Excel File Text File All mouse models of congenital nervous system abnormality with phenotypic similarity to the human disease
        Disease Term Allelic Composition Genetic Background Reference Phenotypes
      holoprosencephaly 2 Six3tm1Gco/Six3tm1Gco involves: 129S1/Sv J:81797 View
holoprosencephaly 2 Six3tm3.1Gco/Six3+
Shhtm1Chg/Shh+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 J:140315 View
holoprosencephaly 2 Six3tm3Gco/Six3tm3Gco
Foxg1tm1(cre)Skm/Foxg1+
involves: 129S1/Sv * C57BL/6 J:140315 View
holoprosencephaly 2 Six3tm4(cre/ERT2)Gco/Six3+ involves: 129S1/Sv * C57BL/6 J:140315 View
holoprosencephaly 3 Shhtm1Chg/Shhtm1Chg involves: 129S1/Sv * 129X1/SvJ J:35802 View
holoprosencephaly 3 Disp1icb/Disp1tm1Amc
Shhtm1Amc/Shh+
involves: 129X1/SvJ * C57BL/6J J:92058 View
holoprosencephaly 3 Shhtm1Chg/Shhtm1Chg involves: C57BL/6 J:89364 View
holoprosencephaly 5 Zic2Ku/Zic2Ku 129S.CAnNCrl(C3)-Zic2Ku J:238567 View
holoprosencephaly 5 Zic2Ku/Zic2Ku C3.CAnNCrl-Zic2Ku J:138862 View
holoprosencephaly 5 Zic2tm1Jaru/Zic2tm1Jaru involves: 129S4/SvJae * C57BL/6 J:60644 View
holoprosencephaly 11 Boctm1Rsk/Boctm1Rsk
Cdontm1Rsk/Cdontm1Rsk
B6.129-Boctm1Rsk Cdontm1Rsk J:171767 View
holoprosencephaly 11 Boctm2Rsk/Boctm2Rsk
Cdontm1Rsk/Cdontm1Rsk
B6.129-Boctm2Rsk Cdontm1Rsk J:171767 View
holoprosencephaly 11 Boctm1Rsk/Boctm1Rsk
Cdontm1Rsk/Cdontm1Rsk
involves: 129/Sv * 129S6/SvEvTac J:171767 View
holoprosencephaly 11 Boctm1Rsk/Boc+
Cdontm1Rsk/Cdontm1Rsk
involves: 129/Sv * 129S6/SvEvTac J:171767 View
holoprosencephaly 11 Boctm2Rsk/Boctm2Rsk
Cdontm1Rsk/Cdontm1Rsk
involves: 129/Sv * 129S6/SvEvTac J:171767 View
holoprosencephaly 11 Boctm2Rsk/Boc+
Cdontm1Rsk/Cdontm1Rsk
involves: 129/Sv * 129S6/SvEvTac J:171767 View
holoprosencephaly 11 Cdontm1Rsk/Cdontm1Rsk involves: 129/Sv * C57BL/6 J:82221 View
holoprosencephaly 11 Cdontm2Rsk/Cdontm2Rsk involves: 129/Sv * C57BL/6 J:82221 View
periventricular nodular heterotopia FlnaDilp2/Y involves: BALB/cAnN * C3H/HeN * C57BL/6 J:112274 View
primary autosomal recessive microcephaly 2 with or without cortical malformations Wdr62tm1.1Jfch/Wdr62tm1.1Jfch involves: 129S1/SvImJ * C57BL/6N J:282438 View
subcortical band heterotopia Eml1tvrm360/Eml1tvrm360 C57BL/6J-Eml1tvrm360/Pjn J:297748 View
subcortical band heterotopia Eml1tm1.2Ics/Eml1tm1.2Ics C57BL/6N-Eml1tm1.2Ics J:294769 View
      anencephaly Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc 129P2(C)-Cecr2Gt(pGT1)1Hemc J:96325 View
anencephaly Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc C.129P2-Cecr2Gt(pGT1)1Hemc J:96325 View
anencephaly Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc involves: 129P2/OlaHsd * BALB/c J:96325 View
anencephaly Efna5tm1Ddmo/Efna5tm1Ddmo involves: 129S1/Sv * 129X1/SvJ J:77779 View
anencephaly Lmo4tm1.1Gng/Lmo4tm1.1Gng involves: 129X1/SvJ J:96957 View
congenital nervous system abnormality Eml1heco/Eml1heco involves: C57BL/6 * NOR J:208031 View
congenital nervous system abnormality Tuba1aem1Rstot/Tuba1aem1Rstot involves: C57BL/6J * C57BL/6N J:278765 View
congenital nervous system abnormality Tuba1aem1Rstot/Tuba1aquas involves: C57BL/6J * C57BL/6N J:278765 View
congenital nervous system abnormality Tuba1aem2Rstot/Tuba1aem2Rstot involves: C57BL/6J * C57BL/6N J:278765 View
congenital nervous system abnormality Eml1heco/? involves: CD-1 J:211342 View
congenital nervous system abnormality Eml1heco/Eml1heco involves: NOR J:208031 View
holoprosencephaly NosipGt(OST138992)Lex/NosipGt(OST138992)Lex B6.129S5-NosipGt(OST138992)Lex J:245546 View
holoprosencephaly Pignm1Nisw/Pignm1Nisw involves: 129S1/SvImJ * C3H/HeJ * C57BL/6J J:187360 View
holoprosencephaly Pgap1m1Nisw/Pgap1m1Nisw involves: C57BL/6J J:187360 View
lissencephaly Pafah1b1tm1Awb/Pafah1b1+
Ywhaetm1Awb/Ywhae+
either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Black Swiss) J:84075 View
lissencephaly Dcxtm1.2Ffr/Y either: (involves: 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6) J:108229 View
lissencephaly Arxtm1Kki/Y involves: 129P2/OlaHsd * C57BL J:79871 View
lissencephaly Dag1tm1Kcam/Dag1tm2Kcam
Tg(GFAP-cre)25Mes/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N J:86901 View
lissencephaly Dag1tm2Kcam/Dag1tm2Kcam
Tg(GFAP-cre)25Mes/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N J:86901 View
lissencephaly Pafah1b1tm1Awb/Pafah1b1tm2Awb involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss J:49531 View
lissencephaly Pafah1b1tm1Awb/Pafah1b1+ involves: 129S6/SvEvTac * NIH Black Swiss J:49531, J:59817 View
lissencephaly Pafah1b1tm2.2Awb/Pafah1b1+ involves: 129S6/SvEvTac * NIH Black Swiss J:49531 View
lissencephaly Arxtm2Kki/Y involves: 129S/SvEv * C57BL/6J J:197588 View
lissencephaly Tuba1aJna/Tuba1a+ involves: BALB/cAnN * C3H/HeH J:117881 View
lissencephaly Pafah1b1tm1Or/Pafah1b1+ Not Specified J:69631 View
microcephaly Cdk5rap2an/Cdk5rap2an B6.Cg-Cdk5rap2an J:160533 View
microcephaly Ppil1em3Jgg/Ppil1em3Jgg C57BL/6-Ppil1em3Jgg J:300487 View
microcephaly Ppil1em4Jgg/Ppil1em4Jgg C57BL/6-Ppil1em4Jgg J:300487 View
microcephaly AspmGt(AA0137)Wtsi/AspmGt(AA0137)Wtsi involves: 129P2/OlaHsd * C57BL/6JOlaHsd J:164424 View
microcephaly AspmGt(AJ0069)Wtsi/AspmGt(AJ0069)Wtsi involves: 129P2/OlaHsd * C57BL/6JOlaHsd J:164424 View
microcephaly Mcph1Gt(RRO608)Byg/Mcph1Gt(RRO608)Byg involves: 129P2/OlaHsd * C57BL/6 J:157993 View
microcephaly Tubb5tm1.1Dak/Tubb5tm1.1Dak
Tg(Nes-cre)1Kln/0
involves: 129P2/OlaHsd * C57BL/6 * SJL J:240157 View
microcephaly Tubb5tm2.1Dak/Tubb5+
Tg(Nes-cre)1Kln/0
involves: 129P2/OlaHsd * C57BL/6 * SJL J:240157 View
microcephaly Kif20bmagoo/Kif20bmagoo involves: BALB/c * C57BL/6 J:242310 View
microcephaly Copb2em1Rstot/Copb2em2Rstot involves: C57BL/6 * C57BL/6J * CD-1 * DBA/2 J:252710 View
microcephaly Aspmtm1(cre)Mrc/Aspmtm1(cre)Mrc Not Specified J:228026 View
microcephaly Cdk5rap2an/Cdk5rap2an
Tyrp1B-lt/Tyrp1B-lt
WBB6F1 J:160533 View
Additional
Complex
Models
     holoprosencephaly Nogtm1Amc/Nogtm1Amc
Smad3tm1Xfw/Smad3+
involves: 129/Sv * 129S1/Sv J:161524 View
holoprosencephaly Chrdtm1Emdr/Chrdtm1Emdr
Nodaltm1Rob/Nodal+
involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ J:161524 View


       
No similarity to the expected human disease phenotype was found.
        Disease Term Allelic Composition Genetic Background Reference Phenotypes
NOT Models      anencephaly Cecr2Gt(pGT1)1Hemc/Cecr2Gt(pGT1)1Hemc FVB.129P2(C)-Cecr2Gt(pGT1)1Hemc J:96325 View
holoprosencephaly 4 Tgif1tm1.1Caw/Tgif1tm1.1Caw involves: C57BL/6 * FVB/N J:97642 View