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Phenotype Images associated with this Allele
Nomenclature
Symbol: Cd19tm1(cre)Cgn
Name: CD19 antigen; targeted mutation 1, University of Cologne
MGI ID: MGI:1931143
Synonyms: B-Cre, CD19-, Cd19cre, Cd19Cre, CD19-Cre, CD19-KO
Images for
Allele
Click images for details
Image Caption Genotypes involving this allele
Allelic Composition Genetic Background
Increased spleen size in Gt(ROSA)26Sortm1(Ptpn22*)Draw/Gt(ROSA)26Sor+ Cd19tm1(cre)Cgn/Cd19+ miceGt(ROSA)26Sortm1(Ptpn22*)Draw/Gt(ROSA)26Sor+
Cd19tm1(cre)Cgn/Cd19+		involves: 129P2/OlaHsd * C57BL/6
Renal abnormalities in Gt(ROSA)26Sortm1(Ptpn22*)Draw/Gt(ROSA)26Sor+ Cd19tm1(cre)Cgn/Cd19+ miceGt(ROSA)26Sortm1(Ptpn22*)Draw/Gt(ROSA)26Sor+
Cd19tm1(cre)Cgn/Cd19+		involves: 129P2/OlaHsd * C57BL/6
Splenomegaly and lack of germinal center formation in Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+ Cd19tm1(cre)Cgn/Cd19+ (left) and Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+ Ighg1tm1(cre)Cgn/Ighg1+ mice (right)Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+
Cd19tm1(cre)Cgn/Cd19+		either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+
Ighg1tm1(cre)Cgn/Ighg1+		either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
A representative tumor in the nose of a Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+ Cd19tm1(cre)Cgn/Cd19+ mouseGt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+
Cd19tm1(cre)Cgn/Cd19+		either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Tumor characterization in Gt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+ Cd19tm1(cre)Cgn/Cd19+ miceGt(ROSA)26Sortm1(gp80,EGFP)Eces/Gt(ROSA)26Sor+
Cd19tm1(cre)Cgn/Cd19+		either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)
Enlarged spleen and solid organ infiltration with abnormally proliferating T cells in Gt(ROSA)26Sortm1(ITK/SYK)Jrld/Gt(ROSA)26Sor+ Cd19tm1(cre)Cgn/Cd19+ miceCd19tm1(cre)Cgn/Cd19+
Gt(ROSA)26Sortm1(ITK/SYK)Jrld/Gt(ROSA)26Sor+		involves: 129P2/OlaHsd
Enlarged spleen in Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+ Cd19tm1(cre)Cgn/Cd19+ miceGt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+
Cd19tm1(cre)Cgn/Cd19+		involves: 129P2/OlaHsd * BALB/c * C57BL/6
Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+ Cd19tm1(cre)Cgn/Cd19+ mice develop mono- and oligoclonal lymphomasGt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+
Cd19tm1(cre)Cgn/Cd19+		involves: 129P2/OlaHsd * BALB/c * C57BL/6
Gt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+ Cd19tm1(cre)Cgn/Cd19+ mice develop tumors in the spleen, lymph nodes, and liverGt(ROSA)26Sortm2(Lmp1/CD40)Uzs/Gt(ROSA)26Sor+
Cd19tm1(cre)Cgn/Cd19+		involves: 129P2/OlaHsd * BALB/c * C57BL/6
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/30/2024
MGI 6.23 		The Jackson Laboratory