Sequence Detail

ID/Version

P20263 Q63843 (UniProt | EBI)

Last sequence update: 1991-02-01
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=POU domain, class 5, transcription factor 1;AltName: Full=NF-A3;AltName: Full=Octamer-binding protein 3; Short=Oct-3;AltName: Full=Octamer-binding protein 4; Short=Oct-4;AltName: Full=Octamer-binding transcription factor 3;

Provider

SWISS-PROT

Sequence

Polypeptide 352 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pou5f1	POU domain, class 5, transcription factor 1	130	402	4	88

Sequence references in MGI

J:1910 Okazawa H, et al., The oct3 gene, a gene for an embryonic transcription factor, is controlled by a retinoic acid repressible enhancer. EMBO J. 1991 Oct;10(10):2997-3005
J:10293 Okamoto K, et al., A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Cell. 1990 Feb 9;60(3):461-72
J:10576 Rosner MH, et al., A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo. Nature. 1990 Jun 21;345(6277):686-92
J:27203 Scholer HR, et al., New type of POU domain in germ line-specific protein Oct-4. Nature. 1990 Mar 29;344(6265):435-9
J:100846 Maruyama M, et al., Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells. J Biol Chem. 2005 Jul 1;280(26):24371-9
J:116485 Tsuruzoe S, et al., Inhibition of DNA binding of Sox2 by the SUMO conjugation. Biochem Biophys Res Commun. 2006 Dec 29;351(4):920-6
J:140350 van den Berg DL, et al., Estrogen-related receptor beta interacts with Oct4 to positively regulate Nanog gene expression. Mol Cell Biol. 2008 Oct;28(19):5986-95
J:161094 Yu HB, et al., Zfp206, Oct4, and Sox2 are integrated components of a transcriptional regulatory network in embryonic stem cells. J Biol Chem. 2009 Nov 6;284(45):31327-35
J:163434 Liao B, et al., Wwp2 mediates Oct4 ubiquitination and its own auto-ubiquitination in a dosage-dependent manner. Cell Res. 2010 Mar;20(3):332-44
J:195215 Esch D, et al., A unique Oct4 interface is crucial for reprogramming to pluripotency. Nat Cell Biol. 2013 Mar;15(3):295-301
J:255341 Ma H, et al., Zfp322a Regulates mouse ES cell pluripotency and enhances reprogramming efficiency. PLoS Genet. 2014 Feb;10(2):e1004038
J:259122 Bae KB, et al., Serine 347 Phosphorylation by JNKs Negatively Regulates OCT4 Protein Stability in Mouse Embryonic Stem Cells. Stem Cell Reports. 2017 Dec 12;9(6):2050-2064