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Isl1 Gene Detail
Summary
  • Symbol
    Isl1
  • Name
    ISL1 transcription factor, LIM/homeodomain
  • Synonyms
    Islet 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:101791
    NCBI Gene: 16392
  • Gene Overview
    MyGene.info: ISL1
Location & Maps
more
  • Sequence Map
    Chr13:116298281-116309689 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11409 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 64.87 cM, cytoband D2.3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    ISL1, ISL LIM homeobox 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ISL1, ISL LIM homeobox 1
    Orthology source: HomoloGene
  • Synonyms
    Isl-1, ISLET1
  • Links
    NCBI Gene ID: 3670
    neXtProt AC: NX_P61371

  • Chr Location
    5q11.1; chr5:51383124-51394738 (+)  GRCh38.p2

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    60 phenotypes from 10 alleles in 9 genetic backgrounds
    92 phenotypes from multigenic genotypes
    3 images
    135 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Chemically induced (ENU)
    1
  • Targeted
    14
  • Transgenic
    1
  • Incidental Mutations
    APF , CvDC
Homozygotes for a targeted null mutation fail to develop motor neurons and die by embryonic day 11.5 with abnormal heart and pancreas development. Mice heterozygous for an ENU mutation exhibit chronic otitis media and hearing loss.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000039739 VEGA Gene Model | MGI Sequence Detail 11409 C57BL/6J ±  kb
transcript OTTMUST00000103329 VEGA | MGI Sequence Detail 2516 Not Applicable  
polypeptide OTTMUSP00000057705 VEGA | MGI Sequence Detail 349 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    116 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 75
    cDNA 30
    Primer pair 13
    Other 32

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-18599
References
more
  • Summaries
    All 1069
    Developmental Gene Expression 973
    Diseases 1
    Gene Ontology 31
    Phenotypes 135
  • Earliest
    J:32884 Karlsson O, et al., Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domain. Nature. 1990 Apr 26;344(6269):879-82
  • Latest
    J:232855 Yadav SP, et al., Centrosomal protein CP110 controls maturation of the mother centriole during cilia biogenesis. Development. 2016 May 1;143(9):1491-501

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory