Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; promoter-specific chromatin binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including heart development; nervous system development; and positive regulation of cytokine production. Acts upstream of or within several processes, including heart development; neuron differentiation; and positive regulation of macromolecule metabolic process. Located in nucleus. Part of chromatin. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; heart and pericardium; and nervous system. Human ortholog(s) of this gene implicated in atrial fibrillation; congenital heart disease (multiple); diabetes mellitus (multiple); dilated cardiomyopathy; and myocardial infarction. Orthologous to human ISL1 (ISL LIM homeobox 1).