH, Eki2 is upregulated specifically in the testis during mouse sex determination. Gene Expr Patterns. 2004 Apr;4(2):135-40
2J:291217 Huyghe A, Furlan G, Ozmadenci D, Galonska C, Charlton J, Gaume X, Combemorel N, Riemenschneider C, Allegre N, Zhang J, Wajda P, Rama N, Vieugue P, Durand I, Brevet M, Gadot N, Imhof T, Merrill BJ, Koch M, Mehlen P, Chazaud C, Meissner A, Lavial F, Netrin-1 promotes naive pluripotency through Neo1 and Unc5b co-regulation of Wnt and MAPK signalling. Nat Cell Biol. 2020 Apr;22(4):389-400
1*J:157698 Ideguchi M, Palmer TD, Recht LD, Weimann JM, Murine embryonic stem cell-derived pyramidal neurons integrate into the cerebral cortex and appropriately project axons to subcortical targets. J Neurosci. 2010 Jan 20;30(3):894-904
1J:345436 Iha M, Watanabe M, Kihara Y, Sugawara S, Saito K, Soma M, Sato S, Mori Y, Kasuga K, Kojima I, Sasamura R, Murata J, Kobayashi M, Effect of ectopic expression of homeoprotein EGAM1C on the cell morphology, growth, and differentiation in a mouse embryonic stem cell line, MG1.19 cells. Reproduction. 2012 Apr;143(4):477-89
1J:252799 Itou D, Shiromoto Y, Yukiho SY, Ishii C, Nishimura T, Ogonuki N, Ogura A, Hasuwa H, Fujihara Y, Kuramochi-Miyagawa S, Nakano T, Induction of DNA methylation by artificial piRNA production in male germ cells. Curr Biol. 2015 Mar 30;25(7):901-6
6J:189004 Iwafuchi-Doi M, Matsuda K, Murakami K, Niwa H, Tesar PJ, Aruga J, Matsuo I, Kondoh H, Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells. Development. 2012 Nov;139(21):3926-37
4*J:278249 Iwafuchi-Doi M, Yoshida Y, Onichtchouk D, Leichsenring M, Driever W, Takemoto T, Uchikawa M, Kamachi Y, Kondoh H, The Pou5f1/Pou3f-dependent but SoxB-independent regulation of conserved enhancer N2 initiates Sox2 expression during epiblast to neural plate stages in vertebrates. Dev Biol. 2011 Apr 15;352(2):354-66
3J:249818 Izzo A, Ziegler-Birling C, Hill PWS, Brondani L, Hajkova P, Torres-Padilla ME, Schneider R, Dynamic changes in H1 subtype composition during epigenetic reprogramming. J Cell Biol. 2017 Aug 9;
2J:306163 Ji S, Yang Z, Gozali L, Kenney T, Kocabas A, Jinsook Park C, Hynes M, Distinct expression of select and transcriptome-wide isolated 3'UTRs suggests critical roles in development and transition states. PLoS One. 2021;16(5):e0250669
2*J:189008 Jia Y, Viswakarma N, Crawford SE, Sarkar J, Sambasiva Rao M, Karpus WJ, Kanwar YS, Zhu YJ, Reddy JK, Early embryonic lethality of mice with disrupted transcription cofactor PIMT/NCOA6IP/Tgs1 gene. Mech Dev. 2012 Sep;129(9-12):193-207
10*J:148612 Jin Z, Liu L, Bian W, Chen Y, Xu G, Cheng L, Jing N, Different transcription factors regulate nestin gene expression during P19 cell neural differentiation and central nervous system development. J Biol Chem. 2009 Mar 20;284(12):8160-73
6*J:125833 Joshi S, Davies H, Sims LP, Levy SE, Dean J, Ovarian gene expression in the absence of FIGLA, an oocyte-specific transcription factor. BMC Dev Biol. 2007;7:67
1*J:242195 Juan HC, Lin Y, Chen HR, Fann MJ, Cdk12 is essential for embryonic development and the maintenance of genomic stability. Cell Death Differ. 2016 Jun;23(6):1038-48
8*J:118937 Kaji K, Nichols J, Hendrich B, Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells. Development. 2007 Mar;134(6):1123-32
1J:117056 Kan NG, Stemmler MP, Junghans D, Kanzler B, de Vries WN, Dominis M, Kemler R, Gene replacement reveals a specific role for E-cadherin in the formation of a functional trophectoderm. Development. 2007 Jan;134(1):31-41
1J:199283 Kaneko KJ, Depamphilis ML, TEAD4 establishes the energy homeostasis essential for blastocoel formation. Development. 2013 Sep;140(17):3680-90
7*J:210467 Kang E, Wu G, Ma H, Li Y, Tippner-Hedges R, Tachibana M, Sparman M, Wolf DP, Scholer HR, Mitalipov S, Nuclear reprogramming by interphase cytoplasm of two-cell mouse embryos. Nature. 2014 May 1;509(7498):101-4
1J:241994 Kang M, Garg V, Hadjantonakis AK, Lineage Establishment and Progression within the Inner Cell Mass of the Mouse Blastocyst Requires FGFR1 and FGFR2. Dev Cell. 2017 Jun 05;41(5):496-510.e5
1*J:295945 Kawamura N, Takaoka K, Hamada H, Hadjantonakis AK, Sun-Wada GH, Wada Y, Rab7-Mediated Endocytosis Establishes Patterning of Wnt Activity through Inactivation of Dkk Antagonism. Cell Rep. 2020 Jun 9;31(10):107733
5J:90378 Kawase E, Hashimoto K, Pedersen RA, Autocrine and paracrine mechanisms regulating primordial germ cell proliferation. Mol Reprod Dev. 2004 May;68(1):5-16
1J:91055 Kelly OG, Pinson KI, Skarnes WC, The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice. Development. 2004 Jun;131(12):2803-15
2J:94395 Kemler R, Hierholzer A, Kanzler B, Kuppig S, Hansen K, Taketo MM, de Vries WN, Knowles BB, Solter D, Stabilization of {beta}-catenin in the mouse zygote leads to premature epithelial-mesenchymal transition in the epiblast. Development. 2004 Dec;131(23):5817-5824
4*J:168037 Kim B, Kim Y, Sakuma R, Hui CC, Ruther U, Jorgensen JS, Primordial germ cell proliferation is impaired in Fused Toes mutant embryos. Dev Biol. 2011 Jan 15;349(2):417-26
1J:321498 Kim EJY, Sorokin L, Hiiragi T, ECM-integrin signalling instructs cellular position sensing to pattern the early mouse embryo. Development. 2022 Jan 1;149(1):dev200140
1J:159668 Kim GJ, Georg I, Scherthan H, Merkenschlager M, Guillou F, Scherer G, Barrionuevo F, Dicer is required for Sertoli cell function and survival. Int J Dev Biol. 2010;54(5):867-75
10J:219506 Kim S, Gunesdogan U, Zylicz JJ, Hackett JA, Cougot D, Bao S, Lee C, Dietmann S, Allen GE, Sengupta R, Surani MA, PRMT5 protects genomic integrity during global DNA demethylation in primordial germ cells and preimplantation embryos. Mol Cell. 2014 Nov 20;56(4):564-79
3J:327957 Kim YS, Fan R, Lith SC, Dicke AK, Drexler HCA, Kremer L, Kuempel-Rink N, Hekking L, Stehling M, Bedzhov I, Rap1 controls epiblast morphogenesis in sync with the pluripotency states transition. Dev Cell. 2022 Aug 22;57(16):1937-1956.e8
5*J:70278 Kimura C, Shen MM, Takeda N, Aizawa S, Matsuo I, Complementary functions of Otx2 and Cripto in initial patterning of mouse epiblast. Dev Biol. 2001 Jul 1;235(1):12-32
1J:244839 Kimura-Yoshida C, Mochida K, Ellwanger K, Niehrs C, Matsuo I, Fate Specification of Neural Plate Border by Canonical Wnt Signaling and Grhl3 is Crucial for Neural Tube Closure. EBioMedicine. 2015 Jun;2(6):513-27
1J:324183 Kimura-Yoshida C, Mochida K, Kanno SI, Matsuo I, USP39 is essential for mammalian epithelial morphogenesis through upregulation of planar cell polarity components. Commun Biol. 2022 Apr 19;5(1):378
2J:286228 Kiyozumi D, Nakano I, Sato-Nishiuchi R, Tanaka S, Sekiguchi K, Laminin is the ECM niche for trophoblast stem cells. Life Sci Alliance. 2020 Feb;3(2)
1J:279595 Kiyozumi D, Taniguchi Y, Nakano I, Toga J, Yagi E, Hasuwa H, Ikawa M, Sekiguchi K, Laminin gamma1 C-terminal Glu to Gln mutation induces early postimplantation lethality. Life Sci Alliance. 2018 Oct;1(5):e201800064
1*J:337971 Kohler TN, De Jonghe J, Ellermann AL, Yanagida A, Herger M, Slatery EM, Weberling A, Munger C, Fischer K, Mulas C, Winkel A, Ross C, Bergmann S, Franze K, Chalut K, Nichols J, Boroviak TE, Hollfelder F, Plakoglobin is a mechanoresponsive regulator of naive pluripotency. Nat Commun. 2023 Jul 7;14(1):4022
2J:156489 Krentz AD, Murphy MW, Kim S, Cook MS, Capel B, Zhu R, Matin A, Sarver AL, Parker KL, Griswold MD, Looijenga LH, Bardwell VJ, Zarkower D, The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency. Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22323-8
1J:196366 Krentz AD, Murphy MW, Zhang T, Sarver AL, Jain S, Griswold MD, Bardwell VJ, Zarkower D, Interaction between DMRT1 function and genetic background modulates signaling and pluripotency to control tumor susceptibility in the fetal germ line. Dev Biol. 2013 May 1;377(1):67-78
1J:183879 Kropp M, Wilson SI, The expression profile of the tumor suppressor gene Lzts1 suggests a role in neuronal development. Dev Dyn. 2012 May;241(5):984-94
1J:336446 Kshirsagar A, Doroshev SM, Gorelik A, Olender T, Sapir T, Tsuboi D, Rosenhek-Goldian I, Malitsky S, Itkin M, Argoetti A, Mandel-Gutfreund Y, Cohen SR, Hanna JH, Ulitsky I, Kaibuchi K, Reiner O, LIS1 RNA-binding orchestrates the mechanosensitive properties of embryonic stem cells in AGO2-dependent and independent ways. Nat Commun. 2023 Jun 6;14(1):3293
3*J:231594 Kumar M, Syed SM, Taketo MM, Tanwar PS, Epithelial Wnt/betacatenin signalling is essential for epididymal coiling. Dev Biol. 2016 Apr 15;412(2):234-49
19*J:133713 Kuntz S, Kieffer E, Bianchetti L, Lamoureux N, Fuhrmann G, Viville S, Tex19, a mammalian-specific protein with a restricted expression in pluripotent stem cells and germ line. Stem Cells. 2008 Mar;26(3):734-44
4J:234323 Kurian L, Aguirre A, Sancho-Martinez I, Benner C, Hishida T, Nguyen TB, Reddy P, Nivet E, Krause MN, Nelles DA, Esteban CR, Campistol JM, Yeo GW, Belmonte JCI, Identification of novel long noncoding RNAs underlying vertebrate cardiovascular development. Circulation. 2015 Apr 7;131(14):1278-1290
2J:137186 Kurimoto K, Yabuta Y, Ohinata Y, Shigeta M, Yamanaka K, Saitou M, Complex genome-wide transcription dynamics orchestrated by Blimp1 for the specification of the germ cell lineage in mice. Genes Dev. 2008 Jun 15;22(12):1617-35
1*J:286480 Kuroki S, Nakai Y, Maeda R, Okashita N, Akiyoshi M, Yamaguchi Y, Kitano S, Miyachi H, Nakato R, Ichiyanagi K, Shirahige K, Kimura H, Shinkai Y, Tachibana M, Combined Loss of JMJD1A and JMJD1B Reveals Critical Roles for H3K9 Demethylation in the Maintenance of Embryonic Stem Cells and Early Embryogenesis. Stem Cell Reports. 2018 Apr 10;10(4):1340-1354
2*J:270143 Kurowski A, Molotkov A, Soriano P, FGFR1 regulates trophectoderm development and facilitates blastocyst implantation. Dev Biol. 2019 Feb 1;446(1):94-101
1*J:156583 Kwon MC, Koo BK, Moon JS, Kim YY, Park KC, Kim NS, Kwon MY, Kong MP, Yoon KJ, Im SK, Ghim J, Han YM, Jang SK, Shong M, Kong YY, Crif1 is a novel transcriptional coactivator of STAT3. EMBO J. 2008 Feb 20;27(4):642-53
1J:294100 Kyprianou C, Christodoulou N, Hamilton RS, Nahaboo W, Boomgaard DS, Amadei G, Migeotte I, Zernicka-Goetz M, Basement membrane remodelling regulates mouse embryogenesis. Nature. 2020 Jun;582(7811):253-258
1J:162336 La Sala G, Farini D, De Felici M, Rapid estrogen signalling in mouse primordial germ cells. Exp Cell Res. 2010 Jun 10;316(10):1716-27
2*J:80978 Lan ZJ, Chung AC, Xu X, DeMayo FJ, Cooney AJ, The embryonic function of germ cell nuclear factor is dependent on the DNA binding domain. J Biol Chem. 2002 Dec 27;277(52):50660-7
2J:244157 Lange L, Marks M, Liu J, Wittler L, Bauer H, Piehl S, Blass G, Timmermann B, Herrmann BG, Patterning and gastrulation defects caused by the tw18 lethal are due to loss of Ppp2r1a. Biol Open. 2017 Jun 15;6(6):752-764
1*J:137940 Lange UC, Adams DJ, Lee C, Barton S, Schneider R, Bradley A, Surani MA, Normal germ line establishment in mice carrying a deletion of the Ifitm/Fragilis gene family cluster. Mol Cell Biol. 2008 Aug;28(15):4688-96
1J:236825 Langer D, Martianov I, Alpern D, Rhinn M, Keime C, Dolle P, Mengus G, Davidson I, Essential role of the TFIID subunit TAF4 in murine embryogenesis and embryonic stem cell differentiation. Nat Commun. 2016 Mar 30;7:11063
1J:208425 Le Bin GC, Munoz-Descalzo S, Kurowski A, Leitch H, Lou X, Mansfield W, Etienne-Dumeau C, Grabole N, Mulas C, Niwa H, Hadjantonakis AK, Nichols J, Oct4 is required for lineage priming in the developing inner cell mass of the mouse blastocyst. Development. 2014 Mar;141(5):1001-10
7*J:308476 Le Rolle M, Massa F, Siggers P, Turchi L, Loubat A, Koo BK, Clevers H, Greenfield A, Schedl A, Chaboissier MC, Chassot AA, Arrest of WNT/beta-catenin signaling enables the transition from pluripotent to differentiated germ cells in mouse ovaries. Proc Natl Acad Sci U S A. 2021 Jul 27;118(30):e2023376118
3*J:61448 Leatherman JL, Kaestner KH, Jongens TA, Identification of a mouse germ cell-less homologue with conserved activity in Drosophila. Mech Dev. 2000 Apr;92(2):145-53
1*J:147038 Lee HJ, Pazin DE, Kahlon RS, Correa SM, Albrecht KH, Novel markers of early ovarian pre-granulosa cells are expressed in an Sry-like pattern. Dev Dyn. 2009 Apr;238(4):812-25
7J:175097 Lee SH, Jeyapalan JN, Appleby V, Mohamed Noor DA, Sottile V, Scotting PJ, Dynamic methylation and expression of Oct4 in early neural stem cells. J Anat. 2010 Sep;217(3):203-13
1J:297206 Lee YH, Lee HT, Chen CL, Chang CH, Hsu CY, Shyu WC, Role of FOXC1 in regulating APSCs self-renewal via STI-1/PrP(C) signaling. Theranostics. 2019;9(22):6443-6465
1J:128313 Lei N, Hornbaker KI, Rice DA, Karpova T, Agbor VA, Heckert LL, Sex-specific differences in mouse DMRT1 expression are both cell type- and stage-dependent during gonad development. Biol Reprod. 2007 Sep;77(3):466-75
2J:194241 Li C, Finkelstein D, Sherr CJ, Arf tumor suppressor and miR-205 regulate cell adhesion and formation of extraembryonic endoderm from pluripotent stem cells. Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):E1112-21
1J:290444 Li J, Wang C, Feng G, Zhang L, Chen G, Sun H, Wang J, Zhang Y, Zhou Q, Li W, Rbm14 maintains the integrity of genomic DNA during early mouse embryogenesis via mediating alternative splicing. Cell Prolif. 2020 Jan;53(1):e12724
1J:128981 Li JY, Pu MT, Hirasawa R, Li BZ, Huang YN, Zeng R, Jing NH, Chen T, Li E, Sasaki H, Xu GL, Synergistic function of DNA methyltransferases Dnmt3a and Dnmt3b in the methylation of Oct4 and Nanog. Mol Cell Biol. 2007 Dec;27(24):8748-59
1*J:140105 Li L, Baibakov B, Dean J, A subcortical maternal complex essential for preimplantation mouse embryogenesis. Dev Cell. 2008 Sep;15(3):416-25
6*J:170274 Li L, Kwon HJ, Harada H, Ohshima H, Cho SW, Jung HS, Expression patterns of ABCG2, Bmi-1, Oct-3/4, and Yap in the developing mouse incisor. Gene Expr Patterns. 2011 Mar-Apr;11(3-4):163-70
1J:345904 Li L, Lai F, Liu L, Lu X, Hu X, Liu B, Lin Z, Fan Q, Kong F, Xu Q, Xie W, Lineage regulators TFAP2C and NR5A2 function as bipotency activators in totipotent embryos. Nat Struct Mol Biol. 2024 Jan 19;
4*J:204971 Li L, Liu C, Biechele S, Zhu Q, Song L, Lanner F, Jing N, Rossant J, Location of transient ectodermal progenitor potential in mouse development. Development. 2013 Nov;140(22):4533-43
3*J:156527 Li L, Sun L, Gao F, Jiang J, Yang Y, Li C, Gu J, Wei Z, Yang A, Lu R, Ma Y, Tang F, Kwon SW, Zhao Y, Li J, Jin Y, Stk40 links the pluripotency factor Oct4 to the Erk/MAPK pathway and controls extraembryonic endoderm differentiation. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1402-7
1*J:243694 Li L, Walsh RM, Wagh V, James MF, Beauchamp RL, Chang YS, Gusella JF, Hochedlinger K, Ramesh V, Mediator Subunit Med28 Is Essential for Mouse Peri-Implantation Development and Pluripotency. PLoS One. 2015;10(10):e0140192
2*J:258384 Li R, Vannitamby A, Yue SSK, Handelsman D, Hutson J, Mouse minipuberty coincides with gonocyte transformation into spermatogonial stem cells: a model for human minipuberty. Reprod Fertil Dev. 2017 Nov;29(12):2430-2436
1J:222090 Liang QX, Zhang QH, Qi ST, Wang ZW, Hu MW, Ma XS, Zhu MS, Schatten H, Wang ZB, Sun QY, Deletion of Mylk1 in oocytes causes delayed morula-to-blastocyst transition and reduced fertility without affecting folliculogenesis and oocyte maturation in mice. Biol Reprod. 2015 Apr;92(4):97
6J:288962 Liang X, Jin Y, Wang H, Meng X, Tan Z, Huang T, Fan S, Transgelin 2 is required for embryo implantation by promoting actin polymerization. FASEB J. 2019 Apr;33(4):5667-5675
1J:213579 Liao HF, Chen WS, Chen YH, Kao TH, Tseng YT, Lee CY, Chiu YC, Lee PL, Lin QJ, Ching YH, Hata K, Cheng WT, Tsai MH, Sasaki H, Ho HN, Wu SC, Huang YH, Yen P, Lin SP, DNMT3L promotes quiescence in postnatal spermatogonial progenitor cells. Development. 2014 Jun;141(12):2402-13
1J:168622 Lighthouse JK, Zhang L, Hsieh JC, Rosenquist T, Holdener BC, MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm. Dev Dyn. 2011 Mar;240(3):577-88
2J:270950 Lin K, Zhang S, Shi Q, Zhu M, Gao L, Xia W, Geng B, Zheng Z, Xu EY, Essential requirement of mammalian Pumilio family in embryonic development. Mol Biol Cell. 2018 Nov 26;29(24):2922-2932
2*J:104848 Lin Y, Page DC, Dazl deficiency leads to embryonic arrest of germ cell development in XY C57BL/6 mice. Dev Biol. 2005 Dec 15;288(2):309-16
1*J:122205 Little MH, Brennan J, Georgas K, Davies JA, Davidson DR, Baldock RA, Beverdam A, Bertram JF, Capel B, Chiu HS, Clements D, Cullen-McEwen L, Fleming J, Gilbert T, Herzlinger D, Houghton D, Kaufman MH, Kleymenova E, Koopman PA, Lewis AG, McMahon AP, Mendelsohn CL, Mitchell EK, Rumballe BA, Sweeney DE, Valerius MT, Yamada G, Yang Y, Yu J, A high-resolution anatomical ontology of the developing murine genitourinary tract. Gene Expr Patterns. 2007 Jun;7(6):680-99
1J:322043 Liu M, Deng W, Tang L, Liu M, Bao H, Guo C, Zhang C, Lu J, Wang H, Lu Z, Kong S, Menin directs regionalized decidual transformation through epigenetically setting PTX3 to balance FGF and BMP signaling. Nat Commun. 2022 Feb 22;13(1):1006
1J:56511 Liu P, Wakamiya M, Shea MJ, Albrecht U, Behringer RR, Bradley A, Requirement for Wnt3 in vertebrate axis formation. Nat Genet. 1999 Aug;22(4):361-5
1J:244859 Liu W, Wang F, Xu Q, Shi J, Zhang X, Lu X, Zhao ZA, Gao Z, Ma H, Duan E, Gao F, Gao S, Yi Z, Li L, BCAS2 is involved in alternative mRNA splicing in spermatogonia and the transition to meiosis. Nat Commun. 2017 Jan 27;8:14182
1*J:314924 Liu Y, Sun J, Su Y, Lin J, Lv C, Mo K, Xu S, Wang S, Nuclear-localized eukaryotic translation initiation factor 1A is involved in mouse preimplantation embryo development. J Mol Histol. 2021 Oct;52(5):965-973
1*J:86683 Loebel DA, Watson CM, De Young RA, Tam PP, Lineage choice and differentiation in mouse embryos and embryonic stem cells. Dev Biol. 2003 Dec 1;264(1):1-14
1*J:84032 Lu B, Bishop CE, Late onset of spermatogenesis and gain of fertility in POG-deficient mice indicate that POG is not necessary for the proliferation of spermatogonia. Biol Reprod. 2003 Jul;69(1):161-8
2J:40594 Ludwig T, Chapman DL, Papaioannou VE, Efstratiadis A, Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos. Genes Dev. 1997 May 15;11(10):1226-41
3*J:137199 Lupu F, Alves A, Anderson K, Doye V, Lacy E, Nuclear pore composition regulates neural stem/progenitor cell differentiation in the mouse embryo. Dev Cell. 2008 Jun;14(6):831-42
3J:307869 Lynch CJ, Bernad R, Martinez-Val A, Shahbazi MN, Nobrega-Pereira S, Calvo I, Blanco-Aparicio C, Tarantino C, Garreta E, Richart-Gines L, Alcazar N, Grana-Castro O, Gomez-Lopez G, Aksoy I, Munoz-Martin M, Martinez S, Ortega S, Prieto S, Simboeck E, Camasses A, Stephan-Otto Attolini C, Fernandez AF, Sierra MI, Fraga MF, Pastor J, Fisher D, Montserrat N, Savatier P, Munoz J, Zernicka-Goetz M, Serrano M, Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases. Nat Cell Biol. 2020 Oct;22(10):1223-1238
3*J:162220 Magdaleno S, Jensen P, Brumwell CL, Seal A, Lehman K, Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T, BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006 Apr;4(4):e86
10*J:116231 Maldonado-Saldivia J, van den Bergen J, Krouskos M, Gilchrist M, Lee C, Li R, Sinclair AH, Surani MA, Western PS, Dppa2 and Dppa4 Are Closely Linked SAP Motif Genes Restricted to Pluripotent Cells and the Germ Line. Stem Cells. 2007 Jan;25(1):19-28
1J:264943 Manganelli G, Fico A, Masullo U, Pizzolongo F, Cimmino A, Filosa S, Modulation of the pentose phosphate pathway induces endodermal differentiation in embryonic stem cells. PLoS One. 2012;7(1):e29321
1J:161421 Mann W, Haaf T, Single cell RT-PCR on mouse embryos: a general approach for developmental biology. Methods Mol Biol. 2010;630:3-12
1J:306136 Manti M, Pui HP, Edstrom S, Risal S, Lu H, Lindgren E, Ohlsson C, Jerlhag E, Benrick A, Deng Q, Stener-Victorin E, Excess of ovarian nerve growth factor impairs embryonic development and causes reproductive and metabolic dysfunction in adult female mice. FASEB J. 2020 Nov;34(11):14440-14457
1J:143586 Manuylov NL, Smagulova FO, Leach L, Tevosian SG, Ovarian development in mice requires the GATA4-FOG2 transcription complex. Development. 2008 Nov;135(22):3731-43
1J:173838 Manuylov NL, Zhou B, Ma Q, Fox SC, Pu WT, Tevosian SG, Conditional ablation of Gata4 and Fog2 genes in mice reveals their distinct roles in mammalian sexual differentiation. Dev Biol. 2011 May 15;353(2):229-41
1*J:329326 Marta C, Dawid W, Silvestre S, Pawel G, Salvatore P, Modlinski JA, Pasqualino L, Mitochondrial function and intracellular distribution is severely affected in in vitro cultured mouse embryos. Sci Rep. 2022 Sep 27;12(1):16152
3*J:336176 Mathew V, Mei A, Giwa H, Cheong A, Chander A, Zou A, Blanton RM, Kashpur O, Cui W, Slonim D, Mahmoud T, O'Tierney-Ginn P, Mager J, Draper I, Wallingford MC, hnRNPL expression dynamics in the embryo and placenta. Gene Expr Patterns. 2023 May 4;48:119319
3J:255491 Matsuura T, Miyazaki S, Miyazaki T, Tashiro F, Miyazaki JI, Zfp296 negatively regulates H3K9 methylation in embryonic development as a component of heterochromatin. Sci Rep. 2017 Sep 29;7(1):12462
1J:102860 Matsuyama M, Mizusaki H, Shimono A, Mukai T, Okumura K, Abe K, Shimada K, Morohashi K, A novel isoform of Vinexin, Vinexin gamma, regulates Sox9 gene expression through activation of MAPK cascade in mouse fetal gonad. Genes Cells. 2005 May;10(5):421-34
4*J:145796 May A, Kirchner R, Muller H, Hartmann P, El Hajj N, Tresch A, Zechner U, Mann W, Haaf T, Multiplex rt-PCR expression analysis of developmentally important genes in individual mouse preimplantation embryos and blastomeres. Biol Reprod. 2009 Jan;80(1):194-202
1*J:86589 McClive PJ, Hurley TM, Sarraj MA, van den Bergen JA, Sinclair AH, Subtractive hybridisation screen identifies sexually dimorphic gene expression in the embryonic mouse gonad. Genesis. 2003 Oct;37(2):84-90
1*J:82986 McClive PJ, Sinclair AH, Type II and Type IX Collagen Transcript Isoforms Are Expressed During Mouse Testis Development. Biol Reprod. 2003 May;68(5):1742-7
6*J:182713 McDonel P, Demmers J, Tan DW, Watt F, Hendrich BD, Sin3a is essential for the genome integrity and viability of pluripotent cells. Dev Biol. 2012 Mar 1;363(1):62-73
2*J:258725 Meares GP, Rajbhandari R, Gerigk M, Tien CL, Chang C, Fehling SC, Rowse A, Mulhern KC, Nair S, Gray GK, Berbari NF, Bredel M, Benveniste EN, Nozell SE, MicroRNA-31 is required for astrocyte specification. Glia. 2018 May;66(5):987-998
1J:305254 Mei H, Kozuka C, Hayashi R, Kumon M, Koseki H, Inoue A, H2AK119ub1 guides maternal inheritance and zygotic deposition of H3K27me3 in mouse embryos. Nat Genet. 2021 Apr;53(4):539-550
1J:283320 Meng TG, Lu X, Guo L, Hou GM, Ma XS, Li QN, Huang L, Fan LH, Zhao ZH, Ou XH, OuYang YC, Schatten H, Li L, Wang ZB, Sun QY, Mettl14 is required for mouse postimplantation development by facilitating epiblast maturation. FASEB J. 2019 Jan;33(1):1179-1187
5*J:86170 Menke DB, Koubova J, Page DC, Sexual differentiation of germ cells in XX mouse gonads occurs in an anterior-to-posterior wave. Dev Biol. 2003 Oct 15;262(2):303-12
1J:126078 Merlet J, Racine C, Moreau E, Moreno SG, Habert R, Male fetal germ cells are targets for androgens that physiologically inhibit their proliferation. Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3615-20
1J:165252 Mesnard D, Constam DB, Imaging proprotein convertase activities and their regulation in the implanting mouse blastocyst. J Cell Biol. 2010 Oct 4;191(1):129-39
1J:176435 Mesnard D, Donnison M, Fuerer C, Pfeffer PL, Constam DB, The microenvironment patterns the pluripotent mouse epiblast through paracrine Furin and Pace4 proteolytic activities. Genes Dev. 2011 Sep 1;25(17):1871-80
1J:289378 Mesnard D, Guzman-Ayala M, Constam DB, Nodal specifies embryonic visceral endoderm and sustains pluripotent cells in the epiblast before overt axial patterning. Development. 2006 Jul;133(13):2497-505
2J:232771 Messerschmidt D, de Vries WN, Lorthongpanich C, Balu S, Solter D, Knowles BB, beta-catenin-mediated adhesion is required for successful preimplantation mouse embryo development. Development. 2016 Jun 1;143(11):1993-9
2*J:163559 Messerschmidt DM, Kemler R, Nanog is required for primitive endoderm formation through a non-cell autonomous mechanism. Dev Biol. 2010 Aug 1;344(1):129-37
1*J:299155 Miao X, Sun T, Golan M, Mager J, Cui W, Loss of POLR1D results in embryonic lethality prior to blastocyst formation in mice. Mol Reprod Dev. 2020 Nov;87(11):1152-1158
3*J:236404 Minocha S, Bessonnard S, Sung TL, Moret C, Constam DB, Herr W, Epiblast-specific loss of HCF-1 leads to failure in anterior-posterior axis specification. Dev Biol. 2016 Oct 1;418(1):75-88
1J:231596 Minocha S, Sung TL, Villeneuve D, Lammers F, Herr W, Compensatory embryonic response to allele-specific inactivation of the murine X-linked gene Hcfc1. Dev Biol. 2016 Apr 1;412(1):1-17
6*J:130526 Mitiku N, Baker JC, Genomic analysis of gastrulation and organogenesis in the mouse. Dev Cell. 2007 Dec;13(6):897-907
2*J:83420 Mitsui K, Tokuzawa Y, Itoh H, Segawa K, Murakami M, Takahashi K, Maruyama M, Maeda M, Yamanaka S, The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell. 2003 May 30;113(5):631-42
1*J:89092 Mitsunaga K, Araki K, Mizusaki H, Morohashi K, Haruna K, Nakagata N, Giguere V, Yamamura K, Abe K, Loss of PGC-specific expression of the orphan nuclear receptor ERR-beta results in reduction of germ cell number in mouse embryos. Mech Dev. 2004 Mar;121(3):237-46
1J:177114 Miura S, Mishina Y, Hepatocyte growth factor-regulated tyrosine kinase substrate (Hgs) is involved in BMP signaling through phosphorylation of smads and TAK1 in early mouse embryo. Dev Dyn. 2011 Nov;240(11):2474-81
8J:182605 Miyanari Y, Torres-Padilla ME, Control of ground-state pluripotency by allelic regulation of Nanog. Nature. 2012 Mar 22;483(7390):470-3
6*J:142962 Mizuno N, Kosaka M, Novel variants of Oct-3/4 gene expressed in mouse somatic cells. J Biol Chem. 2008 Nov 7;283(45):30997-1004
1J:306167 Mole MA, Weberling A, Fassler R, Campbell A, Fishel S, Zernicka-Goetz M, Integrin beta1 coordinates survival and morphogenesis of the embryonic lineage upon implantation and pluripotency transition. Cell Rep. 2021 Mar 9;34(10):108834
1J:155518 Molero AE, Gokhan S, Gonzalez S, Feig JL, Alexandre LC, Mehler MF, Impairment of developmental stem cell-mediated striatal neurogenesis and pluripotency genes in a knock-in model of Huntington's disease. Proc Natl Acad Sci U S A. 2009 Dec 22;106(51):21900-5
1J:149544 Moniot B, Declosmenil F, Barrionuevo F, Scherer G, Aritake K, Malki S, Marzi L, Cohen-Solal A, Georg I, Klattig J, Englert C, Kim Y, Capel B, Eguchi N, Urade Y, Boizet-Bonhoure B, Poulat F, The PGD2 pathway, independently of FGF9, amplifies SOX9 activity in Sertoli cells during male sexual differentiation. Development. 2009 Jun;136(11):1813-21
1*J:176205 Moniot B, Farhat A, Aritake K, Declosmenil F, Nef S, Eguchi N, Urade Y, Poulat F, Boizet-Bonhoure B, Hematopoietic prostaglandin D synthase (H-Pgds) is expressed in the early embryonic gonad and participates to the initial nuclear translocation of the SOX9 protein. Dev Dyn. 2011 Oct;240(10):2335-43
3J:214809 Moniot B, Ujjan S, Champagne J, Hirai H, Aritake K, Nagata K, Dubois E, Nidelet S, Nakamura M, Urade Y, Poulat F, Boizet-Bonhoure B, Prostaglandin D2 acts through the Dp2 receptor to influence male germ cell differentiation in the foetal mouse testis. Development. 2014 Sep;141(18):3561-71
1*J:205046 Moore R, Cai KQ, Tao W, Smith ER, Xu XX, Differential requirement for Dab2 in the development of embryonic and extra-embryonic tissues. BMC Dev Biol. 2013;13:39
2*J:315320 Moore R, Tao W, Smith ER, Xu XX, The primitive endoderm segregates from the epiblast in beta1 integrin-deficient early mouse embryos. Mol Cell Biol. 2014 Feb;34(3):560-72
2J:258132 Morgani SM, Metzger JJ, Nichols J, Siggia ED, Hadjantonakis AK, Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning. Elife. 2018 Feb 7;7:e32839
1J:121791 Morita S, Horii T, Kimura M, Goto Y, Ochiya T, Hatada I, One Argonaute family member, Eif2c2 (Ago2), is essential for development and appears not to be involved in DNA methylation. Genomics. 2007 Jun;89(6):687-696
1*J:87222 Morkel M, Huelsken J, Wakamiya M, Ding J, van de Wetering M, Clevers H, Taketo MM, Behringer RR, Shen MM, Birchmeier W, Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation. Development. 2003 Dec;130(25):6283-94
1J:163858 Morsut L, Yan KP, Enzo E, Aragona M, Soligo SM, Wendling O, Mark M, Khetchoumian K, Bressan G, Chambon P, Dupont S, Losson R, Piccolo S, Negative control of Smad activity by ectodermin/Tif1gamma patterns the mammalian embryo. Development. 2010 Aug 1;137(15):2571-8
1*J:161056 Mountford P, Zevnik B, Duwel A, Nichols J, Li M, Dani C, Robertson M, Chambers I, Smith A, Dicistronic targeting constructs: reporters and modifiers of mammalian gene expression. Proc Natl Acad Sci U S A. 1994 May 10;91(10):4303-7
1J:185555 Mugford JW, Yee D, Magnuson T, Failure of extra-embryonic progenitor maintenance in the absence of dosage compensation. Development. 2012 Jun;139(12):2130-8
2J:264114 Mulas C, Chia G, Jones KA, Hodgson AC, Stirparo GG, Nichols J, Oct4 regulates the embryonic axis and coordinates exit from pluripotency and germ layer specification in the mouse embryo. Development. 2018 Jun 18;145(12):dev159103
9J:310907 Nacarino-Palma A, Gonzalez-Rico FJ, Rejano-Gordillo CM, Ordiales-Talavero A, Merino JM, Fernandez-Salguero PM, The aryl hydrocarbon receptor promotes differentiation during mouse preimplantational embryo development. Stem Cell Reports. 2021 Sep 14;16(9):2351-2363
5J:158526 Naillat F, Prunskaite-Hyyrylainen R, Pietila I, Sormunen R, Jokela T, Shan J, Vainio SJ, Wnt4/5a signalling coordinates cell adhesion and entry into meiosis during presumptive ovarian follicle development. Hum Mol Genet. 2010 Apr 15;19(8):1539-50
10*J:193587 Nakagawa E, Zhang L, Kim EJ, Shin JO, Cho SW, Ohshima H, Jung HS, The novel function of Oct3/4 in mouse tooth development. Histochem Cell Biol. 2012 Mar;137(3):367-76
3J:262221 Nakajima R, Okano H, Noce T, JMJD1C Exhibits Multiple Functions in Epigenetic Regulation during Spermatogenesis. PLoS One. 2016;11(9):e0163466
1*J:195277 Nakamura H, Cook RN, Justice MJ, Mouse Tenm4 is required for mesoderm induction. BMC Dev Biol. 2013;13:9
1J:92201 Natoli TA, Alberta JA, Bortvin A, Taglienti ME, Menke DB, Loring J, Jaenisch R, Page DC, Housman DE, Kreidberg JA, Wt1 functions in the development of germ cells in addition to somatic cell lineages of the testis. Dev Biol. 2004 Apr 15;268(2):429-40
1J:202072 Negron-Perez VM, Echevarria FD, Huffman SR, Rivera RM, Determination of allelic expression of h19 in pre- and peri-implantation mouse embryos. Biol Reprod. 2013 Apr;88(4):97
1J:153637 Nichols J, Silva J, Roode M, Smith A, Suppression of Erk signalling promotes ground state pluripotency in the mouse embryo. Development. 2009 Oct;136(19):3215-22
3J:51139 Nichols J, Zevnik B, Anastassiadis K, Niwa H, Klewe-Nebenius D, Chambers I, Scholer H, Smith A, Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell. 1998 Oct 30;95(3):379-91
3J:324629 Nishio M, Matsuura T, Hibi S, Ohta S, Oka C, Sasai N, Ishida Y, Matsuda E, Heterozygous loss of Zbtb38 leads to early embryonic lethality via the suppression of Nanog and Sox2 expression. Cell Prolif. 2022 Apr;55(4):e13215
2*J:130047 Nishioka N, Yamamoto S, Kiyonari H, Sato H, Sawada A, Ota M, Nakao K, Sasaki H, Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos. Mech Dev. 2008 Mar-Apr;125(3-4):270-83
6J:296955 Niu W, Spradling AC, Two distinct pathways of pregranulosa cell differentiation support follicle formation in the mouse ovary. Proc Natl Acad Sci U S A. 2020 Aug 18;117(33):20015-20026
2J:104800 Niwa H, Toyooka Y, Shimosato D, Strumpf D, Takahashi K, Yagi R, Rossant J, Interaction between Oct3/4 and Cdx2 determines trophectoderm differentiation. Cell. 2005 Dec 2;123(5):917-29
1J:198687 Nowotschin S, Costello I, Piliszek A, Kwon GS, Mao CA, Klein WH, Robertson EJ, Hadjantonakis AK, The T-box transcription factor Eomesodermin is essential for AVE induction in the mouse embryo. Genes Dev. 2013 May 1;27(9):997-1002
3J:224146 O'Shaughnessy-Kirwan A, Signolet J, Costello I, Gharbi S, Hendrich B, Constraint of gene expression by the chromatin remodelling protein CHD4 facilitates lineage specification. Development. 2015 Aug 1;142(15):2586-97
1*J:203737 Oda M, Oxley D, Dean W, Reik W, Regulation of lineage specific DNA hypomethylation in mouse trophectoderm. PLoS One. 2013;8(6):e68846
1J:242352 Ogawa R, Fujita K, Ito K, Mouse embryonic dorsal root ganglia contain pluripotent stem cells that show features similar to embryonic stem cells and induced pluripotent stem cells. Biol Open. 2017 May 15;6(5):602-618
4J:342643 Oh Y, Kasu M, Bottoms CJ, Douglas JC, Sekulovski N, Hayashi K, MacLean Ii JA, Rhox8 homeobox gene ablation leads to rete testis abnormality and male subfertility in mice. Biol Reprod. 2023 Oct 13;109(4):520-532
6*J:10293 Okamoto K, Okazawa H, Okuda A, Sakai M, Muramatsu M, Hamada H, A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Cell. 1990 Feb 9;60(3):461-72
1J:191206 Okamura D, Maeda I, Taniguchi H, Tokitake Y, Ikeda M, Ozato K, Mise N, Abe K, Noce T, Izpisua Belmonte JC, Matsui Y, Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells. Genes Dev. 2012 Nov 15;26(22):2477-82
1J:190948 Okamura D, Mochizuki K, Taniguchi H, Tokitake Y, Ikeda M, Yamada Y, Tournier C, Yamaguchi S, Tada T, Scholer HR, Matsui Y, REST and its downstream molecule Mek5 regulate survival of primordial germ cells. Dev Biol. 2012 Dec 15;372(2):190-202
2*J:282332 Okamura E, Tam OH, Posfai E, Li L, Cockburn K, Lee CQE, Garner J, Rossant J, Esrrb function is required for proper primordial germ cell development in presomite stage mouse embryos. Dev Biol. 2019 Nov 15;455(2):382-392
2*J:98254 Okita K, Kiyonari H, Nobuhisa I, Kimura N, Aizawa S, Taga T, Targeted disruption of the mouse ELYS gene results in embryonic death at peri-implantation development. Genes Cells. 2004 Nov;9(11):1083-91
1J:204241 Okumura LM, Lesch BJ, Page DC, The ligand binding domain of GCNF is not required for repression of pluripotency genes in mouse fetal ovarian germ cells. PLoS One. 2013;8(6):e66062
1*J:126326 Olive V, Wagner N, Chan S, Kastner P, Vannetti C, Cuzin F, Rassoulzadegan M, PU.1 (Sfpi1), a pleiotropic regulator expressed from the first embryonic stages with a crucial function in germinal progenitors. Development. 2007 Nov;134(21):3815-25
11J:314890 Osorno R, Tsakiridis A, Wong F, Cambray N, Economou C, Wilkie R, Blin G, Scotting PJ, Chambers I, Wilson V, The developmental dismantling of pluripotency is reversed by ectopic Oct4 expression. Development. 2012 Jul;139(13):2288-98
1*J:51198 Ovitt CE, Scholer HR, The molecular biology of Oct-4 in the early mouse embryo. Mol Hum Reprod. 1998 Nov;4(11):1021-31
3J:167188 Ozaki T, Nagashima K, Kusakabe T, Kakudo K, Kimura S, Development of thyroid gland and ultimobranchial body cyst is independent of p63. Lab Invest. 2011 Jan;91(1):138-46
2J:213801 Padua MB, Fox SC, Jiang T, Morse DA, Tevosian SG, Simultaneous gene deletion of gata4 and gata6 leads to early disruption of follicular development and germ cell loss in the murine ovary. Biol Reprod. 2014 Jul;91(1):24
1J:222045 Padua MB, Jiang T, Morse DA, Fox SC, Hatch HM, Tevosian SG, Combined loss of the GATA4 and GATA6 transcription factors in male mice disrupts testicular development and confers adrenal-like function in the testes. Endocrinology. 2015 May;156(5):1873-86
3J:327416 Pailles M, Hirlemann M, Brochard V, Chebrout M, Oudin JF, Marks H, Jouneau A, Bonnet-Garnier A, H3K27me3 at pericentromeric heterochromatin is a defining feature of the early mouse blastocyst. Sci Rep. 2022 Aug 16;12(1):13908
2*J:21487 Palmieri SL, Peter W, Hess H, Scholer HR, Oct-4 transcription factor is differentially expressed in the mouse embryo during establishment of the first two extraembryonic cell lineages involved in implantation. Dev Biol. 1994 Nov;166(1):259-67
3J:317997 Pamnani M, Sinha P, Singh A, Nara S, Sachan M, Methylation of the Sox9 and Oct4 promoters and its correlation with gene expression during testicular development in the laboratory mouse. Genet Mol Biol. 2016 Jul-Sep;39(3):452-8
1J:202012 Pandey RR, Tokuzawa Y, Yang Z, Hayashi E, Ichisaka T, Kajita S, Asano Y, Kunieda T, Sachidanandam R, Chuma S, Yamanaka S, Pillai RS, Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice. Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16492-7
1J:110210 Pangas SA, Choi Y, Ballow DJ, Zhao Y, Westphal H, Matzuk MM, Rajkovic A, Oogenesis requires germ cell-specific transcriptional regulators Sohlh1 and Lhx8. Proc Natl Acad Sci U S A. 2006 May 23;103(21):8090-5
3J:139967 Parisi S, Passaro F, Aloia L, Manabe I, Nagai R, Pastore L, Russo T, Klf5 is involved in self-renewal of mouse embryonic stem cells. J Cell Sci. 2008 Aug 15;121(Pt 16):2629-34
2*J:320324 Park KS, Cha Y, Kim CH, Ahn HJ, Kim D, Ko S, Kim KH, Chang MY, Ko JH, Noh YS, Han YM, Kim J, Song J, Kim JY, Tesar PJ, Lanza R, Lee KA, Kim KS, Transcription elongation factor Tcea3 regulates the pluripotent differentiation potential of mouse embryonic stem cells via the Lefty1-Nodal-Smad2 pathway. Stem Cells. 2013 Feb;31(2):282-92
2*J:200255 Pasque V, Radzisheuskaya A, Gillich A, Halley-Stott RP, Panamarova M, Zernicka-Goetz M, Surani MA, Silva JC, Histone variant macroH2A marks embryonic differentiation in vivo and acts as an epigenetic barrier to induced pluripotency. J Cell Sci. 2012 Dec 15;125(Pt 24):6094-104
4J:168860 Payne CJ, Gallagher SJ, Foreman O, Dannenberg JH, Depinho RA, Braun RE, Sin3a is required by sertoli cells to establish a niche for undifferentiated spermatogonia, germ cell tumors, and spermatid elongation. Stem Cells. 2010 Aug;28(8):1424-34
3*J:74514 Pelton TA, Sharma S, Schulz TC, Rathjen J, Rathjen PD, Transient pluripotent cell populations during primitive ectoderm formation: correlation of in vivo and in vitro pluripotent cell development. J Cell Sci. 2002 Jan 15;115(Pt 2):329-39
1*J:186533 Pennekamp P, Feldner S, Seesing FJ, Psathaki OE, Scholer HR, Wieacker P, Dworniczak B, Bcar3 is expressed in sertoli cells and germ cells of the developing testis in mice. Sex Dev. 2011;5(4):197-204
2J:88053 Perea-Gomez A, Camus A, Moreau A, Grieve K, Moneron G, Dubois A, Cibert C, Collignon J, Initiation of gastrulation in the mouse embryo is preceded by an apparent shift in the orientation of the anterior-posterior axis. Curr Biol. 2004 Feb 3;14(3):197-207
2*J:53656 Perea-Gomez A, Shawlot W, Sasaki H, Behringer RR, Ang S, HNF3beta and Lim1 interact in the visceral endoderm to regulate primitive streak formation and anterior-posterior polarity in the mouse embryo. Development. 1999 Oct;126(20):4499-511
2J:175756 Pereira PN, Dobreva MP, Graham L, Huylebroeck D, Lawson KA, Zwijsen A, Amnion formation in the mouse embryo: the single amniochorionic fold model. BMC Dev Biol. 2011;11:48
2*J:156953 Pernaute B, Canon S, Crespo M, Fernandez-Tresguerres B, Rayon T, Manzanares M, Comparison of extraembryonic expression of Eomes and Cdx2 in pregastrulation chick and mouse embryo unveils regulatory changes along evolution. Dev Dyn. 2010 Feb;239(2):620-9
8*J:46643 Pesce M, Wang X, Wolgemuth DJ, Scholer H, Differential expression of the Oct-4 transcription factor during mouse germ cell differentiation. Mech Dev. 1998 Feb;71(1-2):89-98
1*J:326689 Phan TP, Boatwright CA, Drown CG, Skinner MW, Strong MA, Jordan PW, Holland AJ, Upstream open reading frames control PLK4 translation and centriole duplication in primordial germ cells. Genes Dev. 2022 Jun 1;36(11-12):718-736
1*J:85093 Pinhasov A, Mandel S, Torchinsky A, Giladi E, Pittel Z, Goldsweig AM, Servoss SJ, Brenneman DE, Gozes I, Activity-dependent neuroprotective protein: a novel gene essential for brain formation. Brain Res Dev Brain Res. 2003 Aug 12;144(1):83-90
4J:223048 Pirouz M, Pilarski S, Kessel M, A critical function of Mad2l2 in primordial germ cell development of mice. PLoS Genet. 2013 Aug;9(8):e1003712
6J:197599 Pitetti JL, Calvel P, Romero Y, Conne B, Truong V, Papaioannou MD, Schaad O, Docquier M, Herrera PL, Wilhelm D, Nef S, Insulin and IGF1 receptors are essential for XX and XY gonadal differentiation and adrenal development in mice. PLoS Genet. 2013;9(1):e1003160
2J:155544 Polanco JC, Wilhelm D, Davidson TL, Knight D, Koopman P, Sox10 gain-of-function causes XX sex reversal in mice: implications for human 22q-linked disorders of sex development. Hum Mol Genet. 2010 Feb 1;19(3):506-16
1J:120969 Pollard PJ, Spencer-Dene B, Shukla D, Howarth K, Nye E, El-Bahrawy M, Deheragoda M, Joannou M, McDonald S, Martin A, Igarashi P, Varsani-Brown S, Rosewell I, Poulsom R, Maxwell P, Stamp GW, Tomlinson IP, Targeted inactivation of fh1 causes proliferative renal cyst development and activation of the hypoxia pathway. Cancer Cell. 2007 Apr;11(4):311-9
2*J:326159 Qin Y, Ni P, Zhang Q, Wang X, Du X, Yin Z, Wang L, Ye L, Chen L, Hbxip is essential for murine embryogenesis and regulates embryonic stem cell differentiation through activating mTORC1. Development. 2022 Jun 15;149(12):dev200527
7J:92421 Rajkovic A, Pangas SA, Ballow D, Suzumori N, Matzuk MM, NOBOX deficiency disrupts early folliculogenesis and oocyte-specific gene expression. Science. 2004 Aug 20;305(5687):1157-9
1J:202060 Rakoczy J, Fernandez-Valverde SL, Glazov EA, Wainwright EN, Sato T, Takada S, Combes AN, Korbie DJ, Miller D, Grimmond SM, Little MH, Asahara H, Mattick JS, Taft RJ, Wilhelm D, MicroRNAs-140-5p/140-3p modulate Leydig cell numbers in the developing mouse testis. Biol Reprod. 2013 Jun;88(6):143
2*J:156174 Ralston A, Cox BJ, Nishioka N, Sasaki H, Chea E, Rugg-Gunn P, Guo G, Robson P, Draper JS, Rossant J, Gata3 regulates trophoblast development downstream of Tead4 and in parallel to Cdx2. Development. 2010 Feb;137(3):395-403
3J:95363 Ramos-Mejia V, Escalante-Alcalde D, Kunath T, Ramirez L, Gertsenstein M, Nagy A, Lomeli H, Phenotypic analyses of mouse embryos with ubiquitous expression of Oct4: effects on mid-hindbrain patterning and gene expression. Dev Dyn. 2005 Jan;232(1):180-90
1J:216158 Rastetter RH, Bernard P, Palmer JS, Chassot AA, Chen H, Western PS, Ramsay RG, Chaboissier MC, Wilhelm D, Marker genes identify three somatic cell types in the fetal mouse ovary. Dev Biol. 2014 Oct 15;394(2):242-52
1*J:76367 Rathjen J, Haines BP, Hudson KM, Nesci A, Dunn S, Rathjen PD, Directed differentiation of pluripotent cells to neural lineages: homogeneous formation and differentiation of a neurectoderm population. Development. 2002 Jun;129(11):2649-61
1J:99393 Raverot G, Weiss J, Park SY, Hurley L, Jameson JL, Sox3 expression in undifferentiated spermatogonia is required for the progression of spermatogenesis. Dev Biol. 2005 Jul 1;283(1):215-25
2J:162678 Reichert N, Wurster S, Ulrich T, Schmitt K, Hauser S, Probst L, Gotz R, Ceteci F, Moll R, Rapp U, Gaubatz S, Lin9, a subunit of the mammalian DREAM complex, is essential for embryonic development, for survival of adult mice, and for tumor suppression. Mol Cell Biol. 2010 Jun;30(12):2896-908
1*J:111998 Reinholdt LG, Munroe RJ, Kamdar S, Schimenti JC, The mouse gcd2 mutation causes primordial germ cell depletion. Mech Dev. 2006 Jul;123(7):559-69
2J:312335 Reyes-Aguirre LI, Lamas M, Oct4 Methylation-Mediated Silencing As an Epigenetic Barrier Preventing Muller Glia Dedifferentiation in a Murine Model of Retinal Injury. Front Neurosci. 2016;10:523
1J:172167 Rieger C, Poppino R, Sheridan R, Moley K, Mitra R, Gottlieb D, Polony analysis of gene expression in ES cells and blastocysts. Nucleic Acids Res. 2007;35(22):e151
1J:85863 Robertson EJ, Norris DP, Brennan J, Bikoff EK, Control of early anterior-posterior patterning in the mouse embryo by TGF-beta signalling. Philos Trans R Soc Lond B Biol Sci. 2003 Aug 29;358(1436):1351-7; discussion 1357
1*J:155888 Rodriguez-Magadan H, Ramirez L, Schnabel D, Vazquez M, Lomeli H, Sexually dimorphic gene expression of the Zimp7 and Zimp10 genes in embryonic gonads. Gene Expr Patterns. 2010 Jan;10(1):16-23
1J:163731 Rohrschneider LR, Custodio JM, Anderson TA, Miller CP, Gu H, The intron 5/6 promoter region of the ship1 gene regulates expression in stem/progenitor cells of the mouse embryo. Dev Biol. 2005 Jul 15;283(2):503-21
1*J:305453 Roman-Trufero M, Ito CM, Pedebos C, Magdalou I, Wang YF, Karimi MM, Moyon B, Webster Z, di Gregorio A, Azuara V, Khalid S, Speck C, Rodriguez T, Dillon N, Evolution of an Amniote-Specific Mechanism for Modulating Ubiquitin Signaling via Phosphoregulation of the E2 Enzyme UBE2D3. Mol Biol Evol. 2020 Jul 1;37(7):1986-2001
12*J:10576 Rosner MH, Vigano MA, Ozato K, Timmons PM, Poirier F, Rigby PW, Staudt LM, A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo. Nature. 1990 Jun 21;345(6277):686-92
1J:137277 Ross A, Munger S, Capel B, Bmp7 regulates germ cell proliferation in mouse fetal gonads. Sex Dev. 2007;1(2):127-37
4J:85864 Rossant J, Chazaud C, Yamanaka Y, Lineage allocation and asymmetries in the early mouse embryo. Philos Trans R Soc Lond B Biol Sci. 2003 Aug 29;358(1436):1341-8; discussion 1349
1*J:274844 Ruan Y, He J, Wu W, He P, Tian Y, Xiao L, Liu G, Wang J, Cheng Y, Zhang S, Yang Y, Xiong J, Zhao K, Wan Y, Huang H, Zhang J, Jian R, Nac1 promotes self-renewal of embryonic stem cells through direct transcriptional regulation of c-Myc. Oncotarget. 2017 Jul 18;8(29):47607-47618
1J:184021 Rugg-Gunn PJ, Cox BJ, Lanner F, Sharma P, Ignatchenko V, McDonald AC, Garner J, Gramolini AO, Rossant J, Kislinger T, Cell-surface proteomics identifies lineage-specific markers of embryo-derived stem cells. Dev Cell. 2012 Apr 17;22(4):887-901
2J:158290 Rybak A, Fuchs H, Hadian K, Smirnova L, Wulczyn EA, Michel G, Nitsch R, Krappmann D, Wulczyn FG, The let-7 target gene mouse lin-41 is a stem cell specific E3 ubiquitin ligase for the miRNA pathway protein Ago2. Nat Cell Biol. 2009 Dec;11(12):1411-20
1J:85868 Saba-El-Leil MK, Vella FD, Vernay B, Voisin L, Chen L, Labrecque N, Ang SL, Meloche S, An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development. EMBO Rep. 2003 Oct;4(10):964-8
1J:204480 Saha B, Home P, Ray S, Larson M, Paul A, Rajendran G, Behr B, Paul S, EED and KDM6B coordinate the first mammalian cell lineage commitment to ensure embryo implantation. Mol Cell Biol. 2013 Jul;33(14):2691-705
3J:42329 Saijoh Y, Fujii H, Meno C, Sato M, Hirota Y, Nagamatsu S, Ikeda M , Hamada H, Identification of putative downstream genes of Oct-3, a pluripotent cell-specific transcription factor. Genes Cells. 1996 Feb;1(2):239-52
4J:159743 Saito K, Abe H, Nakazawa M, Irokawa E, Watanabe M, Hosoi Y, Soma M, Kasuga K, Kojima I, Kobayashi M, Cloning of complementary DNAs encoding structurally related homeoproteins from preimplantation mouse embryos: their involvement in the differentiation of embryonic stem cells. Biol Reprod. 2010 Apr;82(4):687-97
2*J:118119 Sakaki-Yumoto M, Kobayashi C, Sato A, Fujimura S, Matsumoto Y, Takasato M, Kodama T, Aburatani H, Asashima M, Yoshida N, Nishinakamura R, The murine homolog of SALL4, a causative gene in Okihiro syndrome, is essential for embryonic stem cell proliferation, and cooperates with Sall1 in anorectal, heart, brain and kidney development. Development. 2006 Aug;133(15):3005-13
2J:243417 Sakata Y, Nagao K, Hoki Y, Sasaki H, Obuse C, Sado T, Defects in dosage compensation impact global gene regulation in the mouse trophoblast. Development. 2017 Aug 01;144(15):2784-2797
1J:238695 Sampath Kumar A, Seah MK, Ling KY, Wang Y, Tan JH, Nitsch S, Lim SL, Lorthongpanich C, Wollmann H, Low DH, Guccione E, Messerschmidt DM, Loss of maternal Trim28 causes male-predominant early embryonic lethality. Genes Dev. 2017 Jan 01;31(1):12-17
3J:156651 Sarraj MA, Escalona RM, Umbers A, Chua HK, Small C, Griswold M, Loveland K, Findlay JK, Stenvers KL, Fetal testis dysgenesis and compromised Leydig cell function in Tgfbr3 (beta glycan) knockout mice. Biol Reprod. 2010 Jan;82(1):153-62
1*J:121557 Sarraj MA, McClive PJ, Szczepny A, Daggag H, Loveland KL, Sinclair AH, Expression of Wsb2 in the developing and adult mouse testis. Reproduction. 2007 Apr;133(4):753-761
1*J:102851 Sarraj MA, McClive PJ, Wilmore HP, Loveland KL, Sinclair AH, Novel scavenger receptor gene is differentially expressed in the embryonic and adult mouse testis. Dev Dyn. 2005 Dec;234(4):1026-33
1*J:85717 Sarraj MA, Wilmore HP, McClive PJ, Sinclair AH, Sox15 is up regulated in the embryonic mouse testis. (Corrigendum Gene Expr Patterns 2003;3:785). Gene Expr Patterns. 2003 Aug;3(4):413-7
1*J:84530 Schepers G, Wilson M, Wilhelm D, Koopman P, SOX8 is expressed during testis differentiation in mice and synergizes with SF1 to activate the Amh promoter in vitro. J Biol Chem. 2003 Jul 25;278(30):28101-8
8*J:10568 Scholer HR, Dressler GR, Balling R, Rohdewohld H, Gruss P, Oct-4: a germline-specific transcription factor mapping to the mouse t-complex. EMBO J. 1990 Jul;9(7):2185-95
2*J:27203 Scholer HR, Ruppert S, Suzuki N, Chowdhury K, Gruss P, New type of POU domain in germ line-specific protein Oct-4. Nature. 1990 Mar 29;344(6265):435-9
2J:213580 Schrode N, Saiz N, Di Talia S, Hadjantonakis AK, GATA6 levels modulate primitive endoderm cell fate choice and timing in the mouse blastocyst. Dev Cell. 2014 May 27;29(4):454-67
1J:126330 Seandel M, James D, Shmelkov SV, Falciatori I, Kim J, Chavala S, Scherr DS, Zhang F, Torres R, Gale NW, Yancopoulos GD, Murphy A, Valenzuela DM, Hobbs RM, Pandolfi PP, Rafii S, Generation of functional multipotent adult stem cells from GPR125+ germline progenitors. Nature. 2007 Sep 20;449(7160):346-50
2J:165572 Sebastiano V, Dalvai M, Gentile L, Schubart K, Sutter J, Wu GM, Tapia N, Esch D, Ju JY, Hubner K, Bravo MJ, Scholer HR, Cavaleri F, Matthias P, Oct1 regulates trophoblast development during early mouse embryogenesis. Development. 2010 Nov;137(21):3551-60
2J:275024 Senft AD, Bikoff EK, Robertson EJ, Costello I, Genetic dissection of Nodal and Bmp signalling requirements during primordial germ cell development in mouse. Nat Commun. 2019 Mar 6;10(1):1089
1J:273305 Senft AD, Costello I, King HW, Mould AW, Bikoff EK, Robertson EJ, Combinatorial Smad2/3 Activities Downstream of Nodal Signaling Maintain Embryonic/Extra-Embryonic Cell Identities during Lineage Priming. Cell Rep. 2018 Aug 21;24(8):1977-1985.e7
1*J:230729 Shafaq-Zadah M, Gomes-Santos CS, Bardin S, Maiuri P, Maurin M, Iranzo J, Gautreau A, Lamaze C, Caswell P, Goud B, Johannes L, Persistent cell migration and adhesion rely on retrograde transport of beta(1) integrin. Nat Cell Biol. 2016 Jan;18(1):54-64
1J:256730 Shawki HH, Oishi H, Usui T, Kitadate Y, Basha WA, Abdellatif AM, Hasegawa K, Okada R, Mochida K, El-Shemy HA, Muratani M, Ogura A, Yoshida S, Takahashi S, MAFB is dispensable for the fetal testis morphogenesis and the maintenance of spermatogenesis in adult mice. PLoS One. 2018;13(1):e0190800
5*J:320687 Sheban D, Shani T, Maor R, Aguilera-Castrejon A, Mor N, Oldak B, Shmueli MD, Eisenberg-Lerner A, Bayerl J, Hebert J, Viukov S, Chen G, Kacen A, Krupalnik V, Chugaeva V, Tarazi S, Rodriguez-delaRosa A, Zerbib M, Ulman A, Masarwi S, Kupervaser M, Levin Y, Shema E, David Y, Novershtern N, Hanna JH, Merbl Y, SUMOylation of linker histone H1 drives chromatin condensation and restriction of embryonic cell fate identity. Mol Cell. 2022 Jan 6;82(1):106-122.e9
1*J:178313 Shen J, Liu X, Yu WM, Liu J, Groot Nibbelink M, Guo C, Finkel T, Qu CK, A critical role of mitochondrial phosphatase ptpmt1 in embryogenesis reveals a mitochondrial metabolic stress-induced differentiation checkpoint in embryonic stem cells. Mol Cell Biol. 2011 Dec;31(24):4902-16
4*J:275903 Shiura H, Abe K, Xist/Tsix expression dynamics during mouse peri-implantation development revealed by whole-mount 3D RNA-FISH. Sci Rep. 2019 Mar 6;9(1):3637
1J:156018 Shoji M, Tanaka T, Hosokawa M, Reuter M, Stark A, Kato Y, Kondoh G, Okawa K, Chujo T, Suzuki T, Hata K, Martin SL, Noce T, Kuramochi-Miyagawa S, Nakano T, Sasaki H, Pillai RS, Nakatsuji N, Chuma S, The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline. Dev Cell. 2009 Dec;17(6):775-87
2J:216825 Siggers P, Carre GA, Bogani D, Warr N, Wells S, Hilton H, Esapa C, Hajihosseini MK, Greenfield A, A novel mouse Fgfr2 mutant, hobbyhorse (hob), exhibits complete XY gonadal sex reversal. PLoS One. 2014;9(6):e100447
1*J:74486 Siggers P, Smith L, Greenfield A, Sexually dimorphic expression of Gata-2 during mouse gonad development. Mech Dev. 2002 Feb;111(1-2):159-62
3J:212358 Singh AP, Archer TK, Analysis of the SWI/SNF chromatin-remodeling complex during early heart development and BAF250a repression cardiac gene transcription during P19 cell differentiation. Nucleic Acids Res. 2014 Mar;42(5):2958-75
1J:333802 Singh N, Singh D, Bhide A, Sharma R, Bhowmick S, Patel V, Modi D, LHX2 in germ cells control tubular organization in the developing mouse testis. Exp Cell Res. 2023 Feb 14;425(1):113511
1*J:90282 Smith JM, Bowles J, Wilson M, Koopman P, HMG box transcription factor gene Hbp1 is expressed in germ cells of the developing mouse testis. Dev Dyn. 2004 Jun;230(2):366-70
2*J:93161 Smith JM, Bowles J, Wilson M, Teasdale RD, Koopman P, Expression of the tudor-related gene Tdrd5 during development of the male germline in mice. Gene Expr Patterns. 2004 Oct;4(6):701-5
1J:84943 Smith L, Van Hateren N, Willan J, Romero R, Blanco G, Siggers P, Walsh J, Banerjee R, Denny P, Ponting C, Greenfield A, Candidate testis-determining gene, Maestro (Mro), encodes a novel HEAT repeat protein. Dev Dyn. 2003 Aug;227(4):600-7
2J:144349 Smith L, Willan J, Warr N, Brook FA, Cheeseman M, Sharpe R, Siggers P, Greenfield A, The Maestro (Mro) gene is dispensable for normal sexual development and fertility in mice. PLoS One. 2008;3(12):e4091
1J:306228 Song HW, Dann CT, McCarrey JR, Meistrich ML, Cornwall GA, Wilkinson MF, Dynamic expression pattern and subcellular localization of the Rhox10 homeobox transcription factor during early germ cell development. Reproduction. 2012 May;143(5):611-24
3*J:235456 Song L, Chen J, Peng G, Tang K, Jing N, Dynamic Heterogeneity of Brachyury in Mouse Epiblast Stem Cells Mediates Distinct Response to Extrinsic Bone Morphogenetic Protein (BMP) Signaling. J Biol Chem. 2016 Jul 15;291(29):15212-25
2J:239945 Souilhol C, Perea-Gomez A, Camus A, Beck-Cormier S, Vandormael-Pournin S, Escande M, Collignon J, Cohen-Tannoudji M, NOTCH activation interferes with cell fate specification in the gastrulating mouse embryo. Development. 2015 Nov 01;142(21):3649-60
2J:313675 Soygur B, Jaszczak RG, Fries A, Nguyen DH, Malki S, Hu G, Demir N, Arora R, Laird DJ, Intercellular bridges coordinate the transition from pluripotency to meiosis in mouse fetal oocytes. Sci Adv. 2021 Apr;7(15)
1*J:189072 Spiller CM, Feng CW, Jackson A, Gillis AJ, Rolland AD, Looijenga LH, Koopman P, Bowles J, Endogenous Nodal signaling regulates germ cell potency during mammalian testis development. Development. 2012 Nov;139(22):4123-32
3*J:247327 Spiller CM, Wilhelm D, Jans DA, Bowles J, Koopman P, Mice Lacking Hbp1 Function Are Viable and Fertile. PLoS One. 2017;12(1):e0170576
2*J:249296 Spiller CM, Wilhelm D, Koopman P, Retinoblastoma 1 protein modulates XY germ cell entry into G1/G0 arrest during fetal development in mice. Biol Reprod. 2010 Feb;82(2):433-43
1J:163670 Spruce T, Pernaute B, Di-Gregorio A, Cobb BS, Merkenschlager M, Manzanares M, Rodriguez TA, An early developmental role for miRNAs in the maintenance of extraembryonic stem cells in the mouse embryo. Dev Cell. 2010 Aug 17;19(2):207-19
4*J:343201 Srinivasan S, He X, Mirza S, Mager J, Exosome complex components 1 and 2 are vital for early mammalian development. Gene Expr Patterns. 2023 Nov 7;51:119346
2J:284144 St-Jean G, Tsoi M, Abedini A, Levasseur A, Rico C, Morin M, Djordjevic B, Miinalainen I, Kaarteenaho R, Paquet M, Gevry N, Boyer A, Vanderhyden B, Boerboom D, Lats1 and Lats2 are required for the maintenance of multipotency in the Mullerian duct mesenchyme. Development. 2019 Oct 18;146(20):dev180430
2*J:154127 Stanghellini I, Falco G, Lee SL, Monti M, Ko MS, Trim43a, Trim43b, and Trim43c: Novel mouse genes expressed specifically in mouse preimplantation embryos. Gene Expr Patterns. 2009 Dec;9(8):595-602
4J:137356 Strizzi L, Mancino M, Bianco C, Raafat A, Gonzales M, Booth BW, Watanabe K, Nagaoka T, Mack DL, Howard B, Callahan R, Smith GH, Salomon DS, Netrin-1 can affect morphogenesis and differentiation of the mouse mammary gland. J Cell Physiol. 2008 Sep;216(3):824-34
4*J:98502 Strumpf D, Mao CA, Yamanaka Y, Ralston A, Chawengsaksophak K, Beck F, Rossant J, Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst. Development. 2005 May;132(9):2093-102
1J:171680 Stuckey DW, Di Gregorio A, Clements M, Rodriguez TA, Correct patterning of the primitive streak requires the anterior visceral endoderm. PLoS One. 2011;6(3):e17620
1J:144999 Su H, Trombly MI, Chen J, Wang X, Essential and overlapping functions for mammalian Argonautes in microRNA silencing. Genes Dev. 2009 Feb 1;23(3):304-17
2*J:301719 Su J, Miao X, Archambault D, Mager J, Cui W, ZC3H4-a novel Cys-Cys-Cys-His-type zinc finger protein-is essential for early embryogenesis in mice. Biol Reprod. 2021 Feb 11;104(2):325-335
2J:272362 Su X, Wu C, Ye X, Zeng M, Zhang Z, Che Y, Zhang Y, Liu L, Lin Y, Yang R, Embryonic lethality in mice lacking Trim59 due to impaired gastrulation development. Cell Death Dis. 2018 Feb 21;9(3):302
3J:123745 Sugimoto M, Abe K, X chromosome reactivation initiates in nascent primordial germ cells in mice. PLoS Genet. 2007 Jul 27;3(7):e116
1J:190873 Sugimoto M, Kondo M, Hirose M, Suzuki M, Mekada K, Abe T, Kiyonari H, Ogura A, Takagi N, Artzt K, Abe K, Molecular identification of t(w5): Vps52 promotes pluripotential cell differentiation through cell-cell interactions. Cell Rep. 2012 Nov 29;2(5):1363-74
2*J:312380 Sun-Wada GH, Tabata H, Wada Y, Vacuolar-type proton ATPase is required for maintenance of apicobasal polarity of embryonic visceral endoderm. Sci Rep. 2021 Sep 29;11(1):19355
3J:230058 Suzuki A, Niimi Y, Shinmyozu K, Zhou Z, Kiso M, Saga Y, Dead end1 is an essential partner of NANOS2 for selective binding of target RNAs in male germ cell development. EMBO Rep. 2016 Jan;17(1):37-46
4J:223131 Suzuki H, Saba R, Sada A, Saga Y, The Nanos3-3'UTR is required for germ cell specific NANOS3 expression in mouse embryos. PLoS One. 2010;5(2):e9300
1*J:154912 Suzuki H, Sada A, Yoshida S, Saga Y, The heterogeneity of spermatogonia is revealed by their topology and expression of marker proteins including the germ cell-specific proteins Nanos2 and Nanos3. Dev Biol. 2009 Dec 15;336(2):222-31
2J:136687 Suzuki H, Tsuda M, Kiso M, Saga Y, Nanos3 maintains the germ cell lineage in the mouse by suppressing both Bax-dependent and -independent apoptotic pathways. Dev Biol. 2008 Jun 1;318(1):133-42
2*J:122361 Svingen T, Beverdam A, Bernard P, McClive P, Harley VR, Sinclair AH, Koopman P, Sex-specific expression of a novel gene Tmem184a during mouse testis differentiation. Reproduction. 2007 May;133(5):983-9
2*J:120357 Svingen T, Beverdam A, Verma P, Wilhelm D, Koopman P, Aard is specifically up-regulated in Sertoli cells during mouse testis differentiation. Int J Dev Biol. 2007;51:255-258
2J:343100 Takada Y, Fierro L, Sato K, Sanada T, Ishii A, Yamamoto T, Kotani T, Mature mRNA processing that deletes 3' end sequences directs translational activation and embryonic development. Sci Adv. 2023 Nov 24;9(47):eadg6532
10J:298906 Takada Y, Iyyappan R, Susor A, Kotani T, Posttranscriptional regulation of maternal Pou5f1/Oct4 during mouse oogenesis and early embryogenesis. Histochem Cell Biol. 2020 Dec;154(6):609-620
1J:253433 Takahashi N, Davy PM, Gardner LH, Mathews J, Yamazaki Y, Allsopp RC, Hypoxia Inducible Factor 1 Alpha Is Expressed in Germ Cells throughout the Murine Life Cycle. PLoS One. 2016;11(5):e0154309
1J:257216 Takaoka K, Nishimura H, Hamada H, Both Nodal signalling and stochasticity select for prospective distal visceral endoderm in mouse embryos. Nat Commun. 2017 Nov 14;8(1):1492
1J:104381 Takeuchi Y, Molyneaux K, Runyan C, Schaible K, Wylie C, The roles of FGF signaling in germ cell migration in the mouse. Development. 2005 Dec;132(24):5399-409
1J:187963 Talchai C, Xuan S, Lin HV, Sussel L, Accili D, Pancreatic beta Cell Dedifferentiation as a Mechanism of Diabetic beta Cell Failure. Cell. 2012 Sep 14;150(6):1223-34
5*J:138113 Tam WL, Lim CY, Han J, Zhang J, Ang YS, Ng HH, Yang H, Lim B, T-cell factor 3 regulates embryonic stem cell pluripotency and self-renewal by the transcriptional control of multiple lineage pathways. Stem Cells. 2008 Aug;26(8):2019-31
5*J:320624 Tan BSN, Rathjen PD, Harvey AJ, Gardner DK, Rathjen J, Regulation of amino acid transporters in pluripotent cell populations in the embryo and in culture; novel roles for sodium-coupled neutral amino acid transporters. Mech Dev. 2016 Aug;141:32-39
3*J:82212 Tanaka SS, Matsui Y, Developmentally regulated expression of mil-1 and mil-2, mouse interferon-induced transmembrane protein like genes, during formation and differentiation of primordial germ cells. Mech Dev. 2002 Dec;119 Suppl 1:S261-7
1J:199855 Tanaka SS, Nakane A, Yamaguchi YL, Terabayashi T, Abe T, Nakao K, Asashima M, Steiner KA, Tam PP, Nishinakamura R, Dullard/Ctdnep1 modulates WNT signalling activity for the formation of primordial germ cells in the mouse embryo. PLoS One. 2013;8(3):e57428
1J:104972 Tanaka SS, Yamaguchi YL, Tsoi B, Lickert H, Tam PP, IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion. Dev Cell. 2005 Dec;9(6):745-56
7*J:83414 Tanaka TS, Kunath T, Kimber WL, Jaradat SA, Stagg CA, Usuda M, Yokota T, Niwa H, Rossant J, Ko MS, Gene expression profiling of embryo-derived stem cells reveals candidate genes associated with pluripotency and lineage specificity. Genome Res. 2002 Dec;12(12):1921-8
6*J:115671 Tanaka TS, Lopez de Silanes I, Sharova LV, Akutsu H, Yoshikawa T, Amano H, Yamanaka S, Gorospe M, Ko MS, Esg1, expressed exclusively in preimplantation embryos, germline, and embryonic stem cells, is a putative RNA-binding protein with broad RNA targets. Dev Growth Differ. 2006 Aug;48(6):381-90
2*J:174767 Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB, Heard E, Lao K, Surani MA, Deterministic and stochastic allele specific gene expression in single mouse blastomeres. PLoS One. 2011;6(6):e21208
2J:119483 Tang F, Kaneda M, O'Carroll D, Hajkova P, Barton SC, Sun YA, Lee C, Tarakhovsky A, Lao K, Surani MA, Maternal microRNAs are essential for mouse zygotic development. Genes Dev. 2007 Mar 15;21(6):644-8
1J:305205 Tang F, Richardson N, Albina A, Chaboissier MC, Perea-Gomez A, Mouse Gonad Development in the Absence of the Pro-Ovary Factor WNT4 and the Pro-Testis Factor SOX9. Cells. 2020 Apr 29;9(5):1103
1J:183948 Tao H, Inoue K, Kiyonari H, Bassuk AG, Axelrod JD, Sasaki H, Aizawa S, Ueno N, Nuclear localization of Prickle2 is required to establish cell polarity during early mouse embryogenesis. Dev Biol. 2012 Apr 15;364(2):138-48
2J:137165 Tarasov KV, Tarasova YS, Tam WL, Riordon DR, Elliott ST, Kania G, Li J, Yamanaka S, Crider DG, Testa G, Li RA, Lim B, Stewart CL, Liu Y, Van Eyk JE, Wersto RP, Wobus AM, Boheler KR, B-MYB is essential for normal cell cycle progression and chromosomal stability of embryonic stem cells. PLoS One. 2008;3(6):e2478
3J:327970 Tarazi S, Aguilera-Castrejon A, Joubran C, Ghanem N, Ashouokhi S, Roncato F, Wildschutz E, Haddad M, Oldak B, Gomez-Cesar E, Livnat N, Viukov S, Lokshtanov D, Naveh-Tassa S, Rose M, Hanna S, Raanan C, Brenner O, Kedmi M, Keren-Shaul H, Lapidot T, Maza I, Novershtern N, Hanna JH, Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs. Cell. 2022 Sep 1;185(18):3290-3306.e25
4*J:166736 Tee WW, Pardo M, Theunissen TW, Yu L, Choudhary JS, Hajkova P, Surani MA, Prmt5 is essential for early mouse development and acts in the cytoplasm to maintain ES cell pluripotency. Genes Dev. 2010 Dec 15;24(24):2772-7
1*J:277394 Tellier AP, Archambault D, Tremblay KD, Mager J, The elongation factor Elof1 is required for mammalian gastrulation. PLoS One. 2019;14(7):e0219410
3J:168146 Teo AK, Arnold SJ, Trotter MW, Brown S, Ang LT, Chng Z, Robertson EJ, Dunn NR, Vallier L, Pluripotency factors regulate definitive endoderm specification through eomesodermin. Genes Dev. 2011 Feb 1;25(3):238-50
1*J:45579 Thomas PQ, Brown A, Beddington RS, Hex: a homeobox gene revealing peri-implantation asymmetry in the mouse embryo and an early transient marker of endothelial cell precursors. Development. 1998 Jan;125(1):85-94
5*J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1J:197590 Tiozzo C, Danopoulos S, Lavarreda-Pearce M, Baptista S, Varimezova R, Al Alam D, Warburton D, Rehan V, De Langhe S, Di Cristofano A, Bellusci S, Minoo P, Embryonic epithelial Pten deletion through Nkx2.1-cre leads to thyroid tumorigenesis in a strain-dependent manner. Endocr Relat Cancer. 2012 Apr;19(2):111-22
2*J:166346 Tolkunova E, Malashicheva A, Parfenov VN, Sustmann C, Grosschedl R, Tomilin A, PIAS proteins as repressors of Oct4 function. J Mol Biol. 2007 Dec 14;374(5):1200-12
2*J:137798 Tomizawa M, Toyama Y, Ito C, Toshimori K, Iwase K, Takiguchi M, Saisho H, Yokosuka O, Hepatoblast-like cells enriched from mouse embryonic stem cells in medium without glucose, pyruvate, arginine, and tyrosine. Cell Tissue Res. 2008 Jul;333(1):17-27
1J:282925 Tosic J, Kim GJ, Pavlovic M, Schroder CM, Mersiowsky SL, Barg M, Hofherr A, Probst S, Kottgen M, Hein L, Arnold SJ, Eomes and Brachyury control pluripotency exit and germ-layer segregation by changing the chromatin state. Nat Cell Biol. 2019 Dec;21(12):1518-1531
1*J:143535 Toyoda S, Miyazaki T, Miyazaki S, Yoshimura T, Yamamoto M, Tashiro F, Yamato E, Miyazaki J, Sohlh2 affects differentiation of KIT positive oocytes and spermatogonia. Dev Biol. 2009 Jan 1;325(1):238-48
1*J:186556 Trask MC, Tremblay KD, Mager J, Yin-Yang1 is required for epithelial-to-mesenchymal transition and regulation of Nodal signaling during mammalian gastrulation. Dev Biol. 2012 Aug 15;368(2):273-82
2*J:326575 Tsume-Kajioka M, Kimura-Yoshida C, Mochida K, Ueda Y, Matsuo I, BET proteins are essential for the specification and maintenance of the epiblast lineage in mouse preimplantation embryos. BMC Biol. 2022 Mar 9;20(1):64
2J:306323 Ueda Y, Kimura-Yoshida C, Mochida K, Tsume M, Kameo Y, Adachi T, Lefebvre O, Hiramatsu R, Matsuo I, Intrauterine Pressures Adjusted by Reichert's Membrane Are Crucial for Early Mouse Morphogenesis. Cell Rep. 2020 May 19;31(7):107637
1*J:138922 Uez N, Lickert H, Kohlhase J, de Angelis MH, Kuhn R, Wurst W, Floss T, Sall4 isoforms act during proximal-distal and anterior-posterior axis formation in the mouse embryo. Genesis. 2008 Sep 9;46(9):463-477
1J:263202 Ungewitter EK, Rotgers E, Kang HS, Lichti-Kaiser K, Li L, Grimm SA, Jetten AM, Yao HH, Loss of Glis3 causes dysregulation of retrotransposon silencing and germ cell demise in fetal mouse testis. Sci Rep. 2018 Jun 25;8(1):9662
3J:290083 Uyhazi KE, Yang Y, Liu N, Qi H, Huang XA, Mak W, Weatherbee SD, de Prisco N, Gennarino VA, Song X, Lin H, Pumilio proteins utilize distinct regulatory mechanisms to achieve complementary functions required for pluripotency and embryogenesis. Proc Natl Acad Sci U S A. 2020 Apr 7;117(14):7851-7862
1J:52554 Vainio S, Heikkila M, Kispert A, Chin N, McMahon AP, Female development in mammals is regulated by Wnt-4 signalling. Nature. 1999 Feb 4;397(6718):405-9
1J:91601 Van Eynde A, Nuytten M, Dewerchin M, Schoonjans L, Keppens S, Beullens M, Moons L, Carmeliet P, Stalmans W, Bollen M, The nuclear scaffold protein NIPP1 is essential for early embryonic development and cell proliferation. Mol Cell Biol. 2004 Jul;24(13):5863-74
2J:217603 Vanhoutteghem A, Messiaen S, Herve F, Delhomme B, Moison D, Petit JM, Rouiller-Fabre V, Livera G, Djian P, The zinc-finger protein basonuclin 2 is required for proper mitotic arrest, prevention of premature meiotic initiation and meiotic progression in mouse male germ cells. Development. 2014 Nov;141(22):4298-310
1*J:311886 Varghese PC, Rajam SM, Nandy D, Jory A, Mukherjee A, Dutta D, Histone chaperone APLF level dictates the implantation of mouse embryos. J Cell Sci. 2021 Jan 13;134(1):jcs246900
2*J:65596 Voss AK, Thomas T, Petrou P, Anastassiadis K, Scholer H, Gruss P, Taube nuss is a novel gene essential for the survival of pluripotent cells of early mouse embryos. Development. 2000 Dec;127(24):5449-61
1*J:216502 Wainwright EN, Svingen T, Ng ET, Wicking C, Koopman P, Primary cilia function regulates the length of the embryonic trunk axis and urogenital field in mice. Dev Biol. 2014 Nov 15;395(2):342-54
1J:46532 Waldrip WR, Bikoff EK, Hoodless PA, Wrana JL, Robertson EJ, Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo. Cell. 1998 Mar 20;92(6):797-808
1*J:199572 Wallingford MC, Angelo JR, Mager J, Morphogenetic analysis of peri-implantation development. Dev Dyn. 2013 Sep;242(9):1110-20
4*J:290529 Wallingford MC, Hiller J, Zhang K, Mager J, YY1 Is Required for Posttranscriptional Stability of SOX2 and OCT4 Proteins. Cell Reprogram. 2017 Aug;19(4):263-269
2J:146397 Wanderling S, Simen BB, Ostrovsky O, Ahmed NT, Vogen SM, Gidalevitz T, Argon Y, GRP94 is essential for mesoderm induction and muscle development because it regulates insulin-like growth factor secretion. Mol Biol Cell. 2007 Oct;18(10):3764-75
1*J:318603 Wang B, Balakrishnan-Renuka A, Napirei M, Theiss C, Brand-Saberi B, Spatiotemporal expression of Math6 during mouse embryonic development. Histochem Cell Biol. 2015 Jun;143(6):575-82
2*J:136803 Wang H, Ding T, Brown N, Yamamoto Y, Prince LS, Reese J, Paria BC, Zonula occludens-1 (ZO-1) is involved in morula to blastocyst transformation in the mouse. Dev Biol. 2008 Jun 1;318(1):112-25
2J:287165 Wang J, Lee JE, Riemondy K, Yu Y, Marquez SM, Lai EC, Yi R, XPO5 promotes primary miRNA processing independently of RanGTP. Nat Commun. 2020 Apr 15;11(1):1845
7J:306248 Wang L, Du Y, Ward JM, Shimbo T, Lackford B, Zheng X, Miao YL, Zhou B, Han L, Fargo DC, Jothi R, Williams CJ, Wade PA, Hu G, INO80 facilitates pluripotency gene activation in embryonic stem cell self-renewal, reprogramming, and blastocyst development. Cell Stem Cell. 2014 May 1;14(5):575-91
6*J:204143 Wang L, Miao YL, Zheng X, Lackford B, Zhou B, Han L, Yao C, Ward JM, Burkholder A, Lipchina I, Fargo DC, Hochedlinger K, Shi Y, Williams CJ, Hu G, The THO Complex Regulates Pluripotency Gene mRNA Export and Controls Embryonic Stem Cell Self-Renewal and Somatic Cell Reprogramming. Cell Stem Cell. 2013 Dec 5;13(6):676-90
1*J:162420 Wang Y, Hai T, Liu Z, Zhou S, Lv Z, Ding C, Liu L, Niu Y, Zhao X, Tong M, Wang L, Jouneau A, Zhang X, Ji W, Zhou Q, HSPC117 deficiency in cloned embryos causes placental abnormality and fetal death. Biochem Biophys Res Commun. 2010 Jul 2;397(3):407-12
6J:277545 Wang Y, Li Q, Liu C, Han F, Chen M, Zhang L, Cui X, Qin Y, Bao S, Gao F, Protein arginine methyltransferase 5 (Prmt5) is required for germ cell survival during mouse embryonic development. Biol Reprod. 2015 Apr;92(4):104
2J:106144 Ware SM, Harutyunyan KG, Belmont JW, Zic3 is critical for early embryonic patterning during gastrulation. Dev Dyn. 2006 Mar;235(3):776-85
1J:172351 Warr N, Bogani D, Siggers P, Brixey R, Tateossian H, Dopplapudi A, Wells S, Cheeseman M, Xia Y, Ostrer H, Greenfield A, Minor Abnormalities of Testis Development in Mice Lacking the Gene Encoding the MAPK Signalling Component, MAP3K1. PLoS One. 2011;6(5):e19572
3J:191096 Warr N, Carre GA, Siggers P, Faleato JV, Brixey R, Pope M, Bogani D, Childers M, Wells S, Scudamore CL, Tedesco M, del Barco Barrantes I, Nebreda AR, Trainor PA, Greenfield A, Gadd45gamma and Map3k4 interactions regulate mouse testis determination via p38 MAPK-mediated control of Sry expression. Dev Cell. 2012 Nov 13;23(5):1020-31
3J:138862 Warr N, Powles-Glover N, Chappell A, Robson J, Norris D, Arkell RM, Zic2-associated holoprosencephaly is caused by a transient defect in the organizer region during gastrulation. Hum Mol Genet. 2008 Oct 1;17(19):2986-96
1J:147206 Warr N, Siggers P, Bogani D, Brixey R, Pastorelli L, Yates L, Dean CH, Wells S, Satoh W, Shimono A, Greenfield A, Sfrp1 and Sfrp2 are required for normal male sexual development in mice. Dev Biol. 2009 Feb 15;326(2):273-84
1*J:217679 Washkowitz AJ, Schall C, Zhang K, Wurst W, Floss T, Mager J, Papaioannou VE, Mga is essential for the survival of pluripotent cells during peri-implantation development. Development. 2015 Jan 1;142(1):31-40
3*J:79524 Watanabe D, Suetake I, Tada T, Tajima S, Stage- and cell-specific expression of Dnmt3a and Dnmt3b during embryogenesis. Mech Dev. 2002 Oct;118(1-2):187
8*J:198275 Watanabe N, Mii S, Asai N, Asai M, Niimi K, Ushida K, Kato T, Enomoto A, Ishii H, Takahashi M, Murakumo Y, The REV7 subunit of DNA polymerase zeta is essential for primordial germ cell maintenance in the mouse. J Biol Chem. 2013 Apr 12;288(15):10459-71
3J:266780 Watanabe Y, Miyasaka KY, Kubo A, Kida YS, Nakagawa O, Hirate Y, Sasaki H, Ogura T, Notch and Hippo signaling converge on Strawberry Notch 1 (Sbno1) to synergistically activate Cdx2 during specification of the trophectoderm. Sci Rep. 2017 Apr 12;7:46135
2J:306317 Weberling A, Zernicka-Goetz M, Trophectoderm mechanics direct epiblast shape upon embryo implantation. Cell Rep. 2021 Jan 19;34(3):108655
1*J:243676 Wen J, Zeng Y, Fang Z, Gu J, Ge L, Tang F, Qu Z, Hu J, Cui Y, Zhang K, Wang J, Li S, Sun Y, Jin Y, Single-cell analysis reveals lineage segregation in early post-implantation mouse embryos. J Biol Chem. 2017 Jun 09;292(23):9840-9854
15*J:187950 Western P, Maldonado-Saldivia J, van den Bergen J, Hajkova P, Saitou M, Barton S, Surani MA, Analysis of Esg1 expression in pluripotent cells and the germline reveals similarities with Oct4 and Sox2 and differences between human pluripotent cell lines. Stem Cells. 2005 Nov-Dec;23(10):1436-42
3J:174956 Western PS, Ralli RA, Wakeling SI, Lo C, van den Bergen JA, Miles DC, Sinclair AH, Mitotic arrest in teratoma susceptible fetal male germ cells. PLoS One. 2011;6(6):e20736
1*J:253448 Whitmill A, Liu Y, Timani KA, Niu Y, He JJ, Tip110 Deletion Impaired Embryonic and Stem Cell Development Involving Downregulation of Stem Cell Factors Nanog, Oct4, and Sox2. Stem Cells. 2017 Jul;35(7):1674-1686
3J:228855 Wicklow E, Blij S, Frum T, Hirate Y, Lang RA, Sasaki H, Ralston A, HIPPO pathway members restrict SOX2 to the inner cell mass where it promotes ICM fates in the mouse blastocyst. PLoS Genet. 2014 Oct;10(10):e1004618
2J:121150 Wilhelm D, Hiramatsu R, Mizusaki H, Widjaja L, Combes AN, Kanai Y, Koopman P, SOX9 regulates prostaglandin D synthase gene transcription in vivo to ensure testis development. J Biol Chem. 2007 Apr;282(14):10553-60
3*J:101007 Williams LH, McClive PJ, Van Den Bergen JA, Sinclair AH, Annexin XI co-localises with calcyclin in proliferating cells of the embryonic mouse testis. Dev Dyn. 2005 Oct;234(2):432-7
2J:109014 Wilson MJ, Bowles J, Koopman P, The matricellular protein SPARC is internalized in Sertoli, Leydig, and germ cells during testis differentiation. Mol Reprod Dev. 2006 May;73(5):531-9
2J:99574 Wilson MJ, Liaw L, Koopman P, Osteopontin and related SIBLING glycoprotein genes are expressed by Sertoli cells during mouse testis development. Dev Dyn. 2005 Aug;233(4):1488-95
1J:320185 Windley SP, Mayere C, McGovern AE, Harvey NL, Nef S, Schwarz Q, Kumar S, Wilhelm D, Loss of NEDD4 causes complete XY gonadal sex reversal in mice. Cell Death Dis. 2022 Jan 24;13(1):75
1*J:210985 Wolfe AD, Downs KM, Mixl1 localizes to putative axial stem cell reservoirs and their posterior descendants in the mouse embryo. Gene Expr Patterns. 2014 May;15(1):8-20
3*J:242062 Wolfe AD, Rodriguez AM, Downs KM, STELLA collaborates in distinct mesendodermal cell subpopulations at the fetal-placental interface in the mouse gastrula. Dev Biol. 2017 May 01;425(1):44-57
4*J:285725 Wolff E, Suplicki MM, Behr R, Primordial germ cells do not migrate along nerve fibres in marmoset monkey and mouse embryos. Reproduction. 2019 Jan;157(1):101-109
2J:159214 Wong YH, Lu AC, Wang YC, Cheng HC, Chang C, Chen PH, Yu JY, Fann MJ, Protogenin defines a transition stage during embryonic neurogenesis and prevents precocious neuronal differentiation. J Neurosci. 2010 Mar 24;30(12):4428-39
3J:183069 Wongtawan T, Taylor JE, Lawson KA, Wilmut I, Pennings S, Histone H4K20me3 and HP1alpha are late heterochromatin markers in development, but present in undifferentiated embryonic stem cells. J Cell Sci. 2011 Jun 1;124(Pt 11):1878-90
2J:333394 Wu D, Dean J, RNA exosome ribonuclease DIS3 degrades Pou6f1 to promote mouse pre-implantation cell differentiation. Cell Rep. 2023 Jan 30;42(2):112047
6*J:320811 Wu F, Wu Q, Li D, Zhang Y, Wang R, Liu Y, Li W, Oct4 regulates DNA methyltransferase 1 transcription by direct binding of the regulatory element. Cell Mol Biol Lett. 2018;23:39
7J:201607 Wu G, Han D, Gong Y, Sebastiano V, Gentile L, Singhal N, Adachi K, Fischedick G, Ortmeier C, Sinn M, Radstaak M, Tomilin A, Scholer HR, Establishment of totipotency does not depend on Oct4A. Nat Cell Biol. 2013 Sep;15(9):1089-97
1J:223223 Wu Q, Fukuda K, Weinstein M, Graff JM, Saga Y, SMAD2 and p38 signaling pathways act in concert to determine XY primordial germ cell fate in mice. Development. 2015 Feb 1;142(3):575-86
2*J:165972 Wu X, Sandhu S, Patel N, Triggs-Raine B, Ding H, EMG1 is essential for mouse pre-implantation embryo development. BMC Dev Biol. 2010;10:99
1J:320746 Wu X, Wang B, Dong Z, Zhou S, Liu Z, Shi G, Cao Y, Xu Y, A NANOS3 mutation linked to protein degradation causes premature ovarian insufficiency. Cell Death Dis. 2013 Oct 3;4:e825
1J:292794 Xia X, Zhou X, Quan Y, Hu Y, Xing F, Li Z, Xu B, Xu C, Zhang A, Germline deletion of Cdyl causes teratozoospermia and progressive infertility in male mice. Cell Death Dis. 2019 Mar 8;10(3):229
2*J:86912 Xiao C, Shim JH, Kluppel M, Zhang SS, Dong C, Flavell RA, Fu XY, Wrana JL, Hogan BL, Ghosh S, Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. Genes Dev. 2003 Dec 1;17(23):2933-49
4J:311921 Xu Y, Luo X, Fang Z, Zheng X, Zeng Y, Zhu C, Gu J, Tang F, Hu Y, Hu G, Jin Y, Li H, Transcription coactivator Cited1 acts as an inducer of trophoblast-like state from mouse embryonic stem cells through the activation of BMP signaling. Cell Death Dis. 2018 Sep 11;9(9):924
2*J:126338 Yagi R, Kohn MJ, Karavanova I, Kaneko KJ, Vullhorst D, Depamphilis ML, Buonanno A, Transcription factor TEAD4 specifies the trophectoderm lineage at the beginning of mammalian development. Development. 2007 Nov;134(21):3827-36
1J:125701 Yamada M, Terao M, Terashima T, Fujiyama T, Kawaguchi Y, Nabeshima Y, Hoshino M, Origin of climbing fiber neurons and their developmental dependence on Ptf1a. J Neurosci. 2007 Oct 10;27(41):10924-34
7*J:109159 Yamaguchi YL, Tanaka SS, Kasa M, Yasuda K, Tam PP, Matsui Y, Expression of low density lipoprotein receptor-related protein 4 (Lrp4) gene in the mouse germ cells. Gene Expr Patterns. 2006 Aug;6(6):607-612
3J:222493 Yamaguchi YL, Tanaka SS, Kumagai M, Fujimoto Y, Terabayashi T, Matsui Y, Nishinakamura R, Sall4 is essential for mouse primordial germ cell specification by suppressing somatic cell program genes. Stem Cells. 2015 Jan;33(1):289-300
5J:112883 Yamaguchi YL, Tanaka SS, Yasuda K, Matsui Y, Tam PP, Stage-specific Importin13 activity influences meiosis of germ cells in the mouse. Dev Biol. 2006 Sep 15;297(2):350-60
1J:138571 Yamaji M, Seki Y, Kurimoto K, Yabuta Y, Yuasa M, Shigeta M, Yamanaka K, Ohinata Y, Saitou M, Critical function of Prdm14 for the establishment of the germ cell lineage in mice. Nat Genet. 2008 Aug;40(8):1016-22
1J:162904 Yamaji M, Tanaka T, Shigeta M, Chuma S, Saga Y, Saitou M, Functional reconstruction of NANOS3 expression in the germ cell lineage by a novel transgenic reporter reveals distinct subcellular localizations of NANOS3. Reproduction. 2010 Feb;139(2):381-93
5*J:186779 Yamamizu K, Fujihara M, Tachibana M, Katayama S, Takahashi A, Hara E, Imai H, Shinkai Y, Yamashita JK, Protein kinase A determines timing of early differentiation through epigenetic regulation with G9a. Cell Stem Cell. 2012 Jun 14;10(6):759-70
1J:146156 Yamamoto M, Beppu H, Takaoka K, Meno C, Li E, Miyazono K, Hamada H, Antagonism between Smad1 and Smad2 signaling determines the site of distal visceral endoderm formation in the mouse embryo. J Cell Biol. 2009 Jan 26;184(2):323-34
1*J:78164 Yamamoto M, Matsui Y, Testis-specific expression of a novel mouse defensin-like gene, Tdl. Mech Dev. 2002 Aug;116(1-2):217-21
2J:337681 Yang G, Xin Q, Feng I, Wu D, Dean J, Germ cell-specific eIF4E1b regulates maternal mRNA translation to ensure zygotic genome activation. Genes Dev. 2023 May 1;37(9-10):418-431
2*J:330412 Yang M, Liu M, Wang Z, Zhang C, Mice lacking DCAF2 in placenta die at the gastrulation stage. Cell Tissue Res. 2022 Sep;389(3):559-572
4*J:1911 Yeom YI, Ha HS, Balling R, Scholer HR, Artzt K, Structure, expression and chromosomal location of the Oct-4 gene. Mech Dev. 1991 Nov;35(3):171-9
4J:328457 Yin H, Suye S, Zhou Z, Cai H, Fu C, The reduction of oocytes and disruption of the meiotic prophase I in Fanconi anemia E-deficient mice. Reproduction. 2022 Sep 1;164(3):71-82
6J:194892 Yokobayashi S, Liang CY, Kohler H, Nestorov P, Liu Z, Vidal M, van Lohuizen M, Roloff TC, Peters AH, PRC1 coordinates timing of sexual differentiation of female primordial germ cells. Nature. 2013 Mar 14;495(7440):236-40
1*J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
1*J:190555 Yoon Y, Cowley DO, Gallant J, Jones SN, Van Dyke T, Rivera-Perez JA, Conditional Aurora A deficiency differentially affects early mouse embryo patterning. Dev Biol. 2012 Nov 1;371(1):77-85
1*J:102143 Yoshikawa T, Piao Y, Zhong J, Matoba R, Carter MG, Wang Y, Goldberg I, Ko MS, High-throughput screen for genes predominantly expressed in the ICM of mouse blastocysts by whole mount in situ hybridization. Gene Expr Patterns. 2006 Jan;6(2):213-24
1J:256712 Yu C, Ji SY, Dang YJ, Sha QQ, Yuan YF, Zhou JJ, Yan LY, Qiao J, Tang F, Fan HY, Oocyte-expressed yes-associated protein is a key activator of the early zygotic genome in mouse. Cell Res. 2016 Mar;26(3):275-87
2J:205485 Yu C, Zhang YL, Pan WW, Li XM, Wang ZW, Ge ZJ, Zhou JJ, Cang Y, Tong C, Sun QY, Fan HY, CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins. Science. 2013 Dec 20;342(6165):1518-21
3*J:279722 Yu MF, Wang JL, Yi JM, Ma L, Sodium butyrate interrupts the maturation of oocytes and enhances the development of preimplantation embryos. PLoS One. 2019;14(7):e0220479
4J:127021 Zayed AE, Abd-Elnaeim MM, Abd-Elghaffar SKh, Hild A, Brehm R, Steger K, Prenatal development of murine gonads with special reference to germ cell differentiation: a morphological and immunohistochemical study. Andrologia. 2007 Jun;39(3):93-100
2J:145174 Zhang J, Tomasini AJ, Mayer AN, RBM19 is essential for preimplantation development in the mouse. BMC Dev Biol. 2008;8:115
1J:270801 Zhang M, Leitch HG, Tang WWC, Festuccia N, Hall-Ponsele E, Nichols J, Surani MA, Smith A, Chambers I, Esrrb Complementation Rescues Development of Nanog-Null Germ Cells. Cell Rep. 2018 Jan 9;22(2):332-339
1*J:112167 Zhang S, Shi M, Hui CC, Rommens JM, Loss of the mouse ortholog of the shwachman-diamond syndrome gene (Sbds) results in early embryonic lethality. Mol Cell Biol. 2006 Sep;26(17):6656-63
1*J:185123 Zhang Y, Cooke M, Panjwani S, Cao K, Krauth B, Ho PY, Medrzycki M, Berhe DT, Pan C, McDevitt TC, Fan Y, Histone h1 depletion impairs embryonic stem cell differentiation. PLoS Genet. 2012 May;8(5):e1002691
1*J:266543 Zhang YL, Zhao LW, Zhang J, Le R, Ji SY, Chen C, Gao Y, Li D, Gao S, Fan HY, DCAF13 promotes pluripotency by negatively regulating SUV39H1 stability during early embryonic development. EMBO J. 2018 Sep 14;37(18)
2J:281962 Zhang Z, Zwick S, Loew E, Grimley JS, Ramanathan S, Mouse embryo geometry drives formation of robust signaling gradients through receptor localization. Nat Commun. 2019 Oct 4;10(1):4516
1*J:240405 Zhao L, Arsenault M, Ng ET, Longmuss E, Chau TC, Hartwig S, Koopman P, SOX4 regulates gonad morphogenesis and promotes male germ cell differentiation in mice. Dev Biol. 2017 Mar 01;423(1):46-56
4J:327337 Zhao Y, Bai D, Wu Y, Zhang D, Liu M, Tian Y, Lu J, Wang H, Gao S, Lu Z, Maternal Ezh1/2 deficiency in oocyte delays H3K27me2/3 restoration and impairs epiblast development responsible for embryonic sub-lethality in mouse. Development. 2022 Aug 1;149(15):dev200316
2*J:307321 Zhao ZH, Ma JY, Meng TG, Wang ZB, Yue W, Zhou Q, Li S, Feng X, Hou Y, Schatten H, Ou XH, Sun QY, Single-cell RNA sequencing reveals the landscape of early female germ cell development. FASEB J. 2020 Sep;34(9):12634-12645
3J:318865 Zheng B, Zhao D, Zhang P, Shen C, Guo Y, Zhou T, Guo X, Zhou Z, Sha J, Quantitative Proteomics Reveals the Essential Roles of Stromal Interaction Molecule 1 (STIM1) in the Testicular Cord Formation in Mouse Testis. Mol Cell Proteomics. 2015 Oct;14(10):2682-91
2J:316544 Zheng X, Yang P, Lackford B, Bennett BD, Wang L, Li H, Wang Y, Miao Y, Foley JF, Fargo DC, Jin Y, Williams CJ, Jothi R, Hu G, CNOT3-Dependent mRNA Deadenylation Safeguards the Pluripotent State. Stem Cell Reports. 2016 Nov 8;7(5):897-910
2*J:338080 Zhou X, Xu Y, Ren S, Yang N, Sun Y, Yang Q, Zhang Y, Cai H, Deng W, Chen J, Chen D, Cao B, Qi H, Wang H, Lu J, Trophoblast PR-SET7 dysfunction induces viral mimicry response and necroptosis associated with recurrent miscarriage. Proc Natl Acad Sci U S A. 2023 Jun 20;120(25):e2216206120
1J:206436 Zhu D, Holz S, Metzger E, Pavlovic M, Jandausch A, Jilg C, Galgoczy P, Herz C, Moser M, Metzger D, Gunther T, Arnold SJ, Schule R, Lysine-specific demethylase 1 regulates differentiation onset and migration of trophoblast stem cells. Nat Commun. 2014;5:3174
1J:306153 Zhu M, Wang Q, Tian P, Cheng L, Sun Z, Hong Q, Lv P, Ji L, Liu Y, Tang QQ, Wen B, A long non-coding RNA specifically expressed in early embryos programs the metabolic balance in adult mice. Biochim Biophys Acta Mol Basis Dis. 2021 Jan 1;1867(1):165988
1*J:332652 Zhu Q, Ge J, Liu Y, Xu JW, Yan S, Zhou F, Decoding anterior-posterior axis emergence among mouse, monkey, and human embryos. Dev Cell. 2023 Jan 9;58(1):63-79.e4
1J:164224 Zhu R, Heaney J, Nadeau JH, Ali S, Matin A, Deficiency of splicing factor 1 suppresses the occurrence of testicular germ cell tumors. Cancer Res. 2010 Sep 15;70(18):7264-72
1J:228073 Zylicz JJ, Dietmann S, Gunesdogan U, Hackett JA, Cougot D, Lee C, Surani MA, Chromatin dynamics and the role of G9a in gene regulation and enhancer silencing during early mouse development. Elife. 2015;4:e09571

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