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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
H2b
b variant
MGI:3579319
Summary 23 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
H2b/H2b NOD.B10SnJ-H2b MGI:3628773
ht2
H2b/H2d (C57BL/6 x DBA/2)F1 MGI:3630186
ht3
H2b/H2g7 NOD.B10SnJ-H2b MGI:3628790
cx4
H2b/H2b
Ptcratm1Vbo/Ptcratm1Vbo
involves: 129P2/OlaHsd MGI:3807285
cx5
H2b/H2b
Tcratm1Mom/Tcra/Tcrdtm1.1(Tcra)Rsky
Tg(Tcrb)93Vbo/?
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J MGI:3807217
cx6
Tcratm1Mom/Tcra/Tcrdtm1.1(Tcra)Rsky
H2b/H2b
Tg(Tcrb)93Vbo/?
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J MGI:3807222
cx7
H2b/H2b
Tcra/Tcrdtm1.1(Tcra)Rsky/Tcra/Tcrdtm1.1(Tcra)Rsky
Tg(Tcrb)93Vbo/?
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J MGI:3807223
cx8
H2b/H2b
Tcra/Tcrdtm1.1(Tcra)Rsky/Tcra/Tcrdtm1.1(Tcra)Rsky
Tg(Tcrb)93Vbo/?
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J MGI:3807224
cx9
H2b/H2b
Ptcratm1Vbo/Ptcratm1Vbo
Tcratm1Mom/Tcra/Tcrdtm1.1(Tcra)Rsky
Tg(Tcrb)93Vbo/?
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J MGI:3807286
cx10
H2b/H2b
Ptcratm1Vbo/Ptcratm1Vbo
Tg(TcraH-Y,TcrbH-Y)71Vbo/?
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J MGI:3807289
cx11
H2b/H2b
Nfkbidtm1Clay/Nfkbidtm1Clay
Rag2tm1Fwa/Rag2tm1Fwa
Tg(TcraN15,TcrbN15)L2Elre/?
involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 MGI:3777767
cx12
H2b/H2b
Rag2tm1Fwa/Rag2tm1Fwa
Tg(TcraN15,TcrbN15)L2Elre/?
involves: 129S/SvEv * C57BL/6 MGI:3777753
cx13
H2b/H2d
Themistm1Gasc/Themistm1Gasc
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * DBA/2 MGI:4353112
cx14
Apobec3Gt(XN450)Byg/Apobec3Rfv3-s
H2b/H2b
involves: A.BY * C57BL/6 MGI:3809805
cx15
H2b/H2s
Tg(TcraTcrb)1100Mjb/?
involves: A/WySn * C57BL/6 * C57BL/10Sg * Swiss MGI:3783840
cx16
H2b/H2d
Tg(TcraTcrb)1100Mjb/?
involves: BALB/c * C57BL/6 MGI:3783839
cx17
Apobec3Gt(XN450)Byg/Apobec3Rfv3-s
H2b/H2d
involves: BALB/c * C57BL/6 MGI:3809804
cx18
H2b/H2d
Tg(Ins2-E3)1Dvs/0
involves: BALB/c * C57BL/6 * DBA/2J MGI:3785747
cx19
H2b/H2b
Itktm1Ljb/Itktm1Ljb
Tg(TcrAND)53Hed/?
involves: C3H/HeJ * C57BL/6 * C57BL/10 MGI:4354597
cx20
H2b/H2k
Itktm1Ljb/Itktm1Ljb
Tg(TcrAND)53Hed/?
involves: C3H/HeJ * C57BL/6 * C57BL/10 MGI:4354598
cx21
H2b/H2k
Tg(TcraTcrb)1100Mjb/?
involves: C57BL/6 * C57BL/10Sg * C57BR/c MGI:3783836
cx22
H2b/H2g7
Tg(TcraR28,TcrbR28)KRNDim/0
involves: C57BL/6 * NOD * SJL MGI:3842820
cx23
Airetm1.1Doi/Airetm1.1Doi
H2b/H2b
NOD.Cg-Airetm1.1Doi H2b/Doi MGI:3793704


Genotype
MGI:3628773
hm1
Allelic
Composition
H2b/H2b
Genetic
Background
NOD.B10SnJ-H2b
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (25 available); any H2 mutation (263 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• no female mice homozygous for this haplotype develop diabetes after cyclophosphamide injections during 5-13 months of observation

endocrine/exocrine glands
• female mice display spontaneous perivascular and periductal lymphocytic infiltration by 7-10 months of age; mice between 6 and 11 months of age that are treated with cyclophospamide display perivascular and periductal infiltrates

immune system
• female mice display spontaneous perivascular and periductal lymphocytic infiltration by 7-10 months of age; mice between 6 and 11 months of age that are treated with cyclophospamide display perivascular and periductal infiltrates
• no female mice homozygous for the haplotype develop diabetes spontaneously during 5-13 months of observation




Genotype
MGI:3630186
ht2
Allelic
Composition
H2b/H2d
Genetic
Background
(C57BL/6 x DBA/2)F1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (25 available); any H2 mutation (263 available)
H2d mutation (21 available); any H2 mutation (263 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• after malarial infection, large populations of B220+CD3+ cells which are extrathymic T cells (CD3+) carrying a B cell marker (B220+) appear in the livers; this is not seen in the spleens of any mice after infection
• there is an increase of 40% of gamma,delta T cells in DBA/2 mice during infection; most of these are CD4-CD8-
• levels of Ifng and Il4 are lower than in B6 mice with malarial infection
• level of IgM autoantibody is increase to a greater extent than in B6 mice
• recovery from malaria is similar to DBA/2 mice, faster than in B6 mice

hematopoietic system
• after malarial infection, large populations of B220+CD3+ cells which are extrathymic T cells (CD3+) carrying a B cell marker (B220+) appear in the livers; this is not seen in the spleens of any mice after infection
• there is an increase of 40% of gamma,delta T cells in DBA/2 mice during infection; most of these are CD4-CD8-
• decrease in hematocrit is less than in infected C57BL/6 mice

liver/biliary system
• liver injury as estimated by GPT serum levels is lower than in infected B6 mice




Genotype
MGI:3628790
ht3
Allelic
Composition
H2b/H2g7
Genetic
Background
NOD.B10SnJ-H2b
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (25 available); any H2 mutation (263 available)
H2g7 mutation (19 available); any H2 mutation (263 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• no females develop diabetes spontaneously over 5-7 months




Genotype
MGI:3807285
cx4
Allelic
Composition
H2b/H2b
Ptcratm1Vbo/Ptcratm1Vbo
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (25 available); any H2 mutation (263 available)
Ptcratm1Vbo mutation (0 available); any Ptcra mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• thymocyte number is decreased by 10-fold compared to controls
• the percentage of DP thymocytes is severely reduced in the thymocytes
• spleen numbers are reduced by more than 4-fold

immune system
• thymocyte number is decreased by 10-fold compared to controls
• the percentage of DP thymocytes is severely reduced in the thymocytes
• spleen numbers are reduced by more than 4-fold

endocrine/exocrine glands
• thymocyte number is decreased by 10-fold compared to controls




Genotype
MGI:3807217
cx5
Allelic
Composition
H2b/H2b
Tcratm1Mom/Tcra/Tcrdtm1.1(Tcra)Rsky
Tg(Tcrb)93Vbo/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (25 available); any H2 mutation (263 available)
Tcra/Tcrdtm1.1(Tcra)Rsky mutation (0 available); any Tcra mutation (80 available)
Tcratm1Mom mutation (5 available); any Tcra mutation (80 available)
Tg(Tcrb)93Vbo mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• thymocyte number is reduced by about half compared to controls
• 18% of lymph node T cells from female mice bearing H2-Db express the HY-alpha t cell receptor chain
• the majority of T cells in male mice are HYalpha+ CD4-CD8lo or HYalpha+ CD4-CD8-
• 5 of 29 thymocytes from H2-Db background mice not expressing the HY TCR show evidence of receptor editing though the small number of DP and SP thymocytes present suggests this process is inefficient
• thymocytes from male mice on a H2-Db background that express the HY receptor are CD69+ and undergoing apoptosis due to negative selection
• DN thymocytes of both sexes have premature expression of a T cell receptor (TCR)
• this TCR is specific for the male HY antigen and in many cases there is co-expression of CD25 and CD44
• the percentage of DN cells in the thymus is increased
• female mice on a H2-Db background have almost double the number of DP thymocytes compared to female mice carrying just the Tcrbeta transgene
• the majority of these DP thymocytes do not carry the HY TCR
• male mice on a H2-Db background have 4% the number of double positive thymocytes
• the percentage of DP thymocytes is decreased in these mice

hematopoietic system
• thymocyte number is reduced by about half compared to controls
• 18% of lymph node T cells from female mice bearing H2-Db express the HY-alpha t cell receptor chain
• the majority of T cells in male mice are HYalpha+ CD4-CD8lo or HYalpha+ CD4-CD8-
• 5 of 29 thymocytes from H2-Db background mice not expressing the HY TCR show evidence of receptor editing though the small number of DP and SP thymocytes present suggests this process is inefficient
• thymocytes from male mice on a H2-Db background that express the HY receptor are CD69+ and undergoing apoptosis due to negative selection
• DN thymocytes of both sexes have premature expression of a T cell receptor (TCR)
• this TCR is specific for the male HY antigen and in many cases there is co-expression of CD25 and CD44
• the percentage of DN cells in the thymus is increased
• female mice on a H2-Db background have almost double the number of DP thymocytes compared to female mice carrying just the Tcrbeta transgene
• the majority of these DP thymocytes do not carry the HY TCR
• male mice on a H2-Db background have 4% the number of double positive thymocytes
• the percentage of DP thymocytes is decreased in these mice

endocrine/exocrine glands
• thymocyte number is reduced by about half compared to controls




Genotype
MGI:3807222
cx6
Allelic
Composition
Tcratm1Mom/Tcra/Tcrdtm1.1(Tcra)Rsky
H2b/H2b
Tg(Tcrb)93Vbo/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (25 available); any H2 mutation (263 available)
Tcra/Tcrdtm1.1(Tcra)Rsky mutation (0 available); any Tcrd mutation (13 available)
Tcratm1Mom mutation (5 available); any Tcra mutation (80 available)
Tg(Tcrb)93Vbo mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• 18% of lymph node T cells from female mice bearing H2-Db express the HY-alpha t cell receptor chain
• the majority of T cells in male mice are HYalpha+ CD4-CD8lo or HYalpha+ CD4-CD8-
• 5 of 29 HY- thymocytes from H2-Db background mice have some receptor editing though the small number of DP and SP thymocytes present suggests this process is inefficient
• thymocytes from male mice on a H2-Db background that express the HY receptor are CD69+ and undergoing apoptosis due to negative selection
• DN thymocytes of both sexes have premature expression of a T cell receptor (TCR)
• this TCR is specific for the male HY antigen and in many cases there is co-expression of CD25 and CD44
• the percentage of DN cells in the thymus is increased
• female mice on a H2-Db background have almost double the number of DP thymocytes compared to female mice carrying just the Tcrbeta transgene
• the majority of these DP thymocytes do not carry the HY TCR
• male mice on a H2-Db background have 4% the number of double positive thymocytes

immune system
• 18% of lymph node T cells from female mice bearing H2-Db express the HY-alpha t cell receptor chain
• the majority of T cells in male mice are HYalpha+ CD4-CD8lo or HYalpha+ CD4-CD8-
• 5 of 29 HY- thymocytes from H2-Db background mice have some receptor editing though the small number of DP and SP thymocytes present suggests this process is inefficient
• thymocytes from male mice on a H2-Db background that express the HY receptor are CD69+ and undergoing apoptosis due to negative selection
• DN thymocytes of both sexes have premature expression of a T cell receptor (TCR)
• this TCR is specific for the male HY antigen and in many cases there is co-expression of CD25 and CD44
• the percentage of DN cells in the thymus is increased
• female mice on a H2-Db background have almost double the number of DP thymocytes compared to female mice carrying just the Tcrbeta transgene
• the majority of these DP thymocytes do not carry the HY TCR
• male mice on a H2-Db background have 4% the number of double positive thymocytes

endocrine/exocrine glands




Genotype
MGI:3807223
cx7
Allelic
Composition
H2b/H2b
Tcra/Tcrdtm1.1(Tcra)Rsky/Tcra/Tcrdtm1.1(Tcra)Rsky
Tg(Tcrb)93Vbo/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (25 available); any H2 mutation (263 available)
Tcra/Tcrdtm1.1(Tcra)Rsky mutation (0 available); any Tcra mutation (80 available)
Tg(Tcrb)93Vbo mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• male mice on a H2-Db background have no distinct double positive or double negative populations in their thymus
• almost all thymocytes in male mice on a H2-Db background undergo negative selection
• receptor editing is unable to rescue these thymocytes

hematopoietic system
• male mice on a H2-Db background have no distinct double positive or double negative populations in their thymus
• almost all thymocytes in male mice on a H2-Db background undergo negative selection
• receptor editing is unable to rescue these thymocytes




Genotype
MGI:3807224
cx8
Allelic
Composition
H2b/H2b
Tcra/Tcrdtm1.1(Tcra)Rsky/Tcra/Tcrdtm1.1(Tcra)Rsky
Tg(Tcrb)93Vbo/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (25 available); any H2 mutation (263 available)
Tcra/Tcrdtm1.1(Tcra)Rsky mutation (0 available); any Tcrd mutation (13 available)
Tg(Tcrb)93Vbo mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• male mice on a H2-Db background have no distinct double positive or double negative populations in their thymus
• almost all thymocytes in male mice on a H2-Db background undergo negative selection
• receptor editing is unable to rescue these thymocytes

immune system
• male mice on a H2-Db background have no distinct double positive or double negative populations in their thymus
• almost all thymocytes in male mice on a H2-Db background undergo negative selection
• receptor editing is unable to rescue these thymocytes




Genotype
MGI:3807286
cx9
Allelic
Composition
H2b/H2b
Ptcratm1Vbo/Ptcratm1Vbo
Tcratm1Mom/Tcra/Tcrdtm1.1(Tcra)Rsky
Tg(Tcrb)93Vbo/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (25 available); any H2 mutation (263 available)
Ptcratm1Vbo mutation (0 available); any Ptcra mutation (6 available)
Tcra/Tcrdtm1.1(Tcra)Rsky mutation (0 available); any Tcra mutation (80 available)
Tcratm1Mom mutation (5 available); any Tcra mutation (80 available)
Tg(Tcrb)93Vbo mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• thymocyte numbers are reduced by about 3-fold
• the presence of HY TCR alleviates the beta-selection block in Ptcratm1Vbo homozygotes with higher T cell numbers being found in the thymus and the spleen
• despite the increased numbers of thymocytes, the CD25+ thymocyte sub-population still remains very low

hematopoietic system
• thymocyte numbers are reduced by about 3-fold
• the presence of HY TCR alleviates the beta-selection block in Ptcratm1Vbo homozygotes with higher T cell numbers being found in the thymus and the spleen
• despite the increased numbers of thymocytes, the CD25+ thymocyte sub-population still remains very low

endocrine/exocrine glands
• thymocyte numbers are reduced by about 3-fold




Genotype
MGI:3807289
cx10
Allelic
Composition
H2b/H2b
Ptcratm1Vbo/Ptcratm1Vbo
Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (25 available); any H2 mutation (263 available)
Ptcratm1Vbo mutation (0 available); any Ptcra mutation (6 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the presence of HY TCR alleviates the beta-selection block of developing T cells found in Ptcratm1Vbo homozygotes resulting in higher T cell numbers being found in the thymus and the spleen
• the presence of the selecting H2d allele contributes to the rescue of T cell development by the HY-TCR
• despite the increased numbers of thymocytes, the CD25+ thymocyte sub-population still remains very low

hematopoietic system
• the presence of HY TCR alleviates the beta-selection block of developing T cells found in Ptcratm1Vbo homozygotes resulting in higher T cell numbers being found in the thymus and the spleen
• the presence of the selecting H2d allele contributes to the rescue of T cell development by the HY-TCR
• despite the increased numbers of thymocytes, the CD25+ thymocyte sub-population still remains very low




Genotype
MGI:3777767
cx11
Allelic
Composition
H2b/H2b
Nfkbidtm1Clay/Nfkbidtm1Clay
Rag2tm1Fwa/Rag2tm1Fwa
Tg(TcraN15,TcrbN15)L2Elre/?
Genetic
Background
involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (25 available); any H2 mutation (263 available)
Nfkbidtm1Clay mutation (2 available); any Nfkbid mutation (12 available)
Rag2tm1Fwa mutation (41 available); any Rag2 mutation (78 available)
Tg(TcraN15,TcrbN15)L2Elre mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• thymocytes proliferate poorly to irradiated, wild-type spleen cells loaded with VSV8 antigen
• T cells proliferate poorly to irradiated, wild-type spleen cells loaded with VSV8 antigen
• T cells require about 2 logs higher concentration of antigen for proliferation equivalent of wild-type T cells
• lymph node T cells secrete significantly less IL-2 than wild-type T cells in response to irradiated spleen cells loaded with VSV8 antigen

hematopoietic system
• thymocytes proliferate poorly to irradiated, wild-type spleen cells loaded with VSV8 antigen
• T cells proliferate poorly to irradiated, wild-type spleen cells loaded with VSV8 antigen
• T cells require about 2 logs higher concentration of antigen for proliferation equivalent of wild-type T cells

endocrine/exocrine glands
• thymocytes proliferate poorly to irradiated, wild-type spleen cells loaded with VSV8 antigen




Genotype
MGI:3777753
cx12
Allelic
Composition
H2b/H2b
Rag2tm1Fwa/Rag2tm1Fwa
Tg(TcraN15,TcrbN15)L2Elre/?
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (25 available); any H2 mutation (263 available)
Rag2tm1Fwa mutation (41 available); any Rag2 mutation (78 available)
Tg(TcraN15,TcrbN15)L2Elre mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the majority of T cells in the thymus are arrested at the double positive stage
• single positive CD4 positive T cells are absent in the thymus
• there is a reduced percentage of single positive CD8 positive T cells
• however, the TCR transgene rescues the arrestment of T cells in the double negative stage that occurs in Rag2 deficient background
• injection of the VSV8 antigen leads to rapid apoptosis and depletion of double-positive thymocytes with a 3-6 fold drop in total number of thymocytes
• there are almost 10-fold less CD4 T cells in the spleen
• there are about 4-fold more CD8 T cells in the spleen
• CD8 positive T cells exhibit increased cytotoxicity towards cells loaded with VSV8 peptide
• CD8 T cells proliferate when presented VSV8 peptide by antigen presenting cells

hematopoietic system
• the majority of T cells in the thymus are arrested at the double positive stage
• single positive CD4 positive T cells are absent in the thymus
• there is a reduced percentage of single positive CD8 positive T cells
• however, the TCR transgene rescues the arrestment of T cells in the double negative stage that occurs in Rag2 deficient background
• injection of the VSV8 antigen leads to rapid apoptosis and depletion of double-positive thymocytes with a 3-6 fold drop in total number of thymocytes
• there are almost 10-fold less CD4 T cells in the spleen
• there are about 4-fold more CD8 T cells in the spleen
• CD8 positive T cells exhibit increased cytotoxicity towards cells loaded with VSV8 peptide
• CD8 T cells proliferate when presented VSV8 peptide by antigen presenting cells




Genotype
MGI:4353112
cx13
Allelic
Composition
H2b/H2d
Themistm1Gasc/Themistm1Gasc
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (25 available); any H2 mutation (263 available)
H2d mutation (21 available); any H2 mutation (263 available)
Themistm1Gasc mutation (1 available); any Themis mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• superantigen-mediated deletion of T cells expressing Vbeta5, Vbeta11, and Vbeta12 is less efficient in these mice

immune system
• superantigen-mediated deletion of T cells expressing Vbeta5, Vbeta11, and Vbeta12 is less efficient in these mice




Genotype
MGI:3809805
cx14
Allelic
Composition
Apobec3Gt(XN450)Byg/Apobec3Rfv3-s
H2b/H2b
Genetic
Background
involves: A.BY * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apobec3Gt(XN450)Byg mutation (3 available); any Apobec3 mutation (124 available)
Apobec3Rfv3-s mutation (0 available); any Apobec3 mutation (124 available)
H2b mutation (25 available); any H2 mutation (263 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the levels of neutralizing antibody produced to Friend virus 28 days after inoculation is over an order of magnitude lower than in littermate controls

hematopoietic system
• the levels of neutralizing antibody produced to Friend virus 28 days after inoculation is over an order of magnitude lower than in littermate controls




Genotype
MGI:3783840
cx15
Allelic
Composition
H2b/H2s
Tg(TcraTcrb)1100Mjb/?
Genetic
Background
involves: A/WySn * C57BL/6 * C57BL/10Sg * Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (25 available); any H2 mutation (263 available)
H2s mutation (4 available); any H2 mutation (263 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the thymus is smaller than normal
• the transgenic TCR is negatively selected on this genetic background based on the small number of CD8 T cells found in the periphery that express the transgenic TCR
• decreased number of CD8 T cells are found in both the thymus and in the periphery

hematopoietic system
• the thymus is smaller than normal
• the transgenic TCR is negatively selected on this genetic background based on the small number of CD8 T cells found in the periphery that express the transgenic TCR
• decreased number of CD8 T cells are found in both the thymus and in the periphery

endocrine/exocrine glands
• the thymus is smaller than normal




Genotype
MGI:3783839
cx16
Allelic
Composition
H2b/H2d
Tg(TcraTcrb)1100Mjb/?
Genetic
Background
involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (25 available); any H2 mutation (263 available)
H2d mutation (21 available); any H2 mutation (263 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the thymus is smaller than normal
• the transgenic TCR is negatively selected on this genetic background based on the small number of CD8 T cells found in the periphery that express the transgenic TCR
• decreased number of CD8 T cells are found in both the thymus and in the periphery

hematopoietic system
• the thymus is smaller than normal
• the transgenic TCR is negatively selected on this genetic background based on the small number of CD8 T cells found in the periphery that express the transgenic TCR
• decreased number of CD8 T cells are found in both the thymus and in the periphery

endocrine/exocrine glands
• the thymus is smaller than normal




Genotype
MGI:3809804
cx17
Allelic
Composition
Apobec3Gt(XN450)Byg/Apobec3Rfv3-s
H2b/H2d
Genetic
Background
involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apobec3Gt(XN450)Byg mutation (3 available); any Apobec3 mutation (124 available)
Apobec3Rfv3-s mutation (0 available); any Apobec3 mutation (124 available)
H2b mutation (25 available); any H2 mutation (263 available)
H2d mutation (21 available); any H2 mutation (263 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• less than 40% of mice survive viral infection when infected with 140 spleen focus forming units of Friend virus compared to 90% survival in littermate controls

immune system
• the levels of neutralizing antibody produced to Friend virus 28 days after inoculation is over an order of magnitude lower than in controls
• 16-week old mice mice infected with Friend virus have an order of magnitude more virus in their blood 8 days later than in littermate controls
• less than 40% of mice survive viral infection when infected with 140 spleen focus forming units of Friend virus compared to 90% survival in littermate controls

hematopoietic system
• the levels of neutralizing antibody produced to Friend virus 28 days after inoculation is over an order of magnitude lower than in controls




Genotype
MGI:3785747
cx18
Allelic
Composition
H2b/H2d
Tg(Ins2-E3)1Dvs/0
Genetic
Background
involves: BALB/c * C57BL/6 * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (25 available); any H2 mutation (263 available)
H2d mutation (21 available); any H2 mutation (263 available)
Tg(Ins2-E3)1Dvs mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• when transferred into BALB/c hosts, but not C57BL/6 hosts, pancreatic islets from H2 survive much longer than non-transgenic pancreatic islets




Genotype
MGI:4354597
cx19
Allelic
Composition
H2b/H2b
Itktm1Ljb/Itktm1Ljb
Tg(TcrAND)53Hed/?
Genetic
Background
involves: C3H/HeJ * C57BL/6 * C57BL/10
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (25 available); any H2 mutation (263 available)
Itktm1Ljb mutation (0 available); any Itk mutation (21 available)
Tg(TcrAND)53Hed mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• thymocytes take longer to undergo positive selection than wild-type thymocytes based on expression of CD69 and HSA
• expression of CD5, which is correlated with TCR signal strength, is also decreased
• there are almost no mature transgenic CD4 T cells in the periphery

hematopoietic system
• thymocytes take longer to undergo positive selection than wild-type thymocytes based on expression of CD69 and HSA
• expression of CD5, which is correlated with TCR signal strength, is also decreased
• there are almost no mature transgenic CD4 T cells in the periphery




Genotype
MGI:4354598
cx20
Allelic
Composition
H2b/H2k
Itktm1Ljb/Itktm1Ljb
Tg(TcrAND)53Hed/?
Genetic
Background
involves: C3H/HeJ * C57BL/6 * C57BL/10
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (25 available); any H2 mutation (263 available)
H2k mutation (17 available); any H2 mutation (263 available)
Itktm1Ljb mutation (0 available); any Itk mutation (21 available)
Tg(TcrAND)53Hed mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• thymocytes take longer to undergo positive selection than wild-type thymocytes based on expression of CD69 and HSA
• expression of CD5, which is correlated with TCR signal strength, is also decreased
• the development of transgenic CD4 T cells is reduced 2- to 3-fold in these mice

hematopoietic system
• thymocytes take longer to undergo positive selection than wild-type thymocytes based on expression of CD69 and HSA
• expression of CD5, which is correlated with TCR signal strength, is also decreased
• the development of transgenic CD4 T cells is reduced 2- to 3-fold in these mice




Genotype
MGI:3783836
cx21
Allelic
Composition
H2b/H2k
Tg(TcraTcrb)1100Mjb/?
Genetic
Background
involves: C57BL/6 * C57BL/10Sg * C57BR/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (25 available); any H2 mutation (263 available)
H2k mutation (17 available); any H2 mutation (263 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the thymus is smaller than normal
• the transgenic TCR is negatively selected on this genetic background based on the small number of CD8 T cells found in the periphery that express the transgenic TCR
• decreased number of CD8 T cells are found in both the thymus and in the periphery

hematopoietic system
• the thymus is smaller than normal
• the transgenic TCR is negatively selected on this genetic background based on the small number of CD8 T cells found in the periphery that express the transgenic TCR
• decreased number of CD8 T cells are found in both the thymus and in the periphery

endocrine/exocrine glands
• the thymus is smaller than normal




Genotype
MGI:3842820
cx22
Allelic
Composition
H2b/H2g7
Tg(TcraR28,TcrbR28)KRNDim/0
Genetic
Background
involves: C57BL/6 * NOD * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2b mutation (25 available); any H2 mutation (263 available)
H2g7 mutation (19 available); any H2 mutation (263 available)
Tg(TcraR28,TcrbR28)KRNDim mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• rheumatoid arthritis occurs with disease onset transpiring between 25 and 35 days of age
• arthritis occurrence is established by joint inspection and measure of ankle thickness, and histological confirmation in several mice

skeleton
• rheumatoid arthritis occurs with disease onset transpiring between 25 and 35 days of age
• arthritis occurrence is established by joint inspection and measure of ankle thickness, and histological confirmation in several mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
rheumatoid arthritis DOID:7148 OMIM:180300
J:36815




Genotype
MGI:3793704
cx23
Allelic
Composition
Airetm1.1Doi/Airetm1.1Doi
H2b/H2b
Genetic
Background
NOD.Cg-Airetm1.1Doi H2b/Doi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Airetm1.1Doi mutation (2 available); any Aire mutation (20 available)
H2b mutation (25 available); any H2 mutation (263 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• Background Sensitivity: stomach inflammation is present regardless of the alleles found at the H2 locus

digestive/alimentary system
• Background Sensitivity: stomach inflammation is present regardless of the alleles found at the H2 locus

endocrine/exocrine glands
• Background Sensitivity: the pancreatitis associated with the Aire allele on the NOD background is absent when the H2 allele is present at homozygocity





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last database update
04/11/2017
MGI 6.08
The Jackson Laboratory