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Hba Complex/Cluster/Region Detail
Summary
  • Symbol
    Hba
  • Name
    hemoglobin alpha chain complex
  • Feature Type
    complex/cluster/region
  • IDs
    MGI:96014
    NCBI Gene: 15121
  • Cluster Members
    Hba-x, Hba-a1, Hba-a2 (3 members)
Location &
Maps
more
  • Sequence Map
    Genome coordinates not available from the current reference assembly.
  • Genetic Map
    Chromosome 11, cytoband A
  • Mapping Data
    78 experiments
Strain
Comparison
more
  • RFLP
Human Diseases
more
  • Diseases
    1 with Hba mouse models

Human Disease Mouse Models
      
IDs
View 8 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    6 with disease annotations
  • References
    9 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    45 phenotypes from 12 alleles in 14 genetic backgrounds
    78 phenotypes from multigenic genotypes
    178 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one knock-out allele exhibit lethality during fetal development, reduced size and anemia. Mice homozygous for another knock-out allele exhibit preweaning lethality, pallor and anemia.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • Literature Summary
  • Comparison Matrix
    Sequences &
    Gene Models
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 9
      cDNA 4
      Primer pair 1
      Other 9
    Other
    Accession IDs
    less
    MGD-MRK-10623
    References
    more
    • Summaries
      All 290
      Developmental Gene Expression 20
      Diseases 9
      Phenotypes 178
    • Earliest
      J:107 POPP RA, Studies on the mouse hemoglobin loci. II. Position of the hemoglobin locus with respect to albinism and shaker-1 loci. J Hered. 1962 Mar-Apr;53:73-80
    • Latest
      J:345251 Cendali FI, et al., Metabolic correlates to critical speed in murine models of sickle cell disease. Front Physiol. 2023;14:1151268

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory