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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Psen1tm1Mpm
targeted mutation 1, Mark P Mattson
MGI:1930937
Summary 12 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Psen1tm1Mpm/Psen1tm1Mpm involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:2174994
ht2
Psen1tm1Mpm/Psen1tm1Shn involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ MGI:5292245
ht3
Psen1tm1Mpm/Psen1tm1Pcw involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 MGI:3702925
cx4
Apptm1Ck/Apptm1Ck
Psen1tm1Mpm/Psen1tm1Mpm
Tg(MAPT)8cPdav/0
B6.Cg-Psen1tm1Mpm Apptm1Ck Tg(MAPT)8cPdav MGI:5581681
cx5
Psen1tm1Mpm/Psen1tm1Mpm
Tg(APPSwe,tauP301L)1Lfa/?
B6.Cg-Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa MGI:5003275
cx6
Apptm1Ck/Apptm1Ck
Psen1tm1Mpm/Psen1tm1Mpm
involves: 129 * 129S1/Sv * 129X1/SvJ MGI:4847595
cx7
Cx3cr1tm1Litt/Cx3cr1tm1Litt
Psen1tm1Mpm/Psen1tm1Mpm
Tg(APPSwe,tauP301L)1Lfa/0
Tg(Thy1-YFP)HJrs/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:4834196
cx8
Cx3cr1tm1Litt/Cx3cr1+
Psen1tm1Mpm/Psen1tm1Mpm
Tg(APPSwe,tauP301L)1Lfa/0
Tg(Thy1-YFP)HJrs/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:4834197
cx9
Apptm3.1Zhe/Apptm3.1Zhe
Psen1tm1Mpm/Psen1tm1Mpm
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 MGI:4847594
cx10
Psen1tm1Mpm/Psen1tm1Mpm
Tg(APPSwe,tauP301L)1Lfa/Tg(APPSwe,tauP301L)1Lfa
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3720782
cx11
Psen1tm1Mpm/Psen1tm1Mpm
Tg(APPSwe,tauP301L)1Lfa/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3720789
cx12
Psen1tm1Mpm/Psen1tm1Mpm
Tg(APPSWE)2576Kha/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:5292247


Genotype
MGI:2174994
hm1
Allelic
Composition
Psen1tm1Mpm/Psen1tm1Mpm
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Mpm mutation (2 available); any Psen1 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• kainate-induced degeneration and death of CA3, CA1, and hilar neurons is accelerated and increased in mutants compared to wild-type
• cultured hippocampal neurons show increased susceptibility to death induced by glutamate, due to impaired calcium homeostasis, increased oxidative stress, and mitochondrial dysfunction
• homozygotes are hypersensitive to seizure-induced synaptic degeneration and necrotic neuronal death in the hippocampus

behavior/neurological
N
• homozygotes do not exhibit a deficit in contextual fear learning at 3 months of age (J:91277)
• homozygous mice do not differ in performance in Morris water maze or in contextual fear conditioning (J:99604)

homeostasis/metabolism
• kainate-induced degeneration and death of CA3, CA1, and hilar neurons is accelerated and increased in mutants compared to wild-type
• cultured hippocampal neurons show increased susceptibility to death induced by glutamate, due to impaired calcium homeostasis, increased oxidative stress, and mitochondrial dysfunction

cellular
• kainate-induced degeneration and death of CA3, CA1, and hilar neurons is accelerated and increased in mutants compared to wild-type
• cultured hippocampal neurons show increased susceptibility to death induced by glutamate, due to impaired calcium homeostasis, increased oxidative stress, and mitochondrial dysfunction

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease 3 607822 J:51950
Alzheimer Disease; AD 104300 J:51950




Genotype
MGI:5292245
ht2
Allelic
Composition
Psen1tm1Mpm/Psen1tm1Shn
Genetic
Background
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Mpm mutation (2 available); any Psen1 mutation (28 available)
Psen1tm1Shn mutation (2 available); any Psen1 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

limbs/digits/tail
• limb ateliosis
• stubby

cardiovascular system
• in the central nervous system

growth/size/body




Genotype
MGI:3702925
ht3
Allelic
Composition
Psen1tm1Mpm/Psen1tm1Pcw
Genetic
Background
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Mpm mutation (2 available); any Psen1 mutation (28 available)
Psen1tm1Pcw mutation (0 available); any Psen1 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• exhibit impaired hippocampus-dependent contextual fear learning at 3 months of age, showing reduced freezing behavior
• however, show normal cued fear learning, anxiety, motor coordination and shock threshold

nervous system
• exhibit a 35% decrease in the number of newborn cells in the dentate gyrus of 3-month old mutants, indicating impaired adult neurogenesis

cellular
• exhibit a 35% decrease in the number of newborn cells in the dentate gyrus of 3-month old mutants, indicating impaired adult neurogenesis

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease 3 607822 J:91277
Alzheimer Disease; AD 104300 J:91277




Genotype
MGI:5581681
cx4
Allelic
Composition
Apptm1Ck/Apptm1Ck
Psen1tm1Mpm/Psen1tm1Mpm
Tg(MAPT)8cPdav/0
Genetic
Background
B6.Cg-Psen1tm1Mpm Apptm1Ck Tg(MAPT)8cPdav
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apptm1Ck mutation (0 available); any App mutation (20 available)
Psen1tm1Mpm mutation (2 available); any Psen1 mutation (28 available)
Tg(MAPT)8cPdav mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice show increased contextual freezing frequency at 4 and 12 months of age
• however, cued freezing frequency is unaffected and mice do not exhibit spatial memory deficits in the Morris water maze
• in the elevated plus maze, 4 month old mice spend less time on the open arm, indicating increased anxiety
• however, mice show normal nociception in the hot plate assay
• mice show slightly higher pre-shock freezing frequency and increased contextual freezing frequency at 4 and 12 months of age, indicating exaggerated fear response
• in the open field, the total travel distance is reduced at 12, but not 4, months of age, indicating age-dependent reduced activity

homeostasis/metabolism
• mice exhibit amyloid beta plaques on the outer edge of the cortex at 18-22 months of age which progress into inner layers of the cortex and hippocampus by 26-29 months of age

nervous system
• mice exhibit amyloid beta plaques on the outer edge of the cortex at 18-22 months of age which progress into inner layers of the cortex and hippocampus by 26-29 months of age
• increase in phosphorylated tau in the cortex and hippocampus

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:209782




Genotype
MGI:5003275
cx5
Allelic
Composition
Psen1tm1Mpm/Psen1tm1Mpm
Tg(APPSwe,tauP301L)1Lfa/?
Genetic
Background
B6.Cg-Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Mpm mutation (2 available); any Psen1 mutation (28 available)
Tg(APPSwe,tauP301L)1Lfa mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mutants attend less accurately to short, spatially unpredictable stimuli when the attentional demand of the task is high and also show a general tendency to make more perseverative responses than wild-type mice
• mutants initially respond as accurately as wild-type mice, however subsequently they fail to sustain their attention over the duration of the task, indicating reduced vigilance, or ability to sustain attention over a long period of time
• treatment of mice with the cholinesterase inhibitor donepezil results in an enhanced ability to sustain attention

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:170670




Genotype
MGI:4847595
cx6
Allelic
Composition
Apptm1Ck/Apptm1Ck
Psen1tm1Mpm/Psen1tm1Mpm
Genetic
Background
involves: 129 * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apptm1Ck mutation (0 available); any App mutation (20 available)
Psen1tm1Mpm mutation (2 available); any Psen1 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice exhibit decreased amyloid load compared with Apptm3.1Zhe Psen1tm1Mpm double homozygotes
• corticotropin releasing factor levels are increased in the lateral dorsal bed nucleus of the stria terminalis and the paraventricular nucleus

homeostasis/metabolism
• mice exhibit an increase in resting levels of circulating corticosterone
• mice exhibit decreased amyloid load compared with Apptm3.1Zhe Psen1tm1Mpm double homozygotes

behavior/neurological
• mice show increased freezing in the context in which they received the shock compared to wild-type mice but show similar levels of freezing as wild-type mice in cued fear (in response to sound), indicating increased contextual fear
• however, hot plate assay shows normal nociception
• in the alternation T-maze test, mice show decreased alternation, indicating reduced working memory
• in the elevated plus maze, mice spend more time in the closed arms and less time in the open arms and make fewer entries into the open arms and navigate less distance on the open arms, indicating increased levels of anxiety
• in the light-dark box test, mice spend more time in the closed portion of the box and less time in the open side, make fewer entries to the light side of the box, and spend on average more time on each visit to the dark side, suggesting an increase in hiding behavior and reduction in exploring
• mice show increased freezing in the context in which they received the shock compared to wild-type mice but show similar levels of freezing as wild-type mice in cued fear (in response to sound)
• during the cued trial, mice show increased baseline freezing levels in the 3 minutes before presentation of sound, however increased baseline freezing is not seen before mice are shocked

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:191170




Genotype
MGI:4834196
cx7
Allelic
Composition
Cx3cr1tm1Litt/Cx3cr1tm1Litt
Psen1tm1Mpm/Psen1tm1Mpm
Tg(APPSwe,tauP301L)1Lfa/0
Tg(Thy1-YFP)HJrs/0
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cx3cr1tm1Litt mutation (4 available); any Cx3cr1 mutation (19 available)
Psen1tm1Mpm mutation (2 available); any Psen1 mutation (28 available)
Tg(APPSwe,tauP301L)1Lfa mutation (0 available)
Tg(Thy1-YFP)HJrs mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• mice do not exhibit the neuron loss or increase in microglial density and migration velocity observed in Cx3cr1tm1Litt/Cx3cr1+ Psen1tm1Mpm/Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa mice




Genotype
MGI:4834197
cx8
Allelic
Composition
Cx3cr1tm1Litt/Cx3cr1+
Psen1tm1Mpm/Psen1tm1Mpm
Tg(APPSwe,tauP301L)1Lfa/0
Tg(Thy1-YFP)HJrs/0
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cx3cr1tm1Litt mutation (4 available); any Cx3cr1 mutation (19 available)
Psen1tm1Mpm mutation (2 available); any Psen1 mutation (28 available)
Tg(APPSwe,tauP301L)1Lfa mutation (0 available)
Tg(Thy1-YFP)HJrs mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• microglial density increases over time around lost neurons unlike in Cx3cr1tm1Litt/Cx3cr1tm1Litt Psen1tm1Mpm/Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa mice
• microglia migration velocity around lost neurons is 2-fold greater than in Cx3cr1tm1Litt heterozygotes and homozygotes
• of YFP+ layer III neurons at 4 to 6 months

immune system
• microglial density increases over time around lost neurons unlike in Cx3cr1tm1Litt/Cx3cr1tm1Litt Psen1tm1Mpm/Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa mice
• microglia migration velocity around lost neurons is 2-fold greater than in Cx3cr1tm1Litt heterozygotes and homozygotes

hematopoietic system
• microglial density increases over time around lost neurons unlike in Cx3cr1tm1Litt/Cx3cr1tm1Litt Psen1tm1Mpm/Psen1tm1Mpm Tg(APPSwe,tauP301L)1Lfa mice
• microglia migration velocity around lost neurons is 2-fold greater than in Cx3cr1tm1Litt heterozygotes and homozygotes




Genotype
MGI:4847594
cx9
Allelic
Composition
Apptm3.1Zhe/Apptm3.1Zhe
Psen1tm1Mpm/Psen1tm1Mpm
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apptm3.1Zhe mutation (0 available); any App mutation (20 available)
Psen1tm1Mpm mutation (2 available); any Psen1 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Amyloid beta deposits in Apptm3.1Zhe/Apptm3.1Zhe Psen1tm1Mpm/Psen1tm1Mpm mice

nervous system
• mice exhibit increased amyloid load compared with Apptm1Ck Psen1tm1Mpm double homozygotes

homeostasis/metabolism
• mice exhibit increased amyloid load compared with Apptm1Ck Psen1tm1Mpm double homozygotes




Genotype
MGI:3720782
cx10
Allelic
Composition
Psen1tm1Mpm/Psen1tm1Mpm
Tg(APPSwe,tauP301L)1Lfa/Tg(APPSwe,tauP301L)1Lfa
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Mpm mutation (2 available); any Psen1 mutation (28 available)
Tg(APPSwe,tauP301L)1Lfa mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• in Morris water mazed, learning of task is normal but retention is impaired; 6-month old mice require 6 days of training to achieve escape latency of >20 seconds, compared to 3 days in 2 month old control mice
• at 4 and 6 months, mice show longer escape latencies in the first daily trial relative to the last trial of the previous training day indicating day-to-day retention impairment; 2-month old mice do not show this impairment in retention
• short- (1.5 hr posttraining) and long-term (24 hr posttraining) spatial recognition memory in probe trials are impaired at 6 months, whereas 4-month old mice show similar performance at 1.5 hours and impaired retention at 24 hours
• after clearance of intraneuronal Abeta using antibodies, early retention deficits are ablated, whereas long-term retention remains impaired
• at 6 months, naive and trained mice display significantly impaired long- and short-term retention for contextual fear; at 4 months, mice have normal retention for short-term (1.5 hr) contextual fear but impaired memory of contextual fear at 24 hours

nervous system
• at 6 months, extracellular Abeta plaques are observed in the cerebral cortex, and intracellular accumulation is seen in pyramidal neurons of the CA1 region of hippocampus and within basolateral amygdala and cortical neurons
• prominent intraneuronal Abeta accumulation is present at 4 months, preceding extracellular amyloid plaque formation
• treatment of mice with antibodies to Abeta results in clearance of intraneuroanl Abeta in hippocampus and cortex, but not in amygdala

homeostasis/metabolism
• at 6 months, extracellular Abeta plaques are observed in the cerebral cortex, and intracellular accumulation is seen in pyramidal neurons of the CA1 region of hippocampus and within basolateral amygdala and cortical neurons
• prominent intraneuronal Abeta accumulation is present at 4 months, preceding extracellular amyloid plaque formation
• treatment of mice with antibodies to Abeta results in clearance of intraneuroanl Abeta in hippocampus and cortex, but not in amygdala

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:99604




Genotype
MGI:3720789
cx11
Allelic
Composition
Psen1tm1Mpm/Psen1tm1Mpm
Tg(APPSwe,tauP301L)1Lfa/?
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Mpm mutation (2 available); any Psen1 mutation (28 available)
Tg(APPSwe,tauP301L)1Lfa mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• Abeta oligomers begin to accumulate between 2 and 6 months of age, with continued age-dependent increase observed between 12 and 20 months
• intraneuronal oligomers are detected at 4-6 months of age
• tau pathology is detected initially by 6 months of age, and tangle pathology is advanced by 20 months

homeostasis/metabolism
• Abeta oligomers begin to accumulate between 2 and 6 months of age, with continued age-dependent increase observed between 12 and 20 months
• intraneuronal oligomers are detected at 4-6 months of age




Genotype
MGI:5292247
cx12
Allelic
Composition
Psen1tm1Mpm/Psen1tm1Mpm
Tg(APPSWE)2576Kha/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Psen1tm1Mpm mutation (2 available); any Psen1 mutation (28 available)
Tg(APPSWE)2576Kha mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice accumulate more plaques than in Psen1tm1.1Tcs/Psen1tm1.1Tcs Tg(APPSWE)2576Kha mice

homeostasis/metabolism
• mice accumulate more plaques than in Psen1tm1.1Tcs/Psen1tm1.1Tcs Tg(APPSWE)2576Kha mice





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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory