Mouse Genome Informatics
cn1
    Gpr124tm1Cjku/Gpr124tm2Cjku
Tg(Pdgfb-icre/ERT2)1Frut/0

involves: 129/Sv * C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
cardiovascular system
• basally localized glomeruloid malformations in hemorrhagic areas of the CNS
• central nervous system (CNS) angiogenic arrest
• stated to fully recapitulate the phenotype seen in mice homozygous for Gpr124tm1Cjku
• forebrain hemorrhage


Mouse Genome Informatics
cn2
    Ctnnb1tm2Kem/Ctnnb1tm2Kem
Tg(Pdgfb-icre/ERT2)1Frut/0

involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
cardiovascular system
• following treatment with tamoxifen, retinal vascular density is reduced compared to in wild-type retina
• however, endothelial junctional assemblies are normal
• excessive in the retina following tamoxifen treatment

vision/eye
• following treatment with tamoxifen, retinal vascular density is reduced compared to in wild-type retina
• however, endothelial junctional assemblies are normal

cellular
• excessive in the retina following tamoxifen treatment


Mouse Genome Informatics
cn3
    Jag1tm1Jlew/Jag1tm1Grid
Tg(Pdgfb-icre/ERT2)1Frut/0

involves: 129S1/Sv * C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
growth/size
• with postnatal tamoxifen treatment from P1-P3, pups are generally smaller than tamoxifen-treated control littermates

vision/eye
• perpendicular sprouting and neovascularization of the deeper retina are strongly compromised with tamoxifen treatment between P5 and P9

cardiovascular system
N
• stability of blood vessels is not affected in mutants with tamoxifen treatment at P1; stability of established vessels in the superficial capillary plexus is not affected with tamoxifen administration between P5 and P9 (J:157345)
• postnatal tamoxifen treatment from P1-P3 results in decreased coverage of retinal arteries by vascular smooth muscle cells; however pericyte coverage of capillary beds shows no change
• perpendicular sprouting and neovascularization of the deeper retina are strongly compromised with tamoxifen treatment between P5 and P9
• postnatal tamoxifen treatment from P1-P3 to delete Jag1 in endothelial cells results in significant decreases in numbers of filopodia and filopodia-extending endothelial tip cells
• postnatal tamoxifen treatment from P1-P3 results in strong inhibition of angiogenesis in the retina resulting in reduced branching and delayed extension toward the periphery


Mouse Genome Informatics
cn4
    Jag1tm1Jlew/Jag1tm1Jlew
Tg(Pdgfb-icre/ERT2)1Frut/0

involves: C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
cardiovascular system
• postnatal tamoxifen treatment from P1-P3 results in decreased angiogenesis in the retina assessed at P6; significantly decreased vascular branching and endothelial cell coverage at P6


Mouse Genome Informatics
cn5
    Pdcd10tm1Kwhi/Pdcd10tm1.1Kwhi
Tg(Pdgfb-icre/ERT2)1Frut/?

involves: C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• increased early mortality

cardiovascular system
• cerebral cavernous malformations develop by one month after tamoxifen treatment at 1 day of age
• additional abnormalities include capillary telangiectasias, isolated caverns and multiple back to back caverns, thrombosis, hemorrhage, formation of secondary channels
• attenuation of endothelial cells in larger secondary channels but no gaps
• foot processes are missing

nervous system
• cerebral cavernous malformations develop by one month after tamoxifen treatment at 1 day of age
• additional abnormalities include capillary telangiectasias, isolated caverns and multiple back to back caverns, thrombosis, hemorrhage, formation of secondary channels
• attenuation of endothelial cells in larger secondary channels but no gaps
• foci of mononuclear inflammatory cells also seen
• foot processes are missing

immune system
• foci of mononuclear inflammatory cells also seen


Mouse Genome Informatics
cn6
    Ccm2tm1Kwhi/Ccm2tm1.1Kwhi
Tg(Pdgfb-icre/ERT2)1Frut/?

involves: C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• increased early mortality

cardiovascular system
• cerebral cavernous malformations develop as early as two months after tamoxifen treatment at 1 day of age
• most mice have lesions at 4 months and all mice at 6 months
• additional abnormalities include capillary telangiectasias, isolated caverns and multiple back to back caverns, thrombosis, hemorrhage, formation of secondary channels
• attenuation of endothelial cells in larger secondary channels but no gaps
• foot processes are missing

nervous system
• cerebral cavernous malformations develop as early as two months after tamoxifen treatment at 1 day of age
• most mice have lesions at 4 months and all mice at 6 months
• additional abnormalities include capillary telangiectasias, isolated caverns and multiple back to back caverns, thrombosis, hemorrhage, formation of secondary channels
• attenuation of endothelial cells in larger secondary channels but no gaps
• foci of mononuclear inflammatory cells also seen
• foot processes are missing

immune system
• foci of mononuclear inflammatory cells also seen