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Cd86 Gene Detail
Summary
  • Symbol
    Cd86
  • Name
    CD86 antigen
  • Synonyms
    B70, B7-2, B7.2, Cd28l2, Ly58, Ly-58, MB7-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:101773
    NCBI Gene: 12524
  • Gene Overview
    MyGene.info: CD86
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:36603869-36666081 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 25.72 cM, cytoband B5
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    496 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101773
protein coding gene Chr16:36568956-36666081 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022790
protein coding gene Chr16:35003577-35065861 (-)
A/J MGP_AJ_G0022755
protein coding gene Chr16:33284806-33349255 (-)
AKR/J MGP_AKRJ_G0022727
protein coding gene Chr16:34549657-34622733 (-)
BALB/cJ MGP_BALBcJ_G0022756
protein coding gene Chr16:33389223-33451567 (-)
C3H/HeJ MGP_C3HHeJ_G0022520
protein coding gene Chr16:34673317-34735882 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023203
protein coding gene Chr16:35835257-35899839 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020717
protein coding gene Chr16:33656481-33714930 (-)
CAST/EiJ MGP_CASTEiJ_G0022046
protein coding gene Chr16:34785359-34853206 (-)
CBA/J MGP_CBAJ_G0022491
protein coding gene Chr16:37409911-37475966 (-)
DBA/2J MGP_DBA2J_G0022623
protein coding gene Chr16:33176594-33240191 (-)
FVB/NJ MGP_FVBNJ_G0022598
protein coding gene Chr16:33208959-33271245 (-)
LP/J MGP_LPJ_G0022691
protein coding gene Chr16:34720587-34785281 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022617
protein coding gene Chr16:36450606-36518207 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023218
protein coding gene Chr16:34504749-34566374 (-)
PWK/PhJ MGP_PWKPhJ_G0021786
protein coding gene Chr16:33571434-33632793 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021617
protein coding gene Chr16:34426233-34486088 (-)
WSB/EiJ MGP_WSBEiJ_G0022090
protein coding gene Chr16:34555048-34622823 (-)



Homology
more
  • Human Ortholog
    CD86, CD86 molecule
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CD86, CD86 molecule
    Orthology source: HomoloGene, HGNC
  • Synonyms
    B70, B7-2, B7.2, CD28LG2, LAB72
  • Links
    NCBI Gene ID: 942
    neXtProt AC: NX_P42081
    UniProt: P42081

  • Chr Location
    3q13.33; chr3:122055362-122121143 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Cd86 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 5 alleles in 7 genetic backgrounds
    43 phenotypes from multigenic genotypes
    172 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice on an NOD background display a phenotype similar to human Guillain-Barre Syndrome, exhibiting severe peripheral nervous system inflammation, sciatic nerve demyelination, elevated auto-antibodies to myelin protein zero, hindlimb paralysis, and weak forelimb grip.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022901 Ensembl Gene Model | MGI Sequence Detail 62213 C57BL/6J ±  kb
    transcript ENSMUST00000089620 Ensembl | MGI Sequence Detail 2539 Not Applicable  
    polypeptide ENSMUSP00000087047 Ensembl | MGI Sequence Detail 309 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 48
      Genomic 17
      cDNA 31

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-12000, MGD-MRK-12043, MGD-MRK-18572, MGD-MRK-18580
    References
    more
    • Summaries
      All 278
      Developmental Gene Expression 6
      Diseases 3
      Gene Ontology 16
      Phenotypes 172
    • Earliest
      J:7166 Gibson DM, et al., Recombination between kappa chain genetic markers and the Lyt-3 locus. Immunogenetics. 1983;18(2):111-6
    • Latest
      J:265210 Cunningham CA, et al., Cutting Edge: Glycolytic Metabolism and Mitochondrial Metabolism Are Uncoupled in Antigen-Activated CD8(+) Recent Thymic Emigrants. J Immunol. 2018 Sep 15;201(6):1627-1632

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory