Mouse Genome Informatics
hm1
    H2b/H2b
NOD.B10SnJ-H2b
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• no female mice homozygous for this haplotype develop diabetes after cyclophosphamide injections during 5-13 months of observation

endocrine/exocrine glands
• female mice display spontaneous perivascular and periductal lymphocytic infiltration by 7-10 months of age; mice between 6 and 11 months of age that are treated with cyclophospamide display perivascular and periductal infiltrates

immune system
• female mice display spontaneous perivascular and periductal lymphocytic infiltration by 7-10 months of age; mice between 6 and 11 months of age that are treated with cyclophospamide display perivascular and periductal infiltrates
• no female mice homozygous for the haplotype develop diabetes spontaneously during 5-13 months of observation


Mouse Genome Informatics
ht2
    H2b/H2d
(C57BL/6 x DBA/2)F1
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• after malarial infection, large populations of B220+CD3+ cells which are extrathymic T cells (CD3+) carrying a B cell marker (B220+) appear in the livers; this is not seen in the spleens of any mice after infection
• there is an increase of 40% of gamma,delta T cells in DBA/2 mice during infection; most of these are CD4-CD8-
• levels of Ifng and Il4 are lower than in B6 mice with malarial infection
• level of IgM autoantibody is increase to a greater extent than in B6 mice
• recovery from malaria is similar to DBA/2 mice, faster than in B6 mice

hematopoietic system
• after malarial infection, large populations of B220+CD3+ cells which are extrathymic T cells (CD3+) carrying a B cell marker (B220+) appear in the livers; this is not seen in the spleens of any mice after infection
• there is an increase of 40% of gamma,delta T cells in DBA/2 mice during infection; most of these are CD4-CD8-
• decrease in hematocrit is less than in infected C57BL/6 mice

liver/biliary system
• liver injury as estimated by GPT serum levels is lower than in infected B6 mice


Mouse Genome Informatics
ht3
    H2b/H2g7
NOD.B10SnJ-H2b
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• no females develop diabetes spontaneously over 5-7 months


Mouse Genome Informatics
cx4
    H2b/H2b
Ptcratm1Vbo/Ptcratm1Vbo

involves: 129P2/OlaHsd
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• thymocyte number is decreased by 10-fold compared to controls
• the percentage of DP thymocytes is severely reduced in the thymocytes
• spleen numbers are reduced by more than 4-fold

immune system
• thymocyte number is decreased by 10-fold compared to controls
• the percentage of DP thymocytes is severely reduced in the thymocytes
• spleen numbers are reduced by more than 4-fold

endocrine/exocrine glands
• thymocyte number is decreased by 10-fold compared to controls


Mouse Genome Informatics
cx5
    H2b/H2b
Tcratm1Mom/Tcra/Tcrdtm1.1(Tcra)Rsky
Tg(Tcrb)93Vbo/?

involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• thymocyte number is reduced by about half compared to controls
• 18% of lymph node T cells from female mice bearing H2-Db express the HY-alpha t cell receptor chain
• the majority of T cells in male mice are HYalpha+ CD4-CD8lo or HYalpha+ CD4-CD8-
• 5 of 29 thymocytes from H2-Db background mice not expressing the HY TCR show evidence of receptor editing though the small number of DP and SP thymocytes present suggests this process is inefficient
• thymocytes from male mice on a H2-Db background that express the HY receptor are CD69+ and undergoing apoptosis due to negative selection
• DN thymocytes of both sexes have premature expression of a T cell receptor (TCR)
• this TCR is specific for the male HY antigen and in many cases there is co-expression of CD25 and CD44
• the percentage of DN cells in the thymus is increased
• female mice on a H2-Db background have almost double the number of DP thymocytes compared to female mice carrying just the Tcrbeta transgene
• the majority of these DP thymocytes do not carry the HY TCR
• male mice on a H2-Db background have 4% the number of double positive thymocytes
• the percentage of DP thymocytes is decreased in these mice

hematopoietic system
• thymocyte number is reduced by about half compared to controls
• 18% of lymph node T cells from female mice bearing H2-Db express the HY-alpha t cell receptor chain
• the majority of T cells in male mice are HYalpha+ CD4-CD8lo or HYalpha+ CD4-CD8-
• 5 of 29 thymocytes from H2-Db background mice not expressing the HY TCR show evidence of receptor editing though the small number of DP and SP thymocytes present suggests this process is inefficient
• thymocytes from male mice on a H2-Db background that express the HY receptor are CD69+ and undergoing apoptosis due to negative selection
• DN thymocytes of both sexes have premature expression of a T cell receptor (TCR)
• this TCR is specific for the male HY antigen and in many cases there is co-expression of CD25 and CD44
• the percentage of DN cells in the thymus is increased
• female mice on a H2-Db background have almost double the number of DP thymocytes compared to female mice carrying just the Tcrbeta transgene
• the majority of these DP thymocytes do not carry the HY TCR
• male mice on a H2-Db background have 4% the number of double positive thymocytes
• the percentage of DP thymocytes is decreased in these mice

endocrine/exocrine glands
• thymocyte number is reduced by about half compared to controls


Mouse Genome Informatics
cx6
    Tcratm1Mom/Tcra/Tcrdtm1.1(Tcra)Rsky
H2b/H2b
Tg(Tcrb)93Vbo/?

involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• 18% of lymph node T cells from female mice bearing H2-Db express the HY-alpha t cell receptor chain
• the majority of T cells in male mice are HYalpha+ CD4-CD8lo or HYalpha+ CD4-CD8-
• 5 of 29 HY- thymocytes from H2-Db background mice have some receptor editing though the small number of DP and SP thymocytes present suggests this process is inefficient
• thymocytes from male mice on a H2-Db background that express the HY receptor are CD69+ and undergoing apoptosis due to negative selection
• DN thymocytes of both sexes have premature expression of a T cell receptor (TCR)
• this TCR is specific for the male HY antigen and in many cases there is co-expression of CD25 and CD44
• the percentage of DN cells in the thymus is increased
• female mice on a H2-Db background have almost double the number of DP thymocytes compared to female mice carrying just the Tcrbeta transgene
• the majority of these DP thymocytes do not carry the HY TCR
• male mice on a H2-Db background have 4% the number of double positive thymocytes

immune system
• 18% of lymph node T cells from female mice bearing H2-Db express the HY-alpha t cell receptor chain
• the majority of T cells in male mice are HYalpha+ CD4-CD8lo or HYalpha+ CD4-CD8-
• 5 of 29 HY- thymocytes from H2-Db background mice have some receptor editing though the small number of DP and SP thymocytes present suggests this process is inefficient
• thymocytes from male mice on a H2-Db background that express the HY receptor are CD69+ and undergoing apoptosis due to negative selection
• DN thymocytes of both sexes have premature expression of a T cell receptor (TCR)
• this TCR is specific for the male HY antigen and in many cases there is co-expression of CD25 and CD44
• the percentage of DN cells in the thymus is increased
• female mice on a H2-Db background have almost double the number of DP thymocytes compared to female mice carrying just the Tcrbeta transgene
• the majority of these DP thymocytes do not carry the HY TCR
• male mice on a H2-Db background have 4% the number of double positive thymocytes

endocrine/exocrine glands


Mouse Genome Informatics
cx7
    H2b/H2b
Tcra/Tcrdtm1.1(Tcra)Rsky/Tcra/Tcrdtm1.1(Tcra)Rsky
Tg(Tcrb)93Vbo/?

involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• male mice on a H2-Db background have no distinct double positive or double negative populations in their thymus
• almost all thymocytes in male mice on a H2-Db background undergo negative selection
• receptor editing is unable to rescue these thymocytes

hematopoietic system
• male mice on a H2-Db background have no distinct double positive or double negative populations in their thymus
• almost all thymocytes in male mice on a H2-Db background undergo negative selection
• receptor editing is unable to rescue these thymocytes


Mouse Genome Informatics
cx8
    H2b/H2b
Tcra/Tcrdtm1.1(Tcra)Rsky/Tcra/Tcrdtm1.1(Tcra)Rsky
Tg(Tcrb)93Vbo/?

involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• male mice on a H2-Db background have no distinct double positive or double negative populations in their thymus
• almost all thymocytes in male mice on a H2-Db background undergo negative selection
• receptor editing is unable to rescue these thymocytes

immune system
• male mice on a H2-Db background have no distinct double positive or double negative populations in their thymus
• almost all thymocytes in male mice on a H2-Db background undergo negative selection
• receptor editing is unable to rescue these thymocytes


Mouse Genome Informatics
cx9
    H2b/H2b
Ptcratm1Vbo/Ptcratm1Vbo
Tcratm1Mom/Tcra/Tcrdtm1.1(Tcra)Rsky
Tg(Tcrb)93Vbo/?

involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• thymocyte numbers are reduced by about 3-fold
• the presence of HY TCR alleviates the beta-selection block in Ptcratm1Vbo homozygotes with higher T cell numbers being found in the thymus and the spleen
• despite the increased numbers of thymocytes, the CD25+ thymocyte sub-population still remains very low

hematopoietic system
• thymocyte numbers are reduced by about 3-fold
• the presence of HY TCR alleviates the beta-selection block in Ptcratm1Vbo homozygotes with higher T cell numbers being found in the thymus and the spleen
• despite the increased numbers of thymocytes, the CD25+ thymocyte sub-population still remains very low

endocrine/exocrine glands
• thymocyte numbers are reduced by about 3-fold


Mouse Genome Informatics
cx10
    H2b/H2b
Ptcratm1Vbo/