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Tyms Gene Detail
Summary
  • Symbol
    Tyms
  • Name
    thymidylate synthase
  • Synonyms
    TS
  • Feature Type
    protein coding gene
  • IDs
    MGI:98878
    NCBI Gene: 22171
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:30263200-30278615 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 15.81 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    135 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98878
 protein coding gene Chr5:30243544-30279261 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029381
 protein coding gene Chr5:28031837-28046154 (-)
A/J MGP_AJ_G0029347
 protein coding gene Chr5:27103128-27116093 (-)
AKR/J MGP_AKRJ_G0029298
 protein coding gene Chr5:28191195-28203727 (-)
BALB/cJ MGP_BALBcJ_G0029358
 protein coding gene Chr5:27628119-27642087 (-)
C3H/HeJ MGP_C3HHeJ_G0029079
 protein coding gene Chr5:28221619-28235067 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029811
 protein coding gene Chr5:29747075-29773510 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027049
 protein coding gene Chr5:24623728-24638030 (-)
CAST/EiJ MGP_CASTEiJ_G0028490
 protein coding gene Chr5:27318769-27330278 (-)
CBA/J MGP_CBAJ_G0029047
 protein coding gene Chr5:30289548-30302781 (-)
DBA/2J MGP_DBA2J_G0029196
 protein coding gene Chr5:27304640-27317176 (-)
FVB/NJ MGP_FVBNJ_G0029154
 protein coding gene Chr5:26699140-26715175 (-)
LP/J MGP_LPJ_G0029281
 protein coding gene Chr5:28467933-28480949 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029183
 protein coding gene Chr5:31245715-31260014 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029845
 protein coding gene Chr5:27753031-27766010 (-)
PWK/PhJ MGP_PWKPhJ_G0028214
 protein coding gene Chr5:26407472-26419953 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028045
 protein coding gene Chr5:27098157-27110694 (-)
WSB/EiJ MGP_WSBEiJ_G0028570
 protein coding gene Chr5:27807250-27822343 (-)



Homology
more
  • Human Ortholog
    TYMS, thymidylate synthetase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TYMS, thymidylate synthetase
  • Synonyms
    DKCD, HST422, TMS, TS
  • Links
    NCBI Gene ID: 7298
    neXtProt AC: NX_P04818
    UniProt: P04818

  • Chr Location
    18p11.32; chr18:657653-673578 (+)  GRCh38
Human Diseases
more
  • Diseases
    9 with human TYMS associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotype references
  • All Mutations and Alleles
    18
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    1
  • Gene trapped
    8
  • Radiation induced
    3
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    6 involving Tyms
  • Incidental Mutations
    Mutagenetix , APF
  • Find Mice (IMSR)
    20 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1478
  • Tissues
    165
  • cDNA Data
    60
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025747 Ensembl Gene Model | MGI Sequence Detail 15416 C57BL/6J ±  kb
transcript ENSMUST00000026846 Ensembl | MGI Sequence Detail 3163 Not Applicable  
polypeptide ENSMUSP00000026846 Ensembl | MGI Sequence Detail 307 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 71
    Genomic 8
    cDNA 60
    Other 3

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-15313
References
more
  • Summaries
    All 77
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 10
    Phenotypes 29
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory