All Phenotypes Akt2<tm1.1Mbb> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Akt2^tm1.1Mbb
targeted mutation 1.1, Morris J Birnbaum
MGI:2158456

Summary

11 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Akt2^tm1.1Mbb/Akt2^tm1.1Mbb	B6.129P2-Akt2^tm1.1Mbb	MGI:4889116
hm2	Akt2^tm1.1Mbb/Akt2^tm1.1Mbb	involves: 129P2/OlaHsd	MGI:3803967
hm3	Akt2^tm1.1Mbb/Akt2^tm1.1Mbb	involves: 129P2/OlaHsd * C57BL/6	MGI:3629188
cn4	Akt1^tm1Pnt/Akt1^tm1Pnt Akt2^tm1.1Mbb/Akt2^tm1.1Mbb Tg(Lck-cre)1Cwi/0	involves: 129P2/OlaHsd	MGI:3803971
cn5	Akt1^tm1Pnt/Akt1^tm1Pnt Akt2^tm1.1Mbb/Akt2^tm1.1Mbb Akt3^tm1Mbb/Akt3^tm1Mbb Tg(Lck-cre)1Cwi/0	involves: 129P2/OlaHsd	MGI:3803972
cn6	Akt2^tm1.1Mbb/Akt2^tm1.1Mbb Pten^tm1Hwu/Pten^tm1Hwu Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA	MGI:4838529
cx7	Akt2^tm1.1Mbb/Akt2⁺ Lep^ob/Lep^ob	B6.Cg-Lep^ob Akt2^tm1.1Mbb	MGI:4889118
cx8	Akt2^tm1.1Mbb/Akt2^tm1.1Mbb Lep^ob/Lep^ob	B6.Cg-Lep^ob Akt2^tm1.1Mbb	MGI:4889117
cx9	Akt2^tm1.1Mbb/Akt2^tm1.1Mbb Tg(MMTV-Erbb2)NK1Mul/Tg(MMTV-Erbb2)NK1Mul	involves: 129 * C57BL/6 * FVB/N	MGI:3804004
cx10	Akt2^tm1.1Mbb/Akt2^tm1.1Mbb Tg(MMTV-PyVT)634Mul/0	involves: 129 * C57BL/6 * FVB/N	MGI:3804011
cx11	Akt2^tm1.1Mbb/Akt2^tm1.1Mbb Akt3^tm1Mbb/Akt3^tm1Mbb	involves: 129P2/OlaHsd	MGI:3803968

Allelic Composition	Akt2^tm1.1Mbb/Akt2^tm1.1Mbb
Genetic Background	B6.129P2-Akt2^tm1.1Mbb

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt2^tm1.1Mbb mutation (2 available); any Akt2 mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:155432 )

• at 4 months when Surwit fed a high-fat diet

decreased circulating glucose level ( J:155432 )

• in fasted mice Surwit fed a high-fat diet

increased circulating insulin level ( J:155432 )

• in fasted mice Surwit fed a high-fat diet

decreased liver triglyceride level ( J:155432 )

• at 4 months when Surwit fed a high-fat diet

growth/size/body

decreased susceptibility to diet-induced obesity ( J:155432 )

• at 4 months when Surwit fed a high-fat diet

liver/biliary system

decreased liver triglyceride level ( J:155432 )

• at 4 months when Surwit fed a high-fat diet

Allelic Composition	Akt2^tm1.1Mbb/Akt2^tm1.1Mbb
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt2^tm1.1Mbb mutation (2 available); any Akt2 mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:135903 )

N	• no abnormalities in T cell development are observed

homeostasis/metabolism

hyperglycemia ( J:160759 )

• about 25-30% increase in fasting glucose levels at 1 month of age

impaired glucose tolerance ( J:160759 )

• glucose intolerance

decreased liver triglyceride level ( J:160759 )

• 2-fold decrease in liver triglyceride levels

liver/biliary system

decreased liver triglyceride level ( J:160759 )

• 2-fold decrease in liver triglyceride levels

Allelic Composition	Akt2^tm1.1Mbb/Akt2^tm1.1Mbb
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt2^tm1.1Mbb mutation (2 available); any Akt2 mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

hyperglycemia ( J:71491 )

• homozygotes develop into adulthood without apparent growth defects but exhibit a mild but significant fasting hyperglycemia, which is more pronounced during fed states

increased circulating insulin level ( J:71491 )

• homozygotes develop inadequate compensatory hyperinsulinemia

impaired glucose tolerance ( J:71491 )

• in response to oral glucose load, 2-mo-old homozygotes display a mild glucose intolerance, with increased blood glucose levels at all time points measured

insulin resistance ( J:71491 )

• in response to i.p. administration of insulin, homozygotes display significantly elevated blood glucose levels relative to wild-type mice at all time points measured (at 60 min; 70.8 7.9 mg/dl vs 22.3 1.1 mg/dl, respectively)

• in euglycemic-hyperinsulinemic clamp expts, homozygotes exhibit peripheral insulin resistance along with complete failure of insulin to suppress hepatic glucose output

• however, circulating free fatty acid concentrations remain normal

muscle

decreased muscle cell glucose uptake ( J:71491 )

• insulin-stimulated hexose uptake into the glycolytic extensor digitorum longus (EDL) muscle is severely blunted in the presence of 0.33 nM insulin; however, no impairment is noted upon exposure of the mutant EDL to a higher insulin concentration (13.3 nM)

• insulin-stimulated deoxyglucose uptake into the oxidative soleus muscle is not significantly impaired at either an intermediate or maximal concentration of insulin

endocrine/exocrine glands

increased pancreatic islet number ( J:71491 )

• pancreata from 2- to 3-month-old male homozygotes respond to insulin resistance with an increase in islet mass (~4-fold) and number (~2-fold) relative to wild-type mice

adipose tissue

decreased adipocyte glucose uptake ( J:71491 )

• in euglycemic-hyperinsulinemic clamp studies, insulin-stimulated hexose uptake is mildly impaired in mutant adipocytes

cellular

decreased adipocyte glucose uptake ( J:71491 )

• in euglycemic-hyperinsulinemic clamp studies, insulin-stimulated hexose uptake is mildly impaired in mutant adipocytes

decreased muscle cell glucose uptake ( J:71491 )

• insulin-stimulated deoxyglucose uptake into the oxidative soleus muscle is not significantly impaired at either an intermediate or maximal concentration of insulin

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 2 diabetes mellitus		DOID:9352	OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036	J:71491

Allelic Composition	Akt1^tm1Pnt/Akt1^tm1Pnt Akt2^tm1.1Mbb/Akt2^tm1.1Mbb Tg(Lck-cre)1Cwi/0
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt1^tm1Pnt mutation (0 available); any Akt1 mutation (34 available)
Akt2^tm1.1Mbb mutation (2 available); any Akt2 mutation (51 available)
Tg(Lck-cre)1Cwi mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased T cell apoptosis ( J:135903 )

• an increased percentage of double positive thymocytes are apoptotic (15.9% compared to 2.6%)

thymus hypoplasia ( J:135903 )

• thymus cellularity is reduced by about 15-fold

increased double-negative T cell number ( J:135903 )

• the percentage of double negative T cells in the thymus is 56.2% compared to 2.7% in wild-type mice

• there is a significant reduction in proliferating DN4 cells suggesting a partial development block in transitioning to the DP stage

decreased double-positive T cell number ( J:135903 )

• the percentage of double positive T cells in the thymus is reduced to 25% compared to 84.6% in wild-type mice

• the actual number of DP T cells is 50-fold less than is found in wild-type thymuses

arrested T cell differentiation ( J:135903 )

• developing thymocytes are partially blocked at the DN3 to DN4 stage and the DN4 to the DP stage

hematopoietic system

increased T cell apoptosis ( J:135903 )

• an increased percentage of double positive thymocytes are apoptotic (15.9% compared to 2.6%)

thymus hypoplasia ( J:135903 )

• thymus cellularity is reduced by about 15-fold

increased double-negative T cell number ( J:135903 )

• the percentage of double negative T cells in the thymus is 56.2% compared to 2.7% in wild-type mice

• there is a significant reduction in proliferating DN4 cells suggesting a partial development block in transitioning to the DP stage

decreased double-positive T cell number ( J:135903 )

• the percentage of double positive T cells in the thymus is reduced to 25% compared to 84.6% in wild-type mice

• the actual number of DP T cells is 50-fold less than is found in wild-type thymuses

arrested T cell differentiation ( J:135903 )

• developing thymocytes are partially blocked at the DN3 to DN4 stage and the DN4 to the DP stage

cellular

increased T cell apoptosis ( J:135903 )

• an increased percentage of double positive thymocytes are apoptotic (15.9% compared to 2.6%)

endocrine/exocrine glands

thymus hypoplasia ( J:135903 )

• thymus cellularity is reduced by about 15-fold

Allelic Composition	Akt1^tm1Pnt/Akt1^tm1Pnt Akt2^tm1.1Mbb/Akt2^tm1.1Mbb Akt3^tm1Mbb/Akt3^tm1Mbb Tg(Lck-cre)1Cwi/0
Genetic Background	involves: 129P2/OlaHsd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased T cell apoptosis ( J:135903 )

• double negative thymocytes of all stages have higher rates of apoptosis

thymus hypoplasia ( J:135903 )

• thymus cellularity is reduced by about 20-fold

increased double-negative T cell number ( J:135903 )

• the percentage of double negative T cells in the thymus is 85.4% compared to 2.7% in wild-type mice

• there is a significant reduction in proliferating DN4 cells suggesting a partial development block in transitioning to the DP stage

decreased double-positive T cell number ( J:135903 )

• the percentage of double positive T cells in the thymus is reduced to 1.8% compared to 84.6% in wild-type mice

• the actual number of DP T cells is 50-fold less than is found in wild-type thymuses

arrested T cell differentiation ( J:135903 )

• developing thymocytes are almost completely blocked at the DN4 to DP transition

immune system

increased T cell apoptosis ( J:135903 )

• double negative thymocytes of all stages have higher rates of apoptosis

thymus hypoplasia ( J:135903 )

• thymus cellularity is reduced by about 20-fold

increased double-negative T cell number ( J:135903 )

• the percentage of double negative T cells in the thymus is 85.4% compared to 2.7% in wild-type mice

• there is a significant reduction in proliferating DN4 cells suggesting a partial development block in transitioning to the DP stage

decreased double-positive T cell number ( J:135903 )

• the percentage of double positive T cells in the thymus is reduced to 1.8% compared to 84.6% in wild-type mice

• the actual number of DP T cells is 50-fold less than is found in wild-type thymuses

arrested T cell differentiation ( J:135903 )

• developing thymocytes are almost completely blocked at the DN4 to DP transition

cellular

increased T cell apoptosis ( J:135903 )

• double negative thymocytes of all stages have higher rates of apoptosis

endocrine/exocrine glands

thymus hypoplasia ( J:135903 )

• thymus cellularity is reduced by about 20-fold

Allelic Composition	Akt2^tm1.1Mbb/Akt2^tm1.1Mbb Pten^tm1Hwu/Pten^tm1Hwu Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt2^tm1.1Mbb mutation (2 available); any Akt2 mutation (51 available)
Pten^tm1Hwu mutation (16 available); any Pten mutation (81 available)
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

hyperglycemia ( J:160759 )

• about 25-30% increase in fasting glucose levels at 1 month of age

impaired glucose tolerance ( J:160759 )

• glucose intolerance

liver/biliary system

liver/biliary system phenotype ( J:160759 )

N	• the liver phenotype observed in single Pten mutants is significantly reduced, with liver weights, triglyceride levels in the liver and fatty liver almost similar to controls

abnormal liver morphology ( J:218587 )

• progenitor cell accumulation in the periductal region of livers occurs later than in single conditional Pten homozygotes, when injury conditions are already present

decreased susceptibility to hepatic steatosis ( J:218587 )

• mice do not show development of steatosis compared to single conditional Pten homozygotes

neoplasm

increased tumor latency ( J:218587 )

• mice exhibit a 6-month delay in liver tumor onset compared to conditional Pten homozygotes

• no mice develop liver tumors between 9 and 12 months of age and 25% of mice older than 12 months develop liver nodules

• however, treatment of 3 month old mice with 3,5-dietoxycarbonyl-1,4 dihydrocollidine (DDC) to induce liver injury leads to massive expansion of hepatic progenitors and development of premalignant lesions

Allelic Composition	Akt2^tm1.1Mbb/Akt2⁺ Lep^ob/Lep^ob
Genetic Background	B6.Cg-Lep^ob Akt2^tm1.1Mbb

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt2^tm1.1Mbb mutation (2 available); any Akt2 mutation (51 available)
Lep^ob mutation (5 available); any Lep mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:155432 )

• compared with Lep^ob homozygotes

homeostasis/metabolism

decreased liver triglyceride level ( J:155432 )

• compared with Lep^ob homozygotes

liver/biliary system

decreased liver triglyceride level ( J:155432 )

• compared with Lep^ob homozygotes

decreased liver weight ( J:155432 )

• compared with Lep^ob homozygotes

Allelic Composition	Akt2^tm1.1Mbb/Akt2^tm1.1Mbb Lep^ob/Lep^ob
Genetic Background	B6.Cg-Lep^ob Akt2^tm1.1Mbb

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating glucose level ( J:155432 )

• in fasted mice compared with Lep^ob homozygotes

increased circulating insulin level ( J:155432 )

• in fasted mice compared with Lep^ob homozygotes

abnormal lipid homeostasis ( J:155432 )

• mice exhibit reduced lipogenesis compared to in Lep^ob homozygotes

decreased circulating cholesterol level ( J:155432 )

• modest

decreased liver triglyceride level ( J:155432 )

• compared with Lep^ob homozygotes

growth/size/body

decreased body weight ( J:155432 )

• compared with Lep^ob homozygotes

liver/biliary system

decreased liver triglyceride level ( J:155432 )

• compared with Lep^ob homozygotes

decreased liver weight ( J:155432 )

• compared with Lep^ob homozygotes

Allelic Composition	Akt2^tm1.1Mbb/Akt2^tm1.1Mbb Tg(MMTV-Erbb2)NK1Mul/Tg(MMTV-Erbb2)NK1Mul
Genetic Background	involves: 129 * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt2^tm1.1Mbb mutation (2 available); any Akt2 mutation (51 available)
Tg(MMTV-Erbb2)NK1Mul mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:117336 )

• female virgin mice develop mammary tumors by 45 weeks of age which is significantly earlier than occurs in mice carrying the transgene on a wild-type background

• intravascular metastasis of adenocarcinomas into the lung occurs in some mice

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:117336 )

• female virgin mice develop mammary tumors by 45 weeks of age which is significantly earlier than occurs in mice carrying the transgene on a wild-type background

• intravascular metastasis of adenocarcinomas into the lung occurs in some mice

integument

increased mammary adenocarcinoma incidence ( J:117336 )

• female virgin mice develop mammary tumors by 45 weeks of age which is significantly earlier than occurs in mice carrying the transgene on a wild-type background

• intravascular metastasis of adenocarcinomas into the lung occurs in some mice

Allelic Composition	Akt2^tm1.1Mbb/Akt2^tm1.1Mbb Tg(MMTV-PyVT)634Mul/0
Genetic Background	involves: 129 * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt2^tm1.1Mbb mutation (2 available); any Akt2 mutation (51 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:117336 )

• female virgin mice develop mammary tumors by 11 weeks of age which is significantly earlier than in mice carrying the transgene on a wild-type background

• parenchymal metastases of the tumors are found in the lung

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:117336 )

• female virgin mice develop mammary tumors by 11 weeks of age which is significantly earlier than in mice carrying the transgene on a wild-type background

• parenchymal metastases of the tumors are found in the lung

integument

increased mammary adenocarcinoma incidence ( J:117336 )

• female virgin mice develop mammary tumors by 11 weeks of age which is significantly earlier than in mice carrying the transgene on a wild-type background

• parenchymal metastases of the tumors are found in the lung

Allelic Composition	Akt2^tm1.1Mbb/Akt2^tm1.1Mbb Akt3^tm1Mbb/Akt3^tm1Mbb
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt2^tm1.1Mbb mutation (2 available); any Akt2 mutation (51 available)
Akt3^tm1Mbb mutation (0 available); any Akt3 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:135903 )

• no abnormalities in T cell development are observed

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