Ywhae^tm1Awb
Targeted Allele Detail

Summary

• Symbol: Ywhae^tm1Awb
• Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; targeted mutation 1, Anthony Wynshaw-Boris
• MGI ID: MGI:2667341
• Synonyms: 14-3-3epsilon^-, Ywhae-
• Gene: Ywhae Location: Chr11:75623695-75656671 bp, + strand Genetic Position: Chr11, 45.92 cM, cytoband B2
• Alliance: Ywhae^tm1Awb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84075
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 were partially replaced by a neomycin resistance gene and a loxP site. Immunoblot analysis indicated the complete absence of gene product in homozygotes and a reduction by half in heterozygotes. (J:84075)

Disease models

Expression

In Mice Carrying this Mutation:	71 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ywhae Mutation: 62 strains or lines available

References

• Original: J:84075 Toyo-oka K, et al., 14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome. Nat Genet. 2003 Jul;34(3):274-85
• All: 11 reference(s)