Dag1^tm2Kcam
Targeted Allele Detail

Summary

• Symbol: Dag1^tm2Kcam
• Name: dystroglycan 1; targeted mutation 2, Kevin P Campbell
• MGI ID: MGI:2387358
• Synonyms: Dag1^flox, Dag1^L, Dag1^lox, DG-flox, DG^lox, DG (lox)
• Gene: Dag1 Location: Chr9:108082060-108141176 bp, - strand Genetic Position: Chr9, 59.08 cM
• Alliance: Dag1^tm2Kcam page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78838
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2 was floxed by introducing a loxP site downstream of exon 2 and by inserting a floxed neo cassette into the upstream intron via homologous recombination. (J:78838)

Disease models

Expression

In Structures Affected by this Mutation:

16 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Dag1 Mutation: 109 strains or lines available

References

• Original: J:78838 Cohn RD, et al., Disruption of DAG1 in differentiated skeletal muscle reveals a role for dystroglycan in muscle regeneration. Cell. 2002 Sep 6;110(5):639-48
• All: 41 reference(s)