Aspm^{Gt(AJ0069)Wtsi}
Gene trapped Allele Detail

Summary

• Symbol: Aspm^{Gt(AJ0069)Wtsi}
• Name: abnormal spindle microtubule assembly; gene trap AJ0069, Wellcome Trust Sanger Institute
• MGI ID: MGI:4345389
• Gene: Aspm Location: Chr1:139382510-139421829 bp, + strand Genetic Position: Chr1, 61.45 cM, cytoband F
• Alliance: Aspm^{Gt(AJ0069)Wtsi} page

Mutation origin

• Mutant Cell Line: AJ0069
• Germline Transmission: Earliest citation of germline transmission: J:164424
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Sanger Inst. Gene Trap Res.

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0lxr
• Mutation details: Trapped gene association determined by genome coordinate overlap and strand. The gene trap vector was determined to have integrated between exons 25 and 26 such that the predicted protein product only lacks the C-terminal amino acids encoded by the three 3' exons but retains the N-terminal microtubule-binding domain, the calponin homology domains, and the calmodulin-binding isoleucine-glutamine (IQ) repeats. (J:164424)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  AJ0069	CL525053 ; (MGI Seq Detail)	5' RACE	Chr1:139417441-139418190 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  7 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aspm Mutation: 138 strains or lines available

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 2 reference(s)