All Phenotypes Notch1<tm1Con> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Notch1^tm1Con
targeted mutation 1, Ronald L Conlon
MGI:1857230

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Notch1^tm1Con/Notch1^tm1Con	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)	MGI:2175157
hm2	Notch1^tm1Con/Notch1^tm1Con	involves: 129S1/Sv * 129X1/SvJ	MGI:3713582
ht3	Notch1^tm1Con/Notch1⁺	involves: 129S1/Sv * 129X1/SvJ * CD-1	MGI:6236250
cn4	Notch1^tm1Con/Notch1^tm1Grid Tg(Pax2-cre)1Akg/0	involves: 129S1/Sv * 129X1/SvJ	MGI:3713803
cx5	Notch1^tm1Con/Notch1⁺ Notch2^tm3.1Rko/Notch2^tm3.1Grid	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5523684
cx6	Mib1^em2Jlp/Mib1⁺ Notch1^tm1Con/Notch1⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:7544912
cx7	Mib1^em1Jlp/Mib1⁺ Notch1^tm1Con/Notch1⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:7544913

Allelic Composition	Notch1^tm1Con/Notch1^tm1Con
Genetic Background	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch1^tm1Con mutation (3 available); any Notch1 mutation (115 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:25248 )

• most mutants are dead at E10 and all die by E11

embryo

abnormal rostral-caudal axis patterning ( J:25248 )

• show a deficit in posterior development at E9

embryonic growth arrest ( J:25248 , J:62882 )

• growth arrest at the 14 somite stage (J:25248)

decreased embryo size ( J:25248 )

• embryos are smaller at E9

kinked neural tube ( J:62882 )

• neural tube kinks are seen extending posterior to the forelimb

notochord degeneration ( J:25248 )

• the notochord degenerates after growth arrest

abnormal somite development ( J:25248 , J:62882 )

• mutants exhibit a lack of coordination in segmentation of the somites, leading to variable somite size and misalignment of the somites across the midline of the embryo (J:25248)

• transition from presomitic mesoderm to the somite is disordered (J:25248)

• the most recently formed somites are not as tightly packed as those of wild-type and the epithelialization sometimes appears incomplete (J:25248)

abnormal left-right axis symmetry of the somites ( J:25248 )

• lack of coordination across the midline in the segmentation of somites, where segmentation is sometimes present on one side but not the other

abnormal somite size ( J:25248 )

• variable somite size

delayed somite formation ( J:25248 )

• mutants exhibit a delay in segmentation of the somites

growth/size/body

decreased embryo size ( J:25248 )

• embryos are smaller at E9

cardiovascular system

distended pericardium ( J:25248 , J:62882 )

• distended pericardia at E9 (J:25248)

cellular

abnormal cell death ( J:25248 )

• an increase in cell death is seen in embryos after they arrest

nervous system

kinked neural tube ( J:62882 )

• neural tube kinks are seen extending posterior to the forelimb

Allelic Composition	Notch1^tm1Con/Notch1^tm1Con
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch1^tm1Con mutation (3 available); any Notch1 mutation (115 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal myocardium layer morphology ( J:119151 )

• the endocardium does not surround the myocardium, which shows irregular thickness

trabecula carnea hypoplasia ( J:119151 )

disorganized myocardium ( J:119151 )

• less-structured myocardium

muscle

abnormal myocardium layer morphology ( J:119151 )

• the endocardium does not surround the myocardium, which shows irregular thickness

trabecula carnea hypoplasia ( J:119151 )

disorganized myocardium ( J:119151 )

• less-structured myocardium

Allelic Composition	Notch1^tm1Con/Notch1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch1^tm1Con mutation (3 available); any Notch1 mutation (115 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:187551 )

N	• mice fed a hypercholesterolemic diet supplemented with vitamin D (HCVD), exhibit normal echocardiography measurements

calcified aortic valve cusp ( J:187551 )

• mice fed the HCVD diet exhibit a moderate level of aortic valve leaflet calcification

thick aortic valve cusps ( J:187551 )

• leaflets are thicker in mice fed control chow and diet does not have an effect on leaflet thickness

aortic valve inflammation ( J:187551 )

• mice exhibit increased aortic valve inflammation when fed the HCVD diet, showing increased macrophage infiltration in the leaflets

immune system

aortic valve inflammation ( J:187551 )

• mice exhibit increased aortic valve inflammation when fed the HCVD diet, showing increased macrophage infiltration in the leaflets

Allelic Composition	Notch1^tm1Con/Notch1^tm1Grid Tg(Pax2-cre)1Akg/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch1^tm1Con mutation (3 available); any Notch1 mutation (115 available)
Notch1^tm1Grid mutation (0 available); any Notch1 mutation (115 available)
Tg(Pax2-cre)1Akg mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:119907 )

• embryos are normal at E12.5, but die at E13.5

renal/urinary system

renal/urinary system phenotype ( J:119907 )

N	• metanephroi appear normal morphologically and histologically when cultured at E12.5

cardiovascular system

abnormal vascular development ( J:119907 )

internal hemorrhage ( J:119907 )

Allelic Composition	Notch1^tm1Con/Notch1⁺ Notch2^tm3.1Rko/Notch2^tm3.1Grid
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch1^tm1Con mutation (3 available); any Notch1 mutation (115 available)
Notch2^tm3.1Grid mutation (0 available); any Notch2 mutation (97 available)
Notch2^tm3.1Rko mutation (0 available); any Notch2 mutation (97 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:198632 )

N	• kidneys have functional nephrons in normal numbers; one copy of the Notch1 intracellular domain (N1ICD) expressed from the Notch2 locus is sufficient for nephron formation

Allelic Composition	Mib1^em2Jlp/Mib1⁺ Notch1^tm1Con/Notch1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mib1^em2Jlp mutation (0 available); any Mib1 mutation (55 available)
Notch1^tm1Con mutation (3 available); any Notch1 mutation (115 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:338889 )

N	• normal ventricular morphology

abnormal aortic valve morphology ( J:338889 )

• in E16.5 embryos

bicuspid aortic valve ( J:338889 )

• in E16.5 embryos

Allelic Composition	Mib1^em1Jlp/Mib1⁺ Notch1^tm1Con/Notch1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mib1^em1Jlp mutation (0 available); any Mib1 mutation (55 available)
Notch1^tm1Con mutation (3 available); any Notch1 mutation (115 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:338889 )

N	• normal valve morphology in E16.5 embryos

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