Krit1^tm1.1Kwhi
Targeted Allele Detail

Summary

• Symbol: Krit1^tm1.1Kwhi
• Name: KRIT1, ankyrin repeat containing; targeted mutation 1.1, Kevin Whitehead
• MGI ID: MGI:5532526
• Synonyms: Ccm1-, CCM1^-
• Gene: Krit1 Location: Chr5:3853156-3894515 bp, + strand Genetic Position: Chr5, 2.26 cM
• Alliance: Krit1^tm1.1Kwhi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:215458
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Cre-mediated recombination removed exons 4-8. (J:215458)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Krit1 Mutation: 34 strains or lines available

References

• Original: J:215458 Mleynek TM, et al., Lack of CCM1 induces hypersprouting and impairs response to flow. Hum Mol Genet. 2014 Dec 1;23(23):6223-34
• All: 1 reference(s)