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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Isl1tm1(cre)Tmj
targeted mutation 1, Thomas M Jessell
MGI:2447758
Summary 18 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Hand2tm1Dsr/Hand2tm2.1Dsr
Isl1tm1(cre)Tmj/Isl1+
involves: 129 * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 MGI:4940090
cn2
Isl1tm1(cre)Tmj/Isl1+
Mapttm1(Ewsr1/Etv4)Arbr/Mapt+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3716103
cn3
Nrg1tm1Cbm/Nrg1tm3Cbm
Isl1tm1(cre)Tmj/Isl1+
involves: 129P2/OlaHsd * 129X1/SvJ MGI:2653523
cn4
Maftm1.1Cbm/Maftm2.1Cbm
Isl1tm1(cre)Tmj/Isl1+
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * SJL MGI:5316895
cn5
Smotm2Amc/Smotm2Amc
Isl1tm1(cre)Tmj/Isl1+
involves: 129S/Sv * 129X1/SvJ MGI:5563905
cn6
Isl1tm1(cre)Tmj/Isl1+
Shc1tm9Paw/Shc1tm9Paw
involves: 129S1/Sv * 129X1/SvJ MGI:3717100
cn7
Isl1tm1(cre)Tmj/Isl1+
Shc1tm9Paw/Shc1tm9.1Paw
involves: 129S1/Sv * 129X1/SvJ MGI:3717101
cn8
Brsk2tm2.1Jrs/Brsk2tm2.1Jrs
Isl1tm1(cre)Tmj/Isl1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:5524148
cn9
Isl1tm1(cre)Tmj/Isl1+
Phox2btm3Jbr/Phox2btm3Jbr
involves: 129S2/SvPas * 129X1/SvJ MGI:4438214
cn10
Phox2btm3Jbr/Phox2btm3Jbr
Isl1tm1(cre)Tmj/Isl1+
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2 MGI:4418306
cn11
Hand2tm1Dsr/Hand2tm2.1Dsr
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Isl1tm1(cre)Tmj/Isl1+
involves: 129S4/SvJaeSor * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 MGI:4940091
cn12
Stk11tm1.1Rdp/Stk11tm1.1Rdp
Isl1tm1(cre)Tmj/Isl1+
involves: 129S6/SvEvTac * 129X1/SvJ MGI:5524150
cn13
Aldh1a2tm1Soc/Aldh1a2tm2Soc
Isl1tm1(cre)Tmj/Isl1+
involves: 129X1/SvJ MGI:3665269
cn14
Etv1tm1Wds/Etv1tm1.1Wds
Isl1tm1(cre)Tmj/Isl1+
involves: 129X1/SvJ MGI:3720888
cn15
Gt(ROSA)26Sortm1(RARA*)Soc/Gt(ROSA)26Sortm1(RARA*)Soc
Isl1tm1(cre)Tmj/Isl1+
involves: 129X1/SvJ MGI:3795699
cn16
Isl1tm1(cre)Tmj/Isl1+
Tg(SOD1*G37R)1Dwc/0
involves: 129X1/SvJ * C57BL/6 MGI:3629232
cn17
Nkx2-5tm1Krc/Nkx2-5tm1Krc
Isl1tm1(cre)Tmj/Isl1+
involves: 129X1/SvJ * C57BL/6 MGI:5643689
cn18
Rspo3tm1Arte/Rspo3tm1Arte
Isl1tm1(cre)Tmj/Isl1+
involves: 129X1/SvJ * C57BL/6 MGI:5643692


Genotype
MGI:4940090
cn1
Allelic
Composition
Hand2tm1Dsr/Hand2tm2.1Dsr
Isl1tm1(cre)Tmj/Isl1+
Genetic
Background
involves: 129 * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hand2tm1Dsr mutation (0 available); any Hand2 mutation (2 available)
Hand2tm2.1Dsr mutation (0 available); any Hand2 mutation (2 available)
Isl1tm1(cre)Tmj mutation (1 available); any Isl1 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system

cellular
• at E9.0, mice exhibit increased apoptosis in the pharyngeal mesoderm compared with wild-type mice




Genotype
MGI:3716103
cn2
Allelic
Composition
Isl1tm1(cre)Tmj/Isl1+
Mapttm1(Ewsr1/Etv4)Arbr/Mapt+
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1tm1(cre)Tmj mutation (1 available); any Isl1 mutation (14 available)
Mapttm1(Ewsr1/Etv4)Arbr mutation (0 available); any Mapt mutation (401 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice have 25% of the wild-type number of muscle spindles
• while sensory axons reach the skin only rudimentary sensory axon branching is established within the skin
• sensory afferents fail to invade the spinal cord and are found in an extreme lateral position at the dorsal root entry zone
• sensory afferents are bifurcated at the entry point
• sensory afferent fibers fail to approach the midline at the distal segments and continue to occupy an extreme lateral position
• unlike wild-type cells, dorsal root ganglia neurons survive in culture without the addition of neurotrophic agents
• whole dorsal root ganglia require neurotrophin-3 for survival

muscle
• mice have 25% of the wild-type number of muscle spindles




Genotype
MGI:2653523
cn3
Allelic
Composition
Nrg1tm1Cbm/Nrg1tm3Cbm
Isl1tm1(cre)Tmj/Isl1+
Genetic
Background
involves: 129P2/OlaHsd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1tm1(cre)Tmj mutation (1 available); any Isl1 mutation (14 available)
Nrg1tm1Cbm mutation (0 available); any Nrg1 mutation (14 available)
Nrg1tm3Cbm mutation (0 available); any Nrg1 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• mutants exhibit a defect in muscle spindle differentiation in the dorsal root ganglion and motor neurons

nervous system
• mutants exhibit a defect in muscle spindle differentiation in the dorsal root ganglion and motor neurons
• selective absence of Schwann cells at E16.5 in adductor and gracilis muscles but not in other muscles
• parvalbumin+ proprioceptive afferents are present in E16.5 hindlimb muscles and initiate contact with individual myofibers, but they do not develop annulospiral branches around the myofibers
• parvalbumin+ proprioceptive terminals at muscle spindles remain primitive and unbranched at E18.5
• however, survival and initial differentiation of proprioceptive afferent sensory neurons is not impaired




Genotype
MGI:5316895
cn4
Allelic
Composition
Maftm1.1Cbm/Maftm2.1Cbm
Isl1tm1(cre)Tmj/Isl1+
Genetic
Background
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1tm1(cre)Tmj mutation (1 available); any Isl1 mutation (14 available)
Maftm1.1Cbm mutation (0 available); any Maf mutation (12 available)
Maftm2.1Cbm mutation (0 available); any Maf mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• large diameter axons in the saphenous nerve become thinner
• many myelinated axons greater than 4 um are lost in the interosseous nerve
• reduced in number and rudimentary
• however, NF200+ axons innervating the dermal papillae are normal
• reduced in number with axonal loss
• remaining corpuscles are small and have irregularly shaped cores
• innervating Pacinian corpuscles
• following skin indentation, mice exhibit prolonged rapid adapting mechanoreceptor (RAM) firing that continues into the beginning of the static phase with increased RAM spiking over a wide range of displacement amplitudes and shortened spike intervals compared with control mice
• following skin indentation, mice exhibit decreased von Frey thresholds of short adapting mechanoreceptors compared with control mice
• mice treated with linopirdine fail to exhibit a decrease in interspike interval in the saphenous nerve unlike control mice
• however, mice exhibit normal short adapting mechanoreceptor, D-hair receptors and Adelta nociceptor firing following skin indentation
• in large diameter but not medium diameter fibers

integument
• the hair in the dorsal hindpaw is shorter than the hair in the back skin and resembles hair of the tail

growth/size/body
• mild in adults
• however, mice exhibit normal body weight at P15

behavior/neurological
• on a rotarod test




Genotype
MGI:5563905
cn5
Allelic
Composition
Smotm2Amc/Smotm2Amc
Isl1tm1(cre)Tmj/Isl1+
Genetic
Background
involves: 129S/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1tm1(cre)Tmj mutation (1 available); any Isl1 mutation (14 available)
Smotm2Amc mutation (1 available); any Smo mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• embryos show severe inflow tract defects with pulmonary vein atresia
• embryos show severe inflow tract defects with pulmonary vein atresia
• embryos show persistence of aortopulmonary collateral circulation




Genotype
MGI:3717100
cn6
Allelic
Composition
Isl1tm1(cre)Tmj/Isl1+
Shc1tm9Paw/Shc1tm9Paw
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1tm1(cre)Tmj mutation (1 available); any Isl1 mutation (14 available)
Shc1tm9Paw mutation (0 available); any Shc1 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mutants appear normal




Genotype
MGI:3717101
cn7
Allelic
Composition
Isl1tm1(cre)Tmj/Isl1+
Shc1tm9Paw/Shc1tm9.1Paw
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1tm1(cre)Tmj mutation (1 available); any Isl1 mutation (14 available)
Shc1tm9.1Paw mutation (0 available); any Shc1 mutation (54 available)
Shc1tm9Paw mutation (0 available); any Shc1 mutation (54 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mutants appear normal




Genotype
MGI:5524148
cn8
Allelic
Composition
Brsk2tm2.1Jrs/Brsk2tm2.1Jrs
Isl1tm1(cre)Tmj/Isl1+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brsk2tm2.1Jrs mutation (1 available); any Brsk2 mutation (13 available)
Isl1tm1(cre)Tmj mutation (1 available); any Isl1 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• few mice survive beyond 24 hours after birth

nervous system
N
• interneurons exhibit normal migration to proper positions Golgi tendon organs are normally innervated
• reduced outgrowths from type Ia proprioceptive sensory neuron in dorsal root ganglia explants in the presence of NT-3 or NGF
• type Ia proprioceptive sensory neuron projections are disrupted and exhibit arrest at E15.5 as they reach the brainstem or ventral spinal cord in the medial spinal cord adjacent to the central canal and entire rostral-caudal extent of the spinal cord that persists through fetal development until P8 compared to in control mice
• type Ia proprioceptive sensory neuron projections fail to form terminal arbors
• mice exhibit defects in a second population of sensory neurons with few axons of the T12 dorsal root ganglion that cross the midline and only rare occurrences of axons that reach the proper contralateral target compared with control mice
• whisker axons have sparse arbors that fail to reach the correct target region in the bed nucleus of the stria terminalis (BSTC) without extensive branching
• however, mice exhibit normal growth of the sensory axons in the spinal cord and neuron targeting of nociceptive sensory axons in laminae I/IIi/IIo
• however, mice exhibit normal Pv+ proprioceptive axons growth into fore and hind limb muscles, trunk sensory axons form normal disc shaped endings on Merkel cells in the epidermis and axons in the deep vibrissal nerve that innervate whisker follicles
• type Ia proprioceptive sensory neuron projections are disrupted and exhibit arrest at E15.5 as they reach the brainstem or ventral spinal cord in the medial spinal cord adjacent to the central canal and entire rostral-caudal extent of the spinal cord that persists through fetal development until P8 compared to in control mice
• type Ia proprioceptive sensory neuron projections fail to form terminal arbors
• fewer proprioceptor axons in the cuneate nucleus, but not the cuneate fascicle
• however, growth of the sensory axons in the spinal cord is normal

behavior/neurological
• little milk in stomachs
• hypokinetic

cellular
• reduced outgrowths from type Ia proprioceptive sensory neuron in dorsal root ganglia explants in the presence of NT-3 or NGF




Genotype
MGI:4438214
cn9
Allelic
Composition
Isl1tm1(cre)Tmj/Isl1+
Phox2btm3Jbr/Phox2btm3Jbr
Genetic
Background
involves: 129S2/SvPas * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1tm1(cre)Tmj mutation (1 available); any Isl1 mutation (14 available)
Phox2btm3Jbr mutation (0 available); any Phox2b mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• fails to form, on six sides out of eight, in four embryos
• missing, on five sides out of six, in three embryos




Genotype
MGI:4418306
cn10
Allelic
Composition
Phox2btm3Jbr/Phox2btm3Jbr
Isl1tm1(cre)Tmj/Isl1+
Genetic
Background
involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1tm1(cre)Tmj mutation (1 available); any Isl1 mutation (14 available)
Phox2btm3Jbr mutation (0 available); any Phox2b mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 1 week after birth, few mice are still alive

nervous system
• mice exhibit abnormal development of facial neuron precursors that do not migrate into r6 unlike in wild-type mice
• mice exhibit impaired development of retrotapezoid nucleus neurons compared with wild-type mice
• the parafacial area e-pF oscillator exhibits only occasional motor activity bursts with reduced frequency compared to in wild-type mice
• rhythmic phrenic discharges are less frequent than in wild-type mice
• mice fail to exhibit an accelerated respiratory-like rhythm phrenic discharge in response to low pH challenge unlike similarly treated wild-type mice

growth/size/body
• surviving mice are smaller than wild-type mice

cellular
• mice exhibit abnormal development of facial neuron precursors that do not migrate into r6 unlike in wild-type mice
• mice exhibit impaired development of retrotapezoid nucleus neurons compared with wild-type mice




Genotype
MGI:4940091
cn11
Allelic
Composition
Hand2tm1Dsr/Hand2tm2.1Dsr
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Isl1tm1(cre)Tmj/Isl1+
Genetic
Background
involves: 129S4/SvJaeSor * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (310 available)
Hand2tm1Dsr mutation (0 available); any Hand2 mutation (2 available)
Hand2tm2.1Dsr mutation (0 available); any Hand2 mutation (2 available)
Isl1tm1(cre)Tmj mutation (1 available); any Isl1 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• at E9.5, mice exhibit fewer progenitor cells migration into the outflow tract compared with control mice




Genotype
MGI:5524150
cn12
Allelic
Composition
Stk11tm1.1Rdp/Stk11tm1.1Rdp
Isl1tm1(cre)Tmj/Isl1+
Genetic
Background
involves: 129S6/SvEvTac * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1tm1(cre)Tmj mutation (1 available); any Isl1 mutation (14 available)
Stk11tm1.1Rdp mutation (0 available); any Stk11 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• massive gastrointestinal tumors

mortality/aging
• mice are euthanized at 4 to 6 weeks due to massive gastrointestinal tumors
• however, mice survive to birth and postnatally

nervous system
N
• axon bundles are normal in the brainstem trigeminal complex, ascending tracts in the spinal cord (spinocerebellar, spinothalamic and dorsal funiculus), the optic nerve and motor and sensory nerves in the periphery
• mice exhibit normal type Ia proprioceptive sensory neuron projections to the ventral horn
• mice exhibit no sensory or motor deficit
• axons tracts in the cortical intermediate zone are reduced compared to in control mice
• thin-walled

neoplasm
• massive gastrointestinal tumors

behavior/neurological
N
• mice exhibit no sensory or motor deficit




Genotype
MGI:3665269
cn13
Allelic
Composition
Aldh1a2tm1Soc/Aldh1a2tm2Soc
Isl1tm1(cre)Tmj/Isl1+
Genetic
Background
involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aldh1a2tm1Soc mutation (0 available); any Aldh1a2 mutation (16 available)
Aldh1a2tm2Soc mutation (1 available); any Aldh1a2 mutation (16 available)
Isl1tm1(cre)Tmj mutation (1 available); any Isl1 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at E13.5 both ventral and dorsal projecting lateral motor column neurons appear stunted or atrophied and in some cases are retracted
• at E13.5 at the forelimb level the number of lateral motor column medial and lateral motor neurons are reduced by about 30% and 25%, respectively; however no difference in the number of lateral motor column lateral motor neurons is detected at E12.5
• at E13.5 at the hindlimb level the number of lateral motor column medial and lateral motor neurons are reduced by about 17% and 20%, respectively




Genotype
MGI:3720888
cn14
Allelic
Composition
Etv1tm1Wds/Etv1tm1.1Wds
Isl1tm1(cre)Tmj/Isl1+
Genetic
Background
involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv1tm1.1Wds mutation (0 available); any Etv1 mutation (18 available)
Etv1tm1Wds mutation (0 available); any Etv1 mutation (18 available)
Isl1tm1(cre)Tmj mutation (1 available); any Isl1 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• proprioceptive afferents terminate prematurely in the intrmediate zone of the spinal cord




Genotype
MGI:3795699
cn15
Allelic
Composition
Gt(ROSA)26Sortm1(RARA*)Soc/Gt(ROSA)26Sortm1(RARA*)Soc
Isl1tm1(cre)Tmj/Isl1+
Genetic
Background
involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(RARA*)Soc mutation (0 available); any Gt(ROSA)26Sor mutation (310 available)
Isl1tm1(cre)Tmj mutation (1 available); any Isl1 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice exhibit a 35% decrease in Lim1+/Islet2+ motor neurons compared to wild-type mice




Genotype
MGI:3629232
cn16
Allelic
Composition
Isl1tm1(cre)Tmj/Isl1+
Tg(SOD1*G37R)1Dwc/0
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1tm1(cre)Tmj mutation (1 available); any Isl1 mutation (14 available)
Tg(SOD1*G37R)1Dwc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• overall survival is extended 64 days

nervous system
• in transgenic mice expressing a motorneuron specific Cre, disease onset is delayed 18 days
• progression from onset through early disease is delayed 31 days
• later disease progression is slowed with an average extension of 15 days

Mouse Models of Human Disease
OMIM ID Ref(s)
Amyotrophic Lateral Sclerosis 1; ALS1 105400 J:109131




Genotype
MGI:5643689
cn17
Allelic
Composition
Nkx2-5tm1Krc/Nkx2-5tm1Krc
Isl1tm1(cre)Tmj/Isl1+
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1tm1(cre)Tmj mutation (1 available); any Isl1 mutation (14 available)
Nkx2-5tm1Krc mutation (0 available); any Nkx2-5 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• cyanosis and death within a few hours of birth; perinatal lethality is due to outflow tract septation defects

cardiovascular system
• foreshortened outflow tract
• complete penetrance of outflow tract defects
• the proximal outflow tract shows defective endocardial networks, while the neural crest-derived distal outflow tract endocardial cushions appear normal
• smaller developing endocardial cushions in the proximal outflow tract
• the outflow tract cushions show a reduction in the relative proliferation rate in embryos
• 92% of mutants exhibit a single outflow tract arising from the right ventricle
• only a small number of embryos show double outlet right ventricle
• the trabecular myocardium, but not the compact myocardium, shows a reduction in the relative proliferation rate in embryos
• reduction of trabecular networks in the right ventricle, whereas the left ventricle is normal
• decrease in the relative proliferative rate of the second heart field is evident as early as E10, resulting in hypoplastic right ventricle at E12.5

homeostasis/metabolism

muscle
• the trabecular myocardium, but not the compact myocardium, shows a reduction in the relative proliferation rate in embryos




Genotype
MGI:5643692
cn18
Allelic
Composition
Rspo3tm1Arte/Rspo3tm1Arte
Isl1tm1(cre)Tmj/Isl1+
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1tm1(cre)Tmj mutation (1 available); any Isl1 mutation (14 available)
Rspo3tm1Arte mutation (0 available); any Rspo3 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• late gestational lethality at E14.5-E16.5 in most mice due to cardiovascular failure

cardiovascular system
• all mice exhibit small right ventricle and/or double outlet right ventricle
• all mice exhibit small right ventricle and/or double outlet right ventricle

homeostasis/metabolism





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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory