Gt(ROSA)26Sortm1(Ptpn22*)Draw
Targeted Allele Detail
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Symbol: |
Gt(ROSA)26Sortm1(Ptpn22*)Draw |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 1, David Rawlings |
MGI ID: |
MGI:5516595 |
Synonyms: |
Rosa PEP-R619W |
Gene: |
Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
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Alliance: |
Gt(ROSA)26Sortm1(Ptpn22*)Draw page
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Renal abnormalities in Gt(ROSA)26Sortm1(Ptpn22*)Draw/Gt(ROSA)26Sor+ Cd19tm1(cre)Cgn/Cd19+ mice
Show the 2 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:201448
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129
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Allele Type: |
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Targeted (Conditional ready, Inserted expressed sequence, Reporter) |
Mutation: |
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Insertion
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Gt(ROSA)26Sortm1(Ptpn22*)Draw expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Note |
mouse |
Ptpn22 (MGI:107170) |
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Mutation details: The construct targeted to the locus contained a floxed STOP cassette, cDNA with the tryptophan for arginine mutation and a N-terminal HA tag, a 2A self-cleaving linker and GFP gene. The mutation is analogous to the human disease-linked variant (LYP-R620W).
(J:201448)
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Generation of the Gt(ROSA)26Sortm1(Ptpn22*)Draw allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Gt(ROSA)26Sor Mutation: |
942 strains or lines available
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Original: |
J:201448 Dai X, et al., A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models. J Clin Invest. 2013 May 1;123(5):2024-36 |
All: |
1 reference(s) |
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