Phenotypes for Pafah1b1 Ywhae MGI:2670767 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Pafah1b1^tm1Awb/Pafah1b1⁺ Ywhae^tm1Awb/Ywhae⁺
Genetic Background	either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Black Swiss)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pafah1b1^tm1Awb mutation (0 available); any Pafah1b1 mutation (158 available)
Ywhae^tm1Awb mutation (1 available); any Ywhae mutation (60 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased neuronal migration ( J:84075 )

• neuronal migration distances in the cortex and in the hippocampus are shorter than in mice heterozygous for only one of these two loci

abnormal brain morphology ( J:84075 )

abnormal hippocampus morphology ( J:84075 )

• very severe abnormalities in pyramidal cell packing as compared to mice heterozygous at only one of these two loci

cellular

decreased neuronal migration ( J:84075 )

• neuronal migration distances in the cortex and in the hippocampus are shorter than in mice heterozygous for only one of these two loci

Mouse Models of Human Disease	DO ID	OMIM ID(s)	Ref(s)
lissencephaly	DOID:0050453	OMIM:PS607432	J:84075
Miller-Dieker lissencephaly syndrome	DOID:0060469	OMIM:247200	J:84075

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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