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Isl1
Gene Detail
 Symbol
Name
ID
Isl1
ISL1 transcription factor, LIM/homeodomain
MGI:101791
Synonyms Islet 1
Feature Type protein coding gene
Genetic Map
Chromosome 13
64.87 cM, cytoband D2.3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:116298281-116309689 bp, - strand
From VEGA annotation of GRCm38

  11409 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1661  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transcription factor isl-1
Gene Tree: Isl1

Human
homologs
Human Homolog ISL1, ISL LIM homeobox 1
NCBI Gene ID 3670
neXtProt AC  NX_P61371
Human Synonyms  Isl-1, ISLET1
Human Chr (Location)  5q11.1; chr5:51383124-51394730 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Chemically induced (ENU)(1) Targeted(13)
Incidental mutations (data from APF )
 
Homozygotes for a targeted null mutation fail to develop motor neurons and die by embryonic day 11.5 with abnormal heart and pancreas development. Mice heterozygous for an ENU mutation exhibit chronic otitis media and hearing loss.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Isl1 interacts with 260 markers (Mir1b, Mir7-1, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (82 annotations)
Process atrial septum morphogenesis, cardiac cell fate determination, ...
Component intracellular, nucleus
Function bHLH transcription factor binding, chromatin binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (844 records)
Data Summary: Results (1162)    Tissues (492)    Images (574)
Theiler Stages: 2, 3, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 474
RNA in situ 600
In situ reporter (knock in) 5
RT-PCR 83
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(67) cDNA(27) Primer pair(10) Other(30)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000039739 (Evidence)
Ensembl Gene ModelENSMUSG00000042258 (Evidence)
Entrez Gene16392 (Evidence)
DFCITC1577771, TC1654042
DoTSDT.489821, DT.91581227, DT.97373316
NIA Mouse Gene IndexU035209
PDB2RGT, 4JCJ
Consensus CDS ProjectCCDS26790.1
International Mouse Knockout Project StatusIsl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000039739 VEGA Gene Model | MGI Sequence Detail 11409 C57BL/6J ±  kb
transcript OTTMUST00000103329 VEGA | MGI Sequence Detail 2516 Not Applicable 
polypeptide OTTMUSP00000057705 VEGA | MGI Sequence Detail 349 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(6) UniProt(5)
Polymorphisms SNPs within 2kb(117 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000009116 insulin gene enhancer protein ISL-1
References (Earliest) J:32884 Karlsson O, et al., Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domain. Nature. 1990 Apr 26;344(6269):879-82
(Latest) J:210221 Mandai K, et al., Linx Mediates Interaxonal Interactions and Formation of the Internal Capsule. Neuron. 2014 Jun 11;
All references(932)
Other
accession IDs
MGD-MRK-18599

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory