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Isl1
Gene Detail
Symbol

Name
ID
Isl1
ISL1 transcription factor, LIM/homeodomain
MGI:101791
Synonyms
Islet 1
Feature Type
protein coding gene
Genetic Map
Chromosome 13
64.87 cM, cytoband D2.3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr13:116298281-116309689 bp, - strand
From VEGA annotation of GRCm38

  11409 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1661  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: ISL1
Protein SuperFamily: transcription factor isl-1
Gene Tree: Isl1

Human
homologs
ISL1, ISL LIM homeobox 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3670
neXtProt AC: NX_P61371

Human Synonyms: Isl-1, ISLET1

Human Chr (Location): 5q11.1; chr5:51383124-51394738 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Chemically induced (ENU)(1) Targeted(13)
Incidental mutations (data from APF , CvDC )
 
Homozygotes for a targeted null mutation fail to develop motor neurons and die by embryonic day 11.5 with abnormal heart and pancreas development. Mice heterozygous for an ENU mutation exhibit chronic otitis media and hearing loss.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Isl1 interacts with 260 markers (Mir1b, Mir7-1, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (85 annotations)
Process atrial septum morphogenesis, cardiac cell fate determination, ...
Component mitochondrion, nucleoplasm, ...
Function bHLH transcription factor binding, chromatin binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (900 records)
Data Summary: Results (1201)    Tissues (498)    Images (611)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 515
RNA in situ 598
In situ reporter (knock in) 5
RT-PCR 83
cDNA source data(20)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA ISL1 ; Xenbase isl1 ; ZFIN isl1    NEW 
Molecular
reagents
All nucleic(67) cDNA(27) Primer pair(10) Other(30)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000039739 (Evidence)
Ensembl Gene Model ENSMUSG00000042258 (Evidence)
Entrez Gene 16392 (Evidence)
DFCI TC1577771, TC1654042
DoTS DT.489821, DT.91581227, DT.97373316
NIA Mouse Gene Index U035209
PDB 2RGT, 4JCJ
Consensus CDS Project CCDS26790.1
International Mouse Phenotyping Consortium Status Isl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000039739 VEGA Gene Model | MGI Sequence Detail 11409 C57BL/6J ±  kb
transcript OTTMUST00000103329 VEGA | MGI Sequence Detail 2516 Not Applicable 
polypeptide OTTMUSP00000057705 VEGA | MGI Sequence Detail 349 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(6) UniProt(4)
Polymorphisms
SNPs within 2kb(117 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR001781 Zinc finger, LIM-type
Protein Ontology PR:000009116 insulin gene enhancer protein ISL-1
References
(Earliest) J:32884 Karlsson O, et al., Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domain. Nature. 1990 Apr 26;344(6269):879-82
(Latest) J:220452 Nasif S, et al., Islet 1 specifies the identity of hypothalamic melanocortin neurons and is critical for normal food intake and adiposity in adulthood. Proc Natl Acad Sci U S A. 2015 Apr 14;112(15):E1861-70
All references(985)
Other
accession IDs
MGD-MRK-18599

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory