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Tap1 Gene Detail
Summary
  • Symbol
    Tap1
  • Name
    transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
  • Synonyms
    Abcb2, Ham-1, Ham1, MTP1, PSF-1, RING4, TAP, Tap-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98483
    NCBI Gene: 21354
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:34406530-34416199 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98483
 protein coding gene Chr17:34406527-34416199 (+)
129S1/SvImJ ENSMUSG00200050046
 protein coding gene Chr17:30109633-30119317 (+)
A/J ENSMUSG00195046196
 protein coding gene Chr17:30974770-30984425 (+)
AKR/J ENSMUSG00220050257
 protein coding gene Chr17:30002416-30012065 (+)
BALB/cJ ENSMUSG00180028836
 protein coding gene Chr17:30363884-30373531 (+)
C3H/HeJ ENSMUSG00175048945
 protein coding gene Chr17:29888589-29898230 (+)
C57BL/6NJ ENSMUSG00215051139
 protein coding gene Chr17:29949811-29959494 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021447
 protein coding gene Chr17:30519378-30529108 (+)
CAST/EiJ ENSTCUG00005050866
 protein coding gene Chr17:30935192-30944864 (+)
CBA/J ENSMUSG00210049922
 protein coding gene Chr17:29710678-29720333 (+)
DBA/2J ENSMUSG00185051934
 protein coding gene Chr17:32383177-32392814 (+)
FVB/NJ ENSMUSG00205046281
 protein coding gene Chr17:30239011-30248834 (+)
JF1/MsJ ENSUMUG00000042533
 protein coding gene Chr17:31647103-31656791 (+)
LP/J ENSMUSG00230053612
 protein coding gene Chr17:33507981-33517658 (+)
NOD/ShiLtJ ENSMUSG00190050978
 protein coding gene Chr17:29862902-29872584 (+)
NZO/HlLtJ ENSMUSG00225053934
 protein coding gene Chr17:35550828-35560815 (+)
PWK/PhJ ENSLUMG00010041813
 protein coding gene Chr17:29499111-29508927 (+)
SPRET/EiJ ENSMSPG00010037267
 protein coding gene Chr17:30631952-30641836 (+)
WSB/EiJ ENSIUOG00005047108
 protein coding gene Chr17:30567169-30576859 (+)



Homology
more
  • Human Ortholog
    TAP1, transporter 1, ATP binding cassette subfamily B member
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TAP1, transporter 1, ATP binding cassette subfamily B member
  • Synonyms
    ABC17, ABCB2, APT1, D6S114E, MHC1D1, PSF-1, PSF1, RING4, TAP1*0102N, TAP1N
  • Links
    NCBI Gene ID: 6890
    UniProt: Q03518

  • Chr Location
    6p21.32; chr6:32845206-32854018 (-)  GRCh38
Human Diseases
more
  • Diseases
    14 with human TAP1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 6 alleles in 8 genetic backgrounds
    19 phenotypes from multigenic genotypes
    215 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for targeted mutations that inactivate the gene are deficient in antigen presentation, surface class I antigens, and CD4-8+ T cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    72
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    748
  • Tissues
    109
  • cDNA Data
    28
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 21354 NCBI Gene Model | MGI Sequence Detail 9670 C57BL/6J ±  kb
transcript NM_013683 RefSeq | MGI Sequence Detail 2950 ZRU/MplStud  
polypeptide P21958 UniProt | EBI | MGI Sequence Detail 724 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 46
    Genomic 14
    cDNA 29
    Primer pair 2
    Other 1
    Antibodies 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-10612, MGD-MRK-10614, MGD-MRK-14712, MGD-MRK-14714
References
more
  • Summaries
    All 325
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 14
    Phenotypes 215
  • Earliest
    J:10934 Monaco JJ, et al., Transport protein genes in the murine MHC: possible implications for antigen processing. Science. 1990 Dec 21;250(4988):1723-6
  • Latest
    J:384826 Lauder E, et al., MHC class I on target cells regulates CD4(+) T cell-mediated immunity. Nat Immunol. 2026 May;27(5):1000-1012
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory