Phenotypes Associated with This Genotype

Genotype
MGI:8375869

• Allelic Composition: Isl1^tm1Limli/Isl1^tm1Limli
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

decreased insulin secretion ( J:387563 )

• in intraperitoneal glucose tolerance test (IPGTT) at age 16 weeks

homeostasis/metabolism

decreased insulin secretion ( J:387563 )

• in intraperitoneal glucose tolerance test (IPGTT) at age 16 weeks

increased fasting circulating glucose level ( J:387563 )

• in intraperitoneal glucose tolerance test (IPGTT), increasing from age 8 weeks to 16 weeks

hyperglycemia ( J:387563 )

• in intraperitoneal glucose tolerance test (IPGTT), increasing from age 8 weeks to 16 weeks

insulin resistance ( J:387563 )

• in intraperitoneal insulin tolerance test (IPITT) at age 18 weeks

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 2 diabetes mellitus		DOID:9352	OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036	J:387563