Snap25 MGI Mouse Gene Detail - MGI:98331 - synaptosomal-associated protein 25

Symbol

Snap25
Name

synaptosomal-associated protein 25
Synonyms

Bdr, GENA 70, SNAP-25, sp

Feature Type

protein coding gene
IDs

MGI:98331
NCBI Gene: 20614
Alliance

gene page
Transcription Start Sites

29 TSS

Sequence Map

Chr2:136555373-136624348 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 67.56 cM
Mapping Data

18 experiments

SNPs within 2kb

475 from dbSNP Build 142
Strain Annotations

18
RFLP

5

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98331	protein coding gene	Chr2:136555359-136624348 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026559	protein coding gene	Chr2:140504095-140575446 (+)
A/J	MGP_AJ_G0026523	protein coding gene	Chr2:134808184-134877650 (+)
AKR/J	MGP_AKRJ_G0026497	protein coding gene	Chr2:138675097-138744092 (+)
BALB/cJ	MGP_BALBcJ_G0026535	protein coding gene	Chr2:135185303-135254181 (+)
C3H/HeJ	MGP_C3HHeJ_G0026278	protein coding gene	Chr2:139125246-139194769 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026980	protein coding gene	Chr2:144722519-144793058 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024357	protein coding gene	Chr2:129348873-129419949 (+)
CAST/EiJ	MGP_CASTEiJ_G0025739	protein coding gene	Chr2:139500948-139574896 (+)
CBA/J	MGP_CBAJ_G0026258	protein coding gene	Chr2:150116810-150187442 (+)
DBA/2J	MGP_DBA2J_G0026392	protein coding gene	Chr2:134166365-134235515 (+)
FVB/NJ	MGP_FVBNJ_G0026356	protein coding gene	Chr2:132748333-132817203 (+)
LP/J	MGP_LPJ_G0026496	protein coding gene	Chr2:140672848-140743996 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026376	protein coding gene	Chr2:153940436-154010748 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027035	protein coding gene	Chr2:138680033-138752218 (+)
PWK/PhJ	MGP_PWKPhJ_G0025475	protein coding gene	Chr2:133789006-133859021 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025277	protein coding gene	Chr2:137778404-137855380 (+)
WSB/EiJ	MGP_WSBEiJ_G0025813	protein coding gene	Chr2:139593623-139663249 (+)

Human Ortholog

SNAP25, synaptosome associated protein 25

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SNAP25, synaptosome associated protein 25
Synonyms

bA416N4.2, CMS18, dJ1068F16.2, RIC4, RIC-4, SEC9, SNAP, SNAP-25, SUP
Links

HGNC:11132

NCBI Gene ID: 6616

neXtProt AC: NX_P60880

UniProt: P60880
Chr Location

20p12.2; chr20:10172395-10308258 (+) GRCh38

MGI Vertebrate Homology

Snap25 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: SNAP25
Gene Tree

Snap25

Diseases

4 with Snap25 mouse models; 2 with human SNAP25 associations

Human Disease

Mouse Models

attention deficit hyperactivity disorder

IDs

View 2 models

obesity

IDs

View 1 model

schizophrenia

IDs

View 1 model

type 2 diabetes mellitus

IDs

View 1 model

congenital myasthenic syndrome 18

IDs

Down syndrome

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

3 with disease annotations

References

4 with disease annotations

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Phenotype Summary

73 phenotypes from 8 alleles in 11 genetic backgrounds
5 phenotypes from multigenic genotypes
3 images
116 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

2
Targeted

12
Transgenic

1
Genomic Mutations

3 involving Snap25
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a targeted null mutation are small size, blotchy in appearance, have dilated vascular channels, and brain defects, lack spontaneous or reflexive movement and evoked neurotransmitter release at E18.5, and die at birth. An ENU-induced mutant displays neurological abnormalities.

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All GO Annotations

115
GO References

44

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

960
Tissues

79
cDNA Data

16
Literature Summary

65

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA SNAP25

Xenbase snap25

ZFIN snap25a, snap25b

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All Sequences

64
RefSeq

29
UniProt

1
CCDS

CCDS16793.1, CCDS71153.1

Ensembl

ENSMUSG00000027273 (Evidence)
NCBI Gene

20614

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027273	Ensembl Gene Model \| MGI Sequence Detail	68976	C57BL/6J	± kb
transcript	ENSMUST00000028727	Ensembl \| MGI Sequence Detail	2116	Not Applicable
polypeptide	ENSMUSP00000028727	Ensembl \| MGI Sequence Detail	206	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000015312 synaptosomal-associated protein 25

(term hierarchy)
InterPro Domains

IPR000928 SNAP-25 domain

IPR039077 SNAP25, N-terminal SNARE motif, chordates

IPR000727 Target SNARE coiled-coil homology domain

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All nucleic 22

cDNA 19

Primer pair 3

Microarray probesets 3

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MGD-MRK-14461, MGI:1861990

Summaries

All 274

Developmental Gene Expression 65

Diseases 4

Gene Ontology 44

Phenotypes 116
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:339455 Lam RM, et al., PIEZO2 and perineal mechanosensation are essential for sexual function. Science. 2023 Aug 25;381(6660):906-910

TSS for Snap25:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr20405	Chr2:136555215-136555233 (+)	-149 bp
Tssr20406	Chr2:136555364-136555412 (+)	15 bp
Tssr20407	Chr2:136555427-136555448 (+)	65 bp
Tssr20408	Chr2:136555460-136555476 (+)	95 bp
Tssr20409	Chr2:136565694-136565698 (+)	10,323 bp
Tssr20410	Chr2:136597991-136598062 (+)	42,654 bp
Tssr20411	Chr2:136600224-136600250 (+)	44,864 bp
Tssr20412	Chr2:136605956-136605975 (+)	50,593 bp
Tssr20413	Chr2:136607309-136607322 (+)	51,943 bp
Tssr20414	Chr2:136612047-136612062 (+)	56,682 bp
Tssr20415	Chr2:136612066-136612072 (+)	56,696 bp
Tssr20416	Chr2:136614899-136614902 (+)	59,528 bp
Tssr20417	Chr2:136615844-136615881 (+)	60,490 bp
Tssr20418	Chr2:136615893-136615919 (+)	60,533 bp
Tssr20419	Chr2:136619250-136619261 (+)	63,883 bp
Tssr20420	Chr2:136619297-136619368 (+)	63,960 bp
Tssr20421	Chr2:136622991-136623001 (+)	67,623 bp
Tssr20422	Chr2:136623047-136623084 (+)	67,693 bp
Tssr20423	Chr2:136623092-136623144 (+)	67,745 bp
Tssr20424	Chr2:136623206-136623213 (+)	67,837 bp
Tssr20425	Chr2:136623281-136623290 (+)	67,913 bp
Tssr20426	Chr2:136623318-136623340 (+)	67,956 bp
Tssr20427	Chr2:136623377-136623392 (+)	68,012 bp
Tssr20428	Chr2:136623509-136623527 (+)	68,145 bp
Tssr20429	Chr2:136623681-136623690 (+)	68,313 bp
Tssr20430	Chr2:136623742-136623747 (+)	68,372 bp
Tssr20431	Chr2:136623757-136623762 (+)	68,387 bp
Tssr20432	Chr2:136623801-136623808 (+)	68,432 bp
Tssr20433	Chr2:136623855-136623862 (+)	68,486 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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