Isl1
Gene Detail

Symbol Name ID

Isl1 ISL1 transcription factor, LIM/homeodomain MGI:101791

Synonyms

Islet 1

Feature Type

protein coding gene

Genetic Map

Chromosome 13

64.87 cM, cytoband D2.3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr13:116298281-116309688 bp, - strand From VEGA annotation of GRCm38   11408 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Isl1 ± 2 cM)

Protein SuperFamily: transcription factor isl-1
Gene Tree: Isl1

Human ortholog

ISL1 ISL LIM homeobox 1 NCBI Gene ID 3670
Human Synonyms: Isl-1, ISLET1
Human Chr5:50678958-50690564 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(13) : Targeted(13)
 

Homozygotes for a targeted null mutation fail to develop motor neurons and die by embryonic day 11.5. They also show abnormal heart development with absence of heart looping, outflow tract, and the right ventricle and show abnormal pancreas development.

 
Human Diseases Modeled Using Mouse Isl1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (80 annotations)

Process	atrial septum morphogenesis, cardiac cell fate determination, ...
Component	intracellular, nucleus
Function	bHLH transcription factor binding, chromatin binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (771 records)
Data Summary: Results (1012)    Tissues (439)    Images (478)
Theiler Stages: 2, 3, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	369
RNA in situ	559
In situ reporter (knock in)	5
RT-PCR	79

cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(59) cDNA(27) Primer pair(8) Other(24)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000039739 (Evidence)
Ensembl Gene Model	ENSMUSG00000042258 (Evidence)
Entrez Gene	16392 (Evidence)
DFCI	TC1577771, TC1654042
DoTS	DT.489821, DT.91581227, DT.97373316
NIA Mouse Gene Index	U035209
PDB	2RGT
Consensus CDS Project	CCDS26790.1
International Mouse Knockout Project Status	Isl1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000039739	VEGA Gene Model | MGI Sequence Detail	11408	C57BL/6J
transcript	OTTMUST00000103329	VEGA | MGI Sequence Detail	2515	Not Applicable
polypeptide	OTTMUSP00000057705	VEGA | MGI Sequence Detail	349	Not Applicable

All sequences(41) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(74 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR001781	Zinc finger, LIM-type
Protein Ontology	PR:000009116	insulin gene enhancer protein ISL-1

References

(Earliest) J:32884 Karlsson O, et al., Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domain. Nature. 1990 Apr 26;344(6269):879-82
(Latest) J:192831 Lin JC, et al., RBM4 promotes pancreas cell differentiation and insulin expression. Mol Cell Biol. 2013 Jan;33(2):319-27
All references(844)

Other accession IDs

MGD-MRK-18599