Tyr^c-Bc
Spontaneous Allele Detail

Summary

• Symbol: Tyr^c-Bc
• Name: tyrosinase; albino British Columbia
• MGI ID: MGI:1856301
• Synonyms: c^Bc
• Gene: Tyr Location: Chr7:87073979-87142637 bp, - strand Genetic Position: Chr7, 49.01 cM
• Alliance: Tyr^c-Bc page

Mutation origin

• Strain of Origin: SELH/Bc

Mutation description

• Allele Type: Spontaneous
• Mutation: Intergenic deletion
• Mutation details: This allele involves a deletion of as much as 2 cM including exons 1, 2, and 3 of Tyr, the Mod-2 locus and a gene essential for postimplantation survival. (J:18053)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tyr Mutation: 375 strains or lines available

Notes

Tyr^c-Bc, albino British Columbia, recessive. This spontaneous mutation arose in a male that appeared to be a somatic and germ line mosaic for the new albino allele. Homozygotes die soon after implantation. There is no activity of the Mod2 allele in cis with Tyr^c-Bc, and it is concluded that this mutation represents a deletion including the Tyr locus, Mod2, and a hypothetical locus essential for postimplantation survival (J:62). The Tyr^c-Bc mutation is a deletion of exons 1, 2, and 3, along with other Chr 7 loci (J:18053).

References

• Original: J:62 Juriloff DM, et al., Studies of a spontaneous lethal mutation at the albino locus in SELH/Bc mice. Genome. 1992 Apr;35(2):342-6
• All: 2 reference(s)