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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
H2b
b variant
MGI:3579319
Summary 23 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
H2b/H2b NOD.B10SnJ-H2b MGI:3628773
ht2
H2b/H2d (C57BL/6 x DBA/2)F1 MGI:3630186
ht3
H2b/H2g7 NOD.B10SnJ-H2b MGI:3628790
cx4
H2b/H2b
Ptcratm1Vbo/Ptcratm1Vbo
involves: 129P2/OlaHsd MGI:3807285
cx5
H2b/H2b
Tcratm1Mom/Tcra/Tcrdtm1.1(Tcra)Rsky
Tg(Tcrb)93Vbo/?
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J MGI:3807217
cx6
Tcratm1Mom/Tcra/Tcrdtm1.1(Tcra)Rsky
H2b/H2b
Tg(Tcrb)93Vbo/?
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J MGI:3807222
cx7
H2b/H2b
Tcra/Tcrdtm1.1(Tcra)Rsky/Tcra/Tcrdtm1.1(Tcra)Rsky
Tg(Tcrb)93Vbo/?
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J MGI:3807223
cx8
H2b/H2b
Tcra/Tcrdtm1.1(Tcra)Rsky/Tcra/Tcrdtm1.1(Tcra)Rsky
Tg(Tcrb)93Vbo/?
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J MGI:3807224
cx9
H2b/H2b
Ptcratm1Vbo/Ptcratm1Vbo
Tcratm1Mom/Tcra/Tcrdtm1.1(Tcra)Rsky
Tg(Tcrb)93Vbo/?
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J MGI:3807286
cx10
H2b/H2b
Ptcratm1Vbo/Ptcratm1Vbo
Tg(TcraH-Y,TcrbH-Y)71Vbo/?
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J MGI:3807289
cx11
H2b/H2b
Nfkbidtm1Clay/Nfkbidtm1Clay
Rag2tm1Fwa/Rag2tm1Fwa
Tg(TcraN15,TcrbN15)L2Elre/?
involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 MGI:3777767
cx12
H2b/H2b
Rag2tm1Fwa/Rag2tm1Fwa
Tg(TcraN15,TcrbN15)L2Elre/?
involves: 129S/SvEv * C57BL/6 MGI:3777753
cx13
H2b/H2d
Themistm1Gasc/Themistm1Gasc
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * DBA/2 MGI:4353112
cx14
Apobec3Gt(XN450)Byg/Apobec3Rfv3-s
H2b/H2b
involves: A.BY * C57BL/6 MGI:3809805
cx15
H2b/H2s
Tg(TcraTcrb)1100Mjb/?
involves: A/WySn * C57BL/6 * C57BL/10Sg * Swiss MGI:3783840
cx16
H2b/H2d
Tg(TcraTcrb)1100Mjb/?
involves: BALB/c * C57BL/6 MGI:3783839
cx17
Apobec3Gt(XN450)Byg/Apobec3Rfv3-s
H2b/H2d
involves: BALB/c * C57BL/6 MGI:3809804
cx18
H2b/H2d
Tg(Ins2-E3)1Dvs/0
involves: BALB/c * C57BL/6 * DBA/2J MGI:3785747
cx19
H2b/H2b
Itktm1Ljb/Itktm1Ljb
Tg(TcrAND)53Hed/?
involves: C3H/HeJ * C57BL/6 * C57BL/10 MGI:4354597
cx20
H2b/H2k
Itktm1Ljb/Itktm1Ljb
Tg(TcrAND)53Hed/?
involves: C3H/HeJ * C57BL/6 * C57BL/10 MGI:4354598
cx21
H2b/H2k
Tg(TcraTcrb)1100Mjb/?
involves: C57BL/6 * C57BL/10Sg * C57BR/c MGI:3783836
cx22
H2b/H2g7
Tg(TcraR28,TcrbR28)KRNDim/0
involves: C57BL/6 * NOD * SJL MGI:3842820
cx23
Airetm1.1Doi/Airetm1.1Doi
H2b/H2b
NOD.Cg-Airetm1.1Doi H2b/Doi MGI:3793704


Genotype
MGI:3628773
hm1
Allelic
Composition
H2b/H2b
Genetic
Background
NOD.B10SnJ-H2b
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (25 available); any H2 mutation (251 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• no female mice homozygous for this haplotype develop diabetes after cyclophosphamide injections during 5-13 months of observation

endocrine/exocrine glands
• female mice display spontaneous perivascular and periductal lymphocytic infiltration by 7-10 months of age; mice between 6 and 11 months of age that are treated with cyclophospamide display perivascular and periductal infiltrates

immune system
• female mice display spontaneous perivascular and periductal lymphocytic infiltration by 7-10 months of age; mice between 6 and 11 months of age that are treated with cyclophospamide display perivascular and periductal infiltrates
• no female mice homozygous for the haplotype develop diabetes spontaneously during 5-13 months of observation




Genotype
MGI:3630186
ht2
Allelic
Composition
H2b/H2d
Genetic
Background
(C57BL/6 x DBA/2)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (25 available); any H2 mutation (251 available)
H2d mutation (21 available); any H2 mutation (251 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• after malarial infection, large populations of B220+CD3+ cells which are extrathymic T cells (CD3+) carrying a B cell marker (B220+) appear in the livers; this is not seen in the spleens of any mice after infection
• there is an increase of 40% of gamma,delta T cells in DBA/2 mice during infection; most of these are CD4-CD8-
• levels of Ifng and Il4 are lower than in B6 mice with malarial infection
• level of IgM autoantibody is increase to a greater extent than in B6 mice
• recovery from malaria is similar to DBA/2 mice, faster than in B6 mice

hematopoietic system
• after malarial infection, large populations of B220+CD3+ cells which are extrathymic T cells (CD3+) carrying a B cell marker (B220+) appear in the livers; this is not seen in the spleens of any mice after infection
• there is an increase of 40% of gamma,delta T cells in DBA/2 mice during infection; most of these are CD4-CD8-
• decrease in hematocrit is less than in infected C57BL/6 mice

liver/biliary system
• liver injury as estimated by GPT serum levels is lower than in infected B6 mice




Genotype
MGI:3628790
ht3
Allelic
Composition
H2b/H2g7
Genetic
Background
NOD.B10SnJ-H2b
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (25 available); any H2 mutation (251 available)
H2g7 mutation (18 available); any H2 mutation (251 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• no females develop diabetes spontaneously over 5-7 months




Genotype
MGI:3807285
cx4
Allelic
Composition
H2b/H2b
Ptcratm1Vbo/Ptcratm1Vbo
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (25 available); any H2 mutation (251 available)
Ptcratm1Vbo mutation (0 available); any Ptcra mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• thymocyte number is decreased by 10-fold compared to controls
• the percentage of DP thymocytes is severely reduced in the thymocytes
• spleen numbers are reduced by more than 4-fold

immune system
• thymocyte number is decreased by 10-fold compared to controls
• the percentage of DP thymocytes is severely reduced in the thymocytes
• spleen numbers are reduced by more than 4-fold

endocrine/exocrine glands
• thymocyte number is decreased by 10-fold compared to controls




Genotype
MGI:3807217
cx5
Allelic
Composition
H2b/H2b
Tcratm1Mom/Tcra/Tcrdtm1.1(Tcra)Rsky
Tg(Tcrb)93Vbo/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (25 available); any H2 mutation (251 available)
Tcra/Tcrdtm1.1(Tcra)Rsky mutation (0 available); any Tcra mutation (74 available)
Tcratm1Mom mutation (3 available); any Tcra mutation (74 available)
Tg(Tcrb)93Vbo mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• thymocyte number is reduced by about half compared to controls
• 18% of lymph node T cells from female mice bearing H2-Db express the HY-alpha t cell receptor chain
• the majority of T cells in male mice are HYalpha+ CD4-CD8lo or HYalpha+ CD4-CD8-
• 5 of 29 thymocytes from H2-Db background mice not expressing the HY TCR show evidence of receptor editing though the small number of DP and SP thymocytes present suggests this process is inefficient
• thymocytes from male mice on a H2-Db background that express the HY receptor are CD69+ and undergoing apoptosis due to negative selection
• DN thymocytes of both sexes have premature expression of a T cell receptor (TCR)
• this TCR is specific for the male HY antigen and in many cases there is co-expression of CD25 and CD44
• the percentage of DN cells in the thymus is increased
• female mice on a H2-Db background have almost double the number of DP thymocytes compared to female mice carrying just the Tcrbeta transgene
• the majority of these DP thymocytes do not carry the HY TCR
• male mice on a H2-Db background have 4% the number of double positive thymocytes
• the percentage of DP thymocytes is decreased in these mice

hematopoietic system
• thymocyte number is reduced by about half compared to controls
• 18% of lymph node T cells from female mice bearing H2-Db express the HY-alpha t cell receptor chain
• the majority of T cells in male mice are HYalpha+ CD4-CD8lo or HYalpha+ CD4-CD8-
• 5 of 29 thymocytes from H2-Db background mice not expressing the HY TCR show evidence of receptor editing though the small number of DP and SP thymocytes present suggests this process is inefficient
• thymocytes from male mice on a H2-Db background that express the HY receptor are CD69+ and undergoing apoptosis due to negative selection
• DN thymocytes of both sexes have premature expression of a T cell receptor (TCR)
• this TCR is specific for the male HY antigen and in many cases there is co-expression of CD25 and CD44
• the percentage of DN cells in the thymus is increased
• female mice on a H2-Db background have almost double the number of DP thymocytes compared to female mice carrying just the Tcrbeta transgene
• the majority of these DP thymocytes do not carry the HY TCR
• male mice on a H2-Db background have 4% the number of double positive thymocytes
• the percentage of DP thymocytes is decreased in these mice

endocrine/exocrine glands
• thymocyte number is reduced by about half compared to controls




Genotype
MGI:3807222
cx6
Allelic
Composition
Tcratm1Mom/Tcra/Tcrdtm1.1(Tcra)Rsky
H2b/H2b
Tg(Tcrb)93Vbo/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (25 available); any H2 mutation (251 available)
Tcra/Tcrdtm1.1(Tcra)Rsky mutation (0 available); any Tcrd mutation (13 available)
Tcratm1Mom mutation (3 available); any Tcra mutation (74 available)
Tg(Tcrb)93Vbo mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• 18% of lymph node T cells from female mice bearing H2-Db express the HY-alpha t cell receptor chain
• the majority of T cells in male mice are HYalpha+ CD4-CD8lo or HYalpha+ CD4-CD8-
• 5 of 29 HY- thymocytes from H2-Db background mice have some receptor editing though the small number of DP and SP thymocytes present suggests this process is inefficient
• thymocytes from male mice on a H2-Db background that express the HY receptor are CD69+ and undergoing apoptosis due to negative selection
• DN thymocytes of both sexes have premature expression of a T cell receptor (TCR)
• this TCR is specific for the male HY antigen and in many cases there is co-expression of CD25 and CD44
• the percentage of DN cells in the thymus is increased
• female mice on a H2-Db background have almost double the number of DP thymocytes compared to female mice carrying just the Tcrbeta transgene
• the majority of these DP thymocytes do not carry the HY TCR
• male mice on a H2-Db background have 4% the number of double positive thymocytes

immune system
• 18% of lymph node T cells from female mice bearing H2-Db express the HY-alpha t cell receptor chain
• the majority of T cells in male mice are HYalpha+ CD4-CD8lo or HYalpha+ CD4-CD8-
• 5 of 29 HY- thymocytes from H2-Db background mice have some receptor editing though the small number of DP and SP thymocytes present suggests this process is inefficient
• thymocytes from male mice on a H2-Db background that express the HY receptor are CD69+ and undergoing apoptosis due to negative selection
• DN thymocytes of both sexes have premature expression of a T cell receptor (TCR)
• this TCR is specific for the male HY antigen and in many cases there is co-expression of CD25 and CD44
• the percentage of DN cells in the thymus is increased
• female mice on a H2-Db background have almost double the number of DP thymocytes compared to female mice carrying just the Tcrbeta transgene
• the majority of these DP thymocytes do not carry the HY TCR
• male mice on a H2-Db background have 4% the number of double positive thymocytes

endocrine/exocrine glands




Genotype
MGI:3807223
cx7
Allelic
Composition
H2b/H2b
Tcra/Tcrdtm1.1(Tcra)Rsky/Tcra/Tcrdtm1.1(Tcra)Rsky
Tg(Tcrb)93Vbo/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (25 available); any H2 mutation (251 available)
Tcra/Tcrdtm1.1(Tcra)Rsky mutation (0 available); any Tcra mutation (74 available)
Tg(Tcrb)93Vbo mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• male mice on a H2-Db background have no distinct double positive or double negative populations in their thymus
• almost all thymocytes in male mice on a H2-Db background undergo negative selection
• receptor editing is unable to rescue these thymocytes

hematopoietic system
• male mice on a H2-Db background have no distinct double positive or double negative populations in their thymus
• almost all thymocytes in male mice on a H2-Db background undergo negative selection
• receptor editing is unable to rescue these thymocytes




Genotype
MGI:3807224
cx8
Allelic
Composition
H2b/H2b
Tcra/Tcrdtm1.1(Tcra)Rsky/Tcra/Tcrdtm1.1(Tcra)Rsky
Tg(Tcrb)93Vbo/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (25 available); any H2 mutation (251 available)
Tcra/Tcrdtm1.1(Tcra)Rsky mutation (0 available); any Tcrd mutation (13 available)
Tg(Tcrb)93Vbo mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• male mice on a H2-Db background have no distinct double positive or double negative populations in their thymus
• almost all thymocytes in male mice on a H2-Db background undergo negative selection
• receptor editing is unable to rescue these thymocytes

immune system
• male mice on a H2-Db background have no distinct double positive or double negative populations in their thymus
• almost all thymocytes in male mice on a H2-Db background undergo negative selection
• receptor editing is unable to rescue these thymocytes




Genotype
MGI:3807286
cx9
Allelic
Composition
H2b/H2b
Ptcratm1Vbo/Ptcratm1Vbo
Tcratm1Mom/Tcra/Tcrdtm1.1(Tcra)Rsky
Tg(Tcrb)93Vbo/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (25 available); any H2 mutation (251 available)
Ptcratm1Vbo mutation (0 available); any Ptcra mutation (6 available)
Tcra/Tcrdtm1.1(Tcra)Rsky mutation (0 available); any Tcra mutation (74 available)
Tcratm1Mom mutation (3 available); any Tcra mutation (74 available)
Tg(Tcrb)93Vbo mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• thymocyte numbers are reduced by about 3-fold
• the presence of HY TCR alleviates the beta-selection block in Ptcratm1Vbo homozygotes with higher T cell numbers being found in the thymus and the spleen
• despite the increased numbers of thymocytes, the CD25+ thymocyte sub-population still remains very low

hematopoietic system
• thymocyte numbers are reduced by about 3-fold
• the presence of HY TCR alleviates the beta-selection block in Ptcratm1Vbo homozygotes with higher T cell numbers being found in the thymus and the spleen
• despite the increased numbers of thymocytes, the CD25+ thymocyte sub-population still remains very low

endocrine/exocrine glands
• thymocyte numbers are reduced by about 3-fold




Genotype
MGI:3807289
cx10
Allelic
Composition
H2b/H2b
Ptcratm1Vbo/Ptcratm1Vbo
Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (25 available); any H2 mutation (251 available)
Ptcratm1Vbo mutation (0 available); any Ptcra mutation (6 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the presence of HY TCR alleviates the beta-selection block of developing T cells found in Ptcratm1Vbo homozygotes resulting in higher T cell numbers being found in the thymus and the spleen
• the presence of the selecting H2d allele contributes to the rescue of T cell development by the HY-TCR
• despite the increased numbers of thymocytes, the CD25+ thymocyte sub-population still remains very low

hematopoietic system
• the presence of HY TCR alleviates the beta-selection block of developing T cells found in Ptcratm1Vbo homozygotes resulting in higher T cell numbers being found in the thymus and the spleen
• the presence of the selecting H2d allele contributes to the rescue of T cell development by the HY-TCR
• despite the increased numbers of thymocytes, the CD25+ thymocyte sub-population still remains very low




Genotype
MGI:3777767
cx11
Allelic
Composition
H2b/H2b
Nfkbidtm1Clay/Nfkbidtm1Clay
Rag2tm1Fwa/Rag2tm1Fwa
Tg(TcraN15,TcrbN15)L2Elre/?
Genetic
Background
involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (25 available); any H2 mutation (251 available)
Nfkbidtm1Clay mutation (2 available); any Nfkbid mutation (12 available)
Rag2tm1Fwa mutation (27 available); any Rag2 mutation (64 available)
Tg(TcraN15,TcrbN15)L2Elre mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• thymocytes proliferate poorly to irradiated, wild-type spleen cells loaded with VSV8 antigen
• T cells proliferate poorly to irradiated, wild-type spleen cells loaded with VSV8 antigen
• T cells require about 2 logs higher concentration of antigen for proliferation equivalent of wild-type T cells
• lymph node T cells secrete significantly less IL-2 than wild-type T cells in response to irradiated spleen cells loaded with VSV8 antigen

hematopoietic system
• thymocytes proliferate poorly to irradiated, wild-type spleen cells loaded with VSV8 antigen
• T cells proliferate poorly to irradiated, wild-type spleen cells loaded with VSV8 antigen
• T cells require about 2 logs higher concentration of antigen for proliferation equivalent of wild-type T cells

endocrine/exocrine glands
• thymocytes proliferate poorly to irradiated, wild-type spleen cells loaded with VSV8 antigen




Genotype
MGI:3777753
cx12
Allelic
Composition
H2b/H2b
Rag2tm1Fwa/Rag2tm1Fwa
Tg(TcraN15,TcrbN15)L2Elre/?
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (25 available); any H2 mutation (251 available)
Rag2tm1Fwa mutation (27 available); any Rag2 mutation (64 available)
Tg(TcraN15,TcrbN15)L2Elre mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the majority of T cells in the thymus are arrested at the double positive stage
• single positive CD4 positive T cells are absent in the thymus
• there is a reduced percentage of single positive CD8 positive T cells
• however, the TCR transgene rescues the arrestment of T cells in the double negative stage that occurs in Rag2 deficient background
• injection of the VSV8 antigen leads to rapid apoptosis and depletion of double-positive thymocytes with a 3-6 fold drop in total number of thymocytes
• there are almost 10-fold less CD4 T cells in the spleen
• there are about 4-fold more CD8 T cells in the spleen
• CD8 positive T cells exhibit increased cytotoxicity towards cells loaded with VSV8 peptide
• CD8 T cells proliferate when presented VSV8 peptide by antigen presenting cells

hematopoietic system
• the majority of T cells in the thymus are arrested at the double positive stage
• single positive CD4 positive T cells are absent in the thymus
• there is a reduced percentage of single positive CD8 positive T cells
• however, the TCR transgene rescues the arrestment of T cells in the double negative stage that occurs in Rag2 deficient background
• injection of the VSV8 antigen leads to rapid apoptosis and depletion of double-positive thymocytes with a 3-6 fold drop in total number of thymocytes
• there are almost 10-fold less CD4 T cells in the spleen
• there are about 4-fold more CD8 T cells in the spleen
• CD8 positive T cells exhibit increased cytotoxicity towards cells loaded with VSV8 peptide
• CD8 T cells proliferate when presented VSV8 peptide by antigen presenting cells




Genotype
MGI:4353112
cx13
Allelic
Composition
H2b/H2d
Themistm1Gasc/Themistm1Gasc
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (25 available); any H2 mutation (251 available)
H2d mutation (21 available); any H2 mutation (251 available)
Themistm1Gasc mutation (1 available); any Themis mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• superantigen-mediated deletion of T cells expressing Vbeta5, Vbeta11, and Vbeta12 is less efficient in these mice

immune system
• superantigen-mediated deletion of T cells expressing Vbeta5, Vbeta11, and Vbeta12 is less efficient in these mice




Genotype
MGI:3809805
cx14
Allelic
Composition
Apobec3Gt(XN450)Byg/Apobec3Rfv3-s
H2b/H2b
Genetic
Background
involves: A.BY * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apobec3Gt(XN450)Byg mutation (3 available); any Apobec3 mutation (124 available)
Apobec3Rfv3-s mutation (0 available); any Apobec3 mutation (124 available)
H2b mutation (25 available); any H2 mutation (251 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the levels of neutralizing antibody produced to Friend virus 28 days after inoculation is over an order of magnitude lower than in littermate controls

hematopoietic system
• the levels of neutralizing antibody produced to Friend virus 28 days after inoculation is over an order of magnitude lower than in littermate controls




Genotype
MGI:3783840
cx15
Allelic
Composition
H2b/H2s
Tg(TcraTcrb)1100Mjb/?
Genetic
Background
involves: A/WySn * C57BL/6 * C57BL/10Sg * Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (25 available); any H2 mutation (251 available)
H2s mutation (4 available); any H2 mutation (251 available)
Tg(TcraTcrb)1100Mjb mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the thymus is smaller than normal
• the transgenic TCR is negatively selected on this genetic background based on the small number of CD8 T cells found in the periphery that express the transgenic TCR
• decreased number of CD8 T cells are found in both the thymus and in the periphery

hematopoietic system
• the thymus is smaller than normal
• the transgenic TCR is negatively selected on this genetic background based on the small number of CD8 T cells found in the periphery that express the transgenic TCR
• decreased number of CD8 T cells are found in both the thymus and in the periphery

endocrine/exocrine glands
• the thymus is smaller than normal




Genotype
MGI:3783839
cx16
Allelic
Composition
H2b/H2d
Tg(TcraTcrb)1100Mjb/?
Genetic
Background
involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (25 available); any H2 mutation (251 available)
H2d mutation (21 available); any H2 mutation (251 available)
Tg(TcraTcrb)1100Mjb mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the thymus is smaller than normal
• the transgenic TCR is negatively selected on this genetic background based on the small number of CD8 T cells found in the periphery that express the transgenic TCR
• decreased number of CD8 T cells are found in both the thymus and in the periphery

hematopoietic system
• the thymus is smaller than normal
• the transgenic TCR is negatively selected on this genetic background based on the small number of CD8 T cells found in the periphery that express the transgenic TCR
• decreased number of CD8 T cells are found in both the thymus and in the periphery

endocrine/exocrine glands
• the thymus is smaller than normal




Genotype
MGI:3809804
cx17
Allelic
Composition
Apobec3Gt(XN450)Byg/Apobec3Rfv3-s
H2b/H2d
Genetic
Background
involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apobec3Gt(XN450)Byg mutation (3 available); any Apobec3 mutation (124 available)
Apobec3Rfv3-s mutation (0 available); any Apobec3 mutation (124 available)
H2b mutation (25 available); any H2 mutation (251 available)
H2d mutation (21 available); any H2 mutation (251 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• less than 40% of mice survive viral infection when infected with 140 spleen focus forming units of Friend virus compared to 90% survival in littermate controls

immune system
• the levels of neutralizing antibody produced to Friend virus 28 days after inoculation is over an order of magnitude lower than in controls
• 16-week old mice mice infected with Friend virus have an order of magnitude more virus in their blood 8 days later than in littermate controls
• less than 40% of mice survive viral infection when infected with 140 spleen focus forming units of Friend virus compared to 90% survival in littermate controls

hematopoietic system
• the levels of neutralizing antibody produced to Friend virus 28 days after inoculation is over an order of magnitude lower than in controls




Genotype
MGI:3785747
cx18
Allelic
Composition
H2b/H2d
Tg(Ins2-E3)1Dvs/0
Genetic
Background
involves: BALB/c * C57BL/6 * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (25 available); any H2 mutation (251 available)
H2d mutation (21 available); any H2 mutation (251 available)
Tg(Ins2-E3)1Dvs mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• when transferred into BALB/c hosts, but not C57BL/6 hosts, pancreatic islets from H2 survive much longer than non-transgenic pancreatic islets




Genotype
MGI:4354597
cx19
Allelic
Composition
H2b/H2b
Itktm1Ljb/Itktm1Ljb
Tg(TcrAND)53Hed/?
Genetic
Background
involves: C3H/HeJ * C57BL/6 * C57BL/10
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (25 available); any H2 mutation (251 available)
Itktm1Ljb mutation (0 available); any Itk mutation (21 available)
Tg(TcrAND)53Hed mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• thymocytes take longer to undergo positive selection than wild-type thymocytes based on expression of CD69 and HSA
• expression of CD5, which is correlated with TCR signal strength, is also decreased
• there are almost no mature transgenic CD4 T cells in the periphery

hematopoietic system
• thymocytes take longer to undergo positive selection than wild-type thymocytes based on expression of CD69 and HSA
• expression of CD5, which is correlated with TCR signal strength, is also decreased
• there are almost no mature transgenic CD4 T cells in the periphery




Genotype
MGI:4354598
cx20
Allelic
Composition
H2b/H2k
Itktm1Ljb/Itktm1Ljb
Tg(TcrAND)53Hed/?
Genetic
Background
involves: C3H/HeJ * C57BL/6 * C57BL/10
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (25 available); any H2 mutation (251 available)
H2k mutation (14 available); any H2 mutation (251 available)
Itktm1Ljb mutation (0 available); any Itk mutation (21 available)
Tg(TcrAND)53Hed mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• thymocytes take longer to undergo positive selection than wild-type thymocytes based on expression of CD69 and HSA
• expression of CD5, which is correlated with TCR signal strength, is also decreased
• the development of transgenic CD4 T cells is reduced 2- to 3-fold in these mice

hematopoietic system
• thymocytes take longer to undergo positive selection than wild-type thymocytes based on expression of CD69 and HSA
• expression of CD5, which is correlated with TCR signal strength, is also decreased
• the development of transgenic CD4 T cells is reduced 2- to 3-fold in these mice




Genotype
MGI:3783836
cx21
Allelic
Composition
H2b/H2k
Tg(TcraTcrb)1100Mjb/?
Genetic
Background
involves: C57BL/6 * C57BL/10Sg * C57BR/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (25 available); any H2 mutation (251 available)
H2k mutation (14 available); any H2 mutation (251 available)
Tg(TcraTcrb)1100Mjb mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the thymus is smaller than normal
• the transgenic TCR is negatively selected on this genetic background based on the small number of CD8 T cells found in the periphery that express the transgenic TCR
• decreased number of CD8 T cells are found in both the thymus and in the periphery

hematopoietic system
• the thymus is smaller than normal
• the transgenic TCR is negatively selected on this genetic background based on the small number of CD8 T cells found in the periphery that express the transgenic TCR
• decreased number of CD8 T cells are found in both the thymus and in the periphery

endocrine/exocrine glands
• the thymus is smaller than normal




Genotype
MGI:3842820
cx22
Allelic
Composition
H2b/H2g7
Tg(TcraR28,TcrbR28)KRNDim/0
Genetic
Background
involves: C57BL/6 * NOD * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (25 available); any H2 mutation (251 available)
H2g7 mutation (18 available); any H2 mutation (251 available)
Tg(TcraR28,TcrbR28)KRNDim mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• rheumatoid arthritis occurs with disease onset transpiring between 25 and 35 days of age
• arthritis occurrence is established by joint inspection and measure of ankle thickness, and histological confirmation in several mice

skeleton
• rheumatoid arthritis occurs with disease onset transpiring between 25 and 35 days of age
• arthritis occurrence is established by joint inspection and measure of ankle thickness, and histological confirmation in several mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Rheumatoid Arthritis; RA 180300 J:36815




Genotype
MGI:3793704
cx23
Allelic
Composition
Airetm1.1Doi/Airetm1.1Doi
H2b/H2b
Genetic
Background
NOD.Cg-Airetm1.1Doi H2b/Doi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Airetm1.1Doi mutation (2 available); any Aire mutation (20 available)
H2b mutation (25 available); any H2 mutation (251 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• Background Sensitivity: stomach inflammation is present regardless of the alleles found at the H2 locus

digestive/alimentary system
• Background Sensitivity: stomach inflammation is present regardless of the alleles found at the H2 locus

endocrine/exocrine glands
• Background Sensitivity: the pancreatitis associated with the Aire allele on the NOD background is absent when the H2 allele is present at homozygocity





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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory