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Cd86
Gene Detail
Symbol

Name
ID
Cd86
CD86 antigen
MGI:101773
Synonyms
B70, B7-2, B7.2, Cd28l2, Ly58, Ly-58, MB7-2
Feature Type
protein coding gene
Genetic Map
Chromosome 16
25.72 cM, cytoband B5
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr16:36603869-36666081 bp, - strand
From VEGA annotation of GRCm38

  62213 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10443  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: CD86
Protein SuperFamily: B-lymphocyte restricted antigen B7
Gene Tree: Cd86

Human
homologs
CD86, CD86 molecule
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 942
neXtProt AC: NX_P42081

Human Synonyms: B70, B7-2, B7.2, CD28LG2, LAB72

Human Chr (Location): 3q21; chr3:122055362-122121143 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(3) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice on an NOD background display a phenotype similar to human Guillain-Barre Syndrome, exhibiting severe peripheral nervous system inflammation, sciatic nerve demyelination, elevated auto-antibodies to myelin protein zero, hindlimb paralysis, and weak forelimb grip.
 
Human Diseases Modeled in Mice Using Cd86 (1)    Mutations Annotated to Human Diseases (3)   
Interactions
Cd86 interacts with 238 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process adaptive immune response, B cell activation, ...
Component cell surface, external side of plasma membrane, ...
Function receptor binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (67)    Tissues (45)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 67
cDNA source data(29)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(47) Genomic(17) cDNA(30)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000028661 (Evidence)
Ensembl Gene Model ENSMUSG00000022901 (Evidence)
Entrez Gene 12524 (Evidence)
UniGene 1452
DFCI TC1583244
DoTS DT.528442, DT.87031862, DT.87033375
NIA Mouse Gene Index U037021
Consensus CDS Project CCDS28155.1
International Mouse Phenotyping Consortium Status Cd86
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028661 VEGA Gene Model | MGI Sequence Detail 62213 C57BL/6J ±  kb
transcript OTTMUST00000035568 VEGA | MGI Sequence Detail 2539 Not Applicable 
polypeptide OTTMUSP00000015940 VEGA | MGI Sequence Detail 309 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(7) UniProt(7)
Polymorphisms
RFLP(1) : SNPs within 2kb(278 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR013106 Immunoglobulin V-set
Protein Ontology PR:000001412 CD86 molecule
References
(Earliest) J:7166 Gibson DM, et al., Recombination between kappa chain genetic markers and the Lyt-3 locus. Immunogenetics. 1983;18(2):111-6
(Latest) J:221363 Matheu MP, et al., Imaging regulatory T cell dynamics and CTLA4-mediated suppression of T cell priming. Nat Commun. 2015;6:6219
All references(241)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-12000, MGD-MRK-12043, MGD-MRK-18572, MGD-MRK-18580

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory