Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrc mutation
(79 available);
any
Tyr mutation
(375 available)
Tyrc-13J mutation
(0 available);
any
Tyr mutation
(375 available)
|
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integument
pigmentation
vision/eye
Allelic Composition |
Tyrc/Tyrc-43H
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|
Genetic Background |
involves: 101/H * C3H/HeH |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrc mutation
(79 available);
any
Tyr mutation
(375 available)
Tyrc-43H mutation
(0 available);
any
Tyr mutation
(375 available)
|
|
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integument
pigmentation
vision/eye
Allelic Composition |
Tyrc/Tyrc-44H
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Genetic Background |
involves: 101/H * C3H/HeH |
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pigmentation
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• mice are white, albino as expected
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• some, but not all mice, have eye color darker than typical of albino mice
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vision/eye
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• some, but not all mice, have eye color darker than typical of albino mice
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integument
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• mice are white, albino as expected
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Allelic Composition |
Tyrc-146G/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-14CoS/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-15DSD/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-15R145M/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-15R60L/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-16DFiOD/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-16HATh/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-177G/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-17UThc/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-19DTR/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-1DThWb/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-1FAFyh/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-1FATw/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-1FR60Hb/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-202G/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-20FATw/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-23DVT/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-24R145L/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-24R75M/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-27FrThc/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-2CHLb/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-2MLPm/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-2R145L/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-7R250H/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-4PB/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-39SAS/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-3R60L/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-3R145L/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-9FR60Hb/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-AL/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-4FR60Hd/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-5FR60Hg/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-LA/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-65K/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrc mutation
(79 available);
any
Tyr mutation
(375 available)
Tyrc-65K mutation
(0 available);
any
Tyr mutation
(375 available)
|
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Allelic Composition |
Tyrc-31HATh/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-32DSD/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-38R145L/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-3FAFyh/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-3FR60Hb/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-45DSD/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-4CFO/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-51DTD/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-62DSD/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-65G/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-6THO-IV/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-76UT/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-77HATh/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-7THO-II/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-9Pub/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-36FrS/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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pigmentation
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• hair pigment reduced or altered all over
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integument
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• hair pigment reduced or altered all over
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Allelic Composition |
Tyrc-3DENb/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-8FrS/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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pigmentation
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• hair pigment reduced or altered all over
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integument
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• hair pigment reduced or altered all over
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Allelic Composition |
Tyrc-10FR60L/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-10R75M/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-112K/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-11DSD/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-12HATh/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-2YPSj/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-3YPSd/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc-68G/Tyrc
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Genetic Background |
involves: 101/Rl * C3H/Rl |
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Allelic Composition |
Tyrc/Tyrc-26DVT
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Genetic Background |
involves: 101/Rl * C3H/Rl * T-stock |
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Allelic Composition |
Tyrc/Tyrc-ch83R
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Genetic Background |
involves: 101/Rl * C3H/Rl * T-stock |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrc mutation
(79 available);
any
Tyr mutation
(375 available)
Tyrc-ch83R mutation
(0 available);
any
Tyr mutation
(375 available)
|
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integument
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• hair pigmentation is reduced to a greater extent than that of mice homozygous for Tyrc-ch83R, but not absent as in that of Tyrc (albino) homozygotes
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pigmentation
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• hair pigmentation is reduced to a greater extent than that of mice homozygous for Tyrc-ch83R, but not absent as in that of Tyrc (albino) homozygotes
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Allelic Composition |
Tyrc-h/Tyrc
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Genetic Background |
involves: AKR/J * DBA/2J |
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pigmentation
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• coats of juvenile mice are very pale buff
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• coloring is intermediate between pink of albinos and deep ruby of homozygous himalayan
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vision/eye
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• coloring is intermediate between pink of albinos and deep ruby of homozygous himalayan
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integument
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• although indistinguishable from albino at birth coat color is intermediate between albino and homozygous himalayan at about one week of age
• with the first molt extremities darken but not as dark as seen in the homozygote
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• coats of juvenile mice are very pale buff
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Allelic Composition |
Tyrc/Tyrc-ch62H
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Genetic Background |
involves: BALB/c * C3H/HeH |
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integument
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• the hair coats of mice with this allele combination are cream colored
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pigmentation
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• the hair coats of mice with this allele combination are cream colored
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• mice with this allele combination have cream colored hair coats and ruby colored eyes
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• the eyes of mice with this allele combination are ruby colored
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vision/eye
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• the eyes of mice with this allele combination are ruby colored
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Allelic Composition |
Tyrc/Tyrc-ch49H
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Genetic Background |
involves: C3H/HeH |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrc mutation
(79 available);
any
Tyr mutation
(375 available)
Tyrc-ch49H mutation
(0 available);
any
Tyr mutation
(375 available)
|
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Allelic Composition |
Tyrc/Tyrc-a
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Genetic Background |
involves: C3H/HeJ |
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pigmentation
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• slightly off-white coat color
• ear and tail hairs are slightly sooty
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• eyes are dark but no comparison to wild-type given
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vision/eye
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• eyes are dark but no comparison to wild-type given
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integument
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• slightly off-white coat color
• ear and tail hairs are slightly sooty
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Allelic Composition |
Tyrcm1OR/Tyrc
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Genetic Background |
involves: C3H/Rl |
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pigmentation
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• areas of white and wild-type agouti fur
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integument
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• areas of white and wild-type agouti fur
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Allelic Composition |
Tyrc/Tyrem3Ove
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Genetic Background |
involves: C57BL/6 * FVB |
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vision/eye
integument
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• these compound heterozygotes have white fur and black eyes
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pigmentation
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• these compound heterozygotes have white fur and black eyes
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Allelic Composition |
Tyrc/Tyrem5Ove
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Genetic Background |
involves: C57BL/6 * FVB |
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craniofacial
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• the ears of these compound heterozygous mice appear lighter gray than those of Tyrem5Ove homozygotes
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growth/size/body
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• the ears of these compound heterozygous mice appear lighter gray than those of Tyrem5Ove homozygotes
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hearing/vestibular/ear
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• the ears of these compound heterozygous mice appear lighter gray than those of Tyrem5Ove homozygotes
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integument
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• the ears of these compound heterozygous mice appear lighter gray than those of Tyrem5Ove homozygotes
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pigmentation
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• the ears of these compound heterozygous mice appear lighter gray than those of Tyrem5Ove homozygotes
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vision/eye
Allelic Composition |
Tyrc/Tyrem8Ove
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Genetic Background |
involves: C57BL/6 * FVB |
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integument
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• the fur of these Tyr compound heterozygous mice is very light-colored
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pigmentation
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• the fur of these Tyr compound heterozygous mice is very light-colored
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• the eyes of these mice are lightly pigmented
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vision/eye
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• the eyes of these mice are lightly pigmented
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Allelic Composition |
Tyrc-Bc/Tyrc
|
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Genetic Background |
involves: SELH/Bc * SWV/Bc |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrc mutation
(79 available);
any
Tyr mutation
(375 available)
Tyrc-Bc mutation
(0 available);
any
Tyr mutation
(375 available)
|
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|
pigmentation
|
• affected mice are albino
|
vision/eye
integument
|
• affected mice are albino
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Allelic Composition |
Tyrc-p/Tyrc
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Genetic Background |
Not Specified |
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pigmentation
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• the coat is intermediate between the homozygote and albino
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integument
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• the coat is intermediate between the homozygote and albino
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(7)Tyrc-3H mutation
(0 available);
any
Del(7)Tyrc-3H mutation
(0 available)
Tyrc mutation
(79 available);
any
Tyr mutation
(375 available)
|
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mortality/aging
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• embryonic lethality, however time of lethality is not provided
• treatment of pregnant heterozygous females with L-Dopa, a catecholamine precursor compound, from E8.5 until birth, can rescue the embryonic lethality of homozygotes
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homeostasis/metabolism
pigmentation
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• hair follicles lack stage III and IV melanosomes
• however, stage I and II melanosomes are normal
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integument
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• hair follicles lack stage III and IV melanosomes
• however, stage I and II melanosomes are normal
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pigmentation
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• absence of fibrillar melanosomes in the choroid and retina
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• number of granules diminishes in adults after birth
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• number of granules diminishes in adults after birth
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• absence of melanin deposition on premelanosome filaments
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vision/eye
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• number of granules diminishes in adults after birth
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• number of granules diminishes in adults after birth
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integument
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• the fur of these Tyr compound heterozygous mice on a nonagouti background appears medium gray
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pigmentation
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• the fur of these Tyr compound heterozygous mice on a nonagouti background appears medium gray
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Allelic Composition |
a/a Tyrc/Tyrem2Ove
|
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Genetic Background |
involves: C57BL/6 * FVB |
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integument
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• on a nonagouti background, the fur of these compound Tyr heterozygotes appears lighter gray than that of mice homozygous for Tyrem2Ove
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pigmentation
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• on a nonagouti background, the fur of these compound Tyr heterozygotes appears lighter gray than that of mice homozygous for Tyrem2Ove
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• these mice exhibit lighter ocular pigmentation than Tyrem2Ove homozygotes
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vision/eye
|
• these mice exhibit lighter ocular pigmentation than Tyrem2Ove homozygotes
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Allelic Composition |
A/? Tyrc/Tyrem12Ove
|
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Genetic Background |
involves: C57BL/6 * FVB |
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integument
|
• the fur of these Tyr compound heterozygous mice on an agouti background appears very light brown
|
pigmentation
|
• the fur of these Tyr compound heterozygous mice on an agouti background appears very light brown
|
Allelic Composition |
A/? Tyrc/Tyrem1Ove
|
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Genetic Background |
involves: C57BL/6 * FVB |
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integument
|
• mice with this compound heterozygous tyrosinase genotype on an agouti background appear light agouti.
|
pigmentation
|
• mice with this compound heterozygous tyrosinase genotype on an agouti background appear light agouti.
|
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• these compound Tyr heterozygotes on an agouti background exhibit reduced eye pigmentation at birth.
|
vision/eye
|
• these compound Tyr heterozygotes on an agouti background exhibit reduced eye pigmentation at birth.
|
Allelic Composition |
a/a Tyrc/Tyrem4Ove
|
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Genetic Background |
involves: C57BL/6 * FVB |
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integument
|
• the fur of these mice appears medium gray
|
pigmentation
|
• the fur of these mice appears medium gray
|
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• the eyes of these mice exhibit altered pigmentation
|
vision/eye
|
• the eyes of these mice exhibit altered pigmentation
|
Allelic Composition |
A/? Tyrc/Tyrem6Ove
|
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Genetic Background |
involves: C57BL/6 * FVB |
|
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|
integument
|
• the fur of these Tyr compound heterozygous mice on an agouti background appears lighter tan than that of Tyrem6Ove homozygotes.
|
pigmentation
|
• the fur of these Tyr compound heterozygous mice on an agouti background appears lighter tan than that of Tyrem6Ove homozygotes.
|
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• eyes are dark with mosaic pigmentation
|
vision/eye
|
• eyes are dark with mosaic pigmentation
|
Allelic Composition |
A/? Tyrc/Tyrem7Ove
|
|
Genetic Background |
involves: C57BL/6 * FVB |
|
|
|
integument
|
• the fur of these compound Tyr mutant mice appears light agouti
|
pigmentation
|
• the fur of these compound Tyr mutant mice appears light agouti
|
Allelic Composition |
a/a Tyrc/Tyrem9Ove
|
|
Genetic Background |
involves: C57BL/6 * FVB |
|
|
|
integument
|
• the fur of these Tyr compound heterozygous mice on a nonagouti background appears dark gray
|
pigmentation
|
• the fur of these Tyr compound heterozygous mice on a nonagouti background appears dark gray
|
Allelic Composition |
A/? Tyrc/Tyrem13Ove
|
|
Genetic Background |
involves: C57BL/6 * FVB |
|
|
|
pigmentation
N |
• normal agouti pigmentation
|
Allelic Composition |
a/a Tyrc/Tyrc
|
|
Genetic Background |
involves: C57BL/6J |
|
|
|
pigmentation
|
• premelanosomes form normally but melanin is not deposited on the filaments and they never mature and eventually disappear in the retina
|
Pale yellow coat and cataracts in the Tdo2chky/Tdo2chky Tyrc/Tyrc mouse
pigmentation
|
• on an albino background mice homozygous for the chick yellow mutation have a slightly yellow coat color, which is evident by approximately 10 days of age when the first coat comes in
|
vision/eye
|
• very early signs of cataracts are found at one month of age, lens extrusion and early signs of cataracts are found at 3 months of age, and retinal degeneration and cataracts are found at 7 months of age and thereafter
|
integument
|
• on an albino background mice homozygous for the chick yellow mutation have a slightly yellow coat color, which is evident by approximately 10 days of age when the first coat comes in
|