Cd86
Gene Detail

Symbol Name ID

Cd86 CD86 antigen MGI:101773

Synonyms

B70, B7-2, B7.2, Cd28l2, Ly58, Ly-58, MB7-2

Feature Type

protein coding gene

Genetic Map

Chromosome 16

25.72 cM, cytoband B5
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr16:36603869-36666081 bp, - strand From VEGA annotation of GRCm38   62213 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:10443  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: B-lymphocyte restricted antigen B7
Gene Tree: Cd86

Human homologs

Human Homolog		CD86, CD86 molecule
NCBI Gene ID		942
neXtProt AC		NX_P42081
Human Synonyms		B70, B7-2, B7.2, CD28LG2, LAB72
Human Chr (Location)		3q21; chr3:121774209-121839990 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(3) Gene trapped(2)
 

Homozygous null mice on an NOD background display a phenotype similar to human Guillain-Barre Syndrome, exhibiting severe peripheral nervous system inflammation, sciatic nerve demyelination, elevated auto-antibodies to myelin protein zero, hindlimb paralysis, and weak forelimb grip.

 
Human Diseases Modeled Using Mouse Cd86 (1)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	B cell activation, defense response to virus, ...
Component	cell surface, external side of plasma membrane, ...
Function	receptor binding

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (67)    Tissues (45)    Images (15)
Theiler Stages: 19, 22, 23, 24, 28

Assay Type	Results
RNA in situ	67

cDNA source data(29)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(47) Genomic(17) cDNA(30)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000028661 (Evidence)
Ensembl Gene Model	ENSMUSG00000022901 (Evidence)
Entrez Gene	12524 (Evidence)
UniGene	1452
DFCI	TC1583244
DoTS	DT.528442, DT.87031862, DT.87033375
NIA Mouse Gene Index	U037021
Consensus CDS Project	CCDS28155.1
International Mouse Knockout Project Status	Cd86

Sequences

Length	Strain/Species
genomic	OTTMUSG00000028661	VEGA Gene Model | MGI Sequence Detail	62213	C57BL/6J
transcript	OTTMUST00000035568	VEGA | MGI Sequence Detail	2539	Not Applicable
polypeptide	OTTMUSP00000015940	VEGA | MGI Sequence Detail	309	Not Applicable

All sequences(54) RefSeq(2) UniProt(6)

Polymorphisms

RFLP(1) : SNPs(115 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR013106	Immunoglobulin V-set
InterPro	IPR003596	Immunoglobulin V-set, subgroup
Protein Ontology	PR:000001412	CD86 molecule

References

(Earliest) J:7166 Gibson DM, et al., Recombination between kappa chain genetic markers and the Lyt-3 locus. Immunogenetics. 1983;18(2):111-6
(Latest) J:194890 Zeng XL, et al., Divergent effects of T cell costimulation and inflammatory cytokine production on autoimmune peripheral neuropathy provoked by aire deficiency. J Immunol. 2013 Apr 15;190(8):3895-904
All references(223)

Other accession IDs

MGD-MRK-12000, MGD-MRK-12043, MGD-MRK-18572, MGD-MRK-18580