Mouse Genome Informatics
hm1
    Tcra-Jtm1Tgi/Tcra-Jtm1Tgi
B6.129-Tcra-Jtm1Tgi
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• the numbers of CD69+ (a marker for activation) B cells in the spleen are reduced (4.1+/-0.5 compared to 5.1+/-0.7 in wild-type mice)
• the numbers of CD69+ (a marker for activation) T cells in the spleen are reduced (9.9+/-1.8 compared to 16.0+/-3.4 in wild-type mice)
• anti OVA IgE levels are about one-eighth of control levels after challenge
• levels of anti CII IgG antibodies are reduced compared to in wild-type mice
• 24 hours after OVA challenge
• following induction of arthritis with collagen (CIA) the incidence (40%) and arthritis score (1.5+/-2.2) is reduced compared to wild-type mice (90% incidence with a score of 5.4+/-3.2)
• marked infiltration of neutrophiles at 24 hours after cauterization
• no further neutrophil or macrophage increases to 96 hours
• increased edema at 96 hours after cauterization
• after BDL, necroinflammatory foci and lymphocytic infiltration are obviously less than in controls
• 42% fewer cells in bronchoalveolar lavage fluid compared to controls after OVA sensitization and challenge
• eosinophiles reduced by 58%
• reduced macrophage and neutrophiles
• normal lymphocyte recruitment
• IL-4 and IL-5 also reduced in bronchoalveolar lavage fluid 24 hours after challenge

homeostasis/metabolism
• 24 hours after OVA challenge
• one day following bile duct ligation (BDL), serum ALT levels are significantly lower than controls

liver/biliary system
• hepatocyte cell death is reduced compared to controls after BDL
• after BDL, necroinflammatory foci and lymphocytic infiltration are obviously less than in controls
• confluent foci of feathery hepatocyte degeneration due to bile acid cytotoxicity are significantly reduced compared to controls 24 hours after BDL
• necroinflammatory foci after BDL are reduced in number compared to controls

hematopoietic system
• the numbers of CD69+ (a marker for activation) B cells in the spleen are reduced (4.1+/-0.5 compared to 5.1+/-0.7 in wild-type mice)
• the numbers of CD69+ (a marker for activation) T cells in the spleen are reduced (9.9+/-1.8 compared to 16.0+/-3.4 in wild-type mice)
• anti OVA IgE levels are about one-eighth of control levels after challenge
• levels of anti CII IgG antibodies are reduced compared to in wild-type mice

skeleton
• following induction of arthritis with collagen (CIA) the incidence (40%) and arthritis score (1.5+/-2.2) is reduced compared to wild-type mice (90% incidence with a score of 5.4+/-3.2)

cardiovascular system
• area of choroidal neovascularization stimulated by photocoagulation is significantly reduced

vision/eye
• area of choroidal neovascularization stimulated by photocoagulation is significantly reduced
• cauterized area of cornea becomes thickened
• marked infiltration of neutrophiles at 24 hours after cauterization
• no further neutrophil or macrophage increases to 96 hours
• increased edema at 96 hours after cauterization
• increased opacity relative to controls 24 hours after corneal cauterization
• opacity increases further by 96 hours

reproductive system
• alpha-galactosylceramide induced abortion does not occur (J:59892)

respiratory system
• 42% fewer cells in bronchoalveolar lavage fluid compared to controls after OVA sensitization and challenge
• eosinophiles reduced by 58%
• reduced macrophage and neutrophiles
• normal lymphocyte recruitment
• IL-4 and IL-5 also reduced in bronchoalveolar lavage fluid 24 hours after challenge
• less airway hypersensitive response develops after OVA sensitization and challenge

cellular
• hepatocyte cell death is reduced compared to controls after BDL


Mouse Genome Informatics
hm2
    Tcra-Jtm1Tgi/Tcra-Jtm1Tgi
C.129-Tcra-Jtm1Tgi
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype

Il17rbtm1Hwata/Il17rbtm1Hwata and Tcra-Jtm1Tgi/Tcra-Jtm1Tgi mice fail to exhibit airway hyperactivity in response to respiratory syncytial virus exposure

immune system
• the bronchoalveolar lavage fluid from mice exposed to respiratory syncytial virus fail to exhibit an increase in IL5, IL9, IL10, IL13, IL17A and IL22 unlike wild-type mice
• the bronchoalveolar lavage fluid from mice exposed to respiratory syncytial virus
• the bronchoalveolar lavage fluid from mice exposed to respiratory syncytial virus
• the bronchoalveolar lavage fluid from mice exposed to respiratory syncytial virus
• the bronchoalveolar lavage fluid from mice exposed to respiratory syncytial virus

respiratory system
• in response to respiratory syncytial virus exposure, mice fail to exhibit airway hyperreactivity unlike wild-type mice
• however, the response could be restored by transfer of wild-type invariant NK T cells


Mouse Genome Informatics
hm3
    Tcra-Jtm1Tgi/Tcra-Jtm1Tgi
involves: 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
cardiovascular system
N
• mice exhibit normal arteriogenesis following occlusion (J:134875)

immune system
• IFN gamma is not induced by LPS administration in Propionibacterium acnes primed mice
• decreased production by CD4 T-cells after exposure to heat killed Propionibacterium acnes
• expression data indicates absence of liver damage in response to LPS administration in Propionibacterium acnes primed

homeostasis/metabolism
• IFN gamma is not induced by LPS administration in Propionibacterium acnes primed mice


Mouse Genome Informatics
hm4
    Tcra-Jtm1Tgi/Tcra-Jtm1Tgi
involves: 129S1/Sv * 129X1/SvJ * BALB/c
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
respiratory system
• hyper-reactivity does not develop in response to OVA challenge

immune system
• substantial reduction in airway eosinophilia in response to OVA challenge
• decreased OVA specific IgE in serum of OVA challenged mice
• less IL-13 found in bronchial lymph nodes of OVA challenged mice
• less IL-4 found in bronchial lymph nodes of OVA challenged mice
• resistant to the IL-12 induced increase in mononuclear cells after partial hepatectomy seen in controls

liver/biliary system
• resistant to the IL-12 induced increase in mononuclear cells after partial hepatectomy seen in controls
• IL-12 fails to cause any liver damage beyond that caused by partial hepatectomy

hematopoietic system
• substantial reduction in airway eosinophilia in response to OVA challenge
• decreased OVA specific IgE in serum of OVA challenged mice


Mouse Genome Informatics
hm5
    Tcra-Jtm1Tgi/Tcra-Jtm1Tgi
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• alpha-galactosylceramide has no protective effect against bleomycin induced mortality
• 65% die by the 28th day

respiratory system
• develops after bleomycin administration in mice treated with alpha-galactosylceramide just as in controls
• initial development of pulmonary inflammation develops after bleomycin administration in mice treated with alpha-galactosylceramide just as in controls

hematopoietic system
• no NKT cells are found in the lungs after bleomycin administration

liver/biliary system
• considerably less liver damage induced by concanavalin A injection than in controls
• as measured by alanine transaminase levels
• reduced concanavalin A induced histological damage

homeostasis/metabolism
• alpha-galactosylceramide has no protective effect against bleomycin induced mortality
• 65% die by the 28th day
• considerably less liver damage induced by concanavalin A injection than in controls
• as measured by alanine transaminase levels
• reduced concanavalin A induced histological damage
• develops after bleomycin administration in mice treated with alpha-galactosylceramide just as in controls

immune system
• no NKT cells are found in the lungs after bleomycin administration
• initial development of pulmonary inflammation develops after bleomycin administration in mice treated with alpha-galactosylceramide just as in controls


Mouse Genome Informatics
cx6
    Ldlrtm1Her/Ldlrtm1Her
Tcra-Jtm1Tgi/Tcra-Jtm1Tgi

B6.129-Ldlrtm1Her Tcra-Jtm1Tgi
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
cardiovascular system
• lesions in the ascending aorta are reduced 20% in males and 28% in females relative to homozygous Ldlrtm1Her
• considerable reduction of lipid containing areas in the lesions
• less IFN-gamma in the lesions

immune system
• less IFN-gamma in atherosclerotic lesions


Mouse Genome Informatics
cx7
    Tcra-Jtm1Tgi/Tcra-Jtm1Tgi
Tg(Pklr-Myc)73Ak/0

B6.Cg-Tcra-Jtm1Tgi Tg(Pklr-Myc)73Ak
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
tumorigenesis
• 40% of double mutants exhibit lung metastasis which is not seen in single Tg(Pklr-Myc)73Ak mice
• tumors have higher grades of malignancy and are less differentiated than those of single Tg(Pklr-Myc)73Ak mice
• mutants develop hepatocellular carcinoma (HCC); stronger promotion of initiation and progression steps of HCC development compared to single Tg(Pklr-Myc)73Ak mice
• the number and size of tumor nodules in double mutants is greater than in single Tg(Pklr-Myc)73Ak mice
• some tumors in double mutants exhibit a very poorly differentiated phenotype (fetal-like phenotype) that is never seen in tumors of single Tg(Pklr-Myc)73Ak mice
• tumors have higher mitotic indices compared with tumors from single Tg(Pklr-Myc)73Ak mice

Mouse Models of Human Disease
OMIM IDRef(s)
Hepatocellular Carcinoma 114550 J:184496


Mouse Genome Informatics
cx8
    Sh2d1atm1Cpt/Sh2d1atm1Cpt
Tcra-Jtm1Tgi/Tcra-Jtm1Tgi

involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• following immunization with NP-KLH (J:189126)
• of NP-specific IgG following immunization with NP-KLH that is more severe than in Sh2d1atm1Cpt homozygotes on a similar background (J:189126)

hematopoietic system
• following immunization with NP-KLH (J:189126)
• of NP-specific IgG following immunization with NP-KLH that is more severe than in Sh2d1atm1Cpt homozygotes on a similar background (J:189126)


Mouse Genome Informatics
cx9
    Sh2d1atm1Cpt/Y
Tcra-Jtm1Tgi/Tcra-Jtm1Tgi

involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
hematopoietic system
• following immunization with NP-KLH (J:189126)
• of NP-specific IgG following immunization with NP-KLH that is more severe than in Sh2d1atm1Cpt homozygotes on a similar background (J:189126)

immune system
• following immunization with NP-KLH (J:189126)
• of NP-specific IgG following immunization with NP-KLH that is more severe than in Sh2d1atm1Cpt homozygotes on a similar background (J:189126)