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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Tbx3

Graphs for Molecular Function, Cellular Component, Biological Process generated Mon Apr 26 17:39:58 2021.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Tbx3
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0003700DNA-binding transcription factor activityTbx3IDAMouseMGI:MGI:3709665|PMID:17473172
Molecular FunctionGO:0001227DNA-binding transcription repressor activity, RNA polymerase II-specificTBX3IDAHumanPMID:11689487
Molecular FunctionGO:0005515protein bindingTBX3IPIUniProtKB:P29590-4HumanPMID:22002537
Molecular FunctionGO:0005515protein bindingTBX3IPIUniProtKB:P35219HumanPMID:25416956
Molecular FunctionGO:0005515protein bindingTBX3IPIUniProtKB:Q08117HumanPMID:25416956
Molecular FunctionGO:0005515protein bindingTBX3IPIUniProtKB:P86480HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingTBX3IPIUniProtKB:Q6NVU6HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingTBX3IPIUniProtKB:Q8N4W3HumanPMID:32296183
Molecular FunctionGO:0005515protein bindingTBX3IPIUniProtKB:Q99471HumanPMID:32296183
Molecular FunctionGO:0001102RNA polymerase II activating transcription factor bindingTbx3IPIUniProtKB:Q9WUI0MouseMGI:MGI:5448510|PMID:22164283
Molecular FunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingTBX3IDAHumanPMID:11689487
Molecular FunctionGO:0001085RNA polymerase II transcription factor bindingTbx3IPIUniProtKB:Q02591MouseMGI:MGI:5448510|PMID:22164283
Molecular FunctionGO:0043565sequence-specific DNA bindingTBX3IDAHumanPMID:11689487
Molecular FunctionGO:1990837sequence-specific double-stranded DNA bindingTBX3IDAHumanPMID:28473536
Cellular ComponentGO:0005634nucleusTBX3IDAHumanPMID:11689487
Cellular ComponentGO:0005634nucleusTbx3IDAMouseMGI:MGI:4440736|PMID:19765559
Cellular ComponentGO:0005634nucleusTbx3IDAMouseMGI:MGI:4412356|PMID:18723448
Cellular ComponentGO:0005634nucleusTbx3IDAMouseMGI:MGI:3801344|PMID:18534921
Cellular ComponentGO:0005667transcription regulator complexTbx3IPIUniProtKB:Q5SSP7MouseMGI:MGI:4461870|PMID:18285513
Biological ProcessGO:0009887animal organ morphogenesisTBX3IDAHumanPMID:9207801
Biological ProcessGO:0008595anterior/posterior axis specification, embryoTBX3IMPHumanPMID:9207801
Biological ProcessGO:0003167atrioventricular bundle cell differentiationTbx3IMPMGI:MGI:3710254MouseMGI:MGI:3847383|PMID:18467625
Biological ProcessGO:0001568blood vessel developmentTbx3IMPMGI:MGI:2655214MouseMGI:MGI:2653226|PMID:12668638
Biological ProcessGO:0060444branching involved in mammary gland duct morphogenesisTbx3IMPMGI:MGI:2655214MouseMGI:MGI:3608166|PMID:16222716
Biological ProcessGO:0055007cardiac muscle cell differentiationTbx3IMPMGI:MGI:2655214MouseMGI:MGI:3783941|PMID:17234970
Biological ProcessGO:0060923cardiac muscle cell fate commitmentTbx3IMPMGI:MGI:3710254MouseMGI:MGI:3847383|PMID:18467625
Biological ProcessGO:0007569cell agingTBX3IDAHumanPMID:11689487
Biological ProcessGO:0007569cell agingTBX3IDAHumanPMID:11748239
Biological ProcessGO:0007569cell agingTbx3IDAMouseMGI:MGI:2159048|PMID:11748239
Biological ProcessGO:0090398cellular senescenceTBX3IDAHumanPMID:22002537
Biological ProcessGO:0042733embryonic digit morphogenesisTBX3IMPHumanPMID:12116211
Biological ProcessGO:0042733embryonic digit morphogenesisTBX3IMPHumanPMID:9207801
Biological ProcessGO:0042733embryonic digit morphogenesisTbx3IMPMGI:MGI:5538565MouseMGI:MGI:5532232|PMID:23844108
Biological ProcessGO:0035115embryonic forelimb morphogenesisTBX3IMPHumanPMID:12116211
Biological ProcessGO:0035050embryonic heart tube developmentTbx3IMPMGI:MGI:5538565MouseMGI:MGI:5532232|PMID:23844108
Biological ProcessGO:0035050embryonic heart tube developmenttbx3aIMPZFIN:ZDB-MRPHLNO-080303-4ZfishPMID:17460765|ZFIN:ZDB-PUB-070504-19
Biological ProcessGO:0035116embryonic hindlimb morphogenesisTbx3IMPMGI:MGI:5538565MouseMGI:MGI:5532232|PMID:23844108
Biological ProcessGO:0030540female genitalia developmentTBX3IMPHumanPMID:12116211
Biological ProcessGO:0046884follicle-stimulating hormone secretionTBX3IMPHumanPMID:12116211
Biological ProcessGO:0035136forelimb morphogenesisTBX3IDAHumanPMID:9207801
Biological ProcessGO:0001947heart loopingTbx3IMPMGI:MGI:3769504MouseMGI:MGI:3769096|PMID:17460765
Biological ProcessGO:0001947heart loopingTbx3IMPMGI:MGI:2655214MouseMGI:MGI:4412356|PMID:18723448
Biological ProcessGO:0003007heart morphogenesisTbx3IMPMGI:MGI:3710254MouseMGI:MGI:3709665|PMID:17473172
Biological ProcessGO:0001701in utero embryonic developmentTbx3IMPMGI:MGI:3710254MouseMGI:MGI:3709665|PMID:17473172
Biological ProcessGO:0035108limb morphogenesisTbx3IMPMGI:MGI:2655214MouseMGI:MGI:2653226|PMID:12668638
Biological ProcessGO:0021761limbic system developmentTbx3IMPMGI:MGI:3710254MouseMGI:MGI:3709665|PMID:17473172
Biological ProcessGO:0032275luteinizing hormone secretionTBX3IMPHumanPMID:12116211
Biological ProcessGO:0030539male genitalia developmentTBX3IMPHumanPMID:12116211
Biological ProcessGO:0030879mammary gland developmentTBX3IMPHumanPMID:12116211
Biological ProcessGO:0030879mammary gland developmentTbx3IMPMGI:MGI:3710254MouseMGI:MGI:3709665|PMID:17473172
Biological ProcessGO:0030879mammary gland developmentTbx3IMPMGI:MGI:2655214MouseMGI:MGI:2653226|PMID:12668638
Biological ProcessGO:0030879mammary gland developmentTbx3IMPMGI:MGI:2655214MouseMGI:MGI:3608166|PMID:16222716
Biological ProcessGO:0060596mammary placode formationTbx3IDAMouseMGI:MGI:3695659|PMID:17071745
Biological ProcessGO:0060596mammary placode formationTbx3IGIMGI:MGI:98494MouseMGI:MGI:3608166|PMID:16222716
Biological ProcessGO:0048332mesoderm morphogenesisTBX3IMPHumanPMID:9207801
Biological ProcessGO:0043066negative regulation of apoptotic processTBX3IDAHumanPMID:12032820
Biological ProcessGO:0043066negative regulation of apoptotic processTbx3IMPRatPMID:15694670|RGD:1601420
Biological ProcessGO:0030857negative regulation of epithelial cell differentiationTbx3IMPMGI:MGI:3769504MouseMGI:MGI:3788969|PMID:18356246
Biological ProcessGO:0045662negative regulation of myoblast differentiationTBX3IDAHumanPMID:12032820
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IITBX3IDAHumanPMID:11689487
Biological ProcessGO:0000122negative regulation of transcription by RNA polymerase IITbx3IMPRatPMID:18285513|RGD:8553896
Biological ProcessGO:0045892negative regulation of transcription, DNA-templatedTBX3IDAHumanPMID:10468588
Biological ProcessGO:0045892negative regulation of transcription, DNA-templatedTBX3IDAHumanPMID:11689487
Biological ProcessGO:0045892negative regulation of transcription, DNA-templatedTbx3IDAMouseMGI:MGI:2159048|PMID:11748239
Biological ProcessGO:0045892negative regulation of transcription, DNA-templatedTbx3IMPMGI:MGI:3710254MouseMGI:MGI:3709665|PMID:17473172
Biological ProcessGO:0003151outflow tract morphogenesisTbx3IMPMGI:MGI:2655214MouseMGI:MGI:4412356|PMID:18723448
Biological ProcessGO:0045787positive regulation of cell cycleTBX3IDAHumanPMID:12032820
Biological ProcessGO:0008284positive regulation of cell population proliferationTBX3IDAHumanPMID:11689487
Biological ProcessGO:0008284positive regulation of cell population proliferationTBX3IDAHumanPMID:11748239
Biological ProcessGO:0008284positive regulation of cell population proliferationTBX3IDAHumanPMID:12032820
Biological ProcessGO:2000648positive regulation of stem cell proliferationTbx3IMPMGI:MGI:3769504MouseMGI:MGI:3788969|PMID:18356246
Biological ProcessGO:0045893positive regulation of transcription, DNA-templatedTbx3IMPMGI:MGI:3710254MouseMGI:MGI:3709665|PMID:17473172
Biological ProcessGO:0042127regulation of cell population proliferationTbx3IMPMGI:MGI:3769504MouseMGI:MGI:3769096|PMID:17460765
Biological ProcessGO:0060021roof of mouth developmentTbx3IGIMGI:MGI:98494MouseMGI:MGI:4411938|PMID:19769959
Biological ProcessGO:0060931sinoatrial node cell developmentTbx3IMPMGI:MGI:3710254MouseMGI:MGI:4366226|PMID:19096026
Biological ProcessGO:0001501skeletal system developmentTBX3IMPHumanPMID:9207801
Biological ProcessGO:0051145smooth muscle cell differentiationTbx3IGIMGI:MGI:98494MouseMGI:MGI:6284231|PMID:30478225
Biological ProcessGO:0010159specification of animal organ positionTbx3IDAMouseMGI:MGI:3695659|PMID:17071745
Biological ProcessGO:0019827stem cell population maintenanceTbx3IMPMGI:MGI:3769504MouseMGI:MGI:3788969|PMID:18356246
Biological ProcessGO:0072105ureteric peristalsisTbx3IGIMGI:MGI:98494MouseMGI:MGI:6284231|PMID:30478225
Biological ProcessGO:0060412ventricular septum morphogenesisTbx3IMPMGI:MGI:3710254MouseMGI:MGI:3847383|PMID:18467625

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory