Gt(ROSA)26Sor^{tm2(Lmp1/CD40)Uzs}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm2(Lmp1/CD40)Uzs}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Ursula Zimber-Strobl
• MGI ID: MGI:5567929
• Synonyms: LMP1/CD40^flSTOP
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm2(Lmp1/CD40)Uzs} page

Gt(ROSA)26Sor^{tm2(Lmp1/CD40)Uzs}/Gt(ROSA)26Sor⁺ Cd19^tm1(cre)Cgn/Cd19⁺ mice develop mono- and oligoclonal lymphomas

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137122
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: BALB/c

Mutation description

• Allele Type: Targeted (Conditional ready, Constitutively active, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm2(Lmp1/CD40)Uzs} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CD40 (958)

  Cd40	(MGI:88336)

• Mutation details: The targeting construct introduced into the locus a floxed neomycin resistance/stop cassette and a fusion of the EBV B95-8 strain Lmp1 coding sequence encoding amino acids 1-190 and the human cDNA encoding amino acids 223-280. This fusion generates a constitutively active receptor that is only expressed after cre-mediated removal of the stop cassette. (J:137122)

Generation of the Gt(ROSA)26Sor^{tm2(Lmp1/CD40)Uzs} allele

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1046 strains or lines available

References

• Original: J:137122 Homig-Holzel C, et al., Constitutive CD40 signaling in B cells selectively activates the noncanonical NF-kappaB pathway and promotes lymphomagenesis. J Exp Med. 2008 Jun 9;205(6):1317-29
• All: 5 reference(s)